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Monitoring endogenous GPCRs: lessons for drug design
| Monitoring endogenous GPCRs: lessons for drug design |
| Autore | Dominique Massotte |
| Pubbl/distr/stampa | Frontiers Media SA, 2015 |
| Descrizione fisica | 1 electronic resource (134 p.) |
| Collana | Frontiers Research Topics |
| Soggetto non controllato |
opioid receptors
G protein coupled receptors CGamP mice FLIM fluorescent knock-in mice receptor heteromerization Endogenous receptors cannabinoid receptors biased signaling Opiate tolerance |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Monitoring endogenous GPCRs |
| Record Nr. | UNINA-9910137094503321 |
Dominique Massotte
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| Frontiers Media SA, 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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New Perspectives in Health : Gut Microbiota
| New Perspectives in Health : Gut Microbiota |
| Autore | Cardona Mena Diana María |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (196 p.) |
| Soggetto topico | Public health & preventive medicine |
| Soggetto non controllato |
gut microbiota
anti-TNFα Crohn's disease Faecalibacterium prausnitzii Escherichia coli and Clostridium coccoides group obesity percutaneous electrical stimulation dermatome T6 microbiota probiotics resistance survivability gastrointestinal passage gut nicotinic acetylcholine receptors α7 and α9 nicotinic receptor subtypes cholinergic anti-inflammatory pathway gut-brain axis gut microbiome dysbiosis inflammatory bowel disease COVID-19 dioxide titanium TiO2 E171 CI 77891 food additive gut barrier immunity toxicity diet memory attention gastrointestinal microbiome fibromyalgia drug therapy neoplasms radiotherapy systematic review autoimmunity multiple sclerosis inflammation cytokines intestinal permeability disease modifying drugs food-derived opioids casomorphin gliadorphin opioid receptors A1 beta-casein beta-casomorphin-7 gut-to-brain microbiome DPP4 fecal microbiota isoflavones equol pyrosequencing menopause fatty acids stool stool collection Cambodia sample collection rural health collection kit allergy osteoporosis bone metabolism food allergy skeletal health osteoimmunology |
| ISBN | 3-0365-5280-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | New Perspectives in Health |
| Record Nr. | UNINA-9910619466203321 |
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Cardona Mena Diana María
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| MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery II
| Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery II |
| Autore | Spetea Mariana |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (260 p.) |
| Soggetto topico |
Research & information: general
Chemistry |
| Soggetto non controllato |
thiazole
piperazine tail-clip hot-plate acetic acid-induced writhing test opioid prodynorphin epigenetics transcription human brain morphine dosing behavior locomotor activity tolerance µ-opioid receptor DAMGO SR-17018 buprenorphine nalbuphine kappa opioid receptor agonist pruritis scratching mice TAT-HIV cholestasis chloroquine deoxycholic acid analgesic δ opioid receptor G-protein-biased agonist opioid peptide rubiscolins µ-opioid analgesics angiotensin receptors chronic pain neuropathic pain delta opioid receptor inverse agonist irreversible antagonist non-competitive antagonist molecular pharmacology free fatty acid receptors lipids opioid receptor colitis chemotype high-throughput screen allosteric modulation beta-arrestin molecular dynamics opioid receptors β-amino acids peptide synthesis receptor binding studies functional assay nociceptin/orphanin FQ receptor NOP receptor ligands nociceptin N/OFQ analgesia GPCR HS-731 peripheral opioid agonist binding selectivity molecular docking molecular dynamics simulations fluorescence cross-correlation spectroscopy (FCCS) G protein-coupled receptor (GPCR) serotonin |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Opioids and Their Receptors |
| Record Nr. | UNINA-9910576875203321 |
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Spetea Mariana
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery
| Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery |
| Autore | Spetea Mariana |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (358 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
opioid receptors
neurokinin-1 receptor peptide synthesis receptor binding studies functional assay writhing test tolerance Leu-enkephalin beta-arrestin mu opioid receptor delta opioid receptor biased signaling DADLE ischemia plasma stability morphinan BNTX δ opioid receptor antagonist 1H-NMR experiments mechanism elucidation peripheral antinociception 14-methoxycodeine-6-O-sulfate codeine-6-O-sulfate opioid peptides and peptidomimetics DAMGO DALDA [Dmt1]DALDA KGOP01 binding molecular docking structure-activity relationships β2-amino acids β2-Homo-amino acids µ-opioid receptor opioid peptides TAPP racemic synthesis of β2-amino acids peripheral µ-opioid receptors analgesia peripheral analgesic tolerance dysbiosis opioid bifunctional ligands (−)-N-phenethylnorhydromorphone analogs [35S]GTPgammaS assay forskolin-induced cAMP accumulation assays β-arrestin recruitment assays MOR and DOR agonists respiratory depression bias factor molecular modeling & simulation δ opioid receptor NTI derivative sulfonamide inverse agonist neutral antagonist agonist opioids mu receptor opioid side effects biased agonism partial agonism zerumbone chronic constriction injury (CCI) allodynia hyperalgesia potassium channels over-the-counter drugs misuse abuse opioid drugs pharmacology codeine dihydrocodeine loperamide opioid peptide macrocyclic tetrapeptide multifunctional ligands kappa opioid receptor analgesics opioid liabilities μ opioid receptor receptor model biased ligands dependence pain therapy neonatal opioid withdrawal syndrome naltrexone 6β-naltrexol buprenorphine G-protein bias arrestin recruitment respiration mitragynine heteromer internalization primary hippocampal culture lysosomes µ opioid receptor molecular dynamics docking interaction fingerprints biased agonists SR-17018 PZM21 morphine fentanyl diphenethylamines design and synthesis partial agonist biased agonist antagonist binding affinity selectivity |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Opioids and Their Receptors |
| Record Nr. | UNINA-9910557108003321 |
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Spetea Mariana
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Radiolabelled Molecules for Brain Imaging with PET and SPECT
| Radiolabelled Molecules for Brain Imaging with PET and SPECT |
| Autore | Brust Peter |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (244 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
SV2A
SV2B SV2C microPET [18F]UCB-H epilepsy PBIF distribution volume blocking assay preclinical imaging Alzheimer’s disease (AD) network measure graph theory brain network positron emission tomography (PET) persistent homology Phosphodiesterase 2A (PDE2A) Positron Emission Tomography (PET) Benzoimidazotriazine (BIT) fluorinated Mouse Liver Microsomes (MLM) cyclic nucleotide phosphodiesterase PDE2A radioligand nitro-precursor fluorine-18 in vitro autoradiography PET imaging opioid receptors positron emission tomography radiotracers μOR-, δOR-, κOR- and ORL1-ligands movement disorders pain drug dependence GBM biomarkers Sigma 1 Sigma 2 PD-L1 PARP IDH Alzheimer’s disease Parkinson’s disease β-amyloid plaques neurofibrillary tangles α-synucleinopathy diagnostic imaging probes orexin receptors PET radiotracer imaging alpha 7 nicotinic acetylcholine receptors nAChR autoradiography amino acid FET FACBC FDOPA immunoPET molecular imaging glioma brain metastases adenosine A2A receptor rotenone-based mouse model [18F]FESCH two-step one-pot radiosynthesis |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557295103321 |
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Brust Peter
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Transcriptome and Genome Analyses Applied to Aquaculture Research
| Transcriptome and Genome Analyses Applied to Aquaculture Research |
| Autore | Pereiro Patricia |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (554 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences Fisheries & related industries |
| Soggetto non controllato |
RNA-Seq
lncRNAs Dicentrarchus labrax viral infection nodavirus immune response fish T lymphocytes infection malnutrition inflammation aquaculture histopathology immunohistochemistry enteromyxosis Philasterides dicentrarchi turbot transcriptomics Chinese mitten crab Eriocheir sinensis transportome transporters salinity osmoregulation transcriptome meta-analysis gills short pentraxins c-reactive protein zebrafish transcript expression antiviral SVCV rag1 mutants skin mucosal immunity hypoxia hypo-metabolic state growth swimming performance metabolic landmarks muscle transcriptome glycolysis lipid metabolism protein turnover gilthead sea bream hepatopancreas necrosis disease metatranscriptomics sequencing hepatopancreatic flora teleost B cells single cell transcriptomics immunoglobulins immune markers transcription factors long non-coding RNAs hepatic transcript expression salmon microarray omega-6/omega-3 ratio nutrigenomics fatty acids liver muscle Misgurnus anguillicaudatus sexual size dimorphism polyploid size dimorphism comparative transcriptome gene expression edible red sea urchin Loxechinus albus RNA-seq reference transcriptome Chinese soft-shelled turtle Aeromonas hydrophila hemorrhagic sepsis molecular immunopathogenesis tripartite motif proteins B30.2 domain antiviral immunity Ctenopharyngodon idella grass carp reovirus metamorphosis brain RNA sequencing intermuscular bone development Megalobrama amblycephala Oreochromis niloticus histological structure Atlantic salmon smoltification genome mRNAs miRNAs sox family genes Pelodiscus sinensis estradiol pseudo-female sex-related heterosis heterobeltiosis environment transgressive genes conserved miRNA high-throughput sequencing lumpfish novel miRNA RT-qPCR heat shock protein co-chaperon network salinity-alkalinity adaptation molecular evolution Lateolabrax maculatus genomics stress response HPI-axis neuroendocrine-immune interaction common carp poly-unsaturated fatty acid fatty acid elongase association study genomic selection bulked segregant analysis SNP association analysis joint effect seawater adaptation microRNAs small-RNA sequencing microarray transcriptome European seabass chronic inflammation opioid receptors immune status whole-transcriptome sequencing sex differentiation non-coding RNAs ceRNA red cusk-eel thermal stress liver transcriptome oxidative damage protein folding hepatic enzymes |
| ISBN | 3-0365-5921-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910637793503321 |
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Pereiro Patricia
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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