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Function and Flexibility: Friend or Foe?
| Function and Flexibility: Friend or Foe? |
| Autore | Peter Tompa |
| Pubbl/distr/stampa | Frontiers Media SA, 2016 |
| Descrizione fisica | 1 online resource (102 p.) |
| Collana | Frontiers Research Topics |
| Soggetto non controllato |
conformational ensemble
conformational selection and induced fit intrinsically disordered proteins Protein Conformation Protein Disorder protein dynamics protein flexibility Protein function protein structure Structural transition |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Function and Flexibility |
| Record Nr. | UNINA-9910220046103321 |
Peter Tompa
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| Frontiers Media SA, 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Functionally Relevant Macromolecular Interactions of Disordered Proteins
| Functionally Relevant Macromolecular Interactions of Disordered Proteins |
| Autore | Simon Istvan |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 online resource (520 p.) |
| Soggetto topico |
Biology, life sciences
Research and information: general |
| Soggetto non controllato |
aggregation
CABS model co-evolution coarse-grained conformational plasticity copper binding correlated mutations decision tree based artificial neural network dehydron differentially regulated genes disorder-to-order regions disordered protein disordered protein platform DNA conformational landscape DNA-protein interactions drug discovery drugs dual threshold eIF4E epiproteome evolution evolutionary couplings extracellular FG-Nups fluorescence anisotropy folding functional analysis gene ontology analysis histone lysine methyltransferase homodimer HOTAIR hydration hydrogen bond immune inter-subunit interaction interaction surface intrinsic disorder intrinsic disorder prediction intrinsically disorder proteins intrinsically disordered intrinsically disordered protein intrinsically disordered proteins intrinsically disordered proteins (IDPs) intrinsically disordered region ion pair leukemia lncRNA MC simulations MEG3 membrane-less organelle meta strategy Microarray MLL proteins MLL4 molecular machines molecular recognition feature molten globule mutual synergistic folding N-terminal prion protein neurodegenerative disease neurodegenerative diseases Nuclear pore complex oligomer p300 HAT acetylation p53 phosphorylation physiological homeostasis plant virus post-translational modification post-translational modifications potyvirus prion disease mutations protein protein aggregation protein conformation protein hydrodynamics protein intrinsic disorder protein stability protein structure protein thermostability protein-protein interaction protein-RNA interactions residue co-variation residue contact network ribosomal protein RIN4 RNA binding RNA sequencing salt bridges secretion sequential DNA bending significance voting smFRET solvent-accessible surface area Sox2 sequential DNA loading spectroscopy stabilization center statistical force fields stress response structural disorder structural domain Tau fibrillation temperature response transcription factor dosage transcription factors transcriptome unstructured proteins VPg wide-line 1H NMR |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557509403321 |
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Simon Istvan
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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In-Cell NMR Spectroscopy: Biomolecular Structure and Function
| In-Cell NMR Spectroscopy: Biomolecular Structure and Function |
| Autore | Burz David S |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 online resource (152 p.) |
| Soggetto topico | Biology, life sciences |
| Soggetto non controllato |
2D INADEQUATE
Adenylate kinase antimicrobial peptide cross-correlated relaxation crystalline and amorphous starch Dihydrofolate reductase DNA DNP drug discovery enzyme activity enzyme kinetics in-cell NMR in-situ NMR intrinsically disordered proteins lipid membrane live cell magic-angle spinning mammalian cells MARK2 phosphorylation mRNA NMR spectroscopy non-uniform sampling 2 paramagnetic effects post-translational modifications protein dynamics protein interactions protein modification protein NMR protein structure protein structure determination 1 protein structure-function review Ribosome rRNA solid-state NMR spectrum reconstruction 3 structural calculation 4 structure function target engagement Tau Thioredoxin Thymidylate synthase time-resolved NMR whole cell NMR |
| ISBN | 3-03928-255-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | In-Cell NMR Spectroscopy |
| Record Nr. | UNINA-9910404084303321 |
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Burz David S
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| MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Integrating Clinical and Translational Research Networks-Building Team Medicine - Series 2
| Integrating Clinical and Translational Research Networks-Building Team Medicine - Series 2 |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2023 |
| Descrizione fisica | 1 online resource (230 p.) |
| Soggetto topico |
Medicine and Nursing
Oncology |
| Soggetto non controllato |
adaptive therapy
advanced soft tissue sarcoma artificial intelligence ATM mutation brain metastases BRIP1 mutation cancer disparities cancer prevention cancer systems biology care satisfaction cisplatin City of Hope clinical care network clinical network systems biology clinical trials collaboration colorectal cancer survivor combinational therapy community clinical network community practice complex case discussions continuous therapy cutaneous cancers decision support delivery of health care drug resistance drug tolerance eco-evolutionary EGFR emergency utilization endometrial cancer epigenetics genetic/nongenetic genomic-driven group behavior gut microbiome IDPs imaging immune checkpoint inhibitors immunotherapy implementation implementation science integration integrative oncology intermittent therapy intrinsically disordered proteins LDCT leptomeningeal metastases low dose Ct scans lung cancer screening mathematical modeling melanoma metastasis-directed therapy Midwest Sarcoma Trials Partnership minority health multidisciplinary tumor board n/a NET VITALS neuroendocrine tumors non-small cell lung cancer Olaparib oligometastatic oncology oncology pathways oncolytic virotherapy pandemic PARP inhibition pathologic complete response pathways to success personalized medicine phase 1 phenotype switching POLE mutation precision medicine prostate cancer PSMA PET RAD51C mutation renal cell carcinoma sarcoma treatment SARS-CoV-2 self-assessment smoking cessation subspecialty expertise T-VEC targeted therapy team medicine Team Medicine TMB high tobacco control translational research tumor board |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910743279303321 |
| MDPI - Multidisciplinary Digital Publishing Institute, 2023 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Intrinsically Disordered Proteins and Chronic Diseases
| Intrinsically Disordered Proteins and Chronic Diseases |
| Autore | Kulkarni Prakash |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (224 p.) |
| Soggetto topico | Research & information: general |
| Soggetto non controllato |
binding mechanism
coactivators conformational ensemble conformational plasticity COR15A depletion interaction diffusion disease-related proteins drug design dynamic configuration electrostatics entropic force extremely fuzzy complex free energy landscape functional segments fuzzy interactions gene regulation glucocorticoid receptor IDP intrinsic disordered protein intrinsically disordered intrinsically disordered protein intrinsically disordered proteins intrinsically disordered regions Kinase-inducible domain interacting domain kinetics Late embryogenesis abundant liquid-liquid phase separation low-complexity sequences membraneless organelles microtubule associated protein microtubules molecular dynamics molecular modelling mouse double minute 2 mouse double minute 4 n/a nuclear magnetic resonance Nuclear magnetic resonance optical tweezer order-disorder transition PAGE4 phosphomimetics phosphorylation protein complementation assays protein diffusion protein interaction protein structure prediction protein-protein interaction replica exchange molecular dynamics split-GFP reassembly subcellular location tau tau-microtubule association transactivation activity transient secondary structure Trifluoroethanol tumor protein p53 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557746903321 |
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Kulkarni Prakash
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Amazing World of IDPs in Human Diseases
| The Amazing World of IDPs in Human Diseases |
| Autore | Monti Simona Maria |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (196 p.) |
| Soggetto topico |
Biology, life sciences
Research & information: general |
| Soggetto non controllato |
actin
alpha-synuclein cancer circular dichroism cytoskeleton remodeling de novo EPR spectroscopy evolutionary origin flexibility fluorescence gene duplications human disease importin interface core and rim intrinsically disordered protein intrinsically disordered protein (IDP) intrinsically disordered proteins intrinsically disordered regions isothermal titration calorimetry isothermal titration calorimetry (ITC) linear motifs Methyl-CpG-binding protein 2 (MeCP2) molecular docking molecular recognition features n/a NADH-26S proteasome neurodegenerative diseases NMR nuclear magnetic resonance (NMR) nuclear protein 1 (NPR1) peptide pre-structured motifs (PreSMos) proline-rich motif protein degradation protein misfolding protein stability protein structural dynamics protein-DNA interaction protein-ligand interaction protein-protein interactions proteostasis Rett syndrome secondary structure propensity SH3 domain single nucleotide variants site-directed spin labeling ubiquitin independent degradation ubiquitin-proteasome system WASp interacting protein |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557334303321 |
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Monti Simona Maria
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Conformational Universe of Proteins and Peptides: Tales of Order and Disorder
| The Conformational Universe of Proteins and Peptides: Tales of Order and Disorder |
| Autore | Leone Marilisa |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (230 p.) |
| Soggetto topico | Research & information: general |
| Soggetto non controllato |
ABC transporter
ACE2 actin advanced sampling 5 antifungal activity apparent gas phase activation energies apparent gas phase dissociation constants ATP analogues ATP hydrolysis backbone atom coordinate variances and uncertainties binding 2 bioinformatics biopesticides cancer charged amino acids cofactor binding and release cytoskeleton deafness denatured state ensemble disordered structure DnaB helicase ELDOR-detected NMR Friedman's test gas phase immune complex dissociation hearing loss High Hydrostatic Pressure IDP 1 immunoglobulin domain insecticidal activity interdomain cleft dynamics intrinsically disordered proteins ion-pairing interaction ITEM-TWO mass spectrometric epitope mapping MDM2 7 mechanism of action MELD×MD 4 mental illness molecular dynamics 3 molecular dynamics simulations n/a NAD(P)H-dependent oxidoreductase nanobody native mass spectrometry NMR p53 6 peptide peptides protein aggregation protein coil library protein folding protein structure SARS-CoV-2 schizophrenia side-chain length solid-state NMR superimposition transgenic crops transmission TRIOBP viral spike receptor-binding domain zinc-containing alcohol dehydrogenase β-hairpin |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Conformational Universe of Proteins and Peptides |
| Record Nr. | UNINA-9910557371103321 |
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Leone Marilisa
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Fuzziness in Molecular, Supramolecular, and Systems Chemistry
| The Fuzziness in Molecular, Supramolecular, and Systems Chemistry |
| Autore | Gentili Pier |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 online resource (154 p.) |
| Soggetto topico |
Biology, life sciences
Research & information: general |
| Soggetto non controllato |
activation
activation energy artificial intelligence artificial neuron chemical artificial intelligence complexity conformational fuzziness conformational heterogeneity conformations d-TST E:Z photoisomerization Euler's formula for the exponential fuzzy complex fuzzy complexes fuzzy logic fuzzy proteins fuzzy set theory GCN4 mimetic higher-order structures human nervous system in materio computing intrinsically disordered protein intrinsically disordered protein region intrinsically disordered proteins liquid-liquid phase transition Maxwell-Boltzmann path metamorphic proteins moonlighting proteins morpheeins n/a neuromorphic computing peptides-DNA photochromic compounds photoelectrochemistry promiscuity protein dynamics protein evolution protein-nucleic acid interaction protein-protein interaction proteinaceous membrane-less organelle qubit solution kinetic transitivity Transitivity plot transport phenomena wide bandgap semiconductor |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557495003321 |
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Gentili Pier
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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