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Monitoring endogenous GPCRs: lessons for drug design
| Monitoring endogenous GPCRs: lessons for drug design |
| Autore | Dominique Massotte |
| Pubbl/distr/stampa | Frontiers Media SA, 2015 |
| Descrizione fisica | 1 online resource (134 p.) |
| Collana | Frontiers Research Topics |
| Soggetto topico | Pharmacology |
| Soggetto non controllato |
biased signaling
cannabinoid receptors CGamP mice Endogenous receptors FLIM fluorescent knock-in mice G protein coupled receptors Opiate tolerance opioid receptors receptor heteromerization |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Monitoring endogenous GPCRs |
| Record Nr. | UNINA-9910137094503321 |
Dominique Massotte
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| Frontiers Media SA, 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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New Perspectives in Health : Gut Microbiota
| New Perspectives in Health : Gut Microbiota |
| Autore | Cardona Mena Diana María |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (196 p.) |
| Soggetto topico | Public health and preventive medicine |
| Soggetto non controllato |
A1 beta-casein
allergy anti-TNFα attention autoimmunity beta-casomorphin-7 bone metabolism Cambodia casomorphin cholinergic anti-inflammatory pathway CI 77891 collection kit COVID-19 Crohn's disease cytokines dermatome T6 diet dioxide titanium disease modifying drugs DPP4 drug therapy dysbiosis E171 equol Escherichia coli and Clostridium coccoides group Faecalibacterium prausnitzii fatty acids fecal microbiota fibromyalgia food additive food allergy food-derived opioids gastrointestinal microbiome gastrointestinal passage gliadorphin gut gut barrier gut microbiome gut microbiota gut-brain axis gut-to-brain immunity inflammation inflammatory bowel disease intestinal permeability isoflavones memory menopause microbiome microbiota multiple sclerosis n/a neoplasms nicotinic acetylcholine receptors obesity opioid receptors osteoimmunology osteoporosis percutaneous electrical stimulation probiotics pyrosequencing radiotherapy resistance rural health sample collection skeletal health stool stool collection survivability systematic review TiO2 toxicity α7 and α9 nicotinic receptor subtypes |
| ISBN | 3-0365-5280-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | New Perspectives in Health |
| Record Nr. | UNINA-9910619466203321 |
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Cardona Mena Diana María
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| MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery II
| Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery II |
| Autore | Spetea Mariana |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (260 p.) |
| Soggetto topico |
Chemistry
Research & information: general |
| Soggetto non controllato |
acetic acid-induced writhing test
allosteric modulation analgesia analgesic angiotensin receptors behavior beta-arrestin binding buprenorphine chemotype chloroquine cholestasis chronic pain colitis DAMGO delta opioid receptor deoxycholic acid epigenetics fluorescence cross-correlation spectroscopy (FCCS) free fatty acid receptors functional assay G protein-coupled receptor (GPCR) G-protein-biased agonist GPCR high-throughput screen hot-plate HS-731 human brain inverse agonist irreversible antagonist kappa opioid receptor agonist ligands lipids locomotor activity mice molecular docking molecular dynamics molecular dynamics simulations molecular pharmacology morphine dosing n/a N/OFQ nalbuphine neuropathic pain nociceptin nociceptin/orphanin FQ receptor non-competitive antagonist NOP receptor opioid opioid peptide opioid receptor opioid receptors peptide synthesis peripheral opioid agonist piperazine prodynorphin pruritis receptor binding studies rubiscolins scratching selectivity serotonin SR-17018 tail-clip TAT-HIV thiazole tolerance transcription β-amino acids δ opioid receptor µ-opioid analgesics µ-opioid receptor |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Opioids and Their Receptors |
| Record Nr. | UNINA-9910576875203321 |
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Spetea Mariana
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery
| Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery |
| Autore | Spetea Mariana |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 online resource (358 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
(−)-N-phenethylnorhydromorphone analogs
[35S]GTPgammaS assay [Dmt1]DALDA 14-methoxycodeine-6-O-sulfate 1H-NMR experiments 6β-naltrexol abuse agonist allodynia analgesia analgesics antagonist arrestin recruitment beta-arrestin bias factor biased agonism biased agonist biased agonists biased ligands biased signaling bifunctional ligands binding binding affinity BNTX buprenorphine chronic constriction injury (CCI) codeine codeine-6-O-sulfate DADLE DALDA DAMGO delta opioid receptor dependence design and synthesis dihydrocodeine diphenethylamines docking dysbiosis fentanyl forskolin-induced cAMP accumulation assays functional assay G-protein bias heteromer hyperalgesia interaction fingerprints internalization inverse agonist ischemia kappa opioid receptor KGOP01 Leu-enkephalin loperamide lysosomes macrocyclic tetrapeptide mechanism elucidation misuse mitragynine molecular docking molecular dynamics molecular modeling & MOR and DOR agonists morphinan morphine mu opioid receptor mu receptor multifunctional ligands n/a naltrexone neonatal opioid withdrawal syndrome neurokinin-1 receptor neutral antagonist NTI derivative opioid opioid drugs opioid liabilities opioid peptide opioid peptides opioid peptides and peptidomimetics opioid receptors opioid side effects opioids over-the-counter drugs pain therapy partial agonism partial agonist peptide synthesis peripheral analgesic tolerance peripheral antinociception peripheral µ-opioid receptors pharmacology plasma stability potassium channels primary hippocampal culture PZM21 racemic synthesis of β2-amino acids receptor binding studies receptor model respiration respiratory depression selectivity simulation SR-17018 structure-activity relationships sulfonamide TAPP tolerance writhing test zerumbone β-arrestin recruitment assays β2-amino acids β2-Homo-amino acids δ opioid receptor δ opioid receptor antagonist μ opioid receptor µ opioid receptor µ-opioid receptor |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Opioids and Their Receptors |
| Record Nr. | UNINA-9910557108003321 |
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Spetea Mariana
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Radiolabelled Molecules for Brain Imaging with PET and SPECT
| Radiolabelled Molecules for Brain Imaging with PET and SPECT |
| Autore | Brust Peter |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 online resource (244 p.) |
| Soggetto topico |
Biology, life sciences
Research and information: general |
| Soggetto non controllato |
[18F]FESCH
[18F]UCB-H adenosine A2A receptor alpha 7 Alzheimer's disease Alzheimer's disease (AD) amino acid autoradiography Benzoimidazotriazine (BIT) biomarkers blocking assay brain metastases brain network cyclic nucleotide phosphodiesterase diagnostic imaging probes distribution volume drug dependence epilepsy FACBC FDOPA FET fluorinated fluorine-18 GBM glioma graph theory IDH imaging immunoPET in vitro autoradiography microPET molecular imaging Mouse Liver Microsomes (MLM) movement disorders nAChR network measure neurofibrillary tangles nicotinic acetylcholine receptors nitro-precursor opioid receptors orexin receptors pain Parkinson's disease PARP PBIF PD-L1 PDE2A radioligand persistent homology PET PET imaging Phosphodiesterase 2A (PDE2A) positron emission tomography positron emission tomography (PET) Positron Emission Tomography (PET) preclinical imaging radiotracer radiotracers rotenone-based mouse model Sigma 1 Sigma 2 SV2A SV2B SV2C two-step one-pot radiosynthesis α-synucleinopathy β-amyloid plaques μOR-, δOR-, κOR- and ORL1-ligands |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557295103321 |
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Brust Peter
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Transcriptome and Genome Analyses Applied to Aquaculture Research
| Transcriptome and Genome Analyses Applied to Aquaculture Research |
| Autore | Pereiro Patricia |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (554 p.) |
| Soggetto topico |
Biology, life sciences
Fisheries & related industries Research & information: general |
| Soggetto non controllato |
Aeromonas hydrophila
antiviral antiviral immunity aquaculture association analysis association study Atlantic salmon B cells B30.2 domain brain bulked segregant analysis c-reactive protein ceRNA Chinese mitten crab Chinese soft-shelled turtle chronic inflammation co-chaperon network common carp comparative transcriptome conserved miRNA Ctenopharyngodon idella development Dicentrarchus labrax edible red sea urchin enteromyxosis environment Eriocheir sinensis estradiol European seabass fatty acid elongase fatty acids fish gene expression genome genomic selection genomics gills gilthead sea bream glycolysis grass carp reovirus growth heat shock protein hemorrhagic sepsis hepatic enzymes hepatic transcript expression hepatopancreas necrosis disease hepatopancreatic flora heterobeltiosis heterosis high-throughput sequencing histological structure histopathology HPI-axis hypo-metabolic state hypoxia immune markers immune response immune status immunoglobulins immunohistochemistry infection inflammation intermuscular bone joint effect Lateolabrax maculatus lipid metabolism liver liver transcriptome lncRNAs long non-coding RNAs Loxechinus albus lumpfish malnutrition Megalobrama amblycephala meta-analysis metabolic landmarks metamorphosis metatranscriptomics sequencing microarray microarray transcriptome microRNAs miRNAs Misgurnus anguillicaudatus molecular evolution molecular immunopathogenesis mRNAs mucosal immunity muscle muscle transcriptome n/a neuroendocrine-immune interaction nodavirus non-coding RNAs novel miRNA nutrigenomics omega-6/omega-3 ratio opioid receptors Oreochromis niloticus osmoregulation oxidative damage Pelodiscus sinensis Philasterides dicentrarchi poly-unsaturated fatty acid polyploid size dimorphism protein folding protein turnover pseudo-female rag1 mutants red cusk-eel reference transcriptome RNA RNA-seq RNA-Seq RT-qPCR salinity salinity-alkalinity adaptation salmon seawater adaptation sequencing sex differentiation sex-related sexual size dimorphism short pentraxins single cell transcriptomics skin small-RNA sequencing smoltification SNP sox family genes stress response SVCV swimming performance T lymphocytes teleost thermal stress transcript expression transcription factors transcriptome transcriptomics transgressive genes transporters transportome tripartite motif proteins turbot viral infection whole-transcriptome sequencing zebrafish |
| ISBN | 3-0365-5921-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910637793503321 |
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Pereiro Patricia
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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