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Amide Bond Activation / Michal Szostak
| Amide Bond Activation / Michal Szostak |
| Autore | Szostak Michal |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (466 p.) |
| Soggetto topico | Chemistry |
| Soggetto non controllato |
N-heterocyclic carbene
non planar amide ruthenium (Ru) physical organic chemistry gemcitabine prodrug pyramidal amides bridged sultams catalysis dipeptides N-(1-naphthyl)acetamide C-N ? bond cleavage steric effects peptide bond cleavage transition-metal-free palladium N-heterocyclic carbenes (NHCs) addition reaction C–O activation rhodium metal complexes carbanions thioamidation amide bond intramolecular catalysis antiviral activity additivity principle pre-catalysts C–N bond cleavage bridged lactams C–H acidity arynes twisted amides organic synthesis amination Suzuki-Miyaura tert-butyl cyclopentadienyl complexes C-S formation enzymes DFT study sulfonamide bond N HERON reaction primaquine entropy amide activation amidation synthesis amide hydrolysis carbonylicity amide bond activation amide bond resonance aminosulfonylation molecular dynamics model compound in situ amide homogeneous catalysis heterocycles anomeric effect multi-component coupling reaction kinetic excited state C–H bond cleavage palladium catalysis amides thiourea formylation alkynes cis/trans isomerization amide C–N bond activation intein C-H functionalization succindiamide amide bonds crown ether aminoacylation directing groups cytostatic activity reaction thermodynamics acyl transfer transition metals N-dimethylformamide DMAc acylative cross-coupling C-H/C-N activation nickel catalysis antibacterial screening sodium aryl thioamides Winkler-Dunitz parameters catalyst N-dimethylacetamide base-catalyed hydrolysis nitrogen heterocycles cross-coupling insertion amidicity nitro-aci tautomerism activation carbonylation transamidation amine distortion Pd-catalysis rotational barrier energy hypersensitivity N–C activation metabolic stability [2+2+2] annulation twisted amide protease cyanation amide resonance trialkylborane catalysts biofilm eradication pharmacokinetics pancreatic cancer cells DMF aryl esters Michael acceptor fumardiamide water solvation ester bond activation cyclization nuclear magnetic resonance secondary amides reaction mechanism density functional theory density-functional theory amino acid transporters |
| ISBN |
9783039212040
3039212044 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346843703321 |
Szostak Michal
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Antimicrobial Peptides Aka Host Defense Peptides – From Basic Research to Therapy
| Antimicrobial Peptides Aka Host Defense Peptides – From Basic Research to Therapy |
| Autore | Petrlova Jitka |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (226 p.) |
| Soggetto topico |
Research & information: general
Chemistry |
| Soggetto non controllato |
ECP
AMPs infection murine model Gram-negative bacteria LPS host defense peptides monocytes neutrophils neutrophil–monocyte interaction extracellular traps host defense peptide innate immunity NF-κB poly I:C toll-like receptor 3 mucus of Cornu aspersum peptide fraction MW < 10 kDa Escherichia coli NBIMCC 8785 SEM fluorescence and digital assays antibacterial effect oral cavity human cathelicidin antimicrobial peptides immunomodulation oncolytic peptides cancer membrane integrity bulky non-nature amino acid DAMPs drug design antimicrobial peptidomimetic hydrogel-based system hyaluronic acid anti-infective activity skin infections antimicrobial peptide expression intein self-cleavage cecropin-like apolipoprotein E host defense aggregation body fluid AMP interaction network chemical barrier cationic antimicrobial peptides length dependent activity antimicrobial activity hemolysis vesicle leakage solid-state 31P-, 15N- and 19F-NMR β-stranded peptides β-sheets structure and orientation of peptides in membranes |
| ISBN | 3-0365-5820-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910639991103321 |
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Petrlova Jitka
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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