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ABC Transporters in Human Diseases
| ABC Transporters in Human Diseases |
| Autore | Falguières Thomas |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (494 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
ABC transporters
drug action regulatory extension regulatory insertion mechanism of action MRP1 MRP4 breast cancer proliferation migration invasion cAMP ABCG2 ABCB1 blood-brain barrier PET Alzheimer's disease beta-amyloid tariquidar erlotinib ABCG5 ABCG8 ATP-binding cassette transporter cholesterol polar relay sitosterolemia 5' untranslated region cis-acting elements ABCA subfamily bioinformatics ABC transporter therapy response disease-free survival next-generation sequencing competitive allele-specific PCR P-glycoprotein amyloid-beta neuron SK-N-SH gene therapy AAV PFIC BSEP ABCB11 bile salts intrahepatic cholestasis chaperones PFIC2 BRIC ATP-binding cassette transporter A1 (ABCA1) cholesterol homeostasis reverse cholesterol transport HDL-C dyslipidemia type 2 diabetes microparticles ABCG2 genotype clinico-genetic analysis ethnic specificity genetic variations precision medicine rare variant Roma serum uric acid SUA-lowering therapy urate transporter bile secretion ABCB4 ABCC2 ABCG5/G8 molecular partners phytosterol xenosterol atherosclerosis gall stone ABC transporter ABC (ATP-binding cassette) transporters multidrug resistance transport trafficking urate mutations polymorphisms ABCC6 TNAP NT5E Pseudoxanthoma elasticum (PXE) cancer membrane protein functional divergence calcification pseudoxanthoma elasticum generalized arterial calcification of infancy pyrophosphate therapies ABCA7 phagocytosis Aβ peptides yeast multidrug transporter anticancer antifungal resistance mechanism peroxisome adrenoleukodystrophy fatty acids gout early-onset gout hyperuricemia uric acid BCRP single nucleotide polymorphism SNP homology modeling substrate-binding site cellular ATP efflux mutagenesis intracellular traffic MDR3 phosphatidylcholine RAB GTPase taxol drug transport |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910674029103321 |
Falguières Thomas
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Advanced Therapy Medicinal Products for Eye Diseases: Goals and Challenges
| Advanced Therapy Medicinal Products for Eye Diseases: Goals and Challenges |
| Autore | Diebold Yolanda |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (207 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
MPC polymer
dry eye ocular surface lacrimal fluid mucin 3D bioprinting cornea retina ophthalmology tissue regeneration electrospinning conjunctiva decellularized tissue matrix small intestinal submucosa urinary bladder matrix polycaprolactone fiber tissue engineering stratification conjunctival epithelial cells hydrogel keratoplasty scaffold collagen advanced therapy medicinal product ATMP cell therapy gene therapy eye ocular regulatory marketing authorization double-crosslinking carbodiimide glutaraldehyde sodium metabisulfite sodium borohydride EDC/NHS stem cells retinal diseases optic nerve diseases cell replacement cell sources advanced therapies ocular mucosa blindness CLET limbal niche limbal stem cell LSCD mesenchymal stem cell transplantation MSCT corneal limbus decellularized xenograft recellularization mesenchymal stem cells |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Advanced Therapy Medicinal Products for Eye Diseases |
| Record Nr. | UNINA-9910557675503321 |
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Diebold Yolanda
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Advances in Parvovirus Research 2020
| Advances in Parvovirus Research 2020 |
| Autore | Gallinella Giorgio |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (258 p.) |
| Soggetto topico | Public health & preventive medicine |
| Soggetto non controllato |
feline parvovirus
virus-like particles VP2 protein antibodies AAV neuro-degenerative disease gene therapy antigenicity sequencing virus canine parvovirus peri-urban wild dogs disease transmission Australia parvovirus B19 G-quadruplex bioinformatics antivirals BRACO-19 pyridostatin oncolytic viruses rodent protoparvovirus H-1PV virus entry clathrin-mediated endocytosis parvovirus minute virus of mice RNA processing gene expression canine COVID-19 veterinary epidemiology B19V VP1u receptor PLA2 erythroid cells biomarker drug delivery nanocarrier B19 parvovirus detection cell cycle permissivity serotype capsid cryo-EM genome packaging gene delivery bocavirus Caribbean region new CPV-2a outbreak endemic nearly complete genomes virus evolution parvoviruses nucleus imaging of viral interactions and dynamics analysis of protein–protein interactions analysis of virus–chromatin interactions AMDV Aleutian disease mink parvovirus Aleutian mink disease virus vaccine |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557370403321 |
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Gallinella Giorgio
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing
| Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing |
| Autore | Pörtner Ralf |
| Pubbl/distr/stampa | Basel, : MDPI Books, 2022 |
| Descrizione fisica | 1 electronic resource (226 p.) |
| Soggetto topico |
Technology: general issues
History of engineering & technology |
| Soggetto non controllato |
clonal cell population
phenotypic diversity inoculum train uncertainty-based cell culture model biopharmaceutical manufacturing Escherichia coli hybrid modeling machine learning model-assisted DoE quality by design upstream bioprocessing surface plasmon resonance (SPR) bioprocess monitoring biosensor quality by design (QbD) process analytical technology (PAT) biotherapeutics production vaccines production CHO DP-12 computational fluid dynamics bioreactor characterization hydrodynamic gradients process development critical shear stress Kolmogorov length scale operational space sensors cell culture spectroscopy PAT smart biomanufacturing soft-sensor Adeno-associated virus transfection PEI continuous gene therapy microcarriers bioreactor transient expression spheroid strength β-cells diabetes shear stress-guided production hydrodynamic stress Gaussian processes Bayes optimization Pareto optimization multi-objective seed train Chinese hamster ovary cells cryopreservation monoclonal antibodies N−1 perfusion process intensification upstream processing |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910595072803321 |
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Pörtner Ralf
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| Basel, : MDPI Books, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Brain-Targeted Drug Delivery
| Brain-Targeted Drug Delivery |
| Autore | Sousa Flávia |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (260 p.) |
| Soggetto topico | Technology: general issues |
| Soggetto non controllato |
drug delivery into the brain
transendothelium based on receptor-mediated transcytosis immunotherapy Alzheimer's disease anti-tau and anti-receptor bispecific monoclonal antibodies Alzheimer's disease-relevant tau species temporal-spatial pathological Aβ and tau distribution interactions between Aβ and tau tau clearance in microglia tau clearance in neurons liposome nanoparticle seizure laser ultrasound naringenin nanostructured lipid carrier intranasal delivery central composite rotatable design depression pomegranate seed oil nasal delivery system memory impairment movement impairment delivery to brain improved memory phospholipid oily gel high-grade glioma diffuse midline glioma glioblastoma IL-13Rα2 IL-13 immunotoxin targeted therapy GB-13 IL13.E13K-PE4E receptor expression acetaminophen blood-brain barrier claudin-5 CNS drug delivery opioids tight junction microdialysis cerebral open flow microperfusion electrochemical biosensors macromolecules tolcapone microparticles nanoparticles PLGA Parkinson's disease nose to brain delivery gene therapy polyplexes hyaluronidase glycol chitosan brain cancer chemoattractant CXCL CXCR glioblastoma multiforme 3D cell culture systems non-human primate convection-enhanced delivery neurosurgery optogenetics brain targeted therapy drug delivery cerebrospinal fluid microcirculation brain biodistribution |
| ISBN | 3-0365-5281-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910619467203321 |
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Sousa Flávia
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| MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Cellular and Molecular Mechanisms of Nephropathic Cystinosis
| Cellular and Molecular Mechanisms of Nephropathic Cystinosis |
| Autore | Levtchenko Elena N |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (230 p.) |
| Soggetto topico |
Medicine
Pharmacology |
| Soggetto non controllato |
cystinosis
cysteamine bone osteoclast genotype CD34+ hematopoietic stem and progenitor cells gene therapy pre-clinical studies investigational new drug application clinical trial disulfiram mice zebrafish fertility azoospermia hypogonadism histopathology mouse model lysosomal storage disease cell and animal models infantile nephropathic cystinosis bone-muscle wasting fibroblast growth factor 23 osteoclasts sclerostin leptin fractures nephropathic cystinosis hollow fiber membrane 3-dimensional models autophagy macrophages inflammasome proximal tubular cells endocytosis apoptosis chitotriosidase interleukins galectin-3 novel therapies endolysosome epithelial cell differentiation homeostasis lysosomal storage diseases mitochondrial distress kidney proximal tubule programmed cell death central nervous system cortical atrophy arterial spin labelling cystine blood level lysosomal storage disorder history treatment strategies for cystinosis newborn screening clinical course CTNS-pathogenic variants newborn screening for cystinosis kidney progenitors cell model biomarkers cystine kidney therapeutic monitoring |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910585941103321 |
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Levtchenko Elena N
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Characterization and Clinical Management of Dilated Cardiomyopathy
| Characterization and Clinical Management of Dilated Cardiomyopathy |
| Autore | Merlo Marco |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (232 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
SCN5A
cardiac sodium channel cardiac channelopathy dilated cardiomyopathy precision medicine arrhythmias atrial fibrillation cardiomyopathy heart failure supraventricular arrhythmia systolic dysfunction tachycardiomyopathy ventricular arrhythmia left atrial strain cardiac resynchronization therapy muscular dystrophy calcium heart gene therapy phospholamban Serca2a mdx oxidative stress membrane stabilization left ventricular noncompaction congenital heart disease congestive heart failure non-ischemic cardiomyopathy genetics desmin mitochondrial dysfunction myopathy whole exome sequencing laminopathy LMNA biomarkers troponin T NT-proBNP malignant ventricular arrhythmia arrhythmic risk stratification DNA methylation alternative splicing epigenetics nonischemic dilated cardiomyopathy cardiac magnetic resonance imaging late gadolinium enhancement long axis strain left ventricle sphericity index major adverse cardiovascular events sex differences left ventricular reverse remodelling long-term outcomes left ventricle non-compaction cardiomyopathy cardiac magnetic resonance titin RNA binding motif protein 20 (RBM20) sarcomere diastolic dysfunction phosphorylation non-sense mRNA decay mammalian target of rapamycin (mTOR) complex-1 duchenne muscular distrophy |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557595503321 |
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Merlo Marco
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Genetics of Hearing Impairment
| Genetics of Hearing Impairment |
| Autore | del Castillo Ignacio |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (314 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences Genetics (non-medical) |
| Soggetto non controllato |
inner ear
hearing impairment gene identification disease-causing mutations genetic epidemiology genotype&ndash phenotype correlations pathophysiological mechanisms omics genome editing gene therapy |
| ISBN | 3-0365-5224-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910637793003321 |
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del Castillo Ignacio
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Lysosomal Storage Disorders: Molecular Basis and Therapeutic Approaches
| Lysosomal Storage Disorders: Molecular Basis and Therapeutic Approaches |
| Autore | Moro Enrico |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (301 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
mucopolysaccharidosis IIIB
quantitative proteomics NAGLU lysosomes Gaucher disease bone involvement enzyme replacement therapy substrate reduction therapy Osteoimmunology RANK/RANKL Osteopontin MIP-1β mucolipidosis II sortilin TGF-beta cathepsin D Fabry disease alpha-galactosidase A endocytosis lysosome IGF2R/M6P clathrin chloroquine lysosomal diseases precision medicine pharmacological chaperones gene therapy Pompe disease lysosomal targeting autophagy muscle satellite cells rhGAA glycogen lysosomal α-glucosidase GAA biomarker Gaucher Disease Wnt/β-catenin Dkk1 Wnt3a iPSC neuronopathy Krabbe disease Twitcher mouse psychosine visual system visual cortex astrogliosis mucopolysaccharidosis type I Hurler syndrome hematopoietic stem cell transplantations animal models experimental therapies axon guidance lysosomal storage disorders neuronal circuit α-galactosidase A A4GALT globotriaosylceramide (Gb3) globotriaosyl-sphingosine (lysoGb3) pharmacological chaperone therapy exosomes endocytic pathways neurodegenerative disease Parkinson disease lysosomal storage disorder viral vectors newborn screening variant interpretation second tier test tandem mass spectrometry lyso-Gb3 dried blood spot GLA gene globotriaosylsphingosine biomarkers |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Lysosomal Storage Disorders |
| Record Nr. | UNINA-9910557545503321 |
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Moro Enrico
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Measurement Technologies for up- and Downstream Bioprocessing
| Measurement Technologies for up- and Downstream Bioprocessing |
| Autore | Mandenius Carl-Fredrik |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (160 p.) |
| Soggetto topico | Technology: general issues |
| Soggetto non controllato |
lactate biosensor
enzyme electrode off-line monitoring screen-printing at-line measurement in-line monitoring cell viability prediction chromatogram fingerprinting filamentous fungi Penicillium chrysogenum Trichoderma reesei Rut-C30 HPLC-SEC AAV-adeno-associated virus insect cell-baculovirus cell culture monitoring digital holographic microscopy process analytical technology pH pCO2 off-gas measurement carbon dioxide cell culture reference CHO automated sampling bioprocess amino acids vitamins Raman spectroscopy mammalian cell culture high-throughput scale-down technologies cation exchange chromatography monitoring PAT IgG titer real-time on-line nanoplasmonic gene therapy dielectric spectroscopy |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557333203321 |
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Mandenius Carl-Fredrik
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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