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Amide Bond Activation / Michal Szostak
| Amide Bond Activation / Michal Szostak |
| Autore | Szostak Michal |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (466 p.) |
| Soggetto topico | Chemistry |
| Soggetto non controllato |
N-heterocyclic carbene
non planar amide ruthenium (Ru) physical organic chemistry gemcitabine prodrug pyramidal amides bridged sultams catalysis dipeptides N-(1-naphthyl)acetamide C-N ? bond cleavage steric effects peptide bond cleavage transition-metal-free palladium N-heterocyclic carbenes (NHCs) addition reaction C–O activation rhodium metal complexes carbanions thioamidation amide bond intramolecular catalysis antiviral activity additivity principle pre-catalysts C–N bond cleavage bridged lactams C–H acidity arynes twisted amides organic synthesis amination Suzuki-Miyaura tert-butyl cyclopentadienyl complexes C-S formation enzymes DFT study sulfonamide bond N HERON reaction primaquine entropy amide activation amidation synthesis amide hydrolysis carbonylicity amide bond activation amide bond resonance aminosulfonylation molecular dynamics model compound in situ amide homogeneous catalysis heterocycles anomeric effect multi-component coupling reaction kinetic excited state C–H bond cleavage palladium catalysis amides thiourea formylation alkynes cis/trans isomerization amide C–N bond activation intein C-H functionalization succindiamide amide bonds crown ether aminoacylation directing groups cytostatic activity reaction thermodynamics acyl transfer transition metals N-dimethylformamide DMAc acylative cross-coupling C-H/C-N activation nickel catalysis antibacterial screening sodium aryl thioamides Winkler-Dunitz parameters catalyst N-dimethylacetamide base-catalyed hydrolysis nitrogen heterocycles cross-coupling insertion amidicity nitro-aci tautomerism activation carbonylation transamidation amine distortion Pd-catalysis rotational barrier energy hypersensitivity N–C activation metabolic stability [2+2+2] annulation twisted amide protease cyanation amide resonance trialkylborane catalysts biofilm eradication pharmacokinetics pancreatic cancer cells DMF aryl esters Michael acceptor fumardiamide water solvation ester bond activation cyclization nuclear magnetic resonance secondary amides reaction mechanism density functional theory density-functional theory amino acid transporters |
| ISBN |
9783039212040
3039212044 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346843703321 |
Szostak Michal
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Antitumoral Properties of Natural Products : Volume 2
| Antitumoral Properties of Natural Products : Volume 2 |
| Autore | Fabiani Roberto |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 online resource (300 p.) |
| Soggetto topico |
Biology, life sciences
Research & information: general |
| Soggetto non controllato |
13-ethylberberine
Akt AKT anthraquinones anti-cancer anti-cancer activity anti-cancer agents anti-tumor activity anticancer Antioxidant activities antioxidants antioxidation antiproliferation agents Antiproliferative antiproliferative activity antitumoral activity antrodin C apoptosis AR Artemisia absinthium ASE Aspergillus fumigatus ATM-Chk2 autophagic flux inhibition autophagy bee venom betulinic acid Brazilian Cerrado biome cancer cancer stem cells capsazepine carrageenan Catalpa speciosa Celastraceae cell cycle arrest cell proliferation cell signaling cephalotaxine cervical cancer Cheiloclinium cognatum chemotherapeutic adjuvant chemotherapy chiral resolution CIP2A CLE-10 CLEFMA Colocasia esculenta colorectal cancer cells copper Cordyceps sinensis coronarin D CrataBL cryptolepine Cucurbitacin B cytotoxic activity cytotoxicity Dendrobium officinale diallyl disulfide dicentrine DLD-1 cells doxorubicin drug resistance ECD calculation EGFR endoplasmic reticulum stress entrapment efficiency Euphorbia tirucalli FAK/S6K1 flavonoids folk medicine food bioactive FOXO1 fruit Ganoderma tsugae gastric cancer gastric cancer cells gefitinib-resistant NSCLC Gene expression glioblastoma glioblastoma multiforme glioma glucose uptake glycosyltransferase grape leaves human neuroblastoma cells IL-6/JAK2/STAT3 inflammation inflammatory diseases ingenol invasion isochromanes isocryptolepine JNK lactoferrin hydrolysate LC3 lichen Licochalcone A lipogenesis lung adenocarcinoma lysosomal degradation lysosomal membrane permeabilization Magnolia acuminata manganese MAPK MCF-7 cells MDA-MB-231 melanoma melittin mesenchymal stem cells metabolic stability metastasis microenvironment migration mitochondrial membrane potential mitochondrial ROS mitochondrial-dependent pathway molecular mechanism mTOR multiple myeloma n/a naringenin natural compounds natural product alkaloids natural products natural yellow Monascus pigments NCI-60 cancer cell line necrotic neferine neocryptolepine NF-κB no-toxicity Nutraceuticals oncogene osteosarcoma p38 patuletin phenols phloretin phytochemicals PI3K/AKT/mTOR PI3K/Akt/mTOR pathway plant lectin plant-derived foods plantation mode Plenckia populnea porphyran preclinical tests pristimerin pro-apoptotic effects proanthocyanins prostate cancer protease inhibitor protein kinase C protein synthesis inhibition Pulsatilla saponin D quality control quercetagetin quercetin ROS RT-R breast cancer cells Salacia crassifolia Salacia elliptica SB365 seaweed secondary metabolites semi-synthetic derivative SREBP-1 stable nanocapsules stemness potential structure activity relationships structure elucidation tarin Taxus cuspidata temozolomide TNF-α TP traditional preparation transcriptional regulation triterpenoids TRPV1 tumidulin ursolic acid vegetable water-soluble zerumbone Zeylenone |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Antitumoral Properties of Natural Products |
| Record Nr. | UNINA-9910557531303321 |
|
Fabiani Roberto
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Antitumoral Properties of Natural Products
| Antitumoral Properties of Natural Products |
| Autore | Fabiani Roberto |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 online resource (344 p.) |
| Soggetto topico |
Biology, life sciences
Research & information: general |
| Soggetto non controllato |
13-ethylberberine
Akt AKT anthraquinones anti-cancer anti-cancer activity anti-cancer agents anti-tumor activity anticancer Antioxidant activities antioxidants antioxidation antiproliferation agents Antiproliferative antiproliferative activity antitumoral activity antrodin C apoptosis AR Artemisia absinthium ASE Aspergillus fumigatus ATM-Chk2 autophagic flux inhibition autophagy bee venom betulinic acid Brazilian Cerrado biome cancer cancer stem cells capsazepine carrageenan Catalpa speciosa Celastraceae cell cycle arrest cell proliferation cell signaling cephalotaxine cervical cancer Cheiloclinium cognatum chemotherapeutic adjuvant chemotherapy chiral resolution CIP2A CLE-10 CLEFMA Colocasia esculenta colorectal cancer cells copper Cordyceps sinensis coronarin D CrataBL cryptolepine Cucurbitacin B cytotoxic activity cytotoxicity Dendrobium officinale diallyl disulfide dicentrine DLD-1 cells doxorubicin drug resistance ECD calculation EGFR endoplasmic reticulum stress entrapment efficiency Euphorbia tirucalli FAK/S6K1 flavonoids folk medicine food bioactive FOXO1 fruit Ganoderma tsugae gastric cancer gastric cancer cells gefitinib-resistant NSCLC Gene expression glioblastoma glioblastoma multiforme glioma glucose uptake glycosyltransferase grape leaves human neuroblastoma cells IL-6/JAK2/STAT3 inflammation inflammatory diseases ingenol invasion isochromanes isocryptolepine JNK lactoferrin hydrolysate LC3 lichen Licochalcone A lipogenesis lung adenocarcinoma lysosomal degradation lysosomal membrane permeabilization Magnolia acuminata manganese MAPK MCF-7 cells MDA-MB-231 melanoma melittin mesenchymal stem cells metabolic stability metastasis microenvironment migration mitochondrial membrane potential mitochondrial ROS mitochondrial-dependent pathway molecular mechanism mTOR multiple myeloma n/a naringenin natural compounds natural product alkaloids natural products natural yellow Monascus pigments NCI-60 cancer cell line necrotic neferine neocryptolepine NF-κB no-toxicity Nutraceuticals oncogene osteosarcoma p38 patuletin phenols phloretin phytochemicals PI3K/AKT/mTOR PI3K/Akt/mTOR pathway plant lectin plant-derived foods plantation mode Plenckia populnea porphyran preclinical tests pristimerin pro-apoptotic effects proanthocyanins prostate cancer protease inhibitor protein kinase C protein synthesis inhibition Pulsatilla saponin D quality control quercetagetin quercetin ROS RT-R breast cancer cells Salacia crassifolia Salacia elliptica SB365 seaweed secondary metabolites semi-synthetic derivative SREBP-1 stable nanocapsules stemness potential structure activity relationships structure elucidation tarin Taxus cuspidata temozolomide TNF-α TP traditional preparation transcriptional regulation triterpenoids TRPV1 tumidulin ursolic acid vegetable water-soluble zerumbone Zeylenone |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557419703321 |
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Fabiani Roberto
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Phospholipases: From Structure to Biological Function
| Phospholipases: From Structure to Biological Function |
| Autore | Balboa María A |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (348 p.) |
| Soggetto topico |
Biology, life sciences
Research & information: general |
| Soggetto non controllato |
acidic sphingomyelinase
adipokines adrenic acid alcoholic and nonalcoholic steatohepatitis anti-inflammatory arachidonic acid atherosclerosis autoinflammatory autotaxin ceramide choline and methionine deficiency chronic non-bacterial osteomyelitis chronic recurrent multifocal osteomyelitis cPLA2α crotoxin cytokines diacylglycerol diet-induced obesity EP receptors fatty acid fatty liver G protein-coupled receptor glioblastoma glucose tolerance Group V phospholipase A2 group VIA phospholipase A2 hepatocellular carcinoma inflammasome inflammation inflammatory response inhibitor insulin resistance insulin secretion knockout mouse lipid mediator lipid mediators lipid signaling lipidomics lipids lipin LIPIN2 lipins LPIN2 lung impairment lysophosphatidate lysophospholipid macrophage macrophages majeed syndrome mass spectrometry membrane metabolic stability metastasis monocytes/macrophages morbidly obesity n/a neuromuscular blocker neutral sphingomyelinase osteoclast oxoesters pancreatic islets PAP-2 phosphatidic acid phospholipase A2 phospholipases phospholipid phospholipid remodeling PLA2G6 preadipocytes proliferation prostaglandins psoriasis signaling snake venom sphingolipid sphingomyelin sphingomyelinase sphingosine-1-phosphate T cells α-methylation β-cells |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Phospholipases |
| Record Nr. | UNINA-9910576879603321 |
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Balboa María A
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Radiopharmaceuticals for PET Imaging - Issue A
| Radiopharmaceuticals for PET Imaging - Issue A |
| Autore | Roivainen Anne |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 online resource (212 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
(S)-(−)-[18F]fluspidine
[11C]carfentanil [18F]AlF [18F]FACH 18F-fluorodeoxyglucose 18F-labeled analog of FACH affibody molecule AlF-radiolabelling animal model bioconjugation bioorthogonal chemistry blood-brain barrier (BBB) carfentanil clinical outcomes EGFR FACH fentanyl fluorine-18 gallium-68 image-based internal dosimetry imaging-based biomarker indium-11 infection inflammation inverse electron-demand Diels-Alder ligation isotopic exchange kinetic analysis linker MCT1/MCT4 lactate transporter inhibitor metabolic stability molecular imaging monocarboxylate transporters (MCTs) multiple myeloma naloxone nanobody NODAGA NOTA OLINDA opioid orthotopic xenograft of glioblastoma in mouse osteomyelitis overdose peptides PET PET imaging PET radiotracers pharmacokinetics PODS positron emission tomography positron emission tomography (PET) imaging positron emission tomography (PET), defluorination positron emission tomography/computed tomography preclinical development preclinical radiopharmaceutical dosimetry proteolysis radiation safety radiochemistry radiopharmaceuticals receptor occupancy Siglec-9 sigma-1 receptor availability silicon-based fluoride acceptor single-domain antibody small animal Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) SPECT Staphylococcus aureus sub-millimetre resolution SV2A protein synaptic loss tetrazine tetrazine ligation thiol-reactive tumor imaging VAP-1 vascular adhesion protein vulnerable plaque α-CCA |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557437003321 |
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Roivainen Anne
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Targets, Tracers and Translation - Novel Radiopharmaceuticals Boost Nuclear Medicine / Gerald Reischl
| Targets, Tracers and Translation - Novel Radiopharmaceuticals Boost Nuclear Medicine / Gerald Reischl |
| Autore | Reischl Gerald |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (214 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
pretargeting
radioiodination neurodegeneration phosphoramidon GRPR molecular imaging allosteric modulator radiosynthesis separation ?-CIT PET/CT imaging technetium-99m gastrin-releasing peptide receptor metabotropic glutamate receptor subtype 5 glutamate oncogenic fusions Fusarinine C hypoxia tirapazamine (TPZ) 68Ga sentinel lymph node 99mTc-radioligand iodine-131 electrophilic radioiodination 4-dioxide (BTDO) minigastrin ceftriaxone tropomyosin receptor kinase carbonic anhydrase IX ABP688 NPY(Y1)R MMPEP radiosensitizer neprilysin-inhibition radiochemistry girentuximab benzotriazine-1 gallium-68 cholecystokinin-2 receptor tumor targeting radioimmunotherapy salivary gland uptake metabolic stability tumor hypoxia multimerization oxidizing agent neuroinflammation gastrin-releasing peptide dextran carbon-11 peptide heterodimers apparent molar activity radiometals microglia rituximab [18F]FMISO [11C]meta-hydroxyephedrine Iodo-Gen® mannose 177Lu-radiopharmaceuticals azomycin nucleosides breast cancer click chemistry small animal imaging SR 4317 benzotriazine-1-monoxide (BTMO) bombesin prostate cancer Chloramine T 99mTc-radiopharmaceuticals ketamine PSMA-617 positron emission tomography hydrazinonicotinic acid (HYNIC) renal cell carcinomas [18F]PSS232 PET endoradiotherapy |
| ISBN |
9783039213146
3039213148 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910367759003321 |
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Reischl Gerald
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||