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Biological Activities of Alkaloids: From Toxicology to Pharmacology
| Biological Activities of Alkaloids: From Toxicology to Pharmacology |
| Autore | Adamski Zbigniew |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (270 p.) |
| Soggetto non controllato |
leukemia
biodistribution glycoalkaloids insect heart Solanum melongena L. antibacterial alkaloid ?-carboline Ovarian cancer Chelidonium majus secondary metabolites lindoldhamine livestock insect chanoclavine bisbenzylisoquinoline alkaloid cytotoxic activity Staphylococcus aureus antioxidant acid-sensing ion channel subtype 1a malonylated form HPLC-DAD ergot alkaloids nociception macrophage Arecoline Macleaya cordata antifungal neuropathic pain Corydalis lutea antiviral Curine lung cancer cells lipopolysaccharide Epichloë Meconopsis cambrica Berberis thunbergii SRC Dicentra spectabilis apoptosis endophyte natural sources dehydrocrenatidine neutrophil EGFR anticancer solamargine berberine isoquinoline alkaloids natural products Radix Aconiti Lateralis preparations short-term and long-term usage inflammation acute toxicity Mahonia aquifolia Palmatine sanguinarine Rutidea parviflora voltage-gated sodium channels cytotoxicity toxicology malonyl-solamargine alkaloids acetylcholinesterase beetles Fumaria officinalis antimicrobial activity solasonine FAK plant secondary metabolites di-ester diterpenoid alkaloids mAchR3 subchronic feeding study mono-ester diterpenoid alkaloids Tenebrio molitor Apoptosis reproduction |
| ISBN | 3-03928-928-4 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Biological Activities of Alkaloids |
| Record Nr. | UNINA-9910404082303321 |
Adamski Zbigniew
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| MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Cutting-Edge Topics in Dry Eye Disease
| Cutting-Edge Topics in Dry Eye Disease |
| Autore | Yoon Kyung Chul |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (158 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
cross-sectional study
dry eye disease systemic comorbidity graves’ ophthalmopathy inflammation meibomian glands morphological changes meibomian gland dysfunction ocular surface disease dry eye symptoms questionnaire Bangladesh global health epidemiology aqueous-deficient dry eye meibomian gland intense pulsed light severe keratitis hyaluronan hylan A multicenter randomized trial gabapentin dry eye neuropathic pain diabetes neuropathic keratopathy neuropathy nerve growth neurotrophic Houttuynia ultrasonic atomization meibography meiboscore TRPM8 agonist cryosim-3 fatty acids vitamin D brief-type self-administered diet history questionnaire Japanese |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557367603321 |
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Yoon Kyung Chul
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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From a Molecule to a Drug: Chemical Features Enhancing Pharmacological Potential
| From a Molecule to a Drug: Chemical Features Enhancing Pharmacological Potential |
| Autore | Ribaudo Giovanni |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (234 p.) |
| Soggetto topico |
Medicine
Pharmacology |
| Soggetto non controllato |
SARS-CoV-2
benzoic acid derivatives gallic acid molecular docking reactivity parameters selenoxide elimination one-pot imine-enamine reaction mechanism DFT calculations selenium anti-inflammatory drugs QSAR pain management cyclooxygenase multitarget drug cannabinoid neuropathic pain clopidogrel NMR study oxone peroxymonosulfate sodium halide thienopyridine drug discovery precision medicine pharmacodynamics pharmacokinetics coronavirus SARS-CoV-2 COVID-19 3-chymotrypsin-like protease pyrimidonic pharmaceuticals molecular dynamics simulations binding free energy β-carrageenan antioxidant activity Box-Behken extraction Eucheuma gelatinae physic-chemistry rheology quercetin quercetin 3-O-glucuronide cisplatin nephrotoxicity cytoprotection lithium therapy neurocytology toxicology neuroprotection chemoinformatics big data methadone hydrochloride pharmaceutical solutions drug compounding high performance liquid chromatography stability study microbiology fucoidan alginate L-selectin E-selectin MCP-1 ICAM-1 THP-1 macrophage monocyte migration protein binding breast milk M/P ratio statistical modeling molecular descriptors chromatographic descriptors affinity chromatography anti-ACE anti-DPP-IV gastrointestinal digestion in silico molecular dynamics paramyosin seafood target fishing |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | From a Molecule to a Drug |
| Record Nr. | UNINA-9910585940503321 |
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Ribaudo Giovanni
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Ion Channels as Marine Drug Targets
| Ion Channels as Marine Drug Targets |
| Autore | Sabatier Jean-Marc |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (134 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
conotoxin
Conus tulipa intraspecific variation venomics transcriptomics proteomics conantokins net hunting strategy nirvana cabal ion channel modulators marine anti-TB compounds PZA MTB latent TB sponges nicotinic chemotherapy paclitaxel taxane neuropathic pain α9α10 saxitoxin zetekitoxin AB voltage-gated sodium channel guanidine alkaloid bioactives conotoxins 2 Kv1 marine toxins modulators potassium channels sea anemone toxins TxVIA mammalian NaV channel selective inhibitor T-type CaV3.2 botulinum toxin A1 chitosan nanoparticles antiarrhythmics pharmacological models of arrhythmia electrically induced arrhythmia |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557396203321 |
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Sabatier Jean-Marc
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Mechanisms and New Targets for the Treatment of Chronic Pain
| Mechanisms and New Targets for the Treatment of Chronic Pain |
| Autore | Prostran Milica S |
| Pubbl/distr/stampa | Frontiers Media SA, 2020 |
| Descrizione fisica | 1 electronic resource (297 p.) |
| Soggetto topico |
Medicine
Neurology & clinical neurophysiology |
| Soggetto non controllato |
Chronic pain
neuropathic pain inflammatory pain visceral pain pain treatment analgesics |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557679603321 |
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Prostran Milica S
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| Frontiers Media SA, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Natural Products and Drug Discovery
| Natural Products and Drug Discovery |
| Autore | Avato Pinarosa |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (392 p.) |
| Soggetto non controllato |
dihydrochalcones
cytotoxicity-guided harpagoside biotechnology synergy Imperata cylindrica 5?-dimethylchalcone (DMC) antioxidant activity marine resources phenolic derivatives secondary metabolites antimicrobial agents antimicrobial resistance metabolomics Humulus lupulus chromatography stereochemistry FSE cytokines cytotoxic activity glutamate angiogenesis traditional medicine Ca2+ L6 cell human colon cancer cell lines siphonous green algae anti-inflammatory activity Phyllanthus chamacristoides spectroscopic analysis Physcomitrella patens Leishmania mexicana mexicana dementia prenylated phenolic compounds T2DM HPLC-ESI-microTOF-Q-MS/MS Eruca sativa Dryopteris fragrans chemosystematics 2? cerebellum Cleistocalyx operculatus inflammation multivariate data analysis Phyllanthus orbicularis HPLC cardiovascular disease Kv7 potassium channels marine peptides proliferation sulfated coumarins Orobanche s.l. phenylpropanoid glycosides Harpagophytum procumbens sesquiterpenoids TRPV1 Fideloside phenylethanoid glycosides Cuba molecular network NMR ketamine aging GLUT4 diabetes oxidative stress Lamiales circular dichroism psychosis antinociceptive immuno-regulation activity terpenoids NADPH oxidases diabetic neuropathy spagyric tincture H2S celastrol isolation and quantification 4?-dihydroxy-6?-methoxy-3? Leea indica C-glycoside neuropathic pain PANC-1 glucosinolates flavonoids bioactivities of natural products cardamonin isoflavones terpenes methicillin-resistant Staphylococcus aureus malaria artemisinin natural products devil's claw ACE inhibitory peptide pPancreatic cancer growth inhibitory activity mass spectrometry flavonoid phenolics Astragalus boeticus L. proanthocyanidins opioid Trifolium Trypanosoma brucei brucei acetylated astragalosides Fabaceae bioactive peptides LC-MS Dasycladus vermicularis Orobanchaceae migration glucoerucin ESI-MS/MS cancer zebrafish antihypertensive Bacopa monnieri chemical derivatization hypertension |
| ISBN | 3-03928-747-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910404086803321 |
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Avato Pinarosa
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| MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery II
| Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery II |
| Autore | Spetea Mariana |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (260 p.) |
| Soggetto topico |
Research & information: general
Chemistry |
| Soggetto non controllato |
thiazole
piperazine tail-clip hot-plate acetic acid-induced writhing test opioid prodynorphin epigenetics transcription human brain morphine dosing behavior locomotor activity tolerance µ-opioid receptor DAMGO SR-17018 buprenorphine nalbuphine kappa opioid receptor agonist pruritis scratching mice TAT-HIV cholestasis chloroquine deoxycholic acid analgesic δ opioid receptor G-protein-biased agonist opioid peptide rubiscolins µ-opioid analgesics angiotensin receptors chronic pain neuropathic pain delta opioid receptor inverse agonist irreversible antagonist non-competitive antagonist molecular pharmacology free fatty acid receptors lipids opioid receptor colitis chemotype high-throughput screen allosteric modulation beta-arrestin molecular dynamics opioid receptors β-amino acids peptide synthesis receptor binding studies functional assay nociceptin/orphanin FQ receptor NOP receptor ligands nociceptin N/OFQ analgesia GPCR HS-731 peripheral opioid agonist binding selectivity molecular docking molecular dynamics simulations fluorescence cross-correlation spectroscopy (FCCS) G protein-coupled receptor (GPCR) serotonin |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Opioids and Their Receptors |
| Record Nr. | UNINA-9910576875203321 |
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Spetea Mariana
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Tight Junction and Its Proteins : More Than Just a Barrier
| The Tight Junction and Its Proteins : More Than Just a Barrier |
| Autore | Fromm Michael |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (432 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
tissue barrier
tight junction claudins tricellulin tight junctions organ preservation intestine transplantation ischemia intestinal mucosa lung epithelia interleukin 13 UBE2Z ubiquitin osmolality hydrostatic pressure cancer sensor tricellular tight junctions endometrial cancer epithelial barrier dysfunction Claudin-7 permeability WNK4 epithelial sodium channel (ENaC), collecting duct cells claudin-1 hydrogen peroxide phosphorylation claudin angulin drug development angubindin-1 Clostridium perfringens enterotoxin Clostridium perfringens iota-toxin antibody Mz-ChA-1 cells biliary epithelial cells phosphatidylcholine mucus paracellular transport atopic dermatitis cytokines STAT3 ZO-2 cholestasis gene transcription hypertrophy tumor suppressor NLS NES CaSR RhoA barrier function paracellular permeability antidiuretic hormone Claudin-14 CLDN14 hearing loss vestibular function cochlear implantation Hepatitis C Virus viral entry epidermal barrier reconstructed human epidermis claudin targeting Campylobacter jejuni curcumin apoptosis co-culture mouse colon TNF NFκB lipolysis-stimulated lipoprotein receptor (LSR) epithelial barrier cell–cell contact caspase kidney stones ion reabsorption quercetin brain barriers blood-brain barrier neurovascular unit blood-cerebrospinal fluid barrier arachnoid barrier glia limitans adherens junctions paracellular sodium transport thick ascending limb nephropathy HELIX syndrome hypokalemia hypermagnesemia anhidrosis gland dysfunction aging blood–brain barrier mutations kidney liver skin human mice disease in silico drug discovery membrane proteins protein interactions molecular dynamics antibiotic-associated hemorrhagic colitis Klebsiella oxytoca tight junction assembly monocytes celiac disease claudin-2 epithelium inflammation fibrosis proliferation migration tricellular tight junction paracellular water transport tight epithelium MDCK C7 cells cell growth endothelia adherens junction apical junctional complex AMP-activated protein kinase (AMPK) paracellular barrier protein structure protein domain occludin junctional adhesion molecule zonula occludens MAGUK proteins PDZ domain stem cell chemoresistance retinal pigment epithelium retinopathy barrier formation collecting duct claudin-5 neuropathic pain nerve injury dorsal root ganglion enteropathogenic E. coli (EPEC) tight junctions (TJ) polarity atypical aPKCζ transepithelial electrical resistance (TER) sorting nexin 9 (SNX9) EspF claudin 1 tumor metastasis epithelial to mesenchymal transition cerebral cavernous malformation endothelial barrier Rho ROCK MEKK3 ion transport ion channel super-resolution microscopy structured illumination microscopy stimulated emission depletion single molecule localization microscopy Claudin blood-biliary barrier chronic liver disease hepatocellular carcinoma cholangiocellular carcinoma NISCH syndrome repair NHE2 ClC-2 inflammatory bowel disease mucosal immunology ZO-1 actomyosin aquaporin drinking rate epithelial fluid transport enterocyte osmoregulation paracellular proximal tubule calcium permeability claudin-12 paracellular channels and barriers cell polarity pathogens immune cells environmental sensors |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Tight Junction and Its Proteins |
| Record Nr. | UNINA-9910557404603321 |
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Fromm Michael
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Tight Junction and Its Proteins: More Than Just a Barrier : More Than Just a Barrier
| The Tight Junction and Its Proteins: More Than Just a Barrier : More Than Just a Barrier |
| Autore | Fromm Michael |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (412 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
tissue barrier
tight junction claudins tricellulin tight junctions organ preservation intestine transplantation ischemia intestinal mucosa lung epithelia interleukin 13 UBE2Z ubiquitin osmolality hydrostatic pressure cancer sensor tricellular tight junctions endometrial cancer epithelial barrier dysfunction Claudin-7 permeability WNK4 epithelial sodium channel (ENaC), collecting duct cells claudin-1 hydrogen peroxide phosphorylation claudin angulin drug development angubindin-1 Clostridium perfringens enterotoxin Clostridium perfringens iota-toxin antibody Mz-ChA-1 cells biliary epithelial cells phosphatidylcholine mucus paracellular transport atopic dermatitis cytokines STAT3 ZO-2 cholestasis gene transcription hypertrophy tumor suppressor NLS NES CaSR RhoA barrier function paracellular permeability antidiuretic hormone Claudin-14 CLDN14 hearing loss vestibular function cochlear implantation Hepatitis C Virus viral entry epidermal barrier reconstructed human epidermis claudin targeting Campylobacter jejuni curcumin apoptosis co-culture mouse colon TNF NFκB lipolysis-stimulated lipoprotein receptor (LSR) epithelial barrier cell–cell contact caspase kidney stones ion reabsorption quercetin brain barriers blood-brain barrier neurovascular unit blood-cerebrospinal fluid barrier arachnoid barrier glia limitans adherens junctions paracellular sodium transport thick ascending limb nephropathy HELIX syndrome hypokalemia hypermagnesemia anhidrosis gland dysfunction aging blood–brain barrier mutations kidney liver skin human mice disease in silico drug discovery membrane proteins protein interactions molecular dynamics antibiotic-associated hemorrhagic colitis Klebsiella oxytoca tight junction assembly monocytes celiac disease claudin-2 epithelium inflammation fibrosis proliferation migration tricellular tight junction paracellular water transport tight epithelium MDCK C7 cells cell growth endothelia adherens junction apical junctional complex AMP-activated protein kinase (AMPK) paracellular barrier protein structure protein domain occludin junctional adhesion molecule zonula occludens MAGUK proteins PDZ domain stem cell chemoresistance retinal pigment epithelium retinopathy barrier formation collecting duct claudin-5 neuropathic pain nerve injury dorsal root ganglion enteropathogenic E. coli (EPEC) tight junctions (TJ) polarity atypical aPKCζ transepithelial electrical resistance (TER) sorting nexin 9 (SNX9) EspF claudin 1 tumor metastasis epithelial to mesenchymal transition cerebral cavernous malformation endothelial barrier Rho ROCK MEKK3 ion transport ion channel super-resolution microscopy structured illumination microscopy stimulated emission depletion single molecule localization microscopy Claudin blood-biliary barrier chronic liver disease hepatocellular carcinoma cholangiocellular carcinoma NISCH syndrome repair NHE2 ClC-2 inflammatory bowel disease mucosal immunology ZO-1 actomyosin aquaporin drinking rate epithelial fluid transport enterocyte osmoregulation paracellular proximal tubule calcium permeability claudin-12 paracellular channels and barriers cell polarity pathogens immune cells environmental sensors |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Tight Junction and Its Proteins |
| Record Nr. | UNINA-9910674057303321 |
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Fromm Michael
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Toxins and Cancer Therapy
| Toxins and Cancer Therapy |
| Autore | Snook Adam E |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (104 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
immunotoxin
ribotoxin α-sarcin RNase T1 furin intracellular trafficking colorectal cancer botulinum toxin botulinum neurotoxin cancer cancer cells neuropathic pain post-surgical pain parotid gland submaxillary gland gustatory hyperhidrosis sialocele parotid fistula immunotherapy vaccine immune checkpoint inhibitors adoptive cell therapy cytokine therapy Coley's Toxins glioblastoma drug discovery cytotoxic necrotizing factor type 1 protein purification recombinant protein production shiga toxins Gb3/CD77 apoptosis ER stress autophagy Burkitt lymphoma |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557123603321 |
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Snook Adam E
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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