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Anticancer Drugs 2021
| Anticancer Drugs 2021 |
| Autore | Meegan Mary J |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (594 p.) |
| Soggetto topico |
Research & information: general
Chemistry |
| Soggetto non controllato |
thymidylate synthase
cytotoxicity 1,2,3-triazole 1,3,4-oxadiazole 5-fluoruracil pemetrexed docking 3,4'-bis-guanidino 3-amino-4'-guanidino diphenyl ether phenyl pyridyl ether intramolecular hydrogen bond cancer cell viability HL-60 BRAF apoptosis thieno[2,3-d][1,2,3]triazine acetamide H1299 HER2 EGFR Bcl-2 inhibitors Indole-based analogues benzimidazole MTT cytotoxic assay cell cycle analysis DNA fragmentation ELISA solid/lipid nanoparticles phenstatin letrozole tubulin polymerisation inhibitor aromatase inhibitor breast cancer hybrid molecule dual-targeting molecule designed multiple ligand NaMSA cyclophosphamide histopathology testis urinary bladder anticancer agents enantioselective synthesis gastric adenocarcinoma tryptophanol concentration-guided dosing model informed dosing physiologically based pharmacokinetics sorafenib tyrosil-DNA-phosphodiesterase 1 adamantane resin acid TDP1 cytotoxic agents apoptosis induction HT-29 cells MDA-MB-231 cells mechanism prediction STAT inhibitors miR-21 hydrazide derivatives nitrogen scaffolds mitoxantrone cardiotoxicity inflammation oxidative stress age cumulative dose Trk NTRK tissue-agnostic larotrectinib entrectinib Trk fusion protein kinase inhibitors USFDA cancer patent review generic product doxazosin MD simulations combretastatin A-4 cytotoxic activity hybrid compounds indazole mucin MUC1 MUC16 immunotherapy cancer vaccine CAR (chimeric antigen receptor) ADC (antibody-drug conjugate) thiourea interleukin-6 trypan blue assay chalcones exportin-1 covalent binding CovDock anticancer activity xanthone in vitro in vivo isolation synthesis heterocyclic compound benzenesulfonamides imidazoles alkylated colony formation tumor spheroids HDAC inhibitors chalcone dual inhibitors carvedilol kidney toxicity 7-deaza-4'-thioadenosine derivatives multi-kinase inhibitor anticancer nucleoside Imiquimod drug efflux multidrug resistance Toll-Like Receptor |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910576874303321 |
Meegan Mary J
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Benefits of Resveratrol Supplementation
| Benefits of Resveratrol Supplementation |
| Autore | Fernandez-Quintela Alfredo |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (260 p.) |
| Soggetto non controllato |
polyphenols
?-viniferin leptin resistance p53 kidney energy restriction grape powder extract cytokines phosphorylation obesity energy metabolism metabolic pathways endothelial function polyol pathway antioxidant caloric restriction rat adipose tissue microparticles pathways angiotensin converting enzyme 2 resistance esRAGE interleukins metabolic syndrome dissolution rate thermogenesis streptozotocin bioavailability solubility metabolism renin-angiotensin system microbiota Sirt-1 magnesium dihydroxide hypertrophy metabolic diseases physiological adaption red wine extract lens distribution MTA1 sirtuin inflammation cardiac function rats cisplatin resveratrol mitochondria breast cancer ischemia-reperfusion cardiovascular metabolites gut microbiota prostate cancer performance type 2 diabetes cafeteria diet high-fat high-sucrose diet resistance exercise aging diabetes oxidative stress |
| ISBN | 3-03921-276-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346854603321 |
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Fernandez-Quintela Alfredo
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Biomechanical Spectrum of Human Sport Performance
| Biomechanical Spectrum of Human Sport Performance |
| Autore | TAIAR Redha |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (356 p.) |
| Soggetto topico | History of engineering & technology |
| Soggetto non controllato |
foot morphology
toes function biomechanics barefoot jumping running jump throwing ability 3D motion analysis acceleration kidney torque exercise physical fitness peritoneal dialysis sports engineering ground reaction forces swimming performance neuromuscular training strength injury prevention young athletes basketball shoe comfort perception foot loading plantar pressure maneuver two-dimensional video analysis validity reliability quantitative biomechanical parameters artistic gymnastics minimalist index patellofemoral contact force patellofemoral contact stress footwear patellofemoral joint pain syndrome virtual reality visual speed perception treadmill running self-motion perception optical flow locomotion forefoot Gait Heel TUG Type 2 diabetes mellitus metabolic syndrome whole body vibration exercise range of motion of the knees surface electromyographic pattern neuromuscular activation sleep quality whole-body vibration exercise Pittsburgh Sleep Quality Index Epworth Sleepiness Scale Berlin Questionnaire mechanical vibration traditional Chinese medicine balance flexibility muscle strength stabilometry ballet dancers ankle injury chronic ankle instability functional movement evaluation assessment screen type 2 diabetes mellitus blood flow velocity skin temperature vibration 3D force modeling rowing biomechanics robot-assisted training individualized training virtual reality simulator training of experts rowing simulator tendon based parallel robot transversal vibration control physical training intensity therapeutic exercises work related neck pain musculoskeletal pain flight time vertical jump center of mass landing anthropometric variables hamstring-to-quadriceps ratio H/Q ratio isometric lower limb measurement acquisitions and techniques strength and conditioning sports training strength abilities anterior cruciate ligament automation drop jump injury risk deep learning machine learning movement screen OpenPose signal complexity texture analysis multiscale entropy analysis wavelet transform photoplethysmography orthosis tensile strength test robotic therapy posture stability football training slackline balancing dynamics reconstruction contact force modeling optimal control subject-specific modeling velocity technique overhead racket swing stroke modeling and simulation in sport science mechanical analyses of sports sport medicine injury in sport human behavior quality of life applied science in musculoskeletal disorders |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557497903321 |
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TAIAR Redha
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Cellular and Molecular Mechanisms of Nephropathic Cystinosis
| Cellular and Molecular Mechanisms of Nephropathic Cystinosis |
| Autore | Levtchenko Elena N |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (230 p.) |
| Soggetto topico |
Medicine
Pharmacology |
| Soggetto non controllato |
cystinosis
cysteamine bone osteoclast genotype CD34+ hematopoietic stem and progenitor cells gene therapy pre-clinical studies investigational new drug application clinical trial disulfiram mice zebrafish fertility azoospermia hypogonadism histopathology mouse model lysosomal storage disease cell and animal models infantile nephropathic cystinosis bone-muscle wasting fibroblast growth factor 23 osteoclasts sclerostin leptin fractures nephropathic cystinosis hollow fiber membrane 3-dimensional models autophagy macrophages inflammasome proximal tubular cells endocytosis apoptosis chitotriosidase interleukins galectin-3 novel therapies endolysosome epithelial cell differentiation homeostasis lysosomal storage diseases mitochondrial distress kidney proximal tubule programmed cell death central nervous system cortical atrophy arterial spin labelling cystine blood level lysosomal storage disorder history treatment strategies for cystinosis newborn screening clinical course CTNS-pathogenic variants newborn screening for cystinosis kidney progenitors cell model biomarkers cystine kidney therapeutic monitoring |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910585941103321 |
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Levtchenko Elena N
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Immunohistochemical Expression
| Immunohistochemical Expression |
| Autore | Caltabiano Rosario |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (168 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
training exercise
NGAL VDR kidney heart immunohistochemistry ABCB5 uveal melanoma prognosis metastasis pericardium cytokeratin c-kit PDGFR initial lymphatics macroH2A prognostic factor SLC22A12 URAT1 hypouricemia uric acid transporters excretion fraction of uric acid Hsp27 Hsp60 Hsp70 Hsp90 molecular chaperone chaperonopathies thyroid follicular adenoma follicular carcinoma differential diagnosis carcinogenesis matrix metalloproteinases temporomandibular joint disorder temporomandibular joint DEN liver inflammation ultra-structural changes oxidative stress EGCG Vitamin D prostate cancer urinary tract malformations megacystis enteric nervous system outcome and prognosis WT1 human embryonal/fetal tissues neoplastic tissue |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557380403321 |
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Caltabiano Rosario
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Kidney Inflammation, Injury and Regeneration
| Kidney Inflammation, Injury and Regeneration |
| Autore | Koch Benjamin |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (496 p.) |
| Soggetto non controllato |
microRNAs
transcription ischemia/reperfusion injury DSS-colitis kidney inflammation therapeutics targets CXCL13 glomerulus interleukin-6 rhabdomyolysis IgA nephropathy CREB Regulated Transcriptional Coactivators (CRTC) slit diaphragm injury xanthine oxidase Salt Inducible Kinase (SIK) acute and chronic kidney disease therapeutic target KIT-IgA score G-protein-coupled bile acid receptor (TGR5) lysophosphatidic acid glomerular injury IL-18 mesenchymal stem cells Taiwan acute kidney injury renal ischemia-reperfusion long non-coding RNA fibrosis acute kidney failure diabetic kidney diseases chronic kidney disease lncRNA LPS-binding protein endotoxemia-induced oliguric kidney injury dapagliflozin cPLA2 and COX-2 NLRP3 inflammasome CmklR1 haem chronic kidney injury omega-3 fatty acid noninvasive inflammation regulated necrosis GLP-1 receptor agonists miRNA AKI SGLT2 inhibitors diabetic kidney disease extracellular vesicles podocin type IV collagen epithelial cells nephrin 2-kidney-1-clip renal fibrosis papilla diagnostics necrosis non-coding RNAs podocyte Thy1.1 nephritis KIT assay oxidative stress conditioned medium C-reactive protein pericyte myofibroblast Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-?B) endotoxemia modifier gene polymorphism renal stem cells kidney polyploidization Class IIa Histone Deacetylases (HDAC) 2k1c molecular signaling proximal tubule arachidonic acid empagliflozin tubular injury signaling cascade signal transduction inflammatory maker niches biomarkers renal progenitors type V collagen cyclooxygenase focal segmental glomerulosclerosis inflammatory bowel disease (IBD) chronic kidney disease (CKD) allograft rejection renovascular hypertension genotype molecular mechanisms ROS prediction glomerular filtration barrier (GFB) alport syndrome scattered tubular cells long non-coding RNAs renal inflammation lysophosphatidic acid receptor cAMP Regulatory Element Binding Protein (CREB) Farnesiferol B differentiation mesenchymal stromal cells modified-MSCs kidney transplantation polyunsaturated fatty acids apoptosis type I collagen diabetes mellitus natural products lipoxygenase stem cell T cell-mediated rejection exosomes renal injury obese kidney fibrosis kidney injury cytotoxicity mesenchymal stem cell pigment nephropathy mesodermal stem cell ischemia-reperfusion cytochrome P450 renal cell carcinoma hematuria B-cell attracting chemokine microRNA chemerin glomerular basement membrane glomerular damage renal tubular cells kidney proximal tubule exosome hypertension diabetic nephropathy |
| ISBN | 3-03928-539-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910404091203321 |
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Koch Benjamin
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| MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Marine Anti-inflammatory and Antioxidant Agents 2021
| Marine Anti-inflammatory and Antioxidant Agents 2021 |
| Autore | Degl'Innocenti Donatella |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (172 p.) |
| Soggetto topico |
Medicine
Pharmacology |
| Soggetto non controllato |
algal biome
polysaccharides bioactive entities engineered cues therapeutic attributes inflammatory bowel disease microalgae Tisochrysis lutea fucoxanthin inflammation RAW 264.7 microRNA astaxanthin dendritic cells sepsis immune dysfunction lipopolysaccharide oxidative stress Ulva lactuca polysaccharide D-galactose kidney oyster peptides spermatogenesis apoptosis hormone testis C-phycoerythrin Phormidium persicinum acute kidney injury mercury endoplasmic reticulum stress bioactive peptide cytoprotective endothelial dysfunction blue mussel acute liver injury ferroptosis oyster peptide pyroptosis zooplankton natural products antioxidant transcriptome mining |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910566461803321 |
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Degl'Innocenti Donatella
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular Basis of Cardiovascular Diseases: Implications of Natriuretic Peptides
| Molecular Basis of Cardiovascular Diseases: Implications of Natriuretic Peptides |
| Autore | Rubattu Speranza |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (212 p.) |
| Soggetto non controllato |
postmortem biochemistry
medulla animal models remodeling BNP PCSK9 guanylyl cyclase/natriuretic peptide receptor-A cardiorenal syndrome forensic medicine preserved ejection fraction kidney renin-angiotensin-aldosterone system atrial fibrillation vasopressor congestive heart failure atrial natriuretic peptide gene-knockout obesity heart failure angiogenesis adipose tissue vascular LDL receptor metabolic syndrome linkage analysis cardiometabolic disease cardiomyocyte cardiac dysfunction cardiac hypertrophy insulin lipid metabolism cGMP Idiopathic Pulmonary Arterial Hypertension (IPAH) Natriuretic Peptide Clearance Receptor (NPR-C) signaling gene-duplication renin–angiotensin system natriuretic peptides angiotensin receptor–neprilysin inhibitor cardiac remodelling ARNi NT-proBNP inflammation pulmonary arterial hypertension vascular homeostasis endothelial cell Atrial Natriuretic peptide natriuretic peptide vasodilator stroke genetic variants arterial hypertension fibroblast MANP hypertension guanylyl cyclase receptor A |
| ISBN | 3-03921-583-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Molecular Basis of Cardiovascular Diseases |
| Record Nr. | UNINA-9910367751403321 |
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Rubattu Speranza
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular mechanisms of body water homeostasis / / Carolyn M. Ecelbarger, Dharmendra Kumar Chaudhary, Hwal Lee, Swasti Tiwari
| Molecular mechanisms of body water homeostasis / / Carolyn M. Ecelbarger, Dharmendra Kumar Chaudhary, Hwal Lee, Swasti Tiwari |
| Autore | Ecelbarger Carolyn M. |
| Pubbl/distr/stampa | [San Rafael, California] : , : Morgan & Claypool, , 2017 |
| Descrizione fisica | 1 online resource (112 pages) : color illustrations |
| Disciplina | 572.3 |
| Collana | Colloquium series on integrated systems physiology |
| Soggetto topico |
Osmoregulation
Water in the body Body Water |
| Soggetto non controllato |
water homeostasis
total body water kidney hydration aquaporin diabetes insipidus hyponatremia vasopressin osmolality |
| ISBN | 1-61504-733-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
1. Water, water everywhere -- 1.1 Chapter overview -- 1.2 Body water composition -- 1.2.1 Changes in water homeostasis over the lifespan -- 1.2.2 Body water intake requirements -- 1.3 Measurement of total body water (TBW) -- 1.3.1 Body water compartmentalization -- 1.4 Dehydration -- 1.4.1 Exercise and water requirements -- 1.5 Environmental modulators of body water composition -- 1.5.1 High altitude -- 1.5.2 Extremes in temperature or humidity -- 1.5.3 Dietary alterations --
2. The brain, AVP, and water balance -- 2.1 Chapter overview -- 2.2 The brain -- 2.3 Vasopressin and related neuropeptides -- 2.3.1 Regulation of vasopressin production and release -- 2.4 Vasopressin receptors -- 2.4.1 Receptor cloning -- 2.4.2 Receptor activation and signaling -- 2.4.3 Receptor localization -- 2.5 Vasopressin actions -- 2.5.1 Vasopressin and glomerular filtration rate (GFR) -- 2.5.2 Vasopressin and blood pressure control -- 2.5.2.1 AVPR2 are coupled to nitric oxide generation -- 2.5.2.2 Hypertension may correlate with urinary concentrating ability -- 3. Renal control of water reabsorption -- 3.1 Chapter overview -- 3.2 Blood filtration -- 3.3 The countercurrent multiplier mechanism -- 3.3.1 The Na-K-2Cl cotransporter (NKCC2) -- 3.3.2 Gradient in the inner medulla -- 3.4 The collecting duct -- 3.5 Urea transporters -- 3.6 Renal aquaporins -- 3.6.1 Aquaporin 1 -- 3.6.2 Aquaporin 2 -- 3.6.2.1 Short-term AQP2 regulation -- 3.6.2.2 Long-term AQP2 regulation -- 3.6.2.3 Regulators of AQP2 -- 3.6.3 Aquaporins 3 and 4 -- 3.6.4 Other aquaporins -- 4. Hyponatremia -- 4.1 Chapter overview -- 4.2 Causes and forms of hyponatremia -- 4.3 Hyponatremia and the brain -- 4.4 Hyponatremia and bone health -- 4.5 The syndrome of inappropriate antidiuretic hormone (SIADH) -- 4.5.1 Exercise-induced hyponatremia -- 4.6 Vasopressin escape and molecular mechanismS -- 4.7 Therapies/interventions -- 5. Diabetes insipidus -- 5.1 Chapter overview -- 5.2 Central diabetes insipidus (CDI) -- 5.3 Nephrogenic diabetes insipidus (NDI) -- 5.3.1 Mutations in the vasopressin V2 receptor -- 5.3.2 Mutations in AQP2 -- 5.4 Acquired NDI -- 5.5 Treatments for DI -- 6. Additional pathophysiological states associated with impaired water balance -- 6.1 Chapter overview -- 6.2 Heart failure -- 6.3 Hypertension -- 6.4 Cirrhosis of the liver -- 6.5 Compulsive water drinking -- 6.6 Burn injuries -- 6.7 Medications that alter fluid dynamics -- 6.7.1 Diuretics -- 6.7.2 Aquaretics -- 6.7.3 Peroxisome proliferator-activated receptor, subtype [gamma] (PPAR [gamma]) agonists -- References -- Author biographies. |
| Record Nr. | UNINA-9910153635703321 |
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Ecelbarger Carolyn M.
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| [San Rafael, California] : , : Morgan & Claypool, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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New Insights into the Pathogenesis and Therapies of IgA Nephropathy
| New Insights into the Pathogenesis and Therapies of IgA Nephropathy |
| Autore | Suzuki Hitoshi |
| Pubbl/distr/stampa | Basel, : MDPI Books, 2022 |
| Descrizione fisica | 1 electronic resource (194 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
obesity
mesangial matrix expansion body mass index IgA nephropathy IgA Vasculitis IgA Nephropathy adults children presentation physiopathology genetics prognosis treatment IgA clinical trials kidney mesangium mouse model aberrantly glycosylated IgA1 galactose-deficient IgA1 glycosylation of IgA1 biomarker complement C3 O-glycosylation IgA1 autoantibody immune complex complement kidney nephrology IgA vasculitis nephritis kidney biopsy plasma cells CD38 renal pathology urinary galactose-deficient IgA1 KM55 crescents proteinuria glomerular filtration rate Oxford score |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910595072403321 |
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Suzuki Hitoshi
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| Basel, : MDPI Books, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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