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Function and Flexibility: Friend or Foe?
| Function and Flexibility: Friend or Foe? |
| Autore | Peter Tompa |
| Pubbl/distr/stampa | Frontiers Media SA, 2016 |
| Descrizione fisica | 1 electronic resource (102 p.) |
| Collana | Frontiers Research Topics |
| Soggetto non controllato |
conformational selection and induced fit
protein structure conformational ensemble Protein function protein dynamics Protein Conformation protein flexibility Protein Disorder intrinsically disordered proteins Structural transition |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Function and Flexibility |
| Record Nr. | UNINA-9910220046103321 |
Peter Tompa
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| Frontiers Media SA, 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Functionally Relevant Macromolecular Interactions of Disordered Proteins
| Functionally Relevant Macromolecular Interactions of Disordered Proteins |
| Autore | Simon Istvan |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (520 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
intrinsically disordered proteins
epiproteome disordered protein platform molecular recognition feature post-translational modifications physiological homeostasis stress response RIN4 p53 molecular machines intrinsically disordered protein membrane-less organelle neurodegenerative disease p300 HAT acetylation post-translational modification protein aggregation Tau fibrillation intrinsically disorder proteins disorder-to-order regions protein–RNA interactions unstructured proteins conformational plasticity disordered protein folding ribosomal protein spectroscopy protein stability temperature response protein thermostability salt bridges meta strategy dual threshold significance voting decision tree based artificial neural network protein intrinsic disorder intrinsic disorder intrinsic disorder prediction intrinsically disordered region protein conformation transcriptome RNA sequencing Microarray differentially regulated genes gene ontology analysis functional analysis intrinsically disordered structural disorder correlated mutations co-evolution evolutionary couplings residue co-variation interaction surface residue contact network dehydron homodimer hydrogen bond inter-subunit interaction ion pair mutual synergistic folding solvent-accessible surface area stabilization center MLL proteins MLL4 lncRNA HOTAIR MEG3 leukemia histone lysine methyltransferase RNA binding protein hydration wide-line 1H NMR secretion immune extracellular protein-protein interaction structural domain evolution transcription factors DNA-protein interactions Sox2 sequential DNA loading smFRET DNA conformational landscape sequential DNA bending transcription factor dosage oligomer N-terminal prion protein copper binding prion disease mutations Nuclear pore complex FG-Nups phosphorylation coarse-grained CABS model MC simulations statistical force fields protein structure intrinsically disordered proteins (IDPs) neurodegenerative diseases aggregation drugs drug discovery plant virus eIF4E VPg potyvirus molten globule fluorescence anisotropy protein hydrodynamics |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557509403321 |
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Simon Istvan
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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In-Cell NMR Spectroscopy: Biomolecular Structure and Function
| In-Cell NMR Spectroscopy: Biomolecular Structure and Function |
| Autore | Burz David S |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (152 p.) |
| Soggetto non controllato |
protein NMR
time-resolved NMR Ribosome structural calculation 4 crystalline and amorphous starch in-cell NMR protein dynamics DNP protein modification Tau spectrum reconstruction 3 mRNA Thioredoxin protein structure protein interactions drug discovery protein structure determination 1 review enzyme activity MARK2 phosphorylation post-translational modifications Dihydrofolate reductase mammalian cells target engagement non-uniform sampling 2 paramagnetic effects protein structure-function cross-correlated relaxation structure function rRNA 2D INADEQUATE lipid membrane Thymidylate synthase whole cell NMR enzyme kinetics magic-angle spinning live cell solid-state NMR Adenylate kinase DNA in-situ NMR antimicrobial peptide NMR spectroscopy intrinsically disordered proteins |
| ISBN | 3-03928-255-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | In-Cell NMR Spectroscopy |
| Record Nr. | UNINA-9910404084303321 |
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Burz David S
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| MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Intrinsically Disordered Proteins and Chronic Diseases
| Intrinsically Disordered Proteins and Chronic Diseases |
| Autore | Kulkarni Prakash |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (224 p.) |
| Soggetto topico | Research & information: general |
| Soggetto non controllato |
IDP
fuzzy interactions protein complementation assays split-GFP reassembly kinetics membraneless organelles optical tweezer liquid-liquid phase separation protein diffusion depletion interaction entropic force low-complexity sequences intrinsically disordered proteins PAGE4 conformational plasticity order-disorder transition phosphorylation intrinsic disordered protein extremely fuzzy complex protein interaction binding mechanism tumor protein p53 mouse double minute 2 mouse double minute 4 Kinase-inducible domain interacting domain phosphomimetics nuclear magnetic resonance transient secondary structure COR15A Late embryogenesis abundant Trifluoroethanol Nuclear magnetic resonance intrinsically disordered regions functional segments disease-related proteins protein-protein interaction subcellular location glucocorticoid receptor intrinsically disordered transactivation activity gene regulation coactivators microtubule associated protein tau intrinsically disordered protein dynamic configuration free energy landscape microtubules electrostatics diffusion protein structure prediction molecular modelling molecular dynamics tau-microtubule association conformational ensemble replica exchange molecular dynamics drug design |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557746903321 |
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Kulkarni Prakash
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Amazing World of IDPs in Human Diseases
| The Amazing World of IDPs in Human Diseases |
| Autore | Monti Simona Maria |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (196 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
alpha-synuclein
NMR secondary structure propensity pre-structured motifs (PreSMos) intrinsically disordered protein ubiquitin-proteasome system intrinsically disordered proteins protein misfolding molecular recognition features cancer neurodegenerative diseases protein degradation EPR spectroscopy isothermal titration calorimetry protein-ligand interaction site-directed spin labeling protein structural dynamics WASp interacting protein protein-protein interactions actin cytoskeleton remodeling SH3 domain proline-rich motif single nucleotide variants interface core and rim human disease intrinsically disordered regions linear motifs gene duplications de novo evolutionary origin circular dichroism flexibility fluorescence importin isothermal titration calorimetry (ITC) molecular docking nuclear magnetic resonance (NMR) nuclear protein 1 (NPR1) peptide Methyl-CpG-binding protein 2 (MeCP2) Rett syndrome intrinsically disordered protein (IDP) protein stability protein-DNA interaction proteostasis ubiquitin independent degradation NADH-26S proteasome |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557334303321 |
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Monti Simona Maria
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Conformational Universe of Proteins and Peptides: Tales of Order and Disorder
| The Conformational Universe of Proteins and Peptides: Tales of Order and Disorder |
| Autore | Leone Marilisa |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (230 p.) |
| Soggetto topico | Research & information: general |
| Soggetto non controllato |
mass spectrometric epitope mapping
gas phase immune complex dissociation apparent gas phase dissociation constants apparent gas phase activation energies ITEM-TWO native mass spectrometry TRIOBP cancer deafness hearing loss mental illness schizophrenia actin cytoskeleton disordered structure protein aggregation solid-state NMR ELDOR-detected NMR ATP hydrolysis ATP analogues DnaB helicase ABC transporter biopesticides antifungal activity insecticidal activity mechanism of action transgenic crops protein folding NMR High Hydrostatic Pressure ACE2 viral spike receptor-binding domain SARS-CoV-2 transmission bioinformatics IDP 1 binding 2 molecular dynamics 3 MELD×MD 4 advanced sampling 5 p53 6 MDM2 7 NAD(P)H-dependent oxidoreductase zinc-containing alcohol dehydrogenase cofactor binding and release interdomain cleft dynamics molecular dynamics simulations denatured state ensemble protein coil library peptides intrinsically disordered proteins ion-pairing interaction side-chain length charged amino acids β-hairpin peptide Friedman's test backbone atom coordinate variances and uncertainties superimposition nanobody protein structure immunoglobulin domain |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Conformational Universe of Proteins and Peptides |
| Record Nr. | UNINA-9910557371103321 |
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Leone Marilisa
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Fuzziness in Molecular, Supramolecular, and Systems Chemistry
| The Fuzziness in Molecular, Supramolecular, and Systems Chemistry |
| Autore | Gentili Pier |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (154 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
fuzzy logic
complexity chemical artificial intelligence human nervous system fuzzy proteins conformations photochromic compounds qubit protein dynamics conformational heterogeneity promiscuity fuzzy complexes higher-order structures protein evolution fuzzy set theory artificial intelligence GCN4 mimetic peptides-DNA E:Z photoisomerization conformational fuzziness photoelectrochemistry wide bandgap semiconductor artificial neuron in materio computing neuromorphic computing intrinsically disordered protein intrinsically disordered protein region liquid-liquid phase transition protein-protein interaction protein-nucleic acid interaction proteinaceous membrane-less organelle fuzzy complex d-TST activation energy Transitivity plot solution kinetic Maxwell-Boltzmann path Euler's formula for the exponential activation transitivity transport phenomena moonlighting proteins intrinsically disordered proteins metamorphic proteins morpheeins |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557495003321 |
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Gentili Pier
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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