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Advances in Artificial and Biological Membranes: Mechanisms of Ionic Sensitivity, Ion-Sensor Designs and Applications for Ions Measurement
| Advances in Artificial and Biological Membranes: Mechanisms of Ionic Sensitivity, Ion-Sensor Designs and Applications for Ions Measurement |
| Autore | Lewenstam Andrzej |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (153 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
potentiometry
reference electrode solid contact heterogenous membranes polymer membranes ion transport water transport epithelium cystic fibrosis mitochondrion calcium carbonates calcium phosphates calcium polyphosphates ATP production hypoxia ischemia pre-conditioning ion selective electrodes wearable sensors solid-contact materials response mechanism anhydrous and hydrous ruthenium dioxide porous microstructure high capacity stable measuring signal chemically modified electrodes membrane-coated voltammetric sensors antidepressant and immunosuppressant drugs detection limit resolution ion-selective membranes components leakage incorporation all-solid-state sensors |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Advances in Artificial and Biological Membranes |
| Record Nr. | UNINA-9910557544603321 |
Lewenstam Andrzej
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Autophagy in Tissue Injury and Homeostasis
| Autophagy in Tissue Injury and Homeostasis |
| Autore | Lin Pei-Hui |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (322 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
aging
dietary restriction acute kidney injury mitochondria autophagy mitophagy ischemia renal tubular cells diabetic nephropathy exosomes mTOR innate immunity immune cell inflammasome Paneth cell inflammatory bowel disease Crohn's disease hepatocytes hepatic stellate cells sinusoidal endothelial cells macrophages fibrosis cirrhosis hepatocellular carcinoma biomarkers cell death glutaminase metabolism molecular rehabilitation kidney diseases oxidative stress inflammation ATGs intestinal homeostasis inflammatory bowel diseases HCC therapy Autophagy acute lung injury idiopathic pulmonary fibrosis COPD tuberculosis PAH cystic fibrosis Beclin-1 cardiac dysfunction sepsis endotoxemia muscle regeneration stem cell immune macrophage senescence exercise caloric restriction diabetic retinopathy PINK1 Notoginsenoside R1 ethanol LC3 apoptosis Sertoli cell Parkin TFEB infertility AMPK FOXO MTOR parkin spinal cord injury traumatic brain injury autophagic flux neuronal cell death lysosomal damage |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557284203321 |
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Lin Pei-Hui
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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BK Channels: Integrators of Cellular Signals in Health and Disease
| BK Channels: Integrators of Cellular Signals in Health and Disease |
| Autore | Alex Dopico |
| Pubbl/distr/stampa | Frontiers Media SA, 2017 |
| Descrizione fisica | 1 electronic resource (183 p.) |
| Collana | Frontiers Research Topics |
| Soggetto non controllato |
BK channel
hydrogensulfide maxi calcium activated potassium channel disease nervous system Slo KCNMA1 health ethanol ischemia |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | BK Channels |
| Record Nr. | UNINA-9910261140303321 |
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Alex Dopico
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| Frontiers Media SA, 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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COVID-19: Current Challenges and Future Perspectives
| COVID-19: Current Challenges and Future Perspectives |
| Autore | Leggat Peter |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (264 p.) |
| Soggetto topico |
Medicine
Environmental medicine |
| Soggetto non controllato |
COVID-19
SARS-CoV-2 hepatitis B and C cirrhosis chronic kidney disease alcohol-related liver disease nonalcoholic steatohepatitis necrosis MDR-TB clinical trials IL-6 inhibitors tocilizumab cytokine release syndrome cytokine storm operational research health systems SORT IT pandemics training pandemic endemic tuberculosis impact control overview malaria preparedness Africa emergency fecal calprotectin bowel perforation D-Dimer thrombosis ischemia efficacy safety kaletra lopinavir/ritonavir meta-analysis coronavirus SARS-CoV-1 MERS SARS influenza healthcare worker healthcare personnel general practitioners medical doctor heart transplant CMV Chagas disease infection severity respiratory viruses coinfections health care workers Philippines rhinovirus severe acute respiratory syndrome coronavirus 2 plasmodium falciparum differential diagnosis cognitive bias diagnostic reasoning recurrence reinfection Bangladesh Kenya Nairobi presumptive tuberculosis TB treatment outcomes HIV antiretroviral therapy EpiCollect5 Malawi Lilongwe Zimbabwe Harare real-time operational research ethics research capacity building India Nepal post-acute COVID-19 syndrome COVID-19 vaccines mortality epidemiology public health healthcare workers attitudes perceptions knowledge |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | COVID-19 |
| Record Nr. | UNINA-9910566469103321 |
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Leggat Peter
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Creatine Supplementation for Health and Clinical Diseases
| Creatine Supplementation for Health and Clinical Diseases |
| Autore | Kreider Richard B |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (562 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences Food & society |
| Soggetto non controllato |
ergogenic aids
cellular metabolism phosphagens sarcopenia cognition diabetes creatine synthesis deficiencies concussion traumatic brain injury spinal cord injury muscle atrophy rehabilitation pregnancy immunity anti-inflammatory antioxidant anticancer creatine nutritional supplements fertility newborn development brain injury post-viral fatigue syndrome chronic fatigue syndrome GAA creatine kinase dietary supplements exercise skeletal muscle glycemic control type 2 diabetes mellitus phosphorylcreatine dietary supplement ergogenic aid youth athletes osteoporosis osteosarcopenia frailty cachexia innate immunity adaptive immunity inflammation macrophage polarization cytotoxic T cells toll-like receptors vascular pathology cardiovascular disease oxidative stress vascular health female menstrual cycle hormones exercise performance menopause mood children height BMI-for-age stature-for-age growth phosphocreatine creatine transporter supplementation treatment heart heart failure ischemia myocardial infarction anthracycline cardiac toxicity energy metabolism cell survival bioinformatics systems biology cellular allostasis dynamic biosensor pleiotropic effects of creatine (Cr) supplementation inflammatory bowel diseases (IBD) ulcerative colitis Crohn’s disease creatine kinase (CK) phosphocreatine (PCr) creatine transporter (CrT) intestinal epithelial cell protection intestinal tissue protection creatine perfusion organ transplantation Adenosine mono-phosphate (AMP) activated protein kinase (AMPK) liver kinase B1 (LKB1) mitochondrial permeability transition pore (mPTP) reactive oxygen species (ROS) glucose transporter (GLUT) T cell antitumor immunity metabolic regulator cancer immunotherapy supplements muscle damage recovery immobilization atrophy muscular dystrophy amyotrophic lateral sclerosis Parkinson’s Disease cardiopulmonary disease mitochondrial cytopathy hypertrophy athletic performance weightlifting resistance exercise training muscular power muscular adaptation muscle fatigue adipose tissue muscle strength physiological adaptation mitochondria thermogenesis MAP kinase signaling system sodium-chloride-dependent neurotransmitter symporters signal transduction intradialytic creatine supplementation hemodialysis muscle protein energy wasting clinical trial muscle weakness chronic fatigue cognitive impairment depression anemia resistance training sports nutrition strength toxicity methylation hyperhomocysteinemia neuromodulation MCDA mitochondriopathia cardiac infarction long COVID hypoxia stroke neurodegenerative diseases noncommunicable disease adenosine 5′-monopnophosphate-activated protein kinase anthracyclines creatine supplementation cardiac signaling cardiotoxicity doxorubicin soy vegetarian/vegan diet amino acids dietary ingredients performance |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910566476003321 |
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Kreider Richard B
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Emerging Role of Lipids in Metabolism and Disease
| Emerging Role of Lipids in Metabolism and Disease |
| Autore | Pallottini Valentina |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (308 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
neutral sphingomyelinase
radiation sphingomyelin metabolism pathology cell signaling brain adipose tissue breast cancer epinephrine breast reconstruction epicardial fat thickness visceral fat thickness high-sensitivity c-reactive protein leptin gender female hippocampus frontal cortex adiponectin haptoglobin lipocalin BDNF synaptic proteins phosphatidylinositol 4,5-bisphosphate phospholipase C cholesterol high-cholesterol diet BET proteins cell proliferation epigenetics HMGCR JQ1 LDLr lipid metabolism SREBP TMEM97 atherosclerosis diabetes mellitus cardiovascular disease chronic inflammation hyperglycemia mutations lipid fatty acid glyceride steroid phospholipid oral drug absorption prodrug phospholipase A2 (PLA2) acid sphingomyelinase SOD liver eicosanoids ischemic stroke ischemia lipoproteins polyunsaturated fatty acids angiogenesis high-density lipoprotein endothelial cell metabolism metabolic reprogramming pulmonary fibrosis lipid mediators sphingolipids sphingosine-1-phosphate sphingosine kinase 1 prostaglandins lysophosphatidic acid autotaxin G-protein coupled receptors lysocardiolipin acyltransferase phospholipase D oxidized phospholipids DNA damage response double strand breaks ATM ionizing radiation metabolic stress oxidative stress p53 nuclear sphingolipids lipophagy lipolysis lipid droplets lipid storage diseases lipid metabolism diseases mTORC1 TFEB Cholesterol Fatty acids Lipid mediators Lipids Lipophagy Sphingolipids |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557800303321 |
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Pallottini Valentina
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches
| Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches |
| Autore | Jeon Byeong Hwa |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (368 p.) |
| Soggetto topico |
Technology: general issues
Biotechnology |
| Soggetto non controllato |
endothelial cells
oxidative stress inflammageing endothelial dysfunction aldehyde dehydrogenase-2 cardiovascular disease neurovascular disease vascular inflammation APE1/Ref-1 cardiovascular diseases subcellular localization serological biomarkers atherosclerosis aerobic exercise PCSK9 LOX-1 insulin resistance macrophage polarity serum γ-glutamyltransferase essential hypertension cardiovascular risk factors angiogenesis nargenicin A1 compound 9 VEGF VEGFR2 HIF-1α electronegative low-density lipoprotein LDL(-) L5 LDL oxidized LDL oxLDL ADMA arginine arginine paradox BH4 blood pressure COVID-19 dietary supplements endothelium eNOS uncoupling heart failure hypertension L-arginine myocardial infarction NADPH nitric oxide peripheral artery disease ApoE knockout mouse atorvastatin VCAM-1 galectin-3 neutrophil/lymphocyte ratio electronegative LDL LDL(−) lectin-like oxLDL receptor-1 dyslipidemia chronic venous insufficiency prolyl oligopeptidase (POP) inflammation endothelial disfunction lung disease endothelial to mesenchymal transition pulmonary hypertension pulmonary fibrosis metformin diabetes CV risk hyperglycemia glycated lipoproteins glycated LDL glycated HDL endothelial cell dysfunction molecular mechanisms epigenetic factors therapeutic approaches vasoactive factors EndoMT TGF-β epigenetics endothelial cell glycolysis metabolism pathological angiogenesis tumor microenvironment MRI (magnetic resonance imaging) high-fat diets plaque burden low-level laser therapy phototherapy vascular disease healing ischemia vascular calcification chronic kidney disease CKD uremic toxins hyperphosphatemia vascular smooth muscle cells VSMCs macrophages |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Endothelial Dysfunction |
| Record Nr. | UNINA-9910566471803321 |
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Jeon Byeong Hwa
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Nanobody
| Nanobody |
| Autore | Rothbauer Ulrich |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (300 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
Bacillus anthracis
immunoassay single-domain antibody genetic fusion Beta galactosidase P-type ATPase nanobody llama Zinc-transport Zinc-transporting P-ATPase ZntA TNF fluorescent nanobodies sensor anti-cytokine therapy autoimmune disease Western equine encephalitis virus MagPlex toxin antibody camelid vaccine biodefense hydrogen exchange-mass spectrometry virus formatting Fc-domain half-life ischemia stroke MCAO single domain antibodies phage display intrabody intracellular antibody GTPase RHO BRET RAS chromobodies live-cell imaging compound screening cellular models single-domain antibody fragments molecular imaging molecular therapy nuclear imaging targeted fluorescence imaging intraoperative imaging Nanobody Single Domain Antibody Cancer Immunotherapy Imaging influenza influenza B virus hemagglutinin single domain antibody NanobodyTM yeast display epitope mapping GFP C. elegans development drosophila zebrafish targeted photodynamic therapy hepatocyte growth factor receptor HGFR c-Met Met VHH photosensitizer single-domain antibodies neurodegenerative diseases brain imaging blood-brain barrier delivery Aids HIV Llama Antibodies bi-specific VHH pepscan competition studies co-crystallisation |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557147503321 |
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Rothbauer Ulrich
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Neuroprotection: Rescue from Neuronal Death in the Brain
| Neuroprotection: Rescue from Neuronal Death in the Brain |
| Autore | Lee Bae Hwan |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (408 p.) |
| Soggetto topico | Research & information: general |
| Soggetto non controllato |
global cerebral ischemia
amiloride sodium-hydrogen exchanger-1 zinc neuronal death neuroprotection neurodegenerative disorder choline acetyltransferase (ChAT) trimethyltin (TMT) bean phosphatidylserine (Bean-PS) brain-derived neurotrophic factor moderate hypoxia physical exercise psychomotor function reaction time cortisol catecholamines nitrite endotheline-1 lactate pyridoxine deficiency ischemia gerbil homocysteine cell death glia neurogenesis N-acetyl-l-cysteine transient receptor potential melastatin 2 neurodegeneration Alzheimer's disease metabolic disease adiponectin insulin antioxidants stroke preventive gene therapy adenoviral vector VEGF GDNF NCAM human umbilical cord blood mononuclear cells antioxidant brain neurodegenerative disease oxidative stress PGC-1α vascular endothelial growth factor vascular endothelial growth factor receptor 2 PI3K/AKT MEK/ERK status epilepticus hippocampus middle cerebral artery occlusion reperfusion injury lipid emulsion excitotoxicity apoptosis GPR4 receptor MPP+ Parkinson's disease CRISPR/cas9 ischemic stroke blood brain barrier nanoparticle-based drug delivery brain targeting BDNF miRNAs synaptic plasticity depression glioblastoma astrocytes astrocytic networks connexin 43 calcium activity neural injury nimodipine subarachnoid haemorrhage acid-sensing ion channels oxygen-glucose deprivation liver growth factor inflammation microglia Tg2576 transgenic mice amyloid-beta oculomotor system trophic factors motoneurons axotomy amyotrophic lateral sclerosis electroneutral transport cation-chloride cotransporters KCCs NKCCs WNK-SPAK/OSR1 ascorbic acid aging organotypic hippocampal slice culture |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Neuroprotection |
| Record Nr. | UNINA-9910557716703321 |
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Lee Bae Hwan
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery
| Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery |
| Autore | Spetea Mariana |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (358 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
opioid receptors
neurokinin-1 receptor peptide synthesis receptor binding studies functional assay writhing test tolerance Leu-enkephalin beta-arrestin mu opioid receptor delta opioid receptor biased signaling DADLE ischemia plasma stability morphinan BNTX δ opioid receptor antagonist 1H-NMR experiments mechanism elucidation peripheral antinociception 14-methoxycodeine-6-O-sulfate codeine-6-O-sulfate opioid peptides and peptidomimetics DAMGO DALDA [Dmt1]DALDA KGOP01 binding molecular docking structure-activity relationships β2-amino acids β2-Homo-amino acids µ-opioid receptor opioid peptides TAPP racemic synthesis of β2-amino acids peripheral µ-opioid receptors analgesia peripheral analgesic tolerance dysbiosis opioid bifunctional ligands (−)-N-phenethylnorhydromorphone analogs [35S]GTPgammaS assay forskolin-induced cAMP accumulation assays β-arrestin recruitment assays MOR and DOR agonists respiratory depression bias factor molecular modeling & simulation δ opioid receptor NTI derivative sulfonamide inverse agonist neutral antagonist agonist opioids mu receptor opioid side effects biased agonism partial agonism zerumbone chronic constriction injury (CCI) allodynia hyperalgesia potassium channels over-the-counter drugs misuse abuse opioid drugs pharmacology codeine dihydrocodeine loperamide opioid peptide macrocyclic tetrapeptide multifunctional ligands kappa opioid receptor analgesics opioid liabilities μ opioid receptor receptor model biased ligands dependence pain therapy neonatal opioid withdrawal syndrome naltrexone 6β-naltrexol buprenorphine G-protein bias arrestin recruitment respiration mitragynine heteromer internalization primary hippocampal culture lysosomes µ opioid receptor molecular dynamics docking interaction fingerprints biased agonists SR-17018 PZM21 morphine fentanyl diphenethylamines design and synthesis partial agonist biased agonist antagonist binding affinity selectivity |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Opioids and Their Receptors |
| Record Nr. | UNINA-9910557108003321 |
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Spetea Mariana
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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