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Drug Repositioning: Current Advances and Future Perspectives
| Drug Repositioning: Current Advances and Future Perspectives |
| Autore | Yuhei Nishimura |
| Pubbl/distr/stampa | Frontiers Media SA, 2019 |
| Descrizione fisica | 1 electronic resource (153 p.) |
| Collana | Frontiers Research Topics |
| Soggetto non controllato |
database
Integrative strategies molecular docking polypharmacology multi-omics computational analysis Drug Repositioning data sharing Patenting |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Drug Repositioning |
| Record Nr. | UNINA-9910346734903321 |
Yuhei Nishimura
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| Frontiers Media SA, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Identification and Characterization of Genetic Components in Autism Spectrum Disorders 2019
| Identification and Characterization of Genetic Components in Autism Spectrum Disorders 2019 |
| Autore | Butler Merlin G |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (256 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences Genetics (non-medical) |
| Soggetto non controllato |
autism spectrum disorders (ASD)
cancer overlapping genes and gene profiling super-pathways phenotypes and diseases molecular functions and processes 15q11.2 BP1-BP2 microdeletion (Burnside-Butler) syndrome imprinting parent-of-origin effects phenotype-genotype correlation autism developmental delays motor delays microbiome gut ProSAP2 Phelan McDermid Syndrome gut–brain interaction leaky gut IL-6 SHANK collapsin response mediator protein 4 autism spectrum disorder neurodevelopmental disorder whole-exome sequencing animal model sex different phenotypes 15q11.2 BP1–BP2 microdeletion (Burnside–Butler syndrome) NIPA1 NIPA2 CYFIP1 TUBGCP5 genes Prader–Willi and Angelman syndromes magnesium transporters and supplementation potential treatment options intellectual disability AMPA receptors NMDA receptors guanine nucleotide exchange factor synaptic plasticity Autism spectrum disorder ASD Obesity Overweight Body mass index BMI autism candidate genes synaptotagmin-like protein 4 (SYTL4) transmembrane protein 187 (TMEM187) SYTL4-protein structure STRING-protein-protein interaction expression profile microRNA- interactions autism spectrum disorders biological networks genomics multi-omics network diffusion data integration genetics quantitative traits stratification by trait severity heterogeneity reduction case-control association analysis fragile X syndrome RNA toxicity DNA methylation mosaicism pediatrics MS-QMA AmplideX cytokine monocyte β-glucan T cell cytokine trained immunity maternal immune activation epigenetics mice postnatal VPA injection SAM gene expression nanostring |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910566483203321 |
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Butler Merlin G
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Integration of Multisource Heterogenous Omics Information in Cancer
| Integration of Multisource Heterogenous Omics Information in Cancer |
| Autore | Jin Victor |
| Pubbl/distr/stampa | Frontiers Media SA, 2020 |
| Descrizione fisica | 1 electronic resource (154 p.) |
| Soggetto topico |
Science: general issues
Medical genetics |
| Soggetto non controllato |
Multisource heterogenous omics
cancer computational cancer biology genetic epigenetic data integration multi-omics genome-wide studies omics data |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910688321703321 |
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Jin Victor
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| Frontiers Media SA, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Integrative Multi-Omics in Biomedical Research
| Integrative Multi-Omics in Biomedical Research |
| Autore | Gerner Christopher |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (178 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
target identification
target validation label-free method for drugs anti-angiogenesis mechanism of action receptor tyrosine kinases curcumin natural products lipid lipidomics cardiac metaplasia Barrett's esophagus esophageal adenocarcinoma microbiota DNA sensing IFI16 cGAS innate immunity protein interactions virus-host interactions post-translational modifications mass spectrometry proteomics transcriptomics multi-omics multi-omics analysis study design bioinformatics machine learning analysis flow metabolomics planned myocardial infarction (PMI) myocardial infarction (MI) exercise heart cheminformatics batch variations eicosanoids fetal calf serum peroxisomes host-pathogen interactions secretome macrophages acute myeloid leukemia HL-60 cell line ATRA induced differentiation transcriptome proteome transcription factors key molecules regulatory pathway modelling SRM endometriosis inflammation |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557769003321 |
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Gerner Christopher
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular Vaccines against Pathogens in the Post-Genomic Era
| Molecular Vaccines against Pathogens in the Post-Genomic Era |
| Autore | Alejandro Oñate Angel |
| Pubbl/distr/stampa | Frontiers Media SA, 2020 |
| Descrizione fisica | 1 electronic resource (158 p.) |
| Soggetto topico |
Science: general issues
Infectious & contagious diseases |
| Soggetto non controllato |
Vaccines
Systems Biology multi-omics immunoinformatics modern vaccinology |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557539203321 |
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Alejandro Oñate Angel
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| Frontiers Media SA, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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New Biomolecules and Drug Delivery Systems as Alternatives to Conventional Antibiotics
| New Biomolecules and Drug Delivery Systems as Alternatives to Conventional Antibiotics |
| Autore | Felgueiras Helena |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (232 p.) |
| Soggetto topico |
Research & information: general
Chemistry |
| Soggetto non controllato |
nanoparticles
4-Nerolidylcatechol antifungals Microsporum canis polycaprolactone nanoprecipitation silver nanoparticles green synthesis method Catharanthus roseus Azadirachta indica multidrug-resistant bacteria wound healing nosocomial infection plant extract grapefruit seed extract antibacterial activity fiber-hydrogel composite biodegradable polymers skin regeneration drug delivery platforms controlled release tetramycin antimicrobial activity kiwifruit disease conventional antibiotics storage quality gold nanoparticles flavonoids Gram-negative bacteria DNA gyrase in silico multidrug-resistant Acinetobacter baumannii (MDR-AB) hypertonic saline antibiotics biofilm aerosol delivery ultrahigh-throughput screening live biosensors antibiotic discovery gram-negative pathogens microfluidic droplet cocultivation efficient promoters polymyxins colistin biosynthetic gene cluster single cell multi-omics quercetin magnesium-doped calcium silicate osteogenic activity bone regeneration and nanofiber scaffold bulk-tank milk mastitis methicillin milk goat somatic cell counts staphylococcus tetracycline total bacterial counts prosthetic joint infection local prevention allicin chitosan Sphaerotheca sp antibiotic Rosa roxburghii cyclic diphenylphosphonate quinoline DNA gyrase inhibitor molecular docking magnesium ion |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910585940303321 |
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Felgueiras Helena
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Nutrition for Brain Development
| Nutrition for Brain Development |
| Autore | Mohajeri M. Hasan |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (262 p.) |
| Soggetto topico |
Medicine
Neurosciences |
| Soggetto non controllato |
cocaine self-administration
high-fat diet high-sugar diet maternal diet pregnancy and lactation melanocortin-4 receptor offspring brain rat offspring maternal nutrition protein restriction fetal brain hypothalamus differentiation neurogenesis transcriptomics epitranscriptomics mitochondria PKU cognitive outcomes cross-cultural cross-countries Phe associations spearmint rosmarinic acid polyphenol amyloid fibril amyloid beta alpha-synuclein Tau dementia human milk oligosaccharides cognition brain development animal behaviour fucosyllactose sialyllactose long term potentiation gut-brain-axis gut microbiome short-chain fatty acids bacterial metabolites SCFA manganese blood-brain barrier blood-cerebrospinal fluid barrier choroid plexus ketogenic supplement ketosis aging lifespan neurodegenerative disease learning memory early childhood nutrition Mediterranean diet body mass index cognitive development multi-omics microvascular brain high glycemic diet soluble epoxide hydrolase inhibitor maless depression affective disorder bacteria probiotics therapy treatment |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910566471203321 |
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Mohajeri M. Hasan
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Statistical and Computational Methods for Microbiome Multi-Omics Data
| Statistical and Computational Methods for Microbiome Multi-Omics Data |
| Autore | Mallick Himel |
| Pubbl/distr/stampa | Frontiers Media SA, 2020 |
| Descrizione fisica | 1 electronic resource (170 p.) |
| Soggetto topico |
Science: general issues
Medical genetics |
| Soggetto non controllato |
microbiome
metagenomics metabolomics multi-omics biostatistics computational biology statistical genomics data science |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557430103321 |
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Mallick Himel
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| Frontiers Media SA, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Systems Analytics and Integration of Big Omics Data
| Systems Analytics and Integration of Big Omics Data |
| Autore | Hardiman Gary |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (202 p.) |
| Soggetto non controllato |
precision medicine informatics
drug sensitivity chromatin modification cell lines biocuration neurodegeneration multivariate analysis artificial intelligence epigenetics missing data sequencing clinical data class imbalance integrative analytics algorithm development for network integration deep phenotype non-omics data feature selection Gene Ontology miRNA-gene expression networks omics data plot visualization Alzheimer's disease tissue classification epidemiological data proteomic analysis genotype RNA expression indirect effect multi-omics dementia multiomics integration data integration phenomics network topology analysis challenges transcriptome enrichment analysis regulatory genomics scalability heterogeneous data systemic lupus erythematosus database microtubule-associated protein tau disease variants genomics joint modeling distance correlation annotation phenotype direct effect curse of dimensionality gene-environment interactions logic forest machine learning KEGG pathways multivariate causal mediation amyloid-beta bioinformatics pipelines support vector machine pharmacogenomics candidate genes tissue-specific expressed genes cognitive impairment causal inference |
| ISBN | 3-03928-745-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910404089603321 |
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Hardiman Gary
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| MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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