Info
- Utilizzare la checkbox di selezione a fianco di ciascun documento per attivare le funzionalità di stampa, invio email, download nei formati disponibili del (i) record.
Computational Approaches: Drug Discovery and Design in Medicinal Chemistry and Bioinformatics
| Computational Approaches: Drug Discovery and Design in Medicinal Chemistry and Bioinformatics |
| Autore | Tutone Marco |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (387 p.) |
| Soggetto topico |
Research & information: general
Chemistry |
| Soggetto non controllato |
3D-QSAR
pharmacophore modeling ligand-based model HDACs isoform-selective histone deacetylase inhibitors aminophenylbenzamide hERG toxicity drug discovery fingerprints machine learning deep learning gene expression signature drug repositioning approaches RNA expression regulation high-throughput virtual screening dual-target lead discovery neurodegenerative disorders Alzheimer's disease dual mode of action multi-modal nicotinic acetylcholine receptor acetylcholinesterase molecular docking methotrexate drug resistance human dihydrofolate reductase virtual screening molecular dynamics simulation epitope binning epitope mapping epitope prediction antibody:antigen interactions protein docking glycoprotein D (gD) herpes simplex virus fusion proteins Src inhibitors pharmacophore model molecular dynamics simulations in silico COX-2 inhibitors molecular modeling sodium-glucose co-transporters 2 FimH uropathogenic bacteria urinary tract infections diabetes drug-resistance mutations HIV-2 protease structural characterization induced structural deformations SARS-CoV-2 COVID-19 multiprotein inhibiting natural compounds MD simulation 3CL-Pro antivirals docking simulations drug repurposing consensus models binding space isomeric space MRP4 SNPs variants protein threading modeling molecular dynamics binding site hTSPO PK11195 cholesterol homology modeling molecular dynamics (MD) simulation carbon nanotubes Stone-Wales defects haeckelite defects doxorubicin encapsulation drug delivery system binding free energies noncovalent interactions main protease mutants inhibitors PF-00835231 Mycobacterium tuberculosis tuberculosis proteasome natural compounds multiscale multitargeting polypharmacology computational biology drug repositioning structural bioinformatics proteomic signature skin aging oxidative stress aging progression mechanism genome-wide genetic and epigenetic network (GWGEN) systems medicine design multiple-molecule drug immunoproteasome non-covalent inhibitors MD binding metadynamics induced-fit docking |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Computational Approaches |
| Record Nr. | UNINA-9910557519403321 |
Tutone Marco
|
||
| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Crosstalk between Depression, Anxiety, and Dementia: Comorbidity in Behavioral Neurology and Neuropsychiatry
| Crosstalk between Depression, Anxiety, and Dementia: Comorbidity in Behavioral Neurology and Neuropsychiatry |
| Autore | Tanaka Masaru |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (266 p.) |
| Soggetto topico |
Medicine
Clinical & internal medicine |
| Soggetto non controllato |
dementia
behavioral and psychological symptoms of dementia systematic review meta-analysis animal-assisted intervention pet-robot intervention G protein-coupled receptors GPR120 FFAR4 schizophrenia polyunsaturated fatty acids long-chain fatty acids omega-3 nutritional psychiatry Alzheimer’s disease psychiatric disease depression anxiety Down’s syndrome inositol nutraceutical insulin signaling antioxidant aging psilocybin clinical trials oxidative stress redox multiple sclerosis biomarker neurodegenerative disease personalized medicine major depressive disorder longitudinal study LC-MS/MS plasma protein biomarker drug response monitoring multiple reaction monitoring diabetes mellitus type 2 dyslipidemias hypertension post-stroke depression disability level mortality late-life depression neuroimaging resting-state functional magnetic resonance imaging default mode network executive control network salience network healthy life expectancy (HALE) morbidity/mortality paradox cognition systolic blood pressure cerebral blood flow arterial properties angiogenesis gender medicine neurodegenerative disorders kisspeptin locomotion Kiss1 receptor HPA axis HPG axis nucleus accumbens stroke lipid diabetes |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Crosstalk between Depression, Anxiety, and Dementia |
| Record Nr. | UNINA-9910580214803321 |
|
Tanaka Masaru
|
||
| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Monoclonal Antibodies and Their Functional Fragments in Research, Diagnosis and Therapy
| Monoclonal Antibodies and Their Functional Fragments in Research, Diagnosis and Therapy |
| Autore | Ruvo Menotti |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (278 p.) |
| Soggetto topico | Technology: general issues |
| Soggetto non controllato |
porcine deltacoronavirus
nucleocapsid monoclonal antibodies neurodegenerative disorders affibody molecules blood–brain barrier receptor-mediated transcytosis transferrin receptor AL amyloidosis CD38 anti-CD38 MoAb Daratumumab Isatuximab myeloma BCMA bispecific T-cell engager antibody-drug conjugates chimeric antigen receptor T-cells belantamab mafodotin idecabtagene vicleucel JNJ-68284528 Mabs Antibody-Drug Conjugate cancer therapy drug targeting payload cross-linking antibody fragment Fab scFv E. coli YKL-40 CHI3L1 monoclonal antibody phage display lung metastasis prostate-specific membrane antigen in vivo imaging prostate cancer glutamate carboxypeptidase II NAALADase immunization antibody protocol guinea pig cDNA chimeric antigen receptor (CAR T) universal CAR T modular CAR T universal immune receptor CAR adaptor adoptive immunotherapy split CAR bispecific polyspecificity pharmacokinetics solubility aggregation viscosity developability stability affinity specificity protein engineering self-association non-specific binding immunogenicity antibody fragments single chain amyloid oligomer neurotoxicity NUsc1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557613003321 |
|
Ruvo Menotti
|
||
| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Optimising Nutrition to Alleviate Age-Associated Functional Decline
| Optimising Nutrition to Alleviate Age-Associated Functional Decline |
| Autore | Kostka Tomasz |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (156 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences Food & society |
| Soggetto non controllato |
citicoline
neurology supplementation treatment tryptophan diet in the elderly depression mood disorders serotonin and kynurenine pathways of tryptophan metabolism olive oil metabolic syndrome obesity women menopause healthy ageing micronutrients aging DNA damage genome stability neurodegenerative disorders cancer older adults nutrition malnutrition epigenetic regulation of gene expression DNA methylation epigenetic diet caloric restriction elderly fragile populations hospitalization hypoalbuminemia public health serum albumin NRS-2002 SGA VES-13 Comprehensive Geriatric Assessment nutritional status education level older people survival geriatrics vitamin D TUG lymphocytes GNRI Charlson Comorbidity Index Bayesian model averaging |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557661503321 |
|
Kostka Tomasz
|
||
| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment
| Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment |
| Autore | Di Meo Sergio |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (236 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
CTCL
apoptosis cell viability c-FLIP XIAP artemisinin SH-SY5Y cells hippocampal neurons H2O2 AMPK pathway atherosclerosis sphingomyelin synthase 2 endothelial dysfunction endoplasmic reticulum stress β-catenin insulin resistance cancer cardiovascular disease neurodegenerative disorders exercise mitochondria oxidative stress PGC-1 Nrf2 UCPs ROS light DNA damage evolution D-box cavefish Spalax trimethylamine N-oxide cardiomyocytes cardiotoxicity mitochondrial membrane potential CORM-2 NADPH oxidase AP-1 HO-1 Renal cell carcinoma (RCC) reactive oxygen species (ROS) glutathione (GSH) metabolism cancer therapy clear cell RCC papillary RCC chromophobe RCC sarcopenia reactive oxygen species redox signaling antioxidant supplementation protein aggregation redox proteinopathy peroxiredoxins tumorigenesis ROS scavengers |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Physiological and Pathological Role of ROS |
| Record Nr. | UNINA-9910557430503321 |
|
Di Meo Sergio
|
||
| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||