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Computational Approaches: Drug Discovery and Design in Medicinal Chemistry and Bioinformatics
| Computational Approaches: Drug Discovery and Design in Medicinal Chemistry and Bioinformatics |
| Autore | Tutone Marco |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (387 p.) |
| Soggetto topico |
Chemistry
Research & information: general |
| Soggetto non controllato |
3CL-Pro
3D-QSAR acetylcholinesterase aging progression mechanism Alzheimer's disease aminophenylbenzamide antibody:antigen interactions antivirals binding free energies binding site binding space carbon nanotubes cholesterol computational biology consensus models COVID-19 COX-2 inhibitors deep learning diabetes docking simulations doxorubicin encapsulation drug delivery system drug discovery drug repositioning drug repositioning approaches drug repurposing drug resistance drug-resistance mutations dual mode of action dual-target lead discovery epitope binning epitope mapping epitope prediction FimH fingerprints gene expression signature genome-wide genetic and epigenetic network (GWGEN) glycoprotein D (gD) haeckelite defects HDACs hERG toxicity herpes simplex virus fusion proteins high-throughput virtual screening HIV-2 protease homology modeling hTSPO human dihydrofolate reductase immunoproteasome in silico induced structural deformations induced-fit docking inhibitors isoform-selective histone deacetylase inhibitors isomeric space ligand-based model machine learning main protease MD binding MD simulation metadynamics methotrexate molecular docking molecular dynamics molecular dynamics (MD) simulation molecular dynamics simulation molecular dynamics simulations molecular modeling MRP4 multi-modal multiple-molecule drug multiprotein inhibiting natural compounds multiscale multitargeting mutants Mycobacterium tuberculosis n/a natural compounds neurodegenerative disorders nicotinic acetylcholine receptor non-covalent inhibitors noncovalent interactions oxidative stress PF-00835231 pharmacophore model pharmacophore modeling PK11195 polypharmacology proteasome protein docking protein threading modeling proteomic signature RNA expression regulation SARS-CoV-2 skin aging SNPs sodium-glucose co-transporters 2 Src inhibitors Stone-Wales defects structural bioinformatics structural characterization systems medicine design tuberculosis urinary tract infections uropathogenic bacteria variants virtual screening |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Computational Approaches |
| Record Nr. | UNINA-9910557519403321 |
Tutone Marco
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Crosstalk between Depression, Anxiety, and Dementia: Comorbidity in Behavioral Neurology and Neuropsychiatry
| Crosstalk between Depression, Anxiety, and Dementia: Comorbidity in Behavioral Neurology and Neuropsychiatry |
| Autore | Tanaka Masaru |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (266 p.) |
| Soggetto topico |
Clinical and internal medicine
Medicine and Nursing |
| Soggetto non controllato |
aging
Alzheimer's disease angiogenesis animal-assisted intervention antioxidant anxiety arterial properties behavioral and psychological symptoms of dementia biomarker cerebral blood flow clinical trials cognition default mode network dementia depression diabetes diabetes mellitus disability level Down's syndrome drug response monitoring dyslipidemias executive control network FFAR4 G protein-coupled receptors gender medicine GPR120 healthy life expectancy (HALE) HPA axis HPG axis hypertension inositol insulin signaling Kiss1 receptor kisspeptin late-life depression LC-MS/MS lipid locomotion long-chain fatty acids longitudinal study major depressive disorder meta-analysis morbidity/mortality paradox mortality multiple reaction monitoring multiple sclerosis neurodegenerative disease neurodegenerative disorders neuroimaging nucleus accumbens nutraceutical nutritional psychiatry omega-3 oxidative stress personalized medicine pet-robot intervention plasma protein biomarker polyunsaturated fatty acids post-stroke depression psilocybin psychiatric disease redox resting-state functional magnetic resonance imaging salience network schizophrenia stroke systematic review systolic blood pressure type 2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Crosstalk between Depression, Anxiety, and Dementia |
| Record Nr. | UNINA-9910580214803321 |
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Tanaka Masaru
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Monoclonal Antibodies and Their Functional Fragments in Research, Diagnosis and Therapy
| Monoclonal Antibodies and Their Functional Fragments in Research, Diagnosis and Therapy |
| Autore | Ruvo Menotti |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (278 p.) |
| Soggetto topico | Technology: general issues |
| Soggetto non controllato |
adoptive immunotherapy
affibody molecules affinity aggregation AL amyloidosis amyloid anti-CD38 MoAb antibody antibody fragment antibody fragments Antibody-Drug Conjugate antibody-drug conjugates BCMA belantamab mafodotin bispecific bispecific T-cell engager blood-brain barrier cancer therapy CAR adaptor CD38 cDNA CHI3L1 chimeric antigen receptor (CAR T) chimeric antigen receptor T-cells cross-linking Daratumumab developability drug targeting E. coli Fab glutamate carboxypeptidase II guinea pig idecabtagene vicleucel immunization immunogenicity in vivo imaging Isatuximab JNJ-68284528 lung metastasis Mabs modular CAR T monoclonal antibodies monoclonal antibody myeloma NAALADase neurodegenerative disorders neurotoxicity non-specific binding nucleocapsid NUsc1 oligomer payload phage display pharmacokinetics polyspecificity porcine deltacoronavirus prostate cancer prostate-specific membrane antigen protein engineering protocol receptor-mediated transcytosis scFv self-association single chain solubility specificity split CAR stability transferrin receptor universal CAR T universal immune receptor viscosity YKL-40 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557613003321 |
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Ruvo Menotti
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Optimising Nutrition to Alleviate Age-Associated Functional Decline
| Optimising Nutrition to Alleviate Age-Associated Functional Decline |
| Autore | Kostka Tomasz |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (156 p.) |
| Soggetto topico |
Biology, life sciences
Food & society Research & information: general |
| Soggetto non controllato |
aging
Bayesian model averaging caloric restriction cancer Charlson Comorbidity Index citicoline Comprehensive Geriatric Assessment depression diet in the elderly DNA damage DNA methylation education level elderly epigenetic diet epigenetic regulation of gene expression fragile populations genome stability geriatrics GNRI healthy ageing hospitalization hypoalbuminemia lymphocytes malnutrition menopause metabolic syndrome micronutrients mood disorders n/a neurodegenerative disorders neurology NRS-2002 nutrition nutritional status obesity older adults older people olive oil public health serotonin and kynurenine pathways of tryptophan metabolism serum albumin SGA supplementation survival treatment tryptophan TUG VES-13 vitamin D women |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557661503321 |
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Kostka Tomasz
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment
| Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment |
| Autore | Di Meo Sergio |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 online resource (236 p.) |
| Soggetto topico |
Biology, life sciences
Research & information: general |
| Soggetto non controllato |
AMPK pathway
antioxidant supplementation AP-1 apoptosis artemisinin atherosclerosis c-FLIP cancer cancer therapy cardiomyocytes cardiotoxicity cardiovascular disease cavefish cell viability chromophobe RCC clear cell RCC CORM-2 CTCL D-box DNA damage endoplasmic reticulum stress endothelial dysfunction evolution exercise glutathione (GSH) metabolism H2O2 hippocampal neurons HO-1 insulin resistance light mitochondria mitochondrial membrane potential n/a NADPH oxidase neurodegenerative disorders Nrf2 oxidative stress papillary RCC peroxiredoxins PGC-1 protein aggregation proteinopathy reactive oxygen species reactive oxygen species (ROS) redox redox signaling Renal cell carcinoma (RCC) ROS ROS scavengers sarcopenia SH-SY5Y cells Spalax sphingomyelin synthase 2 trimethylamine N-oxide tumorigenesis UCPs XIAP β-catenin |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Physiological and Pathological Role of ROS |
| Record Nr. | UNINA-9910557430503321 |
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Di Meo Sergio
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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