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A Personalized Medicine Approach to the Diagnosis and Management of Autism Spectrum Disorder
| A Personalized Medicine Approach to the Diagnosis and Management of Autism Spectrum Disorder |
| Autore | Frye Richard E |
| Pubbl/distr/stampa | Basel, : MDPI Books, 2022 |
| Descrizione fisica | 1 electronic resource (416 p.) |
| Soggetto topico |
Medicine
Neurosciences |
| Soggetto non controllato |
fecal metabolites
ASD microbiome gastrointestinal symptoms Fisher Discriminant Analysis digital biomarkers wearables time series analysis autism social dyads socio-motor parameters network connectivity non-linear complex dynamics stochastic analysis autism spectrum disorders copy number variants females Array-Comparative Genomic Hybridization (Array-CGH) autism spectrum disorder Ehlers-Danlos syndrome hypermobility spectrum disorders autonomic disorder mast cell activation syndrome genetic testing chromosomal microarray analysis whole exome sequencing whole genome sequencing clinical utility polygenic risk scores Temple Grandin biomarker omics precision medicine proteomics transcriptomics epigenetics metabolomics patient stratification mitochondria oxidative stress prenatal environment immune dysfunction immunoglobulin G intravenous immunoglobulin energy metabolism fatty acid oxidation acyl-carnitines resveratrol integrative model concomitant condition disorder autism spectrum disorder (ASD) genomics personalized treatment strategy single nucleotide polymorphisms clinical decision support tool ADHD PANDAS OCD anxiety folate receptor alpha folates pregnancy brain development fetal development cobalamin glutathione methylation methylcobalamin redox metabolism locked-in network syndrome resting-state functional magnetic resonance imaging temporal lobe epilepsy amygdala brain COVID-19 children cytokines flavonoids inflammation luteolin mast cells microglia SARS-CoV-2 stress nutraceuticals survey vitamins minerals B12 folinic acid quality of life parents intervention systematic review medical claims logistic regression analysis retrospective analysis associated risk monoamine neurotransmitters neurotransmitter deficiency cerebral folate deficiency folate receptor alpha autoantibodies leucovorin α-amylase cortisol heart rate variability neuromodulation sleep anxiety transdermal electrical neuromodulation neurostimulation |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910595075503321 |
Frye Richard E
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| Basel, : MDPI Books, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Adipokines 2.0
| Adipokines 2.0 |
| Autore | Büchler Christa |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (406 p.) |
| Soggetto non controllato |
lipids
cathepsins neurodegeneration tocilizumab SGBS adipocytes chemerin receptors cholesterol metabolically healthy obese energy metabolism adipose-brain axis EP3 receptor leptin rheumatoid arthritis excessive gestational weight gain in vitro fat regain secreted frizzled-related protein 5 PCOS EP4 receptor leukocyte exchange protein directly activated by cAMP isoform 2 (EPAC2) extracellular remodeling insulin osteoarthritis lipid metabolism fat mass Tango bioassay fatty liver free fatty acids label-free proteomic profiling interleukin(IL)-33 sick fat polycystic ovary syndrome early-life programming inflammation gestational diabetes glucose restriction adipokines neonatal anthropometry epicardial adipose tissue (EAT) oestrous cycle Cardiovascular Diseases (CVDs) triglycerides G protein-coupled receptor 1 testicular pathologies prognosis ovary ICU biologic activity preeclempsia adipokine critical illness early pregnancy myokine liver steatosis C-C chemokine receptor-like 2 testis stimulating growth factor 2 (ST2) pig fitness human granulosa cells obesity proteolysis annexins adipose tissue biomarker ghrelin brain health sepsis adiponectin rheumatic diseases chemokine-like receptor 1 follicular fluid glucose homeostasis resistin Nonalcoholic fatty liver disease prostaglandin E2 (PGE2) visceral fat microglia weight regain complement factors alpha-fetoprotein polycystic ovary morphology chemerin cancer depression hypertension hypothalamus |
| ISBN | 3-03928-587-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910404092003321 |
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Büchler Christa
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| MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Advances in the Biology of Phototrophic Bacteria
| Advances in the Biology of Phototrophic Bacteria |
| Autore | Imhoff Johannes F |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (274 p.) |
| Soggetto topico | Research & information: general |
| Soggetto non controllato |
phylogeny
photosynthetic reaction center proteins bacteriochlorophyll biosynthesis phototrophic purple bacteria evolution of anoxygenic photosynthesis iron-sulfur cluster isc genes suf genes antisense promoters OxyR IscR Irr anoxygenic phototrophic bacteria purple nonsulfur bacteria massive blooms pufM gene Rhodovulum phylogenomics bioerosion anoxygenic phototroph microbiome euendolith Rhodobacter capsulatus Rhodobacter sphaeroides photooxidative stress transcriptomics proteomics stress defense heliobacteria Heliorestis convoluta alkaliphilic bacteria soda lake bacteriochlorophyll g biological soil crust drylands niche partitioning nitrogen fixing cyanobacteria Alphaproteobacteria Rhodobacteraceae nitric oxide quorum sensing gene transfer agent motility Crp/Fnr Dnr RegA ChpT green sulfur bacteria syntrophy e-pili adhesion protein photosynthetic symbionts large multiheme cytochrome metagenomic binning genomes of photosynthetic bacteria glycine betaine biosynthesis ectoine biosynthesis osmotic adaptation phylogeny of osmolyte biosynthesis filamentous anoxygenic phototroph microbial mats hot springs metatranscriptomics energy metabolism carbon fixation aerobic anoxygenic phototrophic bacteria bacteriochlorophyll a photosynthesis genes rhodopsin Sphingomonadaceae aerobic anoxygenic phototrophs siderophore metallophore CAS assay Chromocurvus halotolerans strain EG19 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557401903321 |
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Imhoff Johannes F
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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AMP-Activated Protein Kinase Signalling
| AMP-Activated Protein Kinase Signalling |
| Autore | Neumann Dietbert |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (452 p.) |
| Soggetto non controllato |
HDACs
transcription epigenetics spermatozoa par complex A769662 MDCK skeletal muscle AID phosphorylation energy metabolism monocytes autophagy CML liver hindlimb suspension pregnancy preeclampsia gestational diabetes mellitus CaMKK2 assisted reproduction techniques nutrient-sensing signals sonic hedgehog protein acetylation glycogen storage disease AMPK adenosine monophosphate-activated protein kinase AICAR indirect calorimetry IL-1? MyHC I(?) HDAC4/5 endothelial cells infection hepatocyte p70S6K lipid metabolism host defense exercise kidney disease heat shock protein ?RIM mycobacteria activation loop developmental origins of health and disease (DOHaD) CREB TAK1 metabolic-inflammation phenylephrine AMP-activated protein kinase (AMPK) KATs 2-methoxyestradiol DNA methylation NLRP3 pump ?-linker steatosis AMPK kinase stress endothelial nitric-oxide synthase vasodilation adherent junctions epithelial cells glycogen Akt synaptic activation cellular energy sensing glucose uptake transporter co-expression atrophy nutrigenomics motility vasoconstriction fatty acid oxidation oxidative stress AS160 membrane histone modification sirtuin 1 (SIRT1) chromatin remodeling insulin signalling dietary fatty acids ULK CMML adaptive thermogenesis mTOR MDS mechanical unloading AML endothelial function medulloblastoma PKA adipose tissue NAD+ membranes nutrition ZO-1 TBC1D4 adipocyte soluble Adenylyl cyclase metabolism renin-angiotensin system energy utilization proteasome differentiation signaling peroxisome proliferator-activated receptor gamma coactivator 1-? (PGC1?) hypertrophy AMP-activated protein kinase metabolic disease LKB1 soleus muscle macrophages Immediate early genes CBS benign motor endplate remodeling ionomycin nectin-afadin tight junctions resveratrol protein kinase B regrowth mitochondria protein synthesis energy deficiency catechol-O-methyltransferase fiber-type microarrays carrier acetyl-CoA hypertension 3T3-L1 hypothalamus food intake |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346858503321 |
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Neumann Dietbert
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Benefits of Resveratrol Supplementation / María P. Portillo, Alfredo Fernandez-Quintela
| Benefits of Resveratrol Supplementation / María P. Portillo, Alfredo Fernandez-Quintela |
| Autore | Portillo María P |
| Pubbl/distr/stampa | Basel, Switzerland : , : MDPI, , 2019 |
| Descrizione fisica | 1 electronic resource (260 p.) |
| Soggetto non controllato |
polyphenols
?-viniferin leptin resistance p53 kidney energy restriction grape powder extract cytokines phosphorylation obesity energy metabolism metabolic pathways endothelial function polyol pathway antioxidant caloric restriction rat adipose tissue microparticles pathways angiotensin converting enzyme 2 resistance esRAGE interleukins metabolic syndrome dissolution rate thermogenesis streptozotocin bioavailability solubility metabolism renin-angiotensin system microbiota Sirt-1 magnesium dihydroxide hypertrophy metabolic diseases physiological adaption red wine extract lens distribution MTA1 sirtuin inflammation cardiac function rats cisplatin resveratrol mitochondria breast cancer ischemia-reperfusion cardiovascular metabolites gut microbiota prostate cancer performance type 2 diabetes cafeteria diet high-fat high-sucrose diet resistance exercise aging diabetes oxidative stress |
| ISBN |
9783039212767
3039212761 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346854603321 |
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Portillo María P
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| Basel, Switzerland : , : MDPI, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Creatine Supplementation for Health and Clinical Diseases
| Creatine Supplementation for Health and Clinical Diseases |
| Autore | Kreider Richard B |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (562 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences Food & society |
| Soggetto non controllato |
ergogenic aids
cellular metabolism phosphagens sarcopenia cognition diabetes creatine synthesis deficiencies concussion traumatic brain injury spinal cord injury muscle atrophy rehabilitation pregnancy immunity anti-inflammatory antioxidant anticancer creatine nutritional supplements fertility newborn development brain injury post-viral fatigue syndrome chronic fatigue syndrome GAA creatine kinase dietary supplements exercise skeletal muscle glycemic control type 2 diabetes mellitus phosphorylcreatine dietary supplement ergogenic aid youth athletes osteoporosis osteosarcopenia frailty cachexia innate immunity adaptive immunity inflammation macrophage polarization cytotoxic T cells toll-like receptors vascular pathology cardiovascular disease oxidative stress vascular health female menstrual cycle hormones exercise performance menopause mood children height BMI-for-age stature-for-age growth phosphocreatine creatine transporter supplementation treatment heart heart failure ischemia myocardial infarction anthracycline cardiac toxicity energy metabolism cell survival bioinformatics systems biology cellular allostasis dynamic biosensor pleiotropic effects of creatine (Cr) supplementation inflammatory bowel diseases (IBD) ulcerative colitis Crohn’s disease creatine kinase (CK) phosphocreatine (PCr) creatine transporter (CrT) intestinal epithelial cell protection intestinal tissue protection creatine perfusion organ transplantation Adenosine mono-phosphate (AMP) activated protein kinase (AMPK) liver kinase B1 (LKB1) mitochondrial permeability transition pore (mPTP) reactive oxygen species (ROS) glucose transporter (GLUT) T cell antitumor immunity metabolic regulator cancer immunotherapy supplements muscle damage recovery immobilization atrophy muscular dystrophy amyotrophic lateral sclerosis Parkinson’s Disease cardiopulmonary disease mitochondrial cytopathy hypertrophy athletic performance weightlifting resistance exercise training muscular power muscular adaptation muscle fatigue adipose tissue muscle strength physiological adaptation mitochondria thermogenesis MAP kinase signaling system sodium-chloride-dependent neurotransmitter symporters signal transduction intradialytic creatine supplementation hemodialysis muscle protein energy wasting clinical trial muscle weakness chronic fatigue cognitive impairment depression anemia resistance training sports nutrition strength toxicity methylation hyperhomocysteinemia neuromodulation MCDA mitochondriopathia cardiac infarction long COVID hypoxia stroke neurodegenerative diseases noncommunicable disease adenosine 5′-monopnophosphate-activated protein kinase anthracyclines creatine supplementation cardiac signaling cardiotoxicity doxorubicin soy vegetarian/vegan diet amino acids dietary ingredients performance |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910566476003321 |
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Kreider Richard B
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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DNA Replication Stress / Robert M. Brosh
| DNA Replication Stress / Robert M. Brosh |
| Autore | Brosh Robert M |
| Pubbl/distr/stampa | Basel, Switzerland : , : MDPI, , 2019 |
| Descrizione fisica | 1 electronic resource (368 p.) |
| Soggetto non controllato |
Werner Syndrome
A549 cells epigenetic neurodegeneration Genome integrity adaptation cellular senescence genome instability Werner Syndrome Protein lipofuscin cell cycle checkpoints exonuclease 1 template-switching energy metabolism mutation frequency DNA replication fork regression motor neuron disease Microsatellites Alzheimer's disease chromatin remodeler repair of DNA damage AP site analogue mutagens replication timing Thermococcus eurythermalis nucleolar stress gene expression mutations spectra origin firing Fanconi Anemia superfamily 2 ATPase DNA translocation DNA repair SSB signaling homologous recombination common fragile sites 8-chloro-adenosine replication genome stability mutagenicity fork reversal multiple sclerosis non-B DNA protein stability heterogeneity ubiquitin SenTraGorTM (GL13) replication restart EdU ?-arrestin NER aging SSB end resection oxidative stress ATR dormant origins R loops DNA damage response Difficult-to-Replicate Sequences DNA double-strand repair endonuclease IV ALS double strand break repair premature aging replication stress EXO1 POL? translesion synthesis strand displacements G2-arrest DNA replication pattern SSB repair genome integrity G protein-coupled receptor kinase interacting protein 2 (GIT2) MMR replicative stress senolytics spacer interactome ATR-Chk1 DDR pathway C9orf72 replication fork restart translesion DNA synthesis DNA damage mismatch repair DNA replication stress DNA helicase Polymerase kappa DNA fiber assay H1299 cells TLS APE2 ageing cell death chromosome TopBP1 barley clock proteins post-translational modification 8-oxoG S phase ataxia telangiectasia mutated (ATM) G protein-coupled receptor (GPCR) Polymerase eta cancer G protein-coupled receptor kinase (GRK) helicase genomic instability Parkinson's disease nucleotide excision repair SupF |
| ISBN |
9783039213900
3039213903 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910367564903321 |
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Brosh Robert M
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| Basel, Switzerland : , : MDPI, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Impaired Mitochondrial Bioenergetics under Pathological Conditions
| Impaired Mitochondrial Bioenergetics under Pathological Conditions |
| Autore | Lenaz Giorgio |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (460 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences Biochemistry |
| Soggetto non controllato |
aging heart
Bcl-2 family mitochondria programmed cell death fatty acid oxidation palmitate oleate m.3243A> G mutation MT-ATP6 m.8909T> C ATP synthase nephropathy oxidative phosphorylation mitochondrial disease cardiolipin Barth syndrome Sengers syndrome respiratory chain Dilated Cardiomyopathy with Ataxia cardiomyopathy mammalian complex I NADH dehydrogenase complex I assembly complex I structure complex I deficiency supernumerary subunits electron transport chain mitochondrial dysfunction Leigh syndrome mitochondrial diseases yeast Saccharomyces cerevisiae pet mutants pancreatic endocrine cells mathematical model cellular bioenergetics diabetes glucagon insulin exercise immune system metabolic disease COVID-19 mitochondrial dynamics viral infections MAVS RIG-I MDA5 innate immune response SARS CoV-2 RSV influenza respiratory supercomplexes ROS ATP synthase/hydrolase mitochondrial permeability transition pore cristae cellular signaling human disease mitochondrial dynamic cell signaling cancer respiratory complexes oxidative stress mitochondrial DNA MTCYB mutations cytochrome b complex III aging energy metabolism entorhinal cortex lipoxidation-derived damage neurodegeneration oxidative damage protein import respiratory complex assembly supercomplexes mitochondrial proteostasis heart failure bioenergetics assembly factor atypical myopathy high-resolution respirometry toxicity assays cell culture equine primary myoblasts fibroblasts frozen tissue leukocytes oxygen consumption platelets respirometry skeletal muscle |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910585934503321 |
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Lenaz Giorgio
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Metabolomics in Neurodegenerative Disease
| Metabolomics in Neurodegenerative Disease |
| Autore | Green Brian |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (184 p.) |
| Soggetto non controllato |
glutamic acid
direct mass spectrometry neurodegeneration 6-OHDA targeted mass spectrometry mitochondrial dysfunction myo-inositol metabolomics bile acids subacute mild traumatic brain injury age-related macular degeneration metabolic pathways energy metabolism midbrain Alzheimer's disease biomarkers 1H NMR Parkinson's disease dementia GC-MS pathogenesis tricarboxylic acid cycle micro-dialysis 13C-labeled succinate metabolism lipidomics dementia with Lewy bodies fatty acid prodromal Parkinson's disease malonate cerebral ischemia mass spectrometry retinal pigment epithelium excitotoxicity endothelin-1 reperfusion C. elegans Streptomyces venezuelae ?-synuclein aggregates natural product fatty acid metabolism imaging mass spectrometry LC-MS drusen cerebral palsy plasma Parkinson's disease |
| ISBN | 3-03928-041-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910404087203321 |
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Green Brian
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| MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Mitochondria in Health and Diseases
| Mitochondria in Health and Diseases |
| Autore | Javadov Sabzali |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (434 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
hypoglycemia
sodium dichloroacetate pyruvate dehydrogenase kinase pyruvate dehydrogenase oxidative stress neuron death cholangiocellular carcinoma mitochondria energy metabolism oxidative phosphorylation 4-HNE DRP1 ERK1/2 hippocampus JNK mitochondrial dynamics PKA protein phosphatases TUNEL DDE high-fat diet mitochondrial UCP2 ROS antioxidant system uncoupling protein mitochondria: energy metabolism lipid handling fatty acid oxidation potassium channel reactive oxygen species antioxidants life span aging BKCa channels pravastatin gemfibrozil liver colon mitochondrial function cyclosporin A mitochondria calcium buffering mitochondria bioenergetics mitochondria permeability transition pore inorganic phosphate hepatic fibrogenesis HtrA2/Omi reactive oxygen species stress mitochondrial homeostasis complex I (CI) deficiency metabolome and proteome profiling reactive oxygen species (ROS) respirasome assembly electron tunneling (ET) perilipin 5 lipid droplet H9c2 cardiomyoblasts adenine nucleotide translocase respiratory supercomplexes ETC complexes dentate granule cell epilepsy hyperforin LONP1 neuroprotection pilocarpine seizure siRNA cardioprotection mitochondrial permeability transition pores mitochondrial connexin 43 cardiolipin iron overload hepcidin transferrin ferritin ZIP inflammation mtDNA mitochondrial dysfunction muscle aging physical performance LHON Siberian population ancient mutation specific genetic background apoptosis human amniotic membrane mitochondrial cell death BAX BCL-2 tensile strength mitochondrial gene expression mtDNA transcription mtRNA post-transcriptional mtRNA processing dsRNA innate immunity interferon response amino acid neurotransmitter cerebellar amino acid metabolism hypoxia 2-oxoglutarate dehydrogenase tricarboxylic acid cycle heart cytoskeletal proteins mitochondrial interactions plectin tubulin beta signaling GW9662 ischemia reperfusion injury Langendorff myocardial pioglitazone redox state rosiglitazone TZD uncoupling ADP/ATP carrier KmADP dextran morphology cardiomyocytes telomere length telomerase activity development regeneration intranuclear mitochondria healthy cells electron and confocal microscopy signaling pathways ion homeostasis human diseases |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557577203321 |
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Javadov Sabzali
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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