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Advances and Novel Treatment Options in Metastatic Melanoma
| Advances and Novel Treatment Options in Metastatic Melanoma |
| Autore | Facchiano Antonio |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (528 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
melanoma
invasion WNT5A MARCKS phosphorylation MANS peptide nanoparticles cell therapy tumor microenvironment sex/gender sex-hormones immunity microRNAs immunotherapy BRAF-mutant melanoma BRAF inhibitor mechanism of action targeted therapy tumour microenvironment plasmacytoid dendritic cells lactate dehydrogenase TLR interferon CXCL10 TPC2 HIPPO SOCE metastasis essential oils angiogenesis apoptosis uveal melanoma (UM) metastatic uveal melanoma (mUM) prognostication adjuvant therapy metastatic therapy metastatic dormancy liver-directed-therapies targeted-therapy combined therapy protein tyrosine phosphatase PTPs inhibitors melanoma immune infiltrate BRAF inhibitors microenvironment resistance therapy therapeutic resistance exosomes extracellular vesicles diagnosis prognosis ctDNA liquid biopsy prediction patient stratification BRAF arthralgia rheumatoid arthritis carbonic anhydrase hedgehog cyclopamine small molecules acetazolamide motility metalloproteinases FAK cancer mucosal melanoma nivolumab pembrolizumab ipilimumab radiotherapy cholinergic system acetylcholine muscarinic receptors nicotinic receptors melanoma metastasis ShcD adaptor protein amoeboid motility Rac1 DOCK4 melanoma PDX target therapy cancer stem cells slow cycling phenotype drug resistance OXPHOS lipid metabolism cancer associated fibroblast melanomagenesis biomarkers checkpoint inhibitor PD-1 melanoma markers cytokines machine learning Support Vector Machine principal component analysis BCL2L10 STAT3 cytotoxicity survival ABT-737 Bcl-2 family ML258 HuR MITF metastases siRNA |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557612103321 |
Facchiano Antonio
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Cancer Immunology
| Cancer Immunology |
| Autore | Subramanian Subree |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (316 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
NKG2D
CAR T IL-7 prostate cancer cell therapy CD19-CAR-T B cell aplasia KIR PD-1 inhibitory CAR tumor-infiltrating lymphocytes tumor microenvironment immunotherapy NK cells cancer stem cells (CSCs) antibody-dependent cellular cytotoxicity (ADCC) differentiation cytotoxicity IFN-γ osteoclasts MICA/B mAb DNA methylation RNA methylation S-adenosylmethionine (SAM) cancer innate immunity adaptive immunity T cells m6A PD-L1 resistance immune checkpoints cancer vaccine combination immunotherapy TCR diversity organ transplantation carcinoma epidemiologic studies immunosuppression CTLA-4 Treg cells immune checkpoint inhibitors CD28 antigen-presenting cells IL15 colon cancer melanoma uveal BAP1 anti-PD-1 anti-CTLA-4 TIL classical and endemic Kaposi Sarcoma systemic treatment multi-state modelling treatment free interval chemotherapy interferon triple negative breast cancer immunomodulation bispecific antibody sortase A chemo-enzymatic approach anti-CD20 antibody Fab BiFab colorectal cancer dendritic cells Atypical Chemokine Receptor 4 (ACKR4) T-cell priming immune checkpoint blockade primary liver cancer kynurenine pathway immune evasion indoleamine 2,3 dioxygenase 1 tryptophan 2,3 dioxygenase 2 IDO inhibitor antigen presenting cells |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557349203321 |
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Subramanian Subree
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Cell Biology of Viral Infections
| Cell Biology of Viral Infections |
| Autore | Lozach Pierre-Yves |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (418 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
ectoderm
mesoderm human development embryogenesis interferon response interferon-induced genes self-organizing map (SOM) data portrayal epigenetic signature embryoid body TGF-β and Wnt/β-catenin pathway interferon tumor necrosis factor STAT interferon regulatory factor antiviral autoimmunity inflammation hepatitis C virus HCV erlin-1 erlin-2 host factor endoplasmic reticulum RNA replication protein production virus production lipid droplet TAP-GFP fluorescent TAP platform antigen presentation MHC I immune evasion BoHV-1 UL49.5 virus calcium channels calcium pumps virus–host interaction Ebola virus filovirus inclusion bodies NXF1 liquid organelles mRNA export cancer immunotherapy oncolytic virus herpes simplex virus immune checkpoint inhibitor angiogenesis inhibitor rabies uDISCO 3D imaging rabies pathogenicity astrocyte infection metabolism apoptosis autophagy HIV-1 spread cell-free infection cell–cell transmission 3D cultures mathematical modeling environmental restriction CAD pyrimidine synthesis HEV particle production viral replication virus entry hantavirus Tula virus replication factory RNA synthesis Golgi stress granules actin cytoskeleton nucleocapsid transport Arp2/3 complex ERAP2 ERAP2/Iso3 microbial infections alternative splicing SARS-CoV-2 host cell response coronavirus MERS-CoV SARS-CoV sialic acid Siglec antiviral peptide enveloped viruses membrane phosphatidylserine envelope disruption membrane damage antiviral autophagy galectin bacterial invasion adenovirus lysophagy ESCRT machinery cedar virus henipavirus fusion protein endocytosis biological activity feline coronavirus feline enteric coronavirus FECV feline infectious peritonitis virus FIPV feline intestinal organoids alphaviruses cell death mosquito tolerance |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557135903321 |
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Lozach Pierre-Yves
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Chronic HCV Infection: Clinical Advances and Eradication Perspectives
| Chronic HCV Infection: Clinical Advances and Eradication Perspectives |
| Autore | Liberto Maria Carla |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (104 p.) |
| Soggetto topico |
Medicine
Epidemiology & medical statistics |
| Soggetto non controllato |
HCV
rheumatic interferon mortality hepatitis C virus (HCV) phylogeny resistance-associated substitution (RAS) chronic hepatitis C vibration controlled transient elastography fibrosis steatosis hepatocellular carcinoma hepatitis C genotype 3 liver cirrhosis pangenotypic children ledipasvir/sofosbuvir real-life sustained virological response elimination model COVID-19 PWID homeless persons HCV eradication direct-acting antivirals out-of-hospital retention in care |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Chronic HCV Infection |
| Record Nr. | UNINA-9910557608603321 |
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Liberto Maria Carla
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Cytokine-mediated Organ Dysfunction and Tissue Damage Induced by Viruses
| Cytokine-mediated Organ Dysfunction and Tissue Damage Induced by Viruses |
| Autore | Lehmann Michael H |
| Pubbl/distr/stampa | Frontiers Media SA, 2020 |
| Descrizione fisica | 1 electronic resource (170 p.) |
| Soggetto topico |
Medicine
Immunology |
| Soggetto non controllato |
chemokine
CVB3 Hantavirus hcmv HIV Inflammation influenza interferon |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557223403321 |
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Lehmann Michael H
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| Frontiers Media SA, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Family Iridoviridae Molecular and Ecological Studies of a Family Infecting Invertebrates and Ectothermic Vertebrates
| Family Iridoviridae Molecular and Ecological Studies of a Family Infecting Invertebrates and Ectothermic Vertebrates |
| Autore | Chinchar Gregory |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (234 p.) |
| Soggetto non controllato |
risk assessment
CQIV mathematical models amphibian iridovirus ISDL Exopalaemon carinicauda viral load virus isolation European chub outbreak Unconventional T cell early detection susceptible species viral immune evasion DNA virus Rana grylio virus antibody intracellular localization Rana grylio virus (RGV) British Columbia Iridoviridae Andrias davidianus ranavirus viral infection susceptible-infected (SI) models yeast two-hybrid (Y2H) prevalence host-pathogen interactions Pacific herring Procambarus clarkii Bayesian inference eDNA amphibians Artemia spp ranavirosis cross-species transmission FV3 SHIV Gryllus bimaculatus Pacific salmon NF-?B cricket IIV-6 virus binding erythrocytic necrosis virus (ENV) envelope protein iridovirus core proteins emerging infection host Ranavirus white head Rana temporaria Imd biosecurity antiviral immunity Decapodiridovirus endemic disease Macrobrachium rosenbergii co-immunoprecipitation (Co-IP) Common frog aquatic animals virus surveillance immunomodulators frog virus 3 ELISA DIV1 megalocytivirus Lymphocystis disease virus bearded dragon susceptibility protein interaction Pogona vitticeps viral erythrocytic necrosis (VEN) histopathology epidemiology native-fish conservation viral transmission Sparus aurata immunohistochemistry lizard disease dynamics immunofluorescence transmission modelling Macrobrachium nipponense interferon nonclassical MHC heparan sulfate ranavirus Mexico |
| ISBN | 3-03921-517-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910367754803321 |
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Chinchar Gregory
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Marine Glycomics
| Marine Glycomics |
| Autore | Fujii Yuki |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (208 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
Acropora tenuis
coral chemoattraction lectin white-spotted charr lectin oncolytic vaccinia virus interferon antiviral response Chlorella vulgaris Dunaliella salina Arthrospira platensis growth rate accumulation of carbohydrates biohydrogen antibacterial activity anticancer activity antifungal activity Aplysia kurodai apoptosis Ehrlich ascites carcinoma sulfated fucose-rich polysaccharides sulfated fucan fucosylated chondroitin sulfate fucoidan oral administration anticoagulant activity fucosylated glycosaminoglycan anticoagulant platelet aggregation contact activation hypotension pulmonary embolism sulfated polysaccharides marine hydrobionts antiparasitic activity protozoa malaria leishmaniasis trypanosomiasis schistosomiasis cryptosporidiosis trichomoniasis bivalve mollusk C1q domain-containing lectin-like pattern recognition receptor polysaccharides interstitial compartment marine worms sipunculids bioactive properties peptides rotifera pattern recognition receptors microbe-associated molecular patterns innate immunity C-type lectins C1q domain-containing proteins galectins bacterial exopolysaccharides bioflocculanting activity microalgae growth-promoting bacterium harmful algal bloom-forming dinoflagellate Alexandrium catenella Mameliella alba |
| ISBN | 3-0365-5822-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910637782803321 |
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Fujii Yuki
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Matrix Metalloproteinase
| Matrix Metalloproteinase |
| Autore | Ågren Magnus S |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (262 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
hemagglutinin-B
transwell co-cultures matrix metalloproteinases TNF-α matrix metalloproteinase peritoneal mesothelial cell gastric cancer metastatic dissemination MT4-MMP cancer diseases aggrecan aggrecanase ADAMTS cartilage arthritis MMP-2 MMP-9 inhibitor allodynia caspase-3 neuropathic pain dorsal root ganglion spinal nerve ligation tuberculosis tuberculous meningitis HIV-TB-associated IRIS extracellular matrix breakdown adult pediatric lung central nervous system matrix-metalloproteinase monocytes inflammation phagocytosis apoptosis blood sampling anticoagulants high-molecular-weight heparin IL-16 sICAM-1 IL-8 T cells a disintegrin and metalloproteinase EMMPRIN CD147 ectodomain shedding MMPs PTMs glycosylation phosphorylation glycosaminoglycans interleukin IL-6 IL-11 trans-signaling metalloproteases ADAM MMP meprin matrix metalloproteinases (MMPs) protease signaling invasion chemokine cytokine proteomics interferon Agkistrodon venom metalloproteinase fibrinogen antithrombotic metabolomics extracellular matrix cytokines proteinases interstitial collagens wound healing |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557717203321 |
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Ågren Magnus S
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Ubiquitination in Health and Diseases
| Ubiquitination in Health and Diseases |
| Autore | Ishigami Tomoaki |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (292 p.) |
| Soggetto topico |
Humanities
Social interaction |
| Soggetto non controllato |
deubiquitinase
degradation therapeutic target cancer hematopoiesis hematopoietic stem cells immune response regulation of gene expression ubiquitin system genetic diseases ubiquitin ligase deubiquitinases monoubiquitin signaling vesicular trafficking protein complex formation inflammation inhibitor innate immune interferon LUBAC NF-κB ubiquitin Parkinson’s disease dopa-responsive dystonia tyrosine hydroxylase α-synuclein fatty acid-binding protein 3 ubiquitination proteasomal degradation ubiquitin-proteasome system mitochondria E3 ubiquitin ligase MITOL/MARCH5 salt-sensitive hypertension Nedd4L/Nedd4-2 epithelial sodium channel aldosterone sensitive distal nephron excitation-transcription coupling RNF183 RNF186 RNF182 RNF152 RING finger mTOR endoplasmic reticulum stress osmotic stress ubiquitin code virus infection virus-host interaction tau protein semisynthesis disulfide-coupling polyubiquitin fibrils aggregation neurodegeneration deubiquitination inhibitors protein quality control proteolysis protein stabilization regulatory T cells mesenchymal stem cell cortical bone derived stem cell myocardial infarction blood pressure renal salt reabsorption vascular function ubiquitin proteasome system ubiquitin–proteasome pathway cilia ciliogenesis differentiation proliferation ciliopathy E3s DUBs UPS neurodegenerative disease immune-related diseases |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557356403321 |
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Ishigami Tomoaki
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Zika Virus and Host Interactions
| Zika Virus and Host Interactions |
| Autore | Hobman Tom |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (256 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
Zika virus
peroxisomes innate immune response interferon astrocytes fetal brain zika virus flaviviruses T cells host-pathogen interactions flavivirus tight junctions claudins ZO-1 blood-placental barrier placenta apoptosis viral replication Bcl-2 protein family ZIKV virus host interactions pathogenesis MR766 guinea pig subcutaneous vaginal sexual transmission virus transmission envelope protein glycosylation fusion loop viral fusion cell entry NS5 protein nuclear localization inflammation innate immunity extracellular vesicles cellular communication C6/36 cells human monocytes endothelial vascular cells protein–protein interaction non-structural viral proteins network JAK/STAT cytokine West Nile virus HSP90 NS5 virus–host interactions anti-viral signaling immune response inflammatory mediator Sertoli cells Leydig cells ZIKA virus arboviruses infertility IFN RIG-I MDA5 IFNAR1 zika host cell death peroxisome mosquito tight junction |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557297503321 |
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Hobman Tom
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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