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Looking Forward to the Future of Heparin: New Sources, Developments and Applications
| Looking Forward to the Future of Heparin: New Sources, Developments and Applications |
| Autore | Fareed Jawed |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2018 |
| Descrizione fisica | 1 electronic resource (282 p.) |
| Soggetto non controllato |
alginate
edema Heparin Red solid lipid nanoparticles Fe3O4·DA-BSA/HA dermatan sulfate sulfated alginate porcine heparin theranostics low-molecular-weight heparin Arixtra® biomaterials hepcidin ovarian cancer iron oxide nanoparticles heparin-induced thrombocytopenia bone morphogenetic protein (BMP) hyaluronic acid (HA) crude heparin platelets resistance sclerostin LMWH gremlin low molecular weight heparin (LMWH) low molecular weight glycosaminoglycans human plasma single crystal X-ray structure iron homeostasis noggin super paramagnetic iron oxide nanoparticles (SPION) manufacturing methods paclitaxel (PTX) brain injury bovine heparin inflammation qNMR antithrombin reference standard quantitative NMR enoxaparin danaparoid sodium NMR GDNF orthogonal multi-analytical methods ternary complex heparan sulphate serglycin bovine serum albumin (BSA) HSQC recombinant expression heparin heparin oligosaccharides functional assay BMP antagonists intestinal lymphatic absorption size exclusion chromatography heparin coating diagnosis bioreactor anemia proteoglycan heparin process PCA chemometric fluorescent probe pharmacopeia affinity chromatography component quantitative analysis Fondaparinux sodium perylene diimide dyes thrombin inhibition extended physicochemical characterization cisplatin glycosaminoglycans TGF-? chondroitin sulfate dalteparin sequence and compositional investigations molecular weight magnetic resonance imaging (MRI) industrial LC-MS iduronic acid conformation heparan sulfate growth and differentiation factor (GDF) assay subarachnoid hemorrhage |
| ISBN | 3-03842-950-3 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Looking Forward to the Future of Heparin |
| Record Nr. | UNINA-9910346841803321 |
Fareed Jawed
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| MDPI - Multidisciplinary Digital Publishing Institute, 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular Basis and Gene Therapies of Cystic Fibrosis
| Molecular Basis and Gene Therapies of Cystic Fibrosis |
| Autore | Engelhardt John |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (210 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
cystic fibrosis
Staphylococcus aureus superantigen enterotoxin gene cluster MRSA exosomes microvesicles lung primary cells newborn screening trypsinogen CFTR gene next generation sequencing health policy rAAV2/HBoV1 baculovirus insect cells lung microbiome metagenomics gut–lung axis Cystic fibrosis CFTR transcriptomics proteostasis small molecules drug development common and new pathogenic variants ethnic Russian population gene therapy cyclophosphamide transient immunosuppression incidence survival genotype-phenotype correlations health policies CFTR modulators human nasal epithelial cells organoids biomarker functional assay pre-clinical in vitro models CFTR-related disorders molecular diagnosis CFTR variants Next Generation Sequencing (NGS) disease liability interpretation penetrance genotype-guided therapy miRNA airway basal cell lentivirus |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557392203321 |
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Engelhardt John
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery II
| Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery II |
| Autore | Spetea Mariana |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (260 p.) |
| Soggetto topico |
Research & information: general
Chemistry |
| Soggetto non controllato |
thiazole
piperazine tail-clip hot-plate acetic acid-induced writhing test opioid prodynorphin epigenetics transcription human brain morphine dosing behavior locomotor activity tolerance µ-opioid receptor DAMGO SR-17018 buprenorphine nalbuphine kappa opioid receptor agonist pruritis scratching mice TAT-HIV cholestasis chloroquine deoxycholic acid analgesic δ opioid receptor G-protein-biased agonist opioid peptide rubiscolins µ-opioid analgesics angiotensin receptors chronic pain neuropathic pain delta opioid receptor inverse agonist irreversible antagonist non-competitive antagonist molecular pharmacology free fatty acid receptors lipids opioid receptor colitis chemotype high-throughput screen allosteric modulation beta-arrestin molecular dynamics opioid receptors β-amino acids peptide synthesis receptor binding studies functional assay nociceptin/orphanin FQ receptor NOP receptor ligands nociceptin N/OFQ analgesia GPCR HS-731 peripheral opioid agonist binding selectivity molecular docking molecular dynamics simulations fluorescence cross-correlation spectroscopy (FCCS) G protein-coupled receptor (GPCR) serotonin |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Opioids and Their Receptors |
| Record Nr. | UNINA-9910576875203321 |
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Spetea Mariana
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery
| Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery |
| Autore | Spetea Mariana |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (358 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
opioid receptors
neurokinin-1 receptor peptide synthesis receptor binding studies functional assay writhing test tolerance Leu-enkephalin beta-arrestin mu opioid receptor delta opioid receptor biased signaling DADLE ischemia plasma stability morphinan BNTX δ opioid receptor antagonist 1H-NMR experiments mechanism elucidation peripheral antinociception 14-methoxycodeine-6-O-sulfate codeine-6-O-sulfate opioid peptides and peptidomimetics DAMGO DALDA [Dmt1]DALDA KGOP01 binding molecular docking structure-activity relationships β2-amino acids β2-Homo-amino acids µ-opioid receptor opioid peptides TAPP racemic synthesis of β2-amino acids peripheral µ-opioid receptors analgesia peripheral analgesic tolerance dysbiosis opioid bifunctional ligands (−)-N-phenethylnorhydromorphone analogs [35S]GTPgammaS assay forskolin-induced cAMP accumulation assays β-arrestin recruitment assays MOR and DOR agonists respiratory depression bias factor molecular modeling & simulation δ opioid receptor NTI derivative sulfonamide inverse agonist neutral antagonist agonist opioids mu receptor opioid side effects biased agonism partial agonism zerumbone chronic constriction injury (CCI) allodynia hyperalgesia potassium channels over-the-counter drugs misuse abuse opioid drugs pharmacology codeine dihydrocodeine loperamide opioid peptide macrocyclic tetrapeptide multifunctional ligands kappa opioid receptor analgesics opioid liabilities μ opioid receptor receptor model biased ligands dependence pain therapy neonatal opioid withdrawal syndrome naltrexone 6β-naltrexol buprenorphine G-protein bias arrestin recruitment respiration mitragynine heteromer internalization primary hippocampal culture lysosomes µ opioid receptor molecular dynamics docking interaction fingerprints biased agonists SR-17018 PZM21 morphine fentanyl diphenethylamines design and synthesis partial agonist biased agonist antagonist binding affinity selectivity |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Opioids and Their Receptors |
| Record Nr. | UNINA-9910557108003321 |
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Spetea Mariana
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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