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AMP-Activated Protein Kinase Signalling
| AMP-Activated Protein Kinase Signalling |
| Autore | Neumann Dietbert |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (452 p.) |
| Soggetto non controllato |
HDACs
transcription epigenetics spermatozoa par complex A769662 MDCK skeletal muscle AID phosphorylation energy metabolism monocytes autophagy CML liver hindlimb suspension pregnancy preeclampsia gestational diabetes mellitus CaMKK2 assisted reproduction techniques nutrient-sensing signals sonic hedgehog protein acetylation glycogen storage disease AMPK adenosine monophosphate-activated protein kinase AICAR indirect calorimetry IL-1? MyHC I(?) HDAC4/5 endothelial cells infection hepatocyte p70S6K lipid metabolism host defense exercise kidney disease heat shock protein ?RIM mycobacteria activation loop developmental origins of health and disease (DOHaD) CREB TAK1 metabolic-inflammation phenylephrine AMP-activated protein kinase (AMPK) KATs 2-methoxyestradiol DNA methylation NLRP3 pump ?-linker steatosis AMPK kinase stress endothelial nitric-oxide synthase vasodilation adherent junctions epithelial cells glycogen Akt synaptic activation cellular energy sensing glucose uptake transporter co-expression atrophy nutrigenomics motility vasoconstriction fatty acid oxidation oxidative stress AS160 membrane histone modification sirtuin 1 (SIRT1) chromatin remodeling insulin signalling dietary fatty acids ULK CMML adaptive thermogenesis mTOR MDS mechanical unloading AML endothelial function medulloblastoma PKA adipose tissue NAD+ membranes nutrition ZO-1 TBC1D4 adipocyte soluble Adenylyl cyclase metabolism renin-angiotensin system energy utilization proteasome differentiation signaling peroxisome proliferator-activated receptor gamma coactivator 1-? (PGC1?) hypertrophy AMP-activated protein kinase metabolic disease LKB1 soleus muscle macrophages Immediate early genes CBS benign motor endplate remodeling ionomycin nectin-afadin tight junctions resveratrol protein kinase B regrowth mitochondria protein synthesis energy deficiency catechol-O-methyltransferase fiber-type microarrays carrier acetyl-CoA hypertension 3T3-L1 hypothalamus food intake |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346858503321 |
Neumann Dietbert
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Antioxidant Activity of Polyphenolic Plant Extracts
| Antioxidant Activity of Polyphenolic Plant Extracts |
| Autore | Stagos Dimitrios |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (388 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
green leafy vegetables
effect of cooking polyphenols antioxidant activity Averrhoa bilimbi Oxalidaceae DPPH xanthine oxidase LC-QTOF-MS/MS molecular docking tentative bioactive constituents Dialium indum exocarp seed antioxidant phenolic acids amino acids GC-MS analysis AGN FIR phenolic flavonoid antioxidant capacity antimicrobial activity polyphenol compounds bixin rosemary extracts method validation HPLC food matrices fruit vinegar phenolics organic acid Ladastacho characterisation properties HPLC/ESI-MS HS-SPME/GC-MS beneficial use antimicrobial hydroxytyrosol rosemary pomegranate fish volatile compounds Rosa canina Rosa sempervivens Pyrocantha coccinea antioxidants endothelial cells glutathione almond skins bioavailability waste by-products flavonoids oxidative stress human reactive oxygen species proinflammatory cytokines Alzheimer's disease cornelian cherry anthocyanins gastrointestinal digestion Opuntia ficus-indica cladode antibiofilm activity olive Olea europaea anthocyanin cyanidin 3-glucoside cyanidin 3-rutinoside oxygen radical absorbance capacity (ORAC) high performance liquid chromatography mass spectrometry (HPLC-MS) tea Camellia sinensis polyphenol catechin caffeine theaflavine insulin resistance diabetes olive oil phenols antidiabetic myrtle ultrasound-assisted extraction phenolic compounds liquid chromatography analysis mass spectrometry mulberry (Morus nigra Morus alba) simple sugars organic acids phenol compounds high performance liquid chromatography/diode array detector/mass spectrometry anthocyanins anti-inflammatory activity extraction central composite design optimization P. officinalis phytochemicals cytotoxicity α-amylase inhibition red-osier dogwood antioxidative effect H2O2 transepithelial resistance (TEER) Caco-2 cells Rubus idaeus L. HPLC-ESI-HR-qTOF-MS/MS antioxidant activities digestive enzymes inhibitors molecular docking analysis olive mill wastewater encapsulation maltodextrin whey protein gelatin spray drying diabetes mellitus Lamiaceae alpha-glucosidase alpha-amylase Salvia africana-lutea terpenoids cape floristic region |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557728403321 |
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Stagos Dimitrios
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Arteriogenesis and Therapeutic Neovascularization
| Arteriogenesis and Therapeutic Neovascularization |
| Autore | Deindl Elisabeth |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (220 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
factor VII activating protease
HABP2 VEGF matrigel neo-vascularization hind limb ischemia angiogenesis arteriogenesis ERK endothelial cells inflammation macrophages atherosclerosis pericyte rAAV capillary microRNA isomiRs epitranscriptome neovascularization A-to-I editing m6A RNA modifications RNA methylation lower extremity arterial disease peripheral arterial disease blood flow restriction activity-based benefits training effects effect mechanism hyperoxygenation vein graft disease vascular biology spinal cord ischemia paraplegia aortic disease TAAA collateral network paraspinous compartment NO NOTCH innate immunity mast cell GH and eNOS IGF-I oxidative stress and arterial inflammation vascular homeostasis GHAS trial collateral artery growth SMC proliferation potassium channel KV1.3 KCa3.1 FGFR-1 Egr-1 PDFG-R αSM-actin TLR2/6 femoral artery ligation blood flow recovery collateral growth VHL loss of function microRNA-212/132 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557495503321 |
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Deindl Elisabeth
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Drug Delivery of siRNA Therapeutics
| Drug Delivery of siRNA Therapeutics |
| Autore | Lamberti Gaetano |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (288 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
oligonucleotide delivery
light-activated release intracellular release liposome indocyanine green drug co-delivery methotrexate siRNA antitumor effect mixed micelles targeted delivery system cationic liposome folate folate receptor cationic cholesterol derivative siRNA delivery gene knockdown tumor-targeting VEGFA VEGFR1 endoglin peptide angiogenesis gene silencing migration proliferation endothelial cells RNAi therapeutics amphiphilic dendrons PAMAM dendrimers self-assembling nanovectors covalent dendrimers NABDs liposomes clinical trials drug delivery nanoparticle carbonate apatite ERBB2 AKT breast cancer ovarian cancer polymer lipid delivery poly(ethylene) imine PEI RNA tyrosine-modification tumor xenograft magnetic nanoparticle iron oxide BCL2 BIRC5/survivin oral cancer aptamers cancer nanoparticles STAT6 polyaspartamide pegylation polyamine polyplexes asthma |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557498903321 |
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Lamberti Gaetano
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Embryo Implantation and Placental Development
| Embryo Implantation and Placental Development |
| Autore | Campagnolo Luisa |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (342 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
fetuin-A
GDM cell growth centrosome primary cilium autophagy implantation endometrium blastocyst embryo chorionic gonadotropin progesterone Notch cytokines placenta amino acid transporter mammalian target of rapamycin gestational diabetes trophectoderm cell proliferation let-7 miRNAs gene regulation fractalkine trophoblast bilaminar co-culture miRNA trophoblast cells ARID3B complex decidualization adverse pregnancy outcome preconception preimplantation genetic screening in-vitro fertilization biopsy euploid embryo pregnancy mosaicism development flow culture KIT receptor KITD816V placental development premature differentiation trophoblast stem cell trophoblast giant cell spongiotrophoblast invasion embryonic growth retardation Jag1 Dll4 endothelial cells decidua angiogenesis capillaries spiral arteries Stabilin-1 Stabilin-2 double knockout hemorrhage RNA-seq ChIP-seq enhancers transcription factors PLAGL1 tube formation blood vessel development PlGF Flt-1/VEGFR1 immune modulation human placenta lopinavir mitochondria Mfn2 UPR IRE1α placental dysfunction assisted reproduction techniques infertility preeclampsia intrauterine growth restriction trophoblast invasion sFLT-1 EGFL7 placenta-derived mesenchymal stromal cells mouse model |
| ISBN | 3-0365-5853-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910639986303321 |
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Campagnolo Luisa
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Emerging immune functions of non-hematopoietic stromal cells / / topic editors: Christopher G. Mueller, Paul Kaye, Mark C. Coles and Burkhard Ludewig
| Emerging immune functions of non-hematopoietic stromal cells / / topic editors: Christopher G. Mueller, Paul Kaye, Mark C. Coles and Burkhard Ludewig |
| Autore | Mark Christopher Coles |
| Pubbl/distr/stampa | Frontiers Media SA, 2014 |
| Descrizione fisica | 1 online resource (161 pages) : illustrations |
| Disciplina | 616.97 |
| Collana | Frontiers Research Topics |
| Soggetto topico |
Clinical Immunology
Medicine Health & Biological Sciences |
| Soggetto non controllato |
development
endothelial cells lymphoid tissue inflammation fibroblast reticular cells |
| ISBN | 9782889193622 (ebook) |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910137235403321 |
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Mark Christopher Coles
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| Frontiers Media SA, 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches
| Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches |
| Autore | Jeon Byeong Hwa |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (368 p.) |
| Soggetto topico |
Technology: general issues
Biotechnology |
| Soggetto non controllato |
endothelial cells
oxidative stress inflammageing endothelial dysfunction aldehyde dehydrogenase-2 cardiovascular disease neurovascular disease vascular inflammation APE1/Ref-1 cardiovascular diseases subcellular localization serological biomarkers atherosclerosis aerobic exercise PCSK9 LOX-1 insulin resistance macrophage polarity serum γ-glutamyltransferase essential hypertension cardiovascular risk factors angiogenesis nargenicin A1 compound 9 VEGF VEGFR2 HIF-1α electronegative low-density lipoprotein LDL(-) L5 LDL oxidized LDL oxLDL ADMA arginine arginine paradox BH4 blood pressure COVID-19 dietary supplements endothelium eNOS uncoupling heart failure hypertension L-arginine myocardial infarction NADPH nitric oxide peripheral artery disease ApoE knockout mouse atorvastatin VCAM-1 galectin-3 neutrophil/lymphocyte ratio electronegative LDL LDL(−) lectin-like oxLDL receptor-1 dyslipidemia chronic venous insufficiency prolyl oligopeptidase (POP) inflammation endothelial disfunction lung disease endothelial to mesenchymal transition pulmonary hypertension pulmonary fibrosis metformin diabetes CV risk hyperglycemia glycated lipoproteins glycated LDL glycated HDL endothelial cell dysfunction molecular mechanisms epigenetic factors therapeutic approaches vasoactive factors EndoMT TGF-β epigenetics endothelial cell glycolysis metabolism pathological angiogenesis tumor microenvironment MRI (magnetic resonance imaging) high-fat diets plaque burden low-level laser therapy phototherapy vascular disease healing ischemia vascular calcification chronic kidney disease CKD uremic toxins hyperphosphatemia vascular smooth muscle cells VSMCs macrophages |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Endothelial Dysfunction |
| Record Nr. | UNINA-9910566471803321 |
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Jeon Byeong Hwa
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Genetics and Genomics of Pulmonary Arterial Hypertension
| Genetics and Genomics of Pulmonary Arterial Hypertension |
| Autore | Southgate Laura |
| Pubbl/distr/stampa | Basel, : MDPI Books, 2022 |
| Descrizione fisica | 1 electronic resource (188 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences Genetics (non-medical) |
| Soggetto non controllato |
pulmonary arterial hypertension
massive parallel sequencing NGS digenic inheritance and genetics BMPR2 promoter pathogenic variant heritable pulmonary arterial hypertension genetic analysis NGS gene panel BMPR2 TBX4 GDF2 EIF2AK4 genomics pediatrics lung disease endothelial cells smooth muscle cells DNA damage DNA repair expression quantitative trait locus eQTL blood genetics exome sequencing molecular genetics paediatrics bone morphogenetic protein receptor type 2 heritable familial estrogen estradiol penetrance gender PAH forward phenotyping forward genetics reverse genetics reverse phenotyping intermediate phenotypes whole-genome sequencing epigenetic inheritance genetic heterogeneity phenotypic heterogeneity pulmonary hypertension bone morphogenetic protein receptor 2 signaling repurposed drugs pharmaceuticals miRNA clinical trials |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910595078603321 |
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Southgate Laura
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| Basel, : MDPI Books, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Hereditary Hemorrhagic Telangiectasia : Recent Advances and Future Challenges
| Hereditary Hemorrhagic Telangiectasia : Recent Advances and Future Challenges |
| Autore | Mager Hans-Jurgen |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (228 p.) |
| Soggetto topico | Research & information: general |
| Soggetto non controllato |
hereditary hemorrhagic telangiectasia
rare diseases telangiectasis transforming growth factor-beta (TGF-β) Smad pathway gastrointestinal bleeding epistaxis nosebleeds tacrolimus nasal ointment genetic disease rare disease hereditary hemorrhagic telangiectasia (HHT) telangiectases mechanical damage sun-induced trauma vascular malformations Endoglin activin-receptor-like kinase 1 Hereditary Hemorrhagic Telangiectasia antithrombotic therapy anticoagulants antiplatelets bleeding safety HHT ALK1 endoglin raloxifene bazedoxifene tranexamic acid propranolol FK506 etamsylate N-acetylcysteine pulmonary arteriovenous malformations transcatheter embolotherapy screening guidelines Hereditary hemorrhagic telangiectasia pediatrics genotype–phenotype correlation arteriovenous malformation ENG ACVRL1 SMAD4 microRNA biomarker plasma arteriovenous malformations (AVMs) angiogenesis activin receptor-like kinase 1 (ALK1) transforming growth factor beta (TGF-β) bone morphogenetic protein (BMP) propranolol gel epistaxis severity score nasal endoscopy antiangiogenic properties non-coding RNAs microRNAs long non-coding RNAs biomarkers endothelial cells hereditary hemorrhagic telangiectasia (HHT), second-hit arteriovenous malformation (AVM) Smad4 inflammation shear stress vascular injury somatic mutation cell adhesion vascular endothelial growth factor (VEGF) telangiectasia hereditary hemorrhagic survival life expectancy pulmonary arteriovenous malformation contrast enhanced magnetic resonance angiography liver MRI ultrasound AVM bevacizumab Osler–Weber–Rendu hereditary hemorrhagic telangiectasia/HHT/osler’s disease cerebral ischemic lesions catheter based embolization therapy |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Hereditary Hemorrhagic Telangiectasia |
| Record Nr. | UNINA-9910557578003321 |
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Mager Hans-Jurgen
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Host Immune Responses and Pathogenesis to Brucella spp. Infection
| Host Immune Responses and Pathogenesis to Brucella spp. Infection |
| Autore | Oliveira Sergio Costa |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (162 p.) |
| Soggetto topico | Research & information: general |
| Soggetto non controllato |
Recombinant vaccine
divalent vaccine brucellosis Omp25 L7/L12 Brucella abortus 544 ST2 receptor Brucella abortus oral infection human endometrial cells internalization intracellular replication decidualization chemokines macrophages Brucella HSC MHC IL-10 cell cycle (p)ppGpp rsh neurobrucellosis platelets brain microvascular endothelial cells endothelial cells adhesins Ig-like domain monomeric autotransporters trimeric autotransporters extracellular matrix polar localization virulence factors vaccine candidates fibronectin canonical inflammasome non-canonical inflammasome NLR pyroptosis ASC caspase-11 caspase-1 IL-1β gDNA replication niche reservoir persistence survival chronic infection |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557578403321 |
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Oliveira Sergio Costa
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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