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ABC Transporters in Human Diseases
| ABC Transporters in Human Diseases |
| Autore | Falguières Thomas |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (494 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
ABC transporters
drug action regulatory extension regulatory insertion mechanism of action MRP1 MRP4 breast cancer proliferation migration invasion cAMP ABCG2 ABCB1 blood-brain barrier PET Alzheimer's disease beta-amyloid tariquidar erlotinib ABCG5 ABCG8 ATP-binding cassette transporter cholesterol polar relay sitosterolemia 5' untranslated region cis-acting elements ABCA subfamily bioinformatics ABC transporter therapy response disease-free survival next-generation sequencing competitive allele-specific PCR P-glycoprotein amyloid-beta neuron SK-N-SH gene therapy AAV PFIC BSEP ABCB11 bile salts intrahepatic cholestasis chaperones PFIC2 BRIC ATP-binding cassette transporter A1 (ABCA1) cholesterol homeostasis reverse cholesterol transport HDL-C dyslipidemia type 2 diabetes microparticles ABCG2 genotype clinico-genetic analysis ethnic specificity genetic variations precision medicine rare variant Roma serum uric acid SUA-lowering therapy urate transporter bile secretion ABCB4 ABCC2 ABCG5/G8 molecular partners phytosterol xenosterol atherosclerosis gall stone ABC transporter ABC (ATP-binding cassette) transporters multidrug resistance transport trafficking urate mutations polymorphisms ABCC6 TNAP NT5E Pseudoxanthoma elasticum (PXE) cancer membrane protein functional divergence calcification pseudoxanthoma elasticum generalized arterial calcification of infancy pyrophosphate therapies ABCA7 phagocytosis Aβ peptides yeast multidrug transporter anticancer antifungal resistance mechanism peroxisome adrenoleukodystrophy fatty acids gout early-onset gout hyperuricemia uric acid BCRP single nucleotide polymorphism SNP homology modeling substrate-binding site cellular ATP efflux mutagenesis intracellular traffic MDR3 phosphatidylcholine RAB GTPase taxol drug transport |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910674029103321 |
Falguières Thomas
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Advances in Ginsenosides
| Advances in Ginsenosides |
| Autore | Chen Jen-Tsung |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (264 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
Ginseng berries
UPLC-QTOF/MS HR-MAS NMR spectroscopy ginsenoside primary metabolite notoginseng leaf triterpenes HMGB1 cerebral ischemia and reperfusion injury inflammation MAPK NF-κB Panax ginseng wild ginseng pharmacopuncture safety clinical trials ocotillol type ginsenoside epimers stereoselective ADME characteristics molecular docking analysis homology modeling molecular interaction Rg3 Th17 RORγt EAE Lactobacillus ginsenosidimutans complete genome sequence novel glycoside hydrolases bioconversion recombinant enzyme ginsenoside Rg3(S) gram unit production Asian ginseng American ginseng Panax quinquefolium L. ginsenosides anti-inflammation pro-resolving ginseng macrophage M2 polarization ginsenoside CK neurogenesis cell proliferation neuroprotection dammarane-type triterpene saponin ginsenoside MT1 transglycosylation biotransformation biotechnology Anxa2 epithelial-mesenchymal transition (20S)G-Rh2 bioreactor cell suspension hairy root polyploidy protoplast Panax sp polysaccharides allergy immune system compound M1 hepatoprotective anti-cancer anti-diabetic |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557766503321 |
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Chen Jen-Tsung
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Computational Approaches: Drug Discovery and Design in Medicinal Chemistry and Bioinformatics
| Computational Approaches: Drug Discovery and Design in Medicinal Chemistry and Bioinformatics |
| Autore | Tutone Marco |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (387 p.) |
| Soggetto topico |
Research & information: general
Chemistry |
| Soggetto non controllato |
3D-QSAR
pharmacophore modeling ligand-based model HDACs isoform-selective histone deacetylase inhibitors aminophenylbenzamide hERG toxicity drug discovery fingerprints machine learning deep learning gene expression signature drug repositioning approaches RNA expression regulation high-throughput virtual screening dual-target lead discovery neurodegenerative disorders Alzheimer's disease dual mode of action multi-modal nicotinic acetylcholine receptor acetylcholinesterase molecular docking methotrexate drug resistance human dihydrofolate reductase virtual screening molecular dynamics simulation epitope binning epitope mapping epitope prediction antibody:antigen interactions protein docking glycoprotein D (gD) herpes simplex virus fusion proteins Src inhibitors pharmacophore model molecular dynamics simulations in silico COX-2 inhibitors molecular modeling sodium-glucose co-transporters 2 FimH uropathogenic bacteria urinary tract infections diabetes drug-resistance mutations HIV-2 protease structural characterization induced structural deformations SARS-CoV-2 COVID-19 multiprotein inhibiting natural compounds MD simulation 3CL-Pro antivirals docking simulations drug repurposing consensus models binding space isomeric space MRP4 SNPs variants protein threading modeling molecular dynamics binding site hTSPO PK11195 cholesterol homology modeling molecular dynamics (MD) simulation carbon nanotubes Stone-Wales defects haeckelite defects doxorubicin encapsulation drug delivery system binding free energies noncovalent interactions main protease mutants inhibitors PF-00835231 Mycobacterium tuberculosis tuberculosis proteasome natural compounds multiscale multitargeting polypharmacology computational biology drug repositioning structural bioinformatics proteomic signature skin aging oxidative stress aging progression mechanism genome-wide genetic and epigenetic network (GWGEN) systems medicine design multiple-molecule drug immunoproteasome non-covalent inhibitors MD binding metadynamics induced-fit docking |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Computational Approaches |
| Record Nr. | UNINA-9910557519403321 |
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Tutone Marco
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Marine Enzymes : Sources, Biochemistry and Bioprocesses for Marine Biotechnology
| Marine Enzymes : Sources, Biochemistry and Bioprocesses for Marine Biotechnology |
| Autore | Trincone Antonio |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (378 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
metalloprotease
adsorption analysis molecular docking affinity purification aminophenylboronic acid alginate degradation 4-deoxy-l-erythro-5-hexoseulose uronic acid (DEH) metabolism Bacteroidetes Proteobacteria Flavobacterium 2-keto-3-deoxy-d-gluconate (KDG) kinase 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase alginate-derived products marine enzymes biocatalysts bioprocesses biorefinery seafood marine biomarkers collagenase fermentation optimization collagen Pseudoalteromonas antioxidant peptides microcystin-degrading bacteria mycotoxin protease esterase inhibitor marine agent Catenovulum alkaline and cold-adapted dextranase isomaltoogligosaccharides biofilm dental caries growing cells resting cells asymmetric reduction marine fungi chiral alcohols alginate lyase marine bacterium Bacillus sp. Alg07 purification alginate oligosaccharides Vibrio weizhoudaoensis PL7 family salt-activated enzyme Serratia marcescens polyM-specific oligosaccharides Isoptericola halotolerans bifunctional alginate lyase α-d-galactosidase homology model GH 36 family mutation transglycosylation marine bacteria Pseudoalteromonas sp. KMM 701 leucine dehydrogenase cold-adapted Antarctic bacterium sea-ice homology modeling fucoidan endo-fucoidanase galactofucan molecular stabilisation Sargassum mcclurei Turbinaria ornata Alteromonas deep sea cold-adapted enzyme β-galactosidase lactose-free milk chitosanases chitin deacetylase deacetylation patterns chitooligosaccharides separating detecting expression deep-sea enzyme pCold vector Ascophyllum nodosum algal cell wall degrading enzymes enzyme-assisted extraction ichip device quorum quenching enzyme error prone PCR high-throughput screening site-directed mutagenesis catalytic ability Pectobacterium carotovorum subsp. carotovorum (Pcc) Alginate lyase Thermo-tolerant pH-stability Endo-manner Vibrio sp. SY01 polysaccharide lyase of family 6 characterization degradation pattern microalgae enzymes marine biotechnology -omics technologies heterologous expression homologous expression |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Marine Enzymes |
| Record Nr. | UNINA-9910557671503321 |
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Trincone Antonio
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular Biocatalysis 2.0
| Molecular Biocatalysis 2.0 |
| Autore | Křen Vladimír |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (166 p.) |
| Soggetto topico | Technology: general issues |
| Soggetto non controllato |
E. coli
recombinant horseradish peroxidase site-directed mutagenesis periplasm glycosylation sites Aspergillus niger quercetin rutin rutinose rutinosidase "solid-state biocatalysis" hyaluronic acid in vitro synthesis one-pot multi-enzyme optimization enzyme cascade Basidiomycota Agaricomycotina nitrilase cyanide hydratase nitrile substrate specificity overproduction homology modeling substrate docking phylogenetic distribution indigo MISO library flavin monooxygenase FMO β-N-acetylhexosaminidases transglycosylation Glide docking Talaromyces flavus muramic acid non-reducing carbohydrate glucose oxidase direct electron transfer amine-reactive phenazine ethosulfate glucose sensor glycemic level monitoring Pseudomonas putida MnB1 biogenic manganese oxides abiotic manganese oxides α-Hydroxy-β-keto esters whole-cell biocatalysis surface display cell wall anchor Lactobacillus plantarum whole-cell biocatalyst Fe(II)/2-ketoglutarate-dependent dioxygenase 2-ketoglutarate generation regio- and stereo-selective synthesis hydroxy amino acids sequential cascade reaction |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557576703321 |
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Křen Vladimír
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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New Insights into Parvovirus Research
| New Insights into Parvovirus Research |
| Autore | Gallinella Giorgio |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (342 p.) |
| Soggetto non controllato |
antivirals
Bombyx mori bidensovirus Bocaparvovirus human bocavirus 1 equine parvovirus-hepatitis NS2 NS1 X-ray crystallography BIRC3 (cIAP-2) glycans children antibody interactions new viruses alpaca cidofovir rodent protoparvoviruses clinical trials structural biology DNA virus human bocavirus caspase-3 viral communities uncoating PLA2 phospholipase-A2 oncolytic virus immune therapy Parvoviridae viral ecology Cryo-EM AAV metagenomics phylogeny oncolytic viruses mite parvovirus evolution Carnivore protoparvovirus 1 adeno-associated virus telbivudine capsid stability virus homology modeling human airway epithelia sequence analysis acute gastroenteritis bisulfite PCR next-generation sequencing single stranded DNA virus overlapping promoters virus diversity prognosis oncolytic activity genome hydroxyurea Lepidoptera genome externalization antiviral compounds circulating angiogenic cells tumor microenvironment coumarin derivatives nuclear targeting densovirus receptor interactions cell cycle arrest transcription profile brincidofovir canine parvovirus endogenous viral elements inflammatory cardiomyopathy erythroid progenitor cells RNA-seq insect chapparvovirus RT-qPCR trafficking AAV2 agricultural pests Adeno-associated virus myocarditis diagnosis parvovirus feline panleukopenia virus chitin B19V transcription mapping flavonoids immunomodulation erythrovirus apoptosis adenoviral vector anti-cancer divalent cations protease genetics preclinical arthropod peritrophins biocontrol dilated cardiomyopathy insect parvovirus combination therapies intravenous immunoglobulin (IVIG) virus phylogeny evolution second generation parvovirus treatments commercial horse serum parvovirus B19 canine chapparvovirus CpG methylation RACE H-1PV viral metagenomics horses |
| ISBN | 3-03928-311-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910404088603321 |
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Gallinella Giorgio
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| MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Synthesis of Marine Natural Products and Molecules Inspired by Marine Substances II
| Synthesis of Marine Natural Products and Molecules Inspired by Marine Substances II |
| Autore | Manzo Emiliano |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (111 p.) |
| Soggetto topico |
Research & information: general
Chemistry |
| Soggetto non controllato |
In-silico drug design
virtual screening Avicennia alba gag polyprotein homology modeling ADMET molecular dynamics simulation divergent total synthesis marine natural products tetracyclic meroterpenoids aureol (−)-majusculoic acid anti-inflammation LPS CCK-8 animal studies marine alkaloids biological activity cancer cardiovascular diseases inflammation chemical synthesis ilamycins rufomycins cyclomarins tuberculosis malaria cyclopeptides biosynthesis total synthesis natural products |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557724503321 |
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Manzo Emiliano
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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