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Cellular and Molecular Mechanisms of Nephropathic Cystinosis
| Cellular and Molecular Mechanisms of Nephropathic Cystinosis |
| Autore | Levtchenko Elena N |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (230 p.) |
| Soggetto topico |
Medicine
Pharmacology |
| Soggetto non controllato |
cystinosis
cysteamine bone osteoclast genotype CD34+ hematopoietic stem and progenitor cells gene therapy pre-clinical studies investigational new drug application clinical trial disulfiram mice zebrafish fertility azoospermia hypogonadism histopathology mouse model lysosomal storage disease cell and animal models infantile nephropathic cystinosis bone-muscle wasting fibroblast growth factor 23 osteoclasts sclerostin leptin fractures nephropathic cystinosis hollow fiber membrane 3-dimensional models autophagy macrophages inflammasome proximal tubular cells endocytosis apoptosis chitotriosidase interleukins galectin-3 novel therapies endolysosome epithelial cell differentiation homeostasis lysosomal storage diseases mitochondrial distress kidney proximal tubule programmed cell death central nervous system cortical atrophy arterial spin labelling cystine blood level lysosomal storage disorder history treatment strategies for cystinosis newborn screening clinical course CTNS-pathogenic variants newborn screening for cystinosis kidney progenitors cell model biomarkers cystine kidney therapeutic monitoring |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910585941103321 |
Levtchenko Elena N
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Oxidative Stress in Diabetic Retinopathy
| Oxidative Stress in Diabetic Retinopathy |
| Autore | Ortega Ángel Luis |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (322 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
eicosanoids
oxidative stress diabetic retinopathy cyclooxygenase lipoxygenase Cytochrome P450 HDAC6 tubastatin A retinal endothelial cells retinal endothelial cell senescence db/db mice Cinnamomi Ramulus Paeoniae Radix CPA4-1 blood-retinal barrier occludin human retina epiretinal membrane internal limiting membrane vitreoretinal surgery macular hole proliferative diabetic retinopathy antioxidants diabetes mellitus free radicals high-mobility group box 1 (HMGB1) inflammatory pathways novel therapies diabetic retinopathy (DR) inflammation angiogenesis extracellular vesicles miRNA biomarkers apoptosis fenofibrate thioredoxin hyperglycemia astaxanthin carotenoid reactive oxygen species photoreceptor cells PI3K Nrf2 eicosapentaenoic acid (EPA) docosahexaenoic acid (DHA) retinal pigment epithelium antioxidant ascorbic acid retinal disease vitamin D GLP-1 superoxide dismutase biomarkers of diabetic retinopathy metabolic memory tear film aqueous humor vitreous humor mitochondria redox photoreceptor glycation aging glyoxalase |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557134903321 |
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Ortega Ángel Luis
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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