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Amide Bond Activation
| Amide Bond Activation |
| Autore | Szostak Michal |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (466 p.) |
| Soggetto non controllato |
N-heterocyclic carbene
non planar amide ruthenium (Ru) physical organic chemistry gemcitabine prodrug pyramidal amides bridged sultams catalysis dipeptides N-(1-naphthyl)acetamide C-N ? bond cleavage steric effects peptide bond cleavage transition-metal-free palladium N-heterocyclic carbenes (NHCs) addition reaction C–O activation rhodium metal complexes carbanions thioamidation amide bond intramolecular catalysis antiviral activity additivity principle pre-catalysts C–N bond cleavage bridged lactams C–H acidity arynes twisted amides organic synthesis amination Suzuki-Miyaura tert-butyl cyclopentadienyl complexes C-S formation enzymes DFT study sulfonamide bond N HERON reaction primaquine entropy amide activation amidation synthesis amide hydrolysis carbonylicity amide bond activation amide bond resonance aminosulfonylation molecular dynamics model compound in situ amide homogeneous catalysis heterocycles anomeric effect multi-component coupling reaction kinetic excited state C–H bond cleavage palladium catalysis amides thiourea formylation alkynes cis/trans isomerization amide C–N bond activation intein C-H functionalization succindiamide amide bonds crown ether aminoacylation directing groups cytostatic activity reaction thermodynamics acyl transfer transition metals N-dimethylformamide DMAc acylative cross-coupling C-H/C-N activation nickel catalysis antibacterial screening sodium aryl thioamides Winkler-Dunitz parameters catalyst N-dimethylacetamide base-catalyed hydrolysis nitrogen heterocycles cross-coupling insertion amidicity nitro-aci tautomerism activation carbonylation transamidation amine distortion Pd-catalysis rotational barrier energy hypersensitivity N–C activation metabolic stability [2+2+2] annulation twisted amide protease cyanation amide resonance trialkylborane catalysts biofilm eradication pharmacokinetics pancreatic cancer cells DMF aryl esters Michael acceptor fumardiamide water solvation ester bond activation cyclization nuclear magnetic resonance secondary amides reaction mechanism density functional theory density-functional theory amino acid transporters |
| ISBN | 3-03921-204-4 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346843703321 |
Szostak Michal
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Antitumoral Properties of Natural Products
| Antitumoral Properties of Natural Products |
| Autore | Fabiani Roberto |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (344 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
cytotoxic activity
NCI-60 cancer cell line pristimerin Salacia crassifolia Celastraceae Brazilian Cerrado biome Salacia elliptica Cheiloclinium cognatum Plenckia populnea Aspergillus fumigatus Cordyceps sinensis isochromanes chiral resolution ECD calculation cytotoxicity coronarin D JNK osteosarcoma Zeylenone gastric cancer invasion migration apoptosis anti-cancer agents anthraquinones glycosyltransferase Dendrobium officinale structure elucidation anti-tumor activity plantation mode AR Ganoderma tsugae lipogenesis prostate cancer SREBP-1 ursolic acid betulinic acid triterpenoids necrotic quercetin quercetagetin patuletin lichen secondary metabolites tumidulin stemness potential colorectal cancer cells oncogene transcriptional regulation neferine FAK/S6K1 autophagy human neuroblastoma cells natural yellow Monascus pigments water-soluble antioxidation MCF-7 cells phloretin cell proliferation inflammation glucose uptake Catalpa speciosa Taxus cuspidata Magnolia acuminata phenols antioxidants anticancer Colocasia esculenta food bioactive tarin stable nanocapsules entrapment efficiency no-toxicity preclinical tests antitumoral activity chemotherapeutic adjuvant grape leaves ASE TP Antioxidant activities Antiproliferative pro-apoptotic effects Gene expression Nutraceuticals Cucurbitacin B gefitinib-resistant NSCLC EGFR lysosomal degradation CIP2A zerumbone cancer NF-κB IL-6/JAK2/STAT3 Akt FOXO1 multiple myeloma quality control naringenin flavonoids traditional preparation cancer stem cells phytochemicals plant-derived foods fruit vegetable cell signaling Artemisia absinthium endoplasmic reticulum stress mitochondrial-dependent pathway melanoma bee venom melittin temozolomide AKT MAPK antrodin C mTOR metabolic stability capsazepine inflammatory diseases ROS TRPV1 PI3K/AKT/mTOR CLE-10 LC3 MDA-MB-231 lactoferrin hydrolysate copper manganese gastric cancer cells anti-cancer activity molecular mechanism natural product alkaloids cephalotaxine protein synthesis inhibition antiproliferation agents folk medicine DLD-1 cells doxorubicin chemotherapy drug resistance CrataBL glioblastoma mesenchymal stem cells microenvironment plant lectin protease inhibitor cryptolepine neocryptolepine isocryptolepine antiproliferative activity structure activity relationships Licochalcone A ATM-Chk2 13-ethylberberine mitochondrial ROS RT-R breast cancer cells diallyl disulfide PI3K/Akt/mTOR pathway Pulsatilla saponin D SB365 glioblastoma multiforme autophagic flux inhibition lysosomal membrane permeabilization mitochondrial membrane potential CLEFMA p38 proanthocyanins TNF-α lung adenocarcinoma natural compounds cervical cancer cell cycle arrest dicentrine metastasis glioma semi-synthetic derivative ingenol Euphorbia tirucalli protein kinase C seaweed porphyran carrageenan anti-cancer natural products |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557419703321 |
|
Fabiani Roberto
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Antitumoral Properties of Natural Products : Volume 2
| Antitumoral Properties of Natural Products : Volume 2 |
| Autore | Fabiani Roberto |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (300 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
cytotoxic activity
NCI-60 cancer cell line pristimerin Salacia crassifolia Celastraceae Brazilian Cerrado biome Salacia elliptica Cheiloclinium cognatum Plenckia populnea Aspergillus fumigatus Cordyceps sinensis isochromanes chiral resolution ECD calculation cytotoxicity coronarin D JNK osteosarcoma Zeylenone gastric cancer invasion migration apoptosis anti-cancer agents anthraquinones glycosyltransferase Dendrobium officinale structure elucidation anti-tumor activity plantation mode AR Ganoderma tsugae lipogenesis prostate cancer SREBP-1 ursolic acid betulinic acid triterpenoids necrotic quercetin quercetagetin patuletin lichen secondary metabolites tumidulin stemness potential colorectal cancer cells oncogene transcriptional regulation neferine FAK/S6K1 autophagy human neuroblastoma cells natural yellow Monascus pigments water-soluble antioxidation MCF-7 cells phloretin cell proliferation inflammation glucose uptake Catalpa speciosa Taxus cuspidata Magnolia acuminata phenols antioxidants anticancer Colocasia esculenta food bioactive tarin stable nanocapsules entrapment efficiency no-toxicity preclinical tests antitumoral activity chemotherapeutic adjuvant grape leaves ASE TP Antioxidant activities Antiproliferative pro-apoptotic effects Gene expression Nutraceuticals Cucurbitacin B gefitinib-resistant NSCLC EGFR lysosomal degradation CIP2A zerumbone cancer NF-κB IL-6/JAK2/STAT3 Akt FOXO1 multiple myeloma quality control naringenin flavonoids traditional preparation cancer stem cells phytochemicals plant-derived foods fruit vegetable cell signaling Artemisia absinthium endoplasmic reticulum stress mitochondrial-dependent pathway melanoma bee venom melittin temozolomide AKT MAPK antrodin C mTOR metabolic stability capsazepine inflammatory diseases ROS TRPV1 PI3K/AKT/mTOR CLE-10 LC3 MDA-MB-231 lactoferrin hydrolysate copper manganese gastric cancer cells anti-cancer activity molecular mechanism natural product alkaloids cephalotaxine protein synthesis inhibition antiproliferation agents folk medicine DLD-1 cells doxorubicin chemotherapy drug resistance CrataBL glioblastoma mesenchymal stem cells microenvironment plant lectin protease inhibitor cryptolepine neocryptolepine isocryptolepine antiproliferative activity structure activity relationships Licochalcone A ATM-Chk2 13-ethylberberine mitochondrial ROS RT-R breast cancer cells diallyl disulfide PI3K/Akt/mTOR pathway Pulsatilla saponin D SB365 glioblastoma multiforme autophagic flux inhibition lysosomal membrane permeabilization mitochondrial membrane potential CLEFMA p38 proanthocyanins TNF-α lung adenocarcinoma natural compounds cervical cancer cell cycle arrest dicentrine metastasis glioma semi-synthetic derivative ingenol Euphorbia tirucalli protein kinase C seaweed porphyran carrageenan anti-cancer natural products |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Antitumoral Properties of Natural Products |
| Record Nr. | UNINA-9910557531303321 |
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Fabiani Roberto
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Drug metabolism, pharmacokinetics and bioanalysis / / special issue editors, Hye Suk Lee, Kwang-Hyeon Liu
| Drug metabolism, pharmacokinetics and bioanalysis / / special issue editors, Hye Suk Lee, Kwang-Hyeon Liu |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (230 p.) |
| Disciplina | 615.1 |
| Soggetto topico | Drugs - Metabolism |
| Soggetto non controllato |
human liver microsomes
alcohol addiction UGT ultra-high-pressure liquid chromatography adalimumab procainamide LC-MS/MS DA-9805 paeonol LC-QTOF-MS/MS YRA-1909 chlorogenic acid immunoprecipitation Eurycoma longifolia CYP caffeic acid rat pharmaceutical excipient Korean red ginseng extract Stauntonia hexaphylla leaf extract bioanalysis HPLC-MS/MS B6 eurycomanone bioavailability drying technology GB3 diclofenac 129-Glatm1Kul/J aglycone caffeic acid O-glucuronides organic anion transporting polypeptide protein precipitation metabolic stability Fabry disease biopharmaceuticals imperatorin neochlorogenic acid gastric ulcer saikosaponin a hair anthraquinone acetyl tributyl citrate pharmacokinetics brain distribution mematine ethyl glucuronide pharmacokinetic loxoprofen liquid chromatography-quadrupole TOF MS glucuronidation esomeprazole metformin cytochrome P450 glycoside AUDIT score protein stability efficacy LC-HR/MS cryptochlorogenic acid aceclofenac drug interaction liquid chromatography-tandem mass spectrometry Osthenol plasma N-acetylprocainamide diabetes |
| ISBN | 3-03897-917-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346664803321 |
| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Phospholipases: From Structure to Biological Function
| Phospholipases: From Structure to Biological Function |
| Autore | Balboa María A |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (348 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
inhibitor
metabolic stability α-methylation oxoesters phospholipase A2 adrenic acid arachidonic acid mass spectrometry lipid signaling inflammation monocytes/macrophages crotoxin snake venom lung impairment inflammatory response lipid mediators neuromuscular blocker lipidomics PAP-2 autotaxin lysophosphatidate G protein-coupled receptor PLA2G6 fatty liver phospholipid remodeling diet-induced obesity morbidly obesity choline and methionine deficiency glioblastoma sphingolipid sphingosine-1-phosphate sphingomyelinase sphingomyelin metastasis phosphatidic acid diacylglycerol lipin signaling cPLA2α psoriasis proliferation anti-inflammatory atherosclerosis phospholipases macrophages T cells lipins pancreatic islets β-cells insulin secretion glucose tolerance insulin resistance group VIA phospholipase A2 fatty acid knockout mouse lipid mediator lysophospholipid membrane phospholipid ceramide acidic sphingomyelinase neutral sphingomyelinase hepatocellular carcinoma alcoholic and nonalcoholic steatohepatitis preadipocytes prostaglandins adipokines cytokines EP receptors Group V phospholipase A2 lipids majeed syndrome LPIN2 LIPIN2 chronic non-bacterial osteomyelitis chronic recurrent multifocal osteomyelitis autoinflammatory inflammasome macrophage osteoclast |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Phospholipases |
| Record Nr. | UNINA-9910576879603321 |
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Balboa María A
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Radiopharmaceuticals for PET Imaging - Issue A
| Radiopharmaceuticals for PET Imaging - Issue A |
| Autore | Roivainen Anne |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (212 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
kinetic analysis
Siglec-9 gallium-68 vascular adhesion protein VAP-1 infection inflammation osteomyelitis animal model Staphylococcus aureus multiple myeloma positron emission tomography/computed tomography radiopharmaceuticals 18F-fluorodeoxyglucose tetrazine ligation PET SPECT indium-11 fluorine-18 positron emission tomography (PET), defluorination isotopic exchange silicon-based fluoride acceptor bioorthogonal chemistry tetrazine inverse electron-demand Diels-Alder ligation opioid naloxone overdose fentanyl carfentanil [11C]carfentanil positron emission tomography receptor occupancy pharmacokinetics [18F]AlF NOTA NODAGA PODS thiol-reactive linker affibody molecule bioconjugation EGFR tumor imaging vulnerable plaque molecular imaging PET imaging nanobody single-domain antibody sub-millimetre resolution AlF-radiolabelling preclinical radiopharmaceutical dosimetry image-based internal dosimetry OLINDA MCT1/MCT4 lactate transporter inhibitor [18F]FACH radiation safety sigma-1 receptor availability orthotopic xenograft of glioblastoma in mouse small animal Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) (S)-(−)-[18F]fluspidine imaging-based biomarker SV2A protein PET radiotracers synaptic loss radiochemistry preclinical development clinical outcomes monocarboxylate transporters (MCTs) FACH 18F-labeled analog of FACH α-CCA blood-brain barrier (BBB) positron emission tomography (PET) imaging peptides proteolysis metabolic stability |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557437003321 |
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Roivainen Anne
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Targets, Tracers and Translation - Novel Radiopharmaceuticals Boost Nuclear Medicine
| Targets, Tracers and Translation - Novel Radiopharmaceuticals Boost Nuclear Medicine |
| Autore | Reischl Gerald |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (214 p.) |
| Soggetto non controllato |
pretargeting
radioiodination neurodegeneration phosphoramidon GRPR molecular imaging allosteric modulator radiosynthesis separation ?-CIT PET/CT imaging technetium-99m gastrin-releasing peptide receptor metabotropic glutamate receptor subtype 5 glutamate oncogenic fusions Fusarinine C hypoxia tirapazamine (TPZ) 68Ga sentinel lymph node 99mTc-radioligand iodine-131 electrophilic radioiodination 4-dioxide (BTDO) minigastrin ceftriaxone tropomyosin receptor kinase carbonic anhydrase IX ABP688 NPY(Y1)R MMPEP radiosensitizer neprilysin-inhibition radiochemistry girentuximab benzotriazine-1 gallium-68 cholecystokinin-2 receptor tumor targeting radioimmunotherapy salivary gland uptake metabolic stability tumor hypoxia multimerization oxidizing agent neuroinflammation gastrin-releasing peptide dextran carbon-11 peptide heterodimers apparent molar activity radiometals microglia rituximab [18F]FMISO [11C]meta-hydroxyephedrine Iodo-Gen® mannose 177Lu-radiopharmaceuticals azomycin nucleosides breast cancer click chemistry small animal imaging SR 4317 benzotriazine-1-monoxide (BTMO) bombesin prostate cancer Chloramine T 99mTc-radiopharmaceuticals ketamine PSMA-617 positron emission tomography hydrazinonicotinic acid (HYNIC) renal cell carcinomas [18F]PSS232 PET endoradiotherapy |
| ISBN | 3-03921-314-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910367759003321 |
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Reischl Gerald
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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