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Advances in the Treatment of Renal Cell Carcinoma
| Advances in the Treatment of Renal Cell Carcinoma |
| Autore | Reynolds Paul |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (221 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
renal cell carcinoma
autophagy hydroxychloroquine chloroquine ROC-325 cysteine cathepsins cysteine cathepsin inhibitors lysosome renal cancer metastatic renal cell carcinoma immune-based combination therapies network meta-analysis PD-L1 predictive biomarker treatment TKIs mRCC biomarkers soluble factors immunotherapy renal cell carcinoma (RCC) sunitib resistance artesunate (ART) Traditional Chinese Medicine (TCM) growth inhibition ferroptosis reactive oxygen species (ROS) clear cell renal cell carcinoma ccRCC RCC kidney cancer evolution evolutionary trajectory metastatic second line therapy renal cell cancer immune checkpoint inhibitors tyrosine kinase inhibitors individualization genomic signature transcriptomic analysis |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557615503321 |
Reynolds Paul
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Bacillus thuringiensis Toxins: Functional Characterization and Mechanism of Action
| Bacillus thuringiensis Toxins: Functional Characterization and Mechanism of Action |
| Autore | Bel Yolanda |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (340 p.) |
| Soggetto topico | Research & information: general |
| Soggetto non controllato |
Bacillus thuringiensis
Plutella xylostella Cry1Ac resistance trypsin-like midgut protease protoxin activation Spodoptera spp., Helicoverpa armigera Mamestra brassicae Anticarsia gemmatalis Ostrinia furnacalis Cry2Ab toxin Bombyx mori ATP-binding cassette subfamily a member 2 (ABCA2) genome editing transcription activator-like effector-nucleases (TALENs) HEK293T cell functional receptor Vip3Aa lysosome mitochondria apoptosis Sf9 cells Cry1Ab oligomer formation Sf21 cell line Ostrinia nubilalis Lobesia botrana Leptinotarsa decemlineata bioassay Cyt2Aa2 toxin protein-lipid binding erythrocyte membrane AFM QCM-D Asian corn borer ABCC2 CRISPR/Cas9 Cry1Fa resistance chitin-binding protein adhesion peritrophic matrix Vip3A Spodoptera litura site-directed mutagenesis Cry Cyt parasporins S-layer proteins Vip Sip membrane receptors insecticidal activity anticancer activity Aedes aegypti minor proteins synergy mosquito control Bti Spodoptera frugiperda cadherin mode of action of Cry toxin insecticidal proteins insect resistance tobacco budworm Bacillus thuringiensis proteins coleopteran pests structure mode of action 3D-structure biological control antimicrobial peptide gut microbiota vegetative insecticidal proteins pyramids 3D-Cry toxins in vitro evolution rational design toxin enhancement |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Bacillus thuringiensis Toxins |
| Record Nr. | UNINA-9910557646103321 |
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Bel Yolanda
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Extracellular Vesicles: Biology and Potentials in Cancer Therapeutics
| Extracellular Vesicles: Biology and Potentials in Cancer Therapeutics |
| Autore | Cho William |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (394 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
extracellular vesicle
precision oncology cancer biomarker prostate cancer drug delivery extracellular vesicles lysosome nanocarriers ultrasound size exclusion chromatography differential ultracentrifugation head and neck squamous cell carcinoma (HNSCC) exosomes cancer biomarker diagnostic therapy liquid biopsy small extracellular vesicles (sEV) tumor-derived exosomes (TEX) melanoma cell-derived exosomes (MTEX) proteomics tumor microenvironment biomarkers ectosomes neoplasia microvesicles small extracellular vesicles isolation purification size-exclusion chromatography ultracentrifugation sucrose density cushion lymph node spleen solid tissue microvesicle exosome cancer therapeutic drug carrier flow cytometry immunophenotyping swarm detection tumor-associated macrophages macrophage polarization mannose receptor HIV-1 Nef glioblastoma microRNA immunoprecipitation CD44 human milk nutrient microbiota microRNAs nanocommunicator diagnostic biomarker drug delivery vehicle personalized cancer immunotherapy therapeutic agents cell-to-cell communication ionising radiation non-targeted effects signalling imaging flow cytometry biomarker reservoirs cancer diagnostics disease monitoring large EVs ovarian cancer cells ES-2 OAW-42 adipose tissue origin mesenchymal stem cells |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Extracellular Vesicles |
| Record Nr. | UNINA-9910557555303321 |
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Cho William
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Killing Cancer : Discovery and Selection of New Target Molecules
| Killing Cancer : Discovery and Selection of New Target Molecules |
| Autore | Kallunki Tuula |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (302 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
ferlin
myoferlin dysferlin otoferlin C2 domain plasma membrane sulconazole NF-κB IL-8 mammosphere breast cancer stem cells AF1Q MLLT11 WNT STAT esophageal cancer prognosis mTORC1 mTORC2 metabolism rapalogs mTOR inhibitors cancer metabolism mTOR in immunotherapy nutrient metabolism kinase inhibitors mTOR signaling MAPK kinase ERK1 ERK2 CD domain Rolled SCH772984 VRT-11E sevenmaker cancer therapy EMT lysosome lysosome-mediated invasion MZF1 phosphorylation PAK4 SUMOylation transcription factor zinc finger glucocorticoids 3D growth nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB) epithelial-mesenchymal transition anoikis proliferation targeted cancer therapy disulfiram NPL4 replication stress DNA damage BRCA1 BRCA2 ATR pathway PDAC TCIRG1 ATP6V0a3 invasion migration matrix degradation pH-regulation autophagy multidrug resistance in cancer drug efflux pumps ATP-binding cassette transporter breast cancer resistance protein (BCRP) ABCG2 pyrazolo-pyrimidine derivative SCO-201 colorectal cancer immunotherapy inflammation microsatellite instability oncofetal chondroitin sulfate chondroitin sulfate cancer solid tumors target pediatric cancer VAR2 dexamethasone thyroid cancer microgravity space environment |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Killing Cancer |
| Record Nr. | UNINA-9910557648103321 |
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Kallunki Tuula
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Lysosomal Storage Disorders: Molecular Basis and Therapeutic Approaches
| Lysosomal Storage Disorders: Molecular Basis and Therapeutic Approaches |
| Autore | Moro Enrico |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (301 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
mucopolysaccharidosis IIIB
quantitative proteomics NAGLU lysosomes Gaucher disease bone involvement enzyme replacement therapy substrate reduction therapy Osteoimmunology RANK/RANKL Osteopontin MIP-1β mucolipidosis II sortilin TGF-beta cathepsin D Fabry disease alpha-galactosidase A endocytosis lysosome IGF2R/M6P clathrin chloroquine lysosomal diseases precision medicine pharmacological chaperones gene therapy Pompe disease lysosomal targeting autophagy muscle satellite cells rhGAA glycogen lysosomal α-glucosidase GAA biomarker Gaucher Disease Wnt/β-catenin Dkk1 Wnt3a iPSC neuronopathy Krabbe disease Twitcher mouse psychosine visual system visual cortex astrogliosis mucopolysaccharidosis type I Hurler syndrome hematopoietic stem cell transplantations animal models experimental therapies axon guidance lysosomal storage disorders neuronal circuit α-galactosidase A A4GALT globotriaosylceramide (Gb3) globotriaosyl-sphingosine (lysoGb3) pharmacological chaperone therapy exosomes endocytic pathways neurodegenerative disease Parkinson disease lysosomal storage disorder viral vectors newborn screening variant interpretation second tier test tandem mass spectrometry lyso-Gb3 dried blood spot GLA gene globotriaosylsphingosine biomarkers |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Lysosomal Storage Disorders |
| Record Nr. | UNINA-9910557545503321 |
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Moro Enrico
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Mitochondrial Dysfunction in Aging and Diseases of Aging
| Mitochondrial Dysfunction in Aging and Diseases of Aging |
| Autore | Haas Richard H |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (270 p.) |
| Soggetto non controllato |
age-related diseases
sphingolipids glaucoma ALS neurodegeneration mitochondrial dysfunction adaptive immunity senescence de-emergence innate immunity cell danger response mitochondrial transfer axonal transport cytokines mitochondrial age-related macular degeneration prevention heart failure purinergic signaling autophagy Alzheimer's disease diabetic retinopathy proteostasis 1 immunosenescence Miro1 ROS metabolism optic nerve polypharmacy eIF2? Parkin coenzyme Q10 neurodegenerative disease DNA damage skin exercise nucleotide metabolism pasteur effect stress response inflammation retina drug-induced mitochondrial toxicity neuroinflammation exosomes reactive oxygen species 25(OH)D cardiomyopathy crabtree effect insulin resistance cardiovascular disease ageing genetic mutations metabokines mitochondria multiple sclerosis aerobic healing cycle SOD1 mitophagy PINK1 type 2 diabetes integrated cell stress response morbidity and mortality ultraviolet photoageing cancer aging 25(OH)2D lysosome NAD+ Parkinson's disease |
| ISBN | 3-03921-328-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910367756303321 |
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Haas Richard H
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Alveolar Epithelium : Mechanisms of Injury and Repair
| The Alveolar Epithelium : Mechanisms of Injury and Repair |
| Autore | Kasper Michael |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (222 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
JAM-A
P2X7 receptor mouse lung alveolar epithelium bleomycin-induced lung injury GSK-3β dietary sugar hyperglycemia lung mechanics alveolar septal composition physical activity extracellular matrix remodeling high-altitude pulmonary edema acute mountain sickness oxygen diffusion limitation surfactant protein B atelectrauma alveolar fluid acinar micromechanics acute lung injury autophagy lysosome lysosomal membrane permeability mitochondria pneumocyte microRNA-21 alveolar micromechanics structural remodeling inflammatory signaling lung alveolus type 1 alveolar epithelial cell type 2 alveolar epithelial cell focused ion beam scanning electron microscopy 3D reconstruction carbon dioxide hypercapnia Na,K-ATPase endoplasmic reticulum sodium transport protein oxidation alveolar epithelial cells pulmonary fibrosis epithelial cell dysfunction stem cell exhaustion pneumonia necrotizing regeneration model bovine chlamydia alveoli air-blood barrier epithelium air-liquid interface alveolar lining layer glycocalyx surfactant lung injury lung regeneration |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Alveolar Epithelium |
| Record Nr. | UNINA-9910557307703321 |
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Kasper Michael
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Ubiquitin and Autophagy
| Ubiquitin and Autophagy |
| Autore | Nazarko Taras Y |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (294 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
PSMD14
ubiquitin retrograde trafficking APP autophagy Cx43 GABARAP gap junction MAPLC3 leukodystrophies globoid cell leukodystrophy psychosine p62 proteasome toll-like receptor 4 TRAF6 BECN1 ATG12~5/16 complex Dictyostelium ubiquitin-like protein phagocytosis pinocytosis UPS ubiquitin-proteasome system crosstalk tissue specificity C. elegans NFAT5 autophagy initiation islet FIP200 unfolded protein response UPR Atg8 LC3 LIR motif SAR UBL neurodegenerative diseases autophagy-lysosome pathway lysosome selective autophagy ubiquitination degradation the ubiquitin-proteasome system plants mitophagy aggrephagy lysophagy xenophagy lipophagy nucleophagy ER-phagy cargo receptors sorting nexins retromer endosome |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557339503321 |
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Nazarko Taras Y
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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