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Advance in the Treatment of Pediatric Leukemia
| Advance in the Treatment of Pediatric Leukemia |
| Autore | Handgretinger Rupert |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (300 p.) |
| Soggetto topico |
Research & information: general
Chemistry |
| Soggetto non controllato |
acute lymphoblastic leukemia
pediatric advances diagnosis treatment immunotherapy bispecific T-cell engager (BiTE) BCP-ALL leukemia TRAIL antibody Fc-engineering xenograft CD19 juvenile myelomonocytic leukemia RAS signaling hematopoietic stem cell transplantation 5-azacitidine myelodysplastic/myeloproliferative disorders targeted therapy ADC antibody-drug conjugate pediatric leukemia ALL AML allogeneic stem cell transplantation acute myeloid leukemia minimal residual disease conditioning regimen alternative donors B-ALL DUX4 IKZF1 PAX5 Ph-like ZNF384 NUTM1 T-ALL NOTCH1 BCL11B transcriptome genome chronic myeloid leukemia CML tyrosine kinase inhibitor immunizations COVID-19 childhood acute lymphoblastic leukemia low-risk ALL risk-stratified treatment treatment related toxicity L-asparaginase acute pancreatitis polymorphism SNV ABCC4 CFTR other extramedullary relapse lymphoblastic leukemia children prognosis evolution of CAR T cells FDA-approved CAR products TcR versus CAR limitations and complications of CAR T cell therapy future directions of CAR T cell therapy |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910576878903321 |
Handgretinger Rupert
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Advances in Nanomaterials in Biomedicine
| Advances in Nanomaterials in Biomedicine |
| Autore | Ryabchikova Elena I |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (472 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
bone marrow-derived mesenchymal stromal cells
rAAV vectors carbon dots SOX9 TGF-β cartilage repair silver nanoparticles Entada spiralis Ceiba pentandra antibacterial assay catalytic dye reduction osteoarthritis human articular cartilage polymeric micelles pro-inflammatory cytokines IL-1β TNF-α nanomaterials nanomedicine immunotherapy oncotherapy immune-checkpoint inhibitors immunogenic cell death nano-vaccines nano-conjugates immune response oxidative stress antioxidants nanoparticles biological nano-antioxidants gold nanoparticles radiation chemotherapy radiosensitizer drug delivery system chemoradiotherapy magnetoliposomes hydrogels magnetolipogels self-assembly fluorescence Förster resonance energy transfer polypropylenimine dendrimers polyethylenimines tyrosine-modified polypropylene-imines tyrosine-modified polyethlyenimines PPI-Y siRNA transfection polymeric nanoparticles carbosilane dendron triazine amphiphile vesicles pH-sensitive doxorubicin methotrexate leukaemia molecular ultrasound nanobubbles active targeting targeted microbubbles angiogenesis inflammation thrombosis clinical translation molecular imaging liver fibrosis diagnosis therapy theranostics targeted drug delivery lipid conjugates amphiphilic oligonucleotides phosphoryl guanidines nucleic acid delivery leukemia iron nanoparticles RNA-Seq cytotoxicity polymers biodegradable drug delivery pharmaceutical SQUID magnetic properties iron content magnetite nanoparticles superoxide aorta heart nano-biomaterials nanotechnology scaffolds hard tissue engineering AuNPs AuPEI-NPs AuBSA-NPs electron microscopy ultrastructure of HepG2 cells and spheroids ultrastructure of HEK293 cells and spheroids penetration of NPs into monolayer and spheroids gold nanostars photothermal therapy photoacoustic imaging computed tomography cancer theranostic agents biocompatible nanomaterials diagnostics nanocarriers tissue engineering |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557724003321 |
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Ryabchikova Elena I
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Bio-Functional Natural Products in Edible Resources for Human Health and Beauty
| Bio-Functional Natural Products in Edible Resources for Human Health and Beauty |
| Autore | Morikawa Toshio |
| Pubbl/distr/stampa | Basel, : MDPI Books, 2022 |
| Descrizione fisica | 1 electronic resource (226 p.) |
| Soggetto topico |
Medicine
Pharmacology |
| Soggetto non controllato |
sweet potato
anthocyanin compositions biosynthesis structural genes transcription factor Vaccinium vitis-idaea lingonberry sugars cultivated berries wild berries HPLC-ELSD banana inflorescences anti-inflammatory activity antiparasitic activity UPLC-ESI-MS arylpropanoid sucroses Lavandula stoechas essential oil topical anti-inflammatory effect anticancer activity melanoma cell lines 1,8-Cineole fallopian tube phytoestrogen ciliated cell secretory cell Notch sea buckthorn phenolic compounds triterpenic compounds carotenoids chlorophyll freeze-drying leaf powder ingredients leukemia leukemic stem cell FLT-3 chemotherapeutic drug curcumin co-treatment tomato seed lycoperoside steroidal saponin ceramide transepidermal water loss anti-inflammation anemia cognition elder hemoglobin iron Oryza sativa rice medicine food homology functional food herbs type 2 diabetes mellitus gut microbiota aging of the human body medicinal plants antioxidant anti-inflammatory anti-glycation anti-neurodegenerative properties sesame oil aroma 2,5-dimethylpyrazine 2-methoxy phenol water-immersion stress antianxiety elevated plus-maze test dual specificity phosphatase 1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910595069303321 |
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Morikawa Toshio
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| Basel, : MDPI Books, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Biological Activities of Alkaloids: From Toxicology to Pharmacology
| Biological Activities of Alkaloids: From Toxicology to Pharmacology |
| Autore | Adamski Zbigniew |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (270 p.) |
| Soggetto non controllato |
leukemia
biodistribution glycoalkaloids insect heart Solanum melongena L. antibacterial alkaloid ?-carboline Ovarian cancer Chelidonium majus secondary metabolites lindoldhamine livestock insect chanoclavine bisbenzylisoquinoline alkaloid cytotoxic activity Staphylococcus aureus antioxidant acid-sensing ion channel subtype 1a malonylated form HPLC-DAD ergot alkaloids nociception macrophage Arecoline Macleaya cordata antifungal neuropathic pain Corydalis lutea antiviral Curine lung cancer cells lipopolysaccharide Epichloë Meconopsis cambrica Berberis thunbergii SRC Dicentra spectabilis apoptosis endophyte natural sources dehydrocrenatidine neutrophil EGFR anticancer solamargine berberine isoquinoline alkaloids natural products Radix Aconiti Lateralis preparations short-term and long-term usage inflammation acute toxicity Mahonia aquifolia Palmatine sanguinarine Rutidea parviflora voltage-gated sodium channels cytotoxicity toxicology malonyl-solamargine alkaloids acetylcholinesterase beetles Fumaria officinalis antimicrobial activity solasonine FAK plant secondary metabolites di-ester diterpenoid alkaloids mAchR3 subchronic feeding study mono-ester diterpenoid alkaloids Tenebrio molitor Apoptosis reproduction |
| ISBN | 3-03928-928-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Biological Activities of Alkaloids |
| Record Nr. | UNINA-9910404082303321 |
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Adamski Zbigniew
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| MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Cells and Materials for Disease Modeling and Regenerative Medicine
| Cells and Materials for Disease Modeling and Regenerative Medicine |
| Autore | Abarrategi Ander |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (270 p.) |
| Soggetto topico | Research & information: general |
| Soggetto non controllato |
Leigh syndrome
mitochondrial disorder iPSC NSC neuron disease modeling mtDNA high hydrostatic pressure devitalization decellularization allografts regenerative medicine bone and cartilage regeneration dentogenesis amelogenesis dentinogenesis cementogenesis drug release materials scaffolds odontogenic cells stem cells whole-tooth regeneration psoriasis cyclic adenosine monophosphate cholera toxin isoproterenol tissue engineering extracellular matrix collagen elastin bladder compliance microarchitecture biomimicry blood cancer bone marrow niche microenvironment 3D models tumor-on-a-chip leukemia myeloma biomaterials cytokines growth factors cardiac tissue regeneration adipose tissue fibrosis in vitro models in vivo models dental pulp stem cells osteogenesis rheumatoid arthritis mesenchymal stromal cells co-culture 3D cell culture explants joint-on-a-chip piezoelectric electroactive patterning cell differentiation bone tissue engineering |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557403303321 |
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Abarrategi Ander
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Functionally Relevant Macromolecular Interactions of Disordered Proteins
| Functionally Relevant Macromolecular Interactions of Disordered Proteins |
| Autore | Simon Istvan |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (520 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
intrinsically disordered proteins
epiproteome disordered protein platform molecular recognition feature post-translational modifications physiological homeostasis stress response RIN4 p53 molecular machines intrinsically disordered protein membrane-less organelle neurodegenerative disease p300 HAT acetylation post-translational modification protein aggregation Tau fibrillation intrinsically disorder proteins disorder-to-order regions protein–RNA interactions unstructured proteins conformational plasticity disordered protein folding ribosomal protein spectroscopy protein stability temperature response protein thermostability salt bridges meta strategy dual threshold significance voting decision tree based artificial neural network protein intrinsic disorder intrinsic disorder intrinsic disorder prediction intrinsically disordered region protein conformation transcriptome RNA sequencing Microarray differentially regulated genes gene ontology analysis functional analysis intrinsically disordered structural disorder correlated mutations co-evolution evolutionary couplings residue co-variation interaction surface residue contact network dehydron homodimer hydrogen bond inter-subunit interaction ion pair mutual synergistic folding solvent-accessible surface area stabilization center MLL proteins MLL4 lncRNA HOTAIR MEG3 leukemia histone lysine methyltransferase RNA binding protein hydration wide-line 1H NMR secretion immune extracellular protein-protein interaction structural domain evolution transcription factors DNA-protein interactions Sox2 sequential DNA loading smFRET DNA conformational landscape sequential DNA bending transcription factor dosage oligomer N-terminal prion protein copper binding prion disease mutations Nuclear pore complex FG-Nups phosphorylation coarse-grained CABS model MC simulations statistical force fields protein structure intrinsically disordered proteins (IDPs) neurodegenerative diseases aggregation drugs drug discovery plant virus eIF4E VPg potyvirus molten globule fluorescence anisotropy protein hydrodynamics |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557509403321 |
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Simon Istvan
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Leukemia
| Leukemia |
| Autore | Li Weijie |
| Pubbl/distr/stampa | Brisbane, Australia, : Exon Publications, 2022 |
| Soggetto topico | MJCL |
| Soggetto non controllato |
leukemia
hematolymphoid tumors infant leukemia hairy cell leukemia measurable residual disease in acute leukemia acute myeloid leukemia with myelodysplasia related changes secondary acute myeloid leukemia myeloid/lymphoid neoplasms PDGFRA rearrangement leukemia pharmacogenomics acute lymphoblastic leukemia |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910617309103321 |
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Li Weijie
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| Brisbane, Australia, : Exon Publications, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Marine Compounds and Cancer 2020
| Marine Compounds and Cancer 2020 |
| Autore | Honecker Friedemann |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (480 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
apoptosis
fucoidan hepatocellular carcinoma reactive oxygen species 3-alkylpyridinium polymers nicotine nicotinic acetylcholine receptor non-small cell lung carcinoma melanoma sinulariolide proteomic mitochondria caspase cascade marine fungus sediment anthranilic acid Penicillium paneum cytotoxicity dibromotyrosine mitochondrial dysfunction oxidative stress topoisomerase epigonal organ bonnethead shark Jurkat tumor cell line hippuristanol PEL AP-1 STAT3 Akt colorectal cancer marine mollusc brominated indoles shrimp chemoprevention fatty acids carotenoids cancer nanoparticle osteosarcoma lung metastasis elisidepsin lipid rafts hydroxylated lipids fatty acid 2-hydroxylase cooperative binding membrane permeabilization marine organisms polysaccharides anticancer anticarcinogenic mechanisms of action fumigaclavine C anti-proliferation mitochondrial pathway anti-cancer anti-proliferative carotenoid cell cycle arrest fucoxanthin azoxymethane bioactive natural product isatin in vivo model Marthasterias glacialis L. palmitic acid ER-stress CHOP Antibody Drug Conjugates (ADCs) marine antitumor agents clinical trials approved antitumor agents AD0157 angiogenesis marine drug pyrrolidinedione secondary metabolites cancer preventive chemopreventive trabectedin plitidepsin tumor-associated macrophages tumor microenvironment preclinical anticancer immunity antiangiogenesis fascaplysin cyclin-dependent kinase small cell lung cancer camptothecin poly(ADP-ribose)-polymerase inhibitor breast cancer seaweed therapeutic compounds autophagy marine drugs autophagy inhibitors autophagy inducers macrolide programmed cell death energy stress araguspongine C c-Met HER2 gemcitabine pazopanib phase I safety soft tissue sarcoma pachastrissamine jaspine B carbocyclic analogue sphingosine kinase inhibitor molecular modeling ET-743 DNA minor groove binder soft tissue sarcoma chemotherapy bis (2,3-dibromo-4,5-dihydroxy-phenyl)-methane (BDDPM) anti-metastatic activity cell adhesion β1-integrin FAK BEL-7402 cell triterpene glycosides sea cucumbers antitumor activities arrest of cell cycle antibacterial marangucyclines deep-sea Streptomyces sp. SCSIO 11594 LS-1 SNU-C5/5-FU TGF-β signaling carcinoembryonic antigen kalkitoxin Moorea producens mitochondria toxin VEGF angiogenesis inhibitor hypoxia-inducible factor-1 HIF-1 Lyngbya majuscula marine metabolites SZ-685C nonfunctioning pituitary adenomas Ecklonia cava phlorotannins dieckol migration sipholenol A ABC transporter multidrug resistance P-gp/ABCB1 BCRP/ABCG2 MRP1/ABCC1 marine natural products glioblastoma xyloketal B proliferation TRPM7 marine compound ribosomal protein genes snoRNA FAU RPS30 SNORA62 evolution Porifera Penicillium brevicompactum Brevianamide Mycochromenic acid derivative antifouling Caribbean sponge plakortide endoperoxide leukemia multi-drug resistant leukemia Sarcophyton ehrenbergi soft coral terpenes cembranoids cytotoxic activity molecular docking uveal melanoma oxidative stress virtual screening Topo I inhibitor low toxic natural product Ulva fasciata selenium-containing polysaccharide-protein complex pseudopterosin NF-κB p65 inflammation cytokine release IL-6 TNFα MCP-1 glucocorticoid receptor paulomycins Micromonospora antitumor Cantabrian Sea-derived actinobacteria puupehenones sponges antiangiogenic antitumoral porifera/sponge cancer genes molecular oncology bromophenol molecular mechanisms cell cycle PI3K/Akt p38/ERK ROS human lung cancer glycosaminoglycans antiproliferative heparan sulphate gliotoxin NSCLC adriamycin resistance Sepia ink polysaccharides antitumour chemosensitization anticoagulation sea anemone drug discovery endothelial cells RGD motif kunitz type inhibitor prostate cancer antioxidant natural marine compounds marine biotechnology microalgae marine sponges Aeroplysinin Isofistularin pheochromocytoma and paraganglioma metastasis cancer progression cell adhesion molecules integrin β1 hypoxia phycocyanin non-small cell lung cancer NF-κB signaling marine-derived drugs bioanalysis chromatography manzamine A epithelial-mesenchymal transition lung cancer circulating tumor cells signal transduction cisplatin Lampetra morii buccal gland cystatin F anti-angiogenesis cystatin superfamily Antimicrobial peptide (AMP) Tilapia piscidin 4 (TP4) non-small cell lung cancer (NSCLC) itampolin A FBDD p38α novel inhibitor tetracenomycin X cyclin D1 proteasomal degradation p38 c-JUN λ-carrageenan heparanase anticoagulant depolymerisation cell migration Aspergillus naphthopyrones endophytic fungus Leathesia nana mangrove-derived actinomycete ansamycins divergolides apoptosis-inducing activity actinomycin EMT invasion low molecular weight fucoidan extract N-Ras neuroblastoma-rat sarcoma Cancer programmed cell death-ligand 1 programmed cell death-ligand 2 human sarcoma cell line (HT1080 cells) human normal diploid fibroblast (TIG-1 cells) chimera chemical conjugation anticancer agent hybridization α9-nicotinic acetylcholine receptors (nAChRs) breast cancer cells αO-conotoxin GeXIVA targeted therapy gorgonian Leptogorgia humulane sesquiterpenoids anticancer activity 12-deacetyl-12-epi-scalaradial HeLa cells Nur77 MAPK/ERK pathway Mycalin A C15 acetogenins synthetic analogues antiproliferative activity A375 and HeLa cell lines polyoxygenated steroids sponge Haliclona gracilis Thalassia testudinum thalassiolin B polyphenols CYP1A1 benzo[a]pyrene JNK1/2 natural products synergism A549 cells cytoskeleton P2X7 receptor pollution anti-angiogenic gene expression HSP90 inhibitor |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557339303321 |
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Honecker Friedemann
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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MicroRNA as Biomarkers in Cancer Diagnostics and Therapy
| MicroRNA as Biomarkers in Cancer Diagnostics and Therapy |
| Autore | Sempere Lorenzo F |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (166 p.) |
| Soggetto topico | MicroRNAs |
| Soggetto non controllato |
leukemia
cell lines hepatitis B virus long non coding RNA normalization of miRNA expression in RT-qPCR children colorectal review bevacizumab tumor budding cells oral cancer liquid biopsy hepatocellular carcinoma small t-antigen colorectal cancer protein-miRNA complex biomarkers biomarker interleukin-1? tissue analysis miRNAs T-cell acute lymphoblastic leukemia (T-ALL) leukoplakia inflammation exosomes circulating free DNA hepatitis C virus miRNA miR-21 extracellular microRNA endogenous controls lymphoma confocal slide scanning microscopy early diagnosis reference genes large T-antigen microRNA miRNA (microRNA) cancer TNF-? plasma |
| ISBN | 3-03921-250-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346847003321 |
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Sempere Lorenzo F
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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mTOR in Human Diseases
| mTOR in Human Diseases |
| Autore | Dormond Olivier |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (480 p.) |
| Soggetto non controllato |
primary cilia
neurodegeneration nutrient sensor PI3K transcriptomics phosphorylation metabolic reprogramming autophagy Alzheimer's disease rapalogs liver angiogenesis mTOR complex MBSCs advanced biliary tract cancers Medulloblastoma epithelial to mesenchymal transition AMPK p70S6K lipid metabolism thyroid cancer sodium iodide symporter (NIS)/SLC5A5 male fertility anesthesia illumina mTOR inhibitor miRNA Hutchinson-Gilford progeria syndrome (HGPS) eIFs Emery-Dreifuss muscular dystrophy (EDMD) glucose AKT oral cavity squamous cell carcinoma (OSCC) glucose and lipid metabolism cellular signaling aging tumor microenvironment rapamycin leukemia chloral hydrate rapalogues schizophrenia T-cell acute lymphoblastic leukemia senescence lamin A/C neurotoxicity neurodevelopment inhibitor methamphetamine pulmonary fibrosis mTOR mTOR inhibitors combination therapy proteolysis fluid shear stress tumour cachexia biomarkers synapse gluconeogenesis mTOR signal pathway Sertoli cells immunosenescence miRNome protein aggregation senolytics metabolism NGS mTORC2 mTORC1 metabolic diseases IonTorrent apoptosis dopamine receptor nocodazole microenvironment everolimus acute myeloid leukemia immunotherapy spermatogenesis bone remodeling signalling targeted therapy ageing therapy NVP-BEZ235 fructose physical activity laminopathies MC3T3-E1 cells cell signaling microRNA cancer lipolysis melatonin Parkinson's disease |
| ISBN | 3-03921-061-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346684303321 |
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Dormond Olivier
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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