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Biochemical Biomarkers and Neurodegenerative Diseases
| Biochemical Biomarkers and Neurodegenerative Diseases |
| Autore | Ciaccio Marcello |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (156 p.) |
| Soggetto topico |
Medicine and Nursing
Neurosciences |
| Soggetto non controllato |
25(OH)D levels
AD ALS Alzheimer's disease Alzheimer's Disease AMPK amyloid beta amyloid precursor protein amyotrophic lateral sclerosis Arylsulfatase A astrocytes beta amyloid biomarker biomarkers cerebral ischemia essential tremor focused ultrasound FOXP3 Fyn tyrosine kinase GATA3 Gaucher's disease genetic GLUT3 GSK3β GWAS high-intensity focused ultrasound ablation image quality inherited neuromuscular disorders iron lysosomes magnetic resonance imaging MCAO MR-guided focused ultrasound multiple sclerosis n/a nervous system neurodegenerative disease neurodegenerative diseases neurodegenerative nisease neuroinflammation neuromelanin nigrosome-1 Parkinson's disease parkinsonian disorders PD polymorphisms prognostic biomarker radiomics rare diseases resveratrol SARS-CoV-2 stereotaxic techniques Tyr682 residue vitamin D Vitamin D Vitamin D deficiency YENPTY motif |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557361103321 |
Ciaccio Marcello
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Lysosomal Storage Disorders: Molecular Basis and Therapeutic Approaches
| Lysosomal Storage Disorders: Molecular Basis and Therapeutic Approaches |
| Autore | Moro Enrico |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (301 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
A4GALT
alpha-galactosidase A animal models astrogliosis autophagy axon guidance biomarkers bone involvement cathepsin D chloroquine clathrin Dkk1 dried blood spot endocytic pathways endocytosis enzyme replacement therapy exosomes experimental therapies Fabry disease GAA biomarker Gaucher disease Gaucher Disease gene therapy GLA gene globotriaosyl-sphingosine (lysoGb3) globotriaosylceramide (Gb3) globotriaosylsphingosine glycogen hematopoietic stem cell transplantations Hurler syndrome IGF2R/M6P iPSC Krabbe disease lyso-Gb3 lysosomal diseases lysosomal storage disorder lysosomal storage disorders lysosomal targeting lysosomal α-glucosidase lysosome lysosomes MIP-1β mucolipidosis II mucopolysaccharidosis IIIB mucopolysaccharidosis type I muscle NAGLU neurodegenerative disease neuronal circuit neuronopathy newborn screening Osteoimmunology Osteopontin Parkinson disease pharmacological chaperone therapy pharmacological chaperones Pompe disease precision medicine psychosine quantitative proteomics RANK/RANKL rhGAA satellite cells second tier test sortilin substrate reduction therapy tandem mass spectrometry TGF-beta Twitcher mouse variant interpretation viral vectors visual cortex visual system Wnt/β-catenin Wnt3a α-galactosidase A |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Lysosomal Storage Disorders |
| Record Nr. | UNINA-9910557545503321 |
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Moro Enrico
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery
| Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery |
| Autore | Spetea Mariana |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 online resource (358 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
(−)-N-phenethylnorhydromorphone analogs
[35S]GTPgammaS assay [Dmt1]DALDA 14-methoxycodeine-6-O-sulfate 1H-NMR experiments 6β-naltrexol abuse agonist allodynia analgesia analgesics antagonist arrestin recruitment beta-arrestin bias factor biased agonism biased agonist biased agonists biased ligands biased signaling bifunctional ligands binding binding affinity BNTX buprenorphine chronic constriction injury (CCI) codeine codeine-6-O-sulfate DADLE DALDA DAMGO delta opioid receptor dependence design and synthesis dihydrocodeine diphenethylamines docking dysbiosis fentanyl forskolin-induced cAMP accumulation assays functional assay G-protein bias heteromer hyperalgesia interaction fingerprints internalization inverse agonist ischemia kappa opioid receptor KGOP01 Leu-enkephalin loperamide lysosomes macrocyclic tetrapeptide mechanism elucidation misuse mitragynine molecular docking molecular dynamics molecular modeling & MOR and DOR agonists morphinan morphine mu opioid receptor mu receptor multifunctional ligands n/a naltrexone neonatal opioid withdrawal syndrome neurokinin-1 receptor neutral antagonist NTI derivative opioid opioid drugs opioid liabilities opioid peptide opioid peptides opioid peptides and peptidomimetics opioid receptors opioid side effects opioids over-the-counter drugs pain therapy partial agonism partial agonist peptide synthesis peripheral analgesic tolerance peripheral antinociception peripheral µ-opioid receptors pharmacology plasma stability potassium channels primary hippocampal culture PZM21 racemic synthesis of β2-amino acids receptor binding studies receptor model respiration respiratory depression selectivity simulation SR-17018 structure-activity relationships sulfonamide TAPP tolerance writhing test zerumbone β-arrestin recruitment assays β2-amino acids β2-Homo-amino acids δ opioid receptor δ opioid receptor antagonist μ opioid receptor µ opioid receptor µ-opioid receptor |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Opioids and Their Receptors |
| Record Nr. | UNINA-9910557108003321 |
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Spetea Mariana
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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