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Drug Absorption Studies: In Situ, In Vitro and In Silico Models
| Drug Absorption Studies: In Situ, In Vitro and In Silico Models |
| Autore | Song Im-Sook |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (171 p.) |
| Soggetto topico |
Medicine
Pharmaceutical industries |
| Soggetto non controllato |
rebamipide
nanocrystals oral mucositis hydrogel endocytosis enoxaparin lipid–polymer hybrid nanoparticles oral intestinal absorption naftidrofuryl oxalate solubility permeability dissolution profiles pharmaceutical availability BCS drug classification non-sink condition solubility–permeability interplay unstirred water layer poorly soluble drugs solubilizer additive phenylketonuria l-phenylalanine ammonia-lyase enzyme kinetics catabolism disorder biomedical drug P-glycoprotein breast cancer resistance protein LY335979 WK-X-34 in vivo–in vitro correlation lipolysis-permeation lipid-based drug delivery system PermeaPad cinnarizine lipolysis amorphous solid dispersion candesartan Cilexetil PVPK30 pH-modulation spray drying bioavailability nasal administration spray-drying chitosan microsphere meloxicam silymarin D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) liver distribution acetaminophen-induced hepatotoxicity extra virgin olive oil secoiridoids metabolism phenolic compounds intestinal permeability drug-phytochemical interaction hepatic metabolism mixed inhibition quercetin repaglinide |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Drug Absorption Studies |
| Record Nr. | UNINA-9910557689203321 |
Song Im-Sook
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Impact of Bioactive Peptides on Human Health
| Impact of Bioactive Peptides on Human Health |
| Autore | Kaustav Majumder (Ed.) |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (212 p.) |
| Soggetto non controllato |
which prevent the occurrence of chronic diseases through their impacts on the gastrointestinal
immune bioavailability and the modulation of human nutrition and nervous systems. Further bioactive peptide discoveries are essential for maintaining human health and commercial development in the area of functional foods and nutraceuticals. This Special Issue covers a wide range of research topics specifically on food-derived bioactive proteins and peptides including the in-vitro and in-vivo evaluation of biological activities the effect on chronic diseases Food-derived bioactive peptides or dietary peptides are increasingly becoming recognized as major food compounds for human health promotion intestinal absorption cardiovascular bio-accessibility |
| ISBN | 3-03897-621-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346667603321 |
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Kaustav Majumder (Ed.)
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Marine Bioactive Peptides: Structure, Function, and Therapeutic Potential
| Marine Bioactive Peptides: Structure, Function, and Therapeutic Potential |
| Autore | Ovchinnikova Tatiana V |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (442 p.) |
| Soggetto non controllato |
cone snail
tilapia animal models BRICHOS domain recombinant peptide calcium absorption plastein reaction antioxidant activity endothelial dysfunction C3a lung cancer invertebrate immunity identification zinc bioavailability NA-inhibitory peptide nuclear magnetic resonance (NMR) review ACE-inhibitory activity intestinal absorption hairtail (Trichiurus japonicas) DU-145 cells peptide crustacean venom duct Kalloconus drug design molecular symmetry arenicin ?-helix APETx2 conotoxins functional diversity docking conotoxin neuraminidase angiotensin II polychaeta influenza virus phylogeny gene expression host defense peptide Perinereis aibuhitensis anti-diabetic activity conopeptides SHRs Chlorella pyrenoidosa protein hydrolysate (CPPH) metastasis Caco-2 cell monolayer Nrf2 caco-2 cells HUVEC PYP15 sea cucumber decapeptide cytotoxic arenicin-1 marine peptides cell proliferation Conus Conus ateralbus self-production of hydrogen peroxide antimicrobial activity molecular dynamics machine learning tachyplesins ion channels gut microbiota Anthopleura anjunae oligopeptide signaling pathways half-fin anchovy hydrolysates NF-?B Chlorella pyrenoidosa protein hydrolysate-calcium chelate (CPPH-Ca) antihypertensive effect QAGLSPVR antimicrobial peptides vasculogenic mimicry antibacterial ?-hairpin innate immunity transcriptome sequencing HIF-1? Gracilariopsis lemaneiformis function ACE-inhibitory peptide complement peptide-zinc complex structure-activity relationship multi-functional peptides cod skin adsorption Maillard reaction products molecular docking antibacterial peptide PI3K/AKT/mTOR signaling pathway Arenicola marina antimicrobial peptide Rana-box acid-sensing ion channel Neptunea arthritica cumingii apoptosis membrane damage proteolytic system toxin polyphemusins computational studies muscle oyster zinc-binding peptide abalone pain relief transport routes cytotoxicity dexamethasone cell death host?microbe relationship anti-LPS factor MMPs protein synthesis structure Pyropia yezoensis peptide cone snails chemical synthesis prostate cancer Ugr 9-1 myotube atrophy |
| ISBN | 3-03921-533-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Marine Bioactive Peptides |
| Record Nr. | UNINA-9910367750603321 |
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Ovchinnikova Tatiana V
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Marine Carotenoids
| Marine Carotenoids |
| Autore | Sugawara Tatsuya |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (744 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
fucoxanthin
scopolamine acetylcholinesterase Alzheimer’s disease cognitive impairments mytiloxanthin anti-oxidative activity singlet oxygen hydroxyl radical lipid peroxidation astaxanthin production carotenoids genome-reduced Corynebacterium glutamicum systematic approach metabolic engineering marine microalgae seaweeds nonconventional extraction electrotechnologies pulsed electric field-assisted extraction supercritical fluid extraction green processing microwave-assisted extraction marine drugs Bangia fuscopurpurea red algae lycopene cyclase carotenoid metabolism astaxanthin Escherichia coli β-carotene ketolase β-carotene hydroxylase Haematococcus pluvialis PII signaling protein nitrogen starvation gene cloning mRNA expression microalgae anti-angiogenic cardioprotective activity anti-cancer anti-diabetic anti-inflammatory anti-obesity anti-oxidant beauty Phaeodactylum tricornutum spectrophotometry high through-put screening antioxidants bioactive compounds blue biotechnology marine microorganisms ozonolysis apo-fucoxanthinone Caco-2 antiproliferative effect Pyropia yezoensis α-cryptoxanthin zeinoxanthin lutein-5,6-epoxide antheraxanthin carotenoid synthesis pathway red seaweed human papillomavirus 16 (HPV16) astaxanthin (Asta) acrosome reaction cholera toxin subunit B (CTB) L1 protein cigarette smoke exposure p38 MAPK antioxidant inflammatory synaptic-associated plasticity comparative transcriptome analyses alcoholic liver disease bioinformatic analysis phytoene fluridone cosmeceuticals anti-obesity effect Phaeodactylum extract Coelastrum canthaxanthin lutein nanoemulsion sublingual delivery ascorbyl palmitate Franz cell alcoholic liver injury oxidative stress Nrf2 TLR4 chronic obstructive pulmonary disease nuclear factor erythroid 2-related factor 2 heme oxygenase-1 siphonaxanthin dehydro-metabolite white adipose tissue metabolic pathway in vivo stereochemistry Tigriopus copepod meso-zeaxanthin zeaxanthin reactive oxygen species immune system antioxidant antibiotics thermal stress disease halocynthiaxanthin intestinal absorption functional food apoptosis inflammation lipid metabolism high-fat diet |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557148503321 |
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Sugawara Tatsuya
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Nutraceutical, Nutrition Supplements and Human Health
| Nutraceutical, Nutrition Supplements and Human Health |
| Autore | Siddiqui Rafat A |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (348 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences Food & society |
| Soggetto non controllato |
Lactobacillus salivarius
otitis probiotic bacteriocin prevention Morus nigra L. black mulberry nutraceutical pharmacological properties coenzyme Q10 (CoQ10) bioavailability intestinal absorption neuroprotection fenugreek protein hydrolysate antiproliferative apoptosis antioxidant Caco2 cells catechins green tea extract herbal dietary supplements hepatotoxicity microbiome Streptococcus agalactiae GBS pregnancy cachexia plum cancer muscle wasting myoblasts protein synthesis graviola weight loss obesity blood glucose food composition metabolic syndrome natural products Carica papaya Bifidobacterium breve M-16V infant health clinical efficacy probiotics gut microbiota Autism spectrum disorder dietary supplements pediatric physician communication frankincense Boswellia boswellic acid lupeolic acid AKBA cytokine breast cancer pentacyclic triterpenic acid triterpenoid chorioallantoic membrane assay Platycodon grandiflorus root BMI body fat mass abdominal fat area wild rice metabolomics atherosclerosis LDL-r-KO mice cytokines 16S rDNA plasma feces proteins carbohydrates functional food curcumin formulated curcumin pharmacokinetics aurora kinase A hepatocellular carcinoma Dietary Supplement Label Database food description food classification FoodEx2 quelites supplementation arsenic vitamin K diet supplement age-related diseases vitamin K-dependent proteins pathological calcification inflammation skeletal muscles Bifidobacterium breve B-3 muscle mass mitochondria |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557507803321 |
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Siddiqui Rafat A
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Nutraceuticals in Human Health
| Nutraceuticals in Human Health |
| Autore | Durazzo Alessandra |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (224 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences Food & society |
| Soggetto non controllato |
bioactive polysaccharides
extraction biomedical applications fenugreek seed garlic linseed copper sulfate yolk cholesterol carotenoid flavonoids oxidative status polyphenols yolk color apigenin luteolin degradation ferrous ions cupric ions cervical cancer cells growth inhibition apoptosis egg quality Haugh unit spirulina antioxidant capacity fulvic acids functional beverage iron mineral Allium sativum β-carboline alkaloids anti-adipogenic effects 3T3-L1 preadipocytes Ac-α-tubulin grape grape seeds FTIR spectroscopy chemometrics fatty acids phenolic compounds biorefinery nutraceuticals Prunus serotine defatted flour soluble protein protein concentrate emulsifying properties emulsion stability ginger water obesity energy homeostasis gene expression rat anti-inflammatory antimicrobial antioxidant anthocyanins medicinal foods Platycodon grandiflorus medicinal food saponins human health applications cherry intestinal absorption nanoparticles nanosystems HUVEC bioactive compounds safety health regulation clinical tests efficacy analysis formulation |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557765703321 |
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Durazzo Alessandra
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Poultry Nutrition
| Poultry Nutrition |
| Autore | Tufarelli Vincenzo |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (754 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences Technology, engineering, agriculture |
| Soggetto non controllato |
Aflatoxin B1
Lactobacillus anti-fungal Aspergillus flavus in vitro poultry chickens ascorbic acid curcumin boric acid necrotic enteritis Salmonella Enteritidis broiler growth intestinal villi Salmonella broilers IBDV soybean isoflavones immune function viral protein 5 mRNA expression ducks zinc oxide phytase growth performance zinc utilization residual feed consumption quail high environmental temperature intestinal morphology duodenum intestinal absorption broilers feeding propolis bee pollen DHA omega-3 fatty acids enrichment selenium sources-levels selenium retention antioxidant capacity frozen meat embryonic development heat shock proteins immunoglobulin intracytoplasmic vacuoles L-arginine amino acids dietary supplementation humoral immunity Moringa oleifera laying performance health status energy requirement meat quality slow-growing broilers nutrient deposition xylanase arabinofuranosidases nutrient utilization immunity strain in ovo injection royal jelly chicken hatchability blood chitooligosaccharide intestinal integrity digestive function heat stress indigenous yellow-feathered breed denatonium benzoate genistein ggTas2Rs bitter taste receptors licorice Glycyrrhiza glabra beneficial effects pharmaceutical health turkey footpad dermatitis charcoal crude protein reduced diet compensatory growth omega-6 fatty acid nutrition performance antioxidant egg and meat quality fertility cholesterol CuZn-SOD HMG-CoA HSP70 laying hens L-Thr vitamin B12 pekin ducks weight gain feed intake feed conversion ratio hematological indicator antibiotic hydrolysable polyphenol monoglyceride pathogen poultry feeding antioxidant status bamboo leaf extract cholesterol metabolism apoptosis autophagy heart kidney Camelina oil Camelina cake polyunsaturated fatty acids broiler chicken threonine metabolism blood parameter polyethylene glycol red grape pomace waste broiler chickens alternative energy source soybean lecithin phospholipids vegetable acid oil digestibility balance free fatty acids triacylglycerols mannanoligosaccharide oxidative status Partridge Shank chickens nanoparticles chromium supplementation electrophysiology Ussing chamber antibiotics intestinal health probiotics methionine reduced crude protein slaughter characteristics medicinal mushrooms Allium feed additive organosulfur compounds polyphenols levels sources carcass betaine Evans blue dye physiological responses feed additives prebiotics phytogenics organic acids anticoccidials Clostridium perfringens production performance essential oils housing system ISA brown production egg production green tea powder huainan partridge chicken lipoprotein lipase plasma lipid cadmium clay blood biochemical parameters multienzymes administration method enzyme dose blood constituents blood chemistry emulsifiers TBARs nutrient requirements growth indices modeling Chinese yellow-feathered chickens probiotic phytobiotic alternative ingredients lipid peroxidation biological nano-curcumin diet pathogens phytobiotics green tea pomegranate drinking water antiradical activity cecal microbiota SNP IGF1 IGFBP2 TGFß3 Hubbard F15 Cobb E meat bilberry leaves walnut leaves digestive enzyme activities blood haematology serum biochemistry |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557422003321 |
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Tufarelli Vincenzo
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Regional Intestinal Drug Absorption : Biopharmaceutics and Drug Formulation
| Regional Intestinal Drug Absorption : Biopharmaceutics and Drug Formulation |
| Autore | Gonzalez-Alvarez Maria Isabel |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (238 p.) |
| Soggetto topico |
Medicine
Pharmaceutical industries |
| Soggetto non controllato |
bioequivalence
Biopharmaceutics Classification System in vitro dissolution test pravastatin oral absorption in silico modeling GastroPlus Phoenix WinNonlin pharmacokinetics clinical studies ibuprofen manometry gastrointestinal mechanistic modeling PBPK PBBM disintegration dissolution enteric-coated ICH quality control regional intestinal permeability permeation enhancers absorption-modifying excipients oral peptide delivery intestinal perfusion pharmaceutical development controlled release drug product biopharmaceutics classification system drug solubility drug permeability location-dependent absorption segregated flow intestinal model (SFM) traditional model (TM) route-dependent intestinal metabolism first-pass effect drug-drug interactions DDI in vitro in vivo extrapolations IVIVE zero-order absorption first-order absorption combined zero- and first-order absorption transit compartment absorption model in situ perfusion microdevices shape mucoadhesion colon absorption nutrient digestion nutrient absorption gastrointestinal hormone postprandial glycaemia energy intake region of the gut obesity type 2 diabetes Franz–PAMPA BCS drugs biomimetic membrane Franz cell passive drug transport BCS class IV drugs segmental-dependent intestinal permeability intestinal absorption oral drug delivery biopharmaceutics physiologically-based pharmacokinetic (PBPK) modeling furosemide intestinal permeability human colon carcinoma cell layer (Caco-2) hierarchical support vector regression (HSVR) drug absorption drug solubility/dissolution regional/segmental-dependent permeability and absorption |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Regional Intestinal Drug Absorption |
| Record Nr. | UNINA-9910566462603321 |
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Gonzalez-Alvarez Maria Isabel
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Health Benefits of the Bioactive Compounds in Foods
| The Health Benefits of the Bioactive Compounds in Foods |
| Autore | Jaime Laura |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (234 p.) |
| Soggetto topico |
Humanities
Social interaction |
| Soggetto non controllato |
phytochemicals
antioxidant antinausea antiobesity anticancer anti-inflammatory ‘Cara Cara’ juice storage hydrophilic and lipophilic antioxidant carotenoid flavonoid degradation dried distilled spent grain (DDSG) melanoidins content structure antioxidant activity ACE-inhibitory activity beverages brewing method antioxidant potential total polyphenols content mineral composition grape stem phenolic compounds central composite rotatable design sustainable food systems pressurized liquid extraction side streams valorisation curcumin milk proteins nanoparticles antimicrobial activities bioactive peptides hypertension functional food metabolic syndrome microbiota insulin sensitivity polyphenols grape pomace donkey milk (DM) donkey colostrum (DC) mammal’s milk cow’s milk protein allergy (CMPA) biologic activity immunosenescence health benefits cryoconcentration calafate juice storage time physicochemical properties bioactive compounds sensorial analysis apitherapy royal jelly propolis bee pollen sarcopenia dietary interventions muscle skeletal muscle wasting physical performance coronavirus disease 2019 COVID-19 body composition lean body mass insulin resistance mitochondrial dysfunction satellite stem cells polysaccharide purification anti-obesity proliferation PPARγ biological activities isolation analysis mechanism of action bioaccessibility intestinal absorption bioavailability |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557361603321 |
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Jaime Laura
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Transmucosal Absorption Enhancers in the Drug Delivery Field
| Transmucosal Absorption Enhancers in the Drug Delivery Field |
| Autore | Maher Sam |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (406 p.) |
| Soggetto non controllato |
chitosan
intestinal epithelial cells ocular delivery amphiphilic polymers cornea tight junction modulator cyclodextrin permeability gemini surfactant transferrin compound 48/80 epithelial permeability cervicovaginal tumors nanoparticles confocal laser scanning microscopy safety formulation salcaprozate sodium intestinal absorption FITC-dextran curcumin block copolymers nasal vaccination whole leaf brush border ocular drug delivery vaccine adjuvant nanoparticle nasal delivery efflux permeation enhancers absorption enhancers nose to brain delivery small intestine epithelium CNS disorders absorption modifying excipients insulin absorption enhancer gel intestinal delivery thermogel system Caco-2 biocompatibility studies absorption enhancement man PN159 poorly absorbed drug tryptophan tight junction oral macromolecule delivery penetration enhancer intestinal permeation enhancers nanocrystals simvastatin nanomedicine enterocyte N-dodecyl-?-D-maltoside (DDM) cell-penetrating peptide quaternization KLAL nasal nasal permeability transmucosal drug delivery Caco-2 cells mast cell activator penetration enhancers drug delivery nose-to-brain bioenhancer polymeric micelles mucoadhesion cell-penetrating peptide (CPP) simulated intestinal fluid vaginal delivery nasal formulation pharmacokinetic interaction sodium caprate clinical trial transmucosal permeation drug absorption enhancer sugar-based surfactants nanocapsules imatinib teriparatide osteoporosis hydrophobization F-actin combined microsphere transepithelial electrical resistance oral delivery ocular conditions metabolism antimicrobial peptide permeation enhancer drug administration antiepileptic drug amino acid in vivo studies sodium cholate (NaC) epithelial transport preclinical nose to brain transport pharmacokinetics chitosan derivatives ophthalmology tight junctions sheep cationic functionalization GLP-1 pulmonary and liposome cytochrome P450 claudin P-glycoprotein in situ hydrogel mucoadhesiveness PTH 1-34 Aloe vera oral peptides |
| ISBN | 3-03921-849-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910372785603321 |
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Maher Sam
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| MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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