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Bayesian Design in Clinical Trials
| Bayesian Design in Clinical Trials |
| Autore | Berchialla Paola |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (190 p.) |
| Soggetto topico |
Humanities
Social interaction |
| Soggetto non controllato |
dose-escalation
combination study modelling assumption interaction adaptive designs adaptive randomization Bayesian designs clinical trials predictive power target allocation Bayesian inference highest posterior density intervals normal approximation predictive analysis sample size determination bayesian meta-analysis clustering binary data priors frequentist validation Bayesian rare disease prior distribution meta-analysis sample size bridging studies distribution distance oncology phase I dose-finding dose–response bayesian inference prior elicitation latent dirichlet allocation clinical trial power-prior poor accrual Bayesian trial cisplatin doxorubicin oxaliplatin dose escalation PIPAC peritoneal carcinomatosis randomized controlled trial causal inference doubly robust estimation propensity score Bayesian monitoring futility rules interim analysis posterior and predictive probabilities stopping boundaries Bayesian trial design early phase dose finding treatment combinations optimal dose combination |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557608103321 |
Berchialla Paola
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Free Radical Research in Cancer
| Free Radical Research in Cancer |
| Autore | Čipak Gašparović Ana |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (192 p.) |
| Soggetto topico | Technology: general issues |
| Soggetto non controllato |
NQO1
NQO1*2 polymorphism quinone breast cancer menadione lapachone doxorubicin ascorbate oxidative stress reactive oxygen species sperm cancer chemotherapy antioxidant therapy antioxidant proteins chemoresistance oxaliplatin 5-Fluorouracil myelodysplastic syndromes carbonylation deferasirox ovary calcium channel Trolox granulosa cell tumor cell death mitochondria photodynamic therapy singlet oxygen nitric oxide light combination therapy antioxidants bleomycin cancer treatment chemotherapy-induced toxicity cisplatin free radicals methotrexate ozone therapy lung cancer cancer metabolism reactive oxygen species (ROS) therapy resistance new therapeutic strategies breast cancer stem cells 4-hydroxy-2-nonenal extracellular matrix NRF2 bardoxolone methyl prostate cancer castration-resistant prostate cancer androgen receptor (AR), AR-V7 anti-androgen enzalutamide androgen deprivation therapy cancer antioxidant triphala ayurveda chemoprevention and chemotherapy |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557152603321 |
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Čipak Gašparović Ana
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Gastrointestinal Cancers and Personalized Medicine
| Gastrointestinal Cancers and Personalized Medicine |
| Autore | Mini Enrico |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (136 p.) |
| Soggetto topico |
Medicine
Pharmacology |
| Soggetto non controllato |
neutrophil-to-lymphocyte ratio
lymphocyte-to-monocyte ratio prognosis rectal cancer mesorectum sphincter preserving molecular oncology precision medicine colorectal cancer targeted therapy molecular profiling pancreatic cysts thermal liquid biopsy differential scanning calorimetry diagnosis generalized linear models gene signature mRNA expression VANGL1 FFPE neurotoxicity oxaliplatin chemotherapy-induced peripheral neuropathy biomarker genomics neuropathy FOLFOX FOLFIRINOX XELOX gastrointestinal cancer LAG-3 immune checkpoint colon cancer survival microsatellite instability immunotherapy |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910566485503321 |
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Mini Enrico
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Micro/Nanofluidic and Lab-on-a-Chip Devices for Biomedical Applications
| Micro/Nanofluidic and Lab-on-a-Chip Devices for Biomedical Applications |
| Autore | Carvalho Violeta |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (232 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
protein biomarker
microarray microfluidic cassette multiplex measurement immunoassay point-of-care testing microfluidic device small intestine ex vivo histology embedded resin sectioning peptide biosensor lab-on-a-chip label-free detection peptide aptamers protein biomarkers microfluidic biochip troponin T computational simulations drug discovery organ-on-a-chip microfluidic devices preclinical models numerical simulations automation non-enzymatic DNA amplification L-DNA microfluidic fluorescence paper microfluidics sweat sensing hydrogels lactate osmotic pumping evaporation capillary wicking biochemical assay microfluidics cell trap RBC evolutionary algorithm generative design artificial intelligence organ-on-chip liver-on-chip liver disease multi-level microfluidic device live cell imaging long-term microscopy imaging focus drifting immersion oil viscosity bacterial population dynamics single-cell studies E. coli mother machine computational fluid dynamics cancer-on-chip xenograft colorectal cancer pharmacodynamics pharmacokinetics drug efficacy oxaliplatin microfabrication microphysiological system biophysical stimuli biochemical stimuli in vitro cell culture cortical neurons hippocampal neurons electrical stimulation Micro-Electrode Arrays engineered neuronal networks polydimethylsiloxane microchannels in vivo micro bioreactor additive manufacturing poly-(ethylene glycol)-diacrylate biocompatibility COVID-19 diagnosis image analysis PCR SARS-CoV-2 |
| ISBN | 3-0365-6099-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910639996703321 |
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Carvalho Violeta
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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PLGA Based Drug Carrier and Pharmaceutical Applications
| PLGA Based Drug Carrier and Pharmaceutical Applications |
| Autore | Pereira Maria Carmo |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (328 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
PLGA
nanoscaled drug delivery LED cancer serum stability reactive oxygen species cellular uptake terahertz spectroscopy microspheres drug delivery formulation development molecular mobility vitamin E tocopherol PLA core-shell nanoparticles controlled drug release BMP-2 PLGA nanoparticles Pluronic F68 oxaliplatin hydrogel intra-abdominal anti-adhesion barrier colorectal cancer experimental design fractional factorial design O6-methylguanine DNA methyltransferase (MGMT) protein glioblastoma multiforme smart nanocarriers folic acid verteporfin cisplatin SKOV-3 cells CHO-K1 cells electroporation theranostic cargo double emulsion approach NSAIDs polymeric film topical drug delivery trolamine salicylate triamcinolone acetonide microcrystal PLGA microsphere local delivery spray-drying technique intra-articular injection joint retention systemic exposure gadolinium drug release polymeric nanocarrier sorafenib theranostic nanoparticles PLGA-PEG nanoparticles platelet activation aggregation binding uptake tissue engineering Huntington's disease siRNA microcarriers mesenchymal stromal cells drug delivery systems microfluidics microparticles BMP-2-microspheres hydrogel system 17-βestradiol release bone regeneration osteoporosis poly-lactide-co-glycolide polylactic acid alginate ophthalmic drug delivery dexamethasone PLGA-NPs nanomedicine gastrointestinal tract paclitaxel in vivo imaging controlled release risperidone microcapsules oleogels electron microscopy three-dimensional X-ray imaging nano-CT biodegradable polymers hydroxy-stearic acid PLGA nanocapsules magnetic resonance imaging photoluminescence magnetic targeting multimodal imaging theranostics silicon microsphere |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557124003321 |
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Pereira Maria Carmo
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Sample Preparation in Metabolomics
| Sample Preparation in Metabolomics |
| Autore | Kuligowski Julia |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (208 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
metabolomics
sample preparation hydrophilic interaction liquid chromatography ion mobility spectrometry high resolution mass spectrometry design of experiments AMOPLS metabonomics metabolic profiling NMR nuclear magnetic resonance spectroscopy cell line human cell line MiaPaCa-2 Panc-1 AsPC-1 extracellular vesicles exosomes microvesicles biomarkers diagnostics metabolic pathways plant metabolomics forestry trees mass spectrometry metabolite extraction GC-MS LC-MS metadata standardization databases multicellular tumor spheroids metallodrugs oxaliplatin KP1339 method development IT-139 20% FCS harvesting extraction metabolites normalization electromembrane extraction cardiovascular disease multi-segment injection capillary electrophoresis–mass spectrometry liquid chromatography–mass spectrometry plant natural products drug discovery liquid chromatography gas chromatography human milk metabolome sampling liquid chromatography–mass spectrometry (LC-MS) nuclear magnetic resonance (NMR) gas chromatography–mass spectrometry (GC-MS) capillary electrophoresis—mass spectrometry (CE-MS) high-resolution magic angle spinning microscopic samples lipidomics LC-MS/MS human plasma |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557141203321 |
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Kuligowski Julia
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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