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Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery
| Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery |
| Autore | Spetea Mariana |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (358 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
opioid receptors
neurokinin-1 receptor peptide synthesis receptor binding studies functional assay writhing test tolerance Leu-enkephalin beta-arrestin mu opioid receptor delta opioid receptor biased signaling DADLE ischemia plasma stability morphinan BNTX δ opioid receptor antagonist 1H-NMR experiments mechanism elucidation peripheral antinociception 14-methoxycodeine-6-O-sulfate codeine-6-O-sulfate opioid peptides and peptidomimetics DAMGO DALDA [Dmt1]DALDA KGOP01 binding molecular docking structure-activity relationships β2-amino acids β2-Homo-amino acids µ-opioid receptor opioid peptides TAPP racemic synthesis of β2-amino acids peripheral µ-opioid receptors analgesia peripheral analgesic tolerance dysbiosis opioid bifunctional ligands (−)-N-phenethylnorhydromorphone analogs [35S]GTPgammaS assay forskolin-induced cAMP accumulation assays β-arrestin recruitment assays MOR and DOR agonists respiratory depression bias factor molecular modeling & simulation δ opioid receptor NTI derivative sulfonamide inverse agonist neutral antagonist agonist opioids mu receptor opioid side effects biased agonism partial agonism zerumbone chronic constriction injury (CCI) allodynia hyperalgesia potassium channels over-the-counter drugs misuse abuse opioid drugs pharmacology codeine dihydrocodeine loperamide opioid peptide macrocyclic tetrapeptide multifunctional ligands kappa opioid receptor analgesics opioid liabilities μ opioid receptor receptor model biased ligands dependence pain therapy neonatal opioid withdrawal syndrome naltrexone 6β-naltrexol buprenorphine G-protein bias arrestin recruitment respiration mitragynine heteromer internalization primary hippocampal culture lysosomes µ opioid receptor molecular dynamics docking interaction fingerprints biased agonists SR-17018 PZM21 morphine fentanyl diphenethylamines design and synthesis partial agonist biased agonist antagonist binding affinity selectivity |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Opioids and Their Receptors |
| Record Nr. | UNINA-9910557108003321 |
Spetea Mariana
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Radiopharmaceuticals for PET Imaging - Issue A
| Radiopharmaceuticals for PET Imaging - Issue A |
| Autore | Roivainen Anne |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (212 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
kinetic analysis
Siglec-9 gallium-68 vascular adhesion protein VAP-1 infection inflammation osteomyelitis animal model Staphylococcus aureus multiple myeloma positron emission tomography/computed tomography radiopharmaceuticals 18F-fluorodeoxyglucose tetrazine ligation PET SPECT indium-11 fluorine-18 positron emission tomography (PET), defluorination isotopic exchange silicon-based fluoride acceptor bioorthogonal chemistry tetrazine inverse electron-demand Diels-Alder ligation opioid naloxone overdose fentanyl carfentanil [11C]carfentanil positron emission tomography receptor occupancy pharmacokinetics [18F]AlF NOTA NODAGA PODS thiol-reactive linker affibody molecule bioconjugation EGFR tumor imaging vulnerable plaque molecular imaging PET imaging nanobody single-domain antibody sub-millimetre resolution AlF-radiolabelling preclinical radiopharmaceutical dosimetry image-based internal dosimetry OLINDA MCT1/MCT4 lactate transporter inhibitor [18F]FACH radiation safety sigma-1 receptor availability orthotopic xenograft of glioblastoma in mouse small animal Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) (S)-(−)-[18F]fluspidine imaging-based biomarker SV2A protein PET radiotracers synaptic loss radiochemistry preclinical development clinical outcomes monocarboxylate transporters (MCTs) FACH 18F-labeled analog of FACH α-CCA blood-brain barrier (BBB) positron emission tomography (PET) imaging peptides proteolysis metabolic stability |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557437003321 |
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Roivainen Anne
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Recent Studies of Rodent Ultrasonic Vocalizations and Their Use in Experimental Models
| Recent Studies of Rodent Ultrasonic Vocalizations and Their Use in Experimental Models |
| Autore | Brudzynski Stefan M |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (352 p.) |
| Soggetto topico |
Medicine
Neurosciences |
| Soggetto non controllato |
ultrasonic vocalization
maternal immune activation autism communication rat sex differences social play rats anxiety observational fear learning USV maternal separation pup vasopressin antagonists righting reflex negative geotaxis ACTH corticosterone Brattleboro rat larynx female male 50-khz ultrasonic vocalizations (USVs) individual differences chronic variable stress (CVS) dopamine nucleus accumbens microdialysis evolution of vocalization 22 kHz calls 50 kHz calls infant isolation calls emotional arousal mesolimbic dopaminergic system mesolimbic cholinergic system hedonia ultrasonic vocalizations cognitive development respiration brain oscillations Cav1.2 calcium animal model rough-and-tumble play social approach playback social contact call alarm call social buffering distress emotional contagion fear contagion aversive state automated scoring addiction mental health machine learning drug discovery drug development Parkinson's disease alpha-synuclein 6-OHDA Pink1 DJ1 exercise pharmacology pathology hypervigilance hyperreactivity exaggerated reactivity generalization PTSD depression heart rate Wistar 22-kHz calls 50-kHz calls affect aversion NOR reward working memory Y maze opioids fentanyl self-administration play food dam-pup interaction ethanol pup isolation rat pup 50 kHz vocalizations 22 kHz vocalizations amphetamine chemogenetics clozapine-n-oxide UMAP males females vocalizations fear extinction pain |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557608903321 |
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Brudzynski Stefan M
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Research Topics in Medicines and How Our Board Members Are Engaged in Them
| Research Topics in Medicines and How Our Board Members Are Engaged in Them |
| Autore | Sakagami Hiroshi |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (480 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
Hedychium
traditional medicine coronarin D villosin anti-acetylcholinesterase antidiabetic anti-inflammatory antimicrobial antioxidant antitumor Genista tridentata Pterospartum tridentatum isoflavones flavonols genistein biochanin A rutin daidzein inflammatory bowel disease Crohn’s disease ulcerative colitis extra-intestinal manifestations orofacial granulomatosis tag-like lesions cobblestoning mucogingivitis lip swelling aphthous stomatitis Angelicae Sinensis Radix Danggui granules herb multivariate analysis ultra-performance liquid chromatography Tai Chi qigong immune system immunity inflammation telemedicine remote monitoring GER-e-TEC elderly patient artificial intelligence geriatric syndromes detection of the precursory signs of decompensation of geriatric syndromes renal cell cancer genomic landscape targeted therapy tumor evolution tumor heterogeneity allergic rhinitis quercetin human CD4+ T cells Th1/Th2 cytokine balance modulation in vitro intravascular catheter CRBSI biofilm CVC antifouling chromone tumor specificity QSAR analysis apoptosis cell cycle analysis contrast-enhanced ultrasound hepatocellular carcinoma LI-RADS chronic liver disease granuloma annulare granulomatous disorders of the skin inflammatory skin conditions medical dermatology biliary tract cancer cholangiocarcinoma PARP BRCA olaparib rucaparib liver cancer pancreatic adenocarcinoma pancreatic cancer sarcoidosis superior vena cava syndrome venous thrombosis RUCAM Roussel Uclaf Causality Assessment Method diagnostic algorithm iDILI iDrug induced liver injury DILI HILI herb induced liver injury Stachys L. traditional uses pharmacological activities phytochemicals bioactive compounds Kampo formulae alkaline extract of Sasa sp pine cone extract povidone-iodine HSV HIV loss of infectivity solubilization method diaphragmatic breathing abdominal breathing breathing exercise systematic review randomized controlled trial respiratory function auricular acupuncture preoperative anxiety protocol randomized controlled trials meta-analysis boiogito knee osteoarthritis rat Yokukansan fentanyl transient receptor potential ankyrin 1 (TRPA1) channel phosphorylated extracellular signal-regulated kinase (pERK) whole-cell patch-clamp recording herbal medicine calcium metabolism bone metabolism protease osteoclast macrophage RANKL LPS TLR4 TREM2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910576874503321 |
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Sakagami Hiroshi
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| MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Structural, Magnetic, Dielectric, Electrical, Optical and Thermal Properties of Nanocrystalline Materials: Synthesis, Characterization and Application
| Structural, Magnetic, Dielectric, Electrical, Optical and Thermal Properties of Nanocrystalline Materials: Synthesis, Characterization and Application |
| Autore | Yadav Raghvendra Singh |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (197 p.) |
| Soggetto topico | Technology: general issues |
| Soggetto non controllato |
α-Fe2O3
photocatalytic activity dielectric properties similarity solution triple solutions stability analysis shooting method three-stage Lobatto III-A formula hybrid nanofluid slender body revolution porous media radiation effect mixed convection nanocrystalline cellulose graphene quantum dots thin film optical sensing glucose surface plasmon resonance Au-ZnO/C2H6O2 heat transfer rotating systems analytical solution sparking process surface energy nanoparticle nucleation vapor deposition beryllium oxide lithium Niobate SAW devices ellipsometry error analysis spectroscopy high-accuracy measurement optical metrology dielectric constants time-dependent flow entropy generation non-linear radiation γ-alumina nanoparticle MHD transition metal phosphorus sulfide van der Waals layered material 2D material low dimensional magnetism magnetic chains crystal growth chemical vapor transport powder X-ray diffraction rietveld refinement metamaterials electronic materials electromagnetic Fano resonances SQUID Ag@Au nanoparticle core–shell structure sea-urchin-like structure SERS fentanyl |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Structural, Magnetic, Dielectric, Electrical, Optical and Thermal Properties of Nanocrystalline Materials |
| Record Nr. | UNINA-9910557621303321 |
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Yadav Raghvendra Singh
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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