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Clinical Utility of Applying PGx and Deprescribing-Based Decision Support in Polypharmacy : Future Perspectives
| Clinical Utility of Applying PGx and Deprescribing-Based Decision Support in Polypharmacy : Future Perspectives |
| Autore | Vermehren Charlotte |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (224 p.) |
| Soggetto topico |
Manufacturing industries
Medicine and Nursing |
| Soggetto non controllato |
2019 Beers criteria
5'nuclease assay 80 and over abacavir acute kidney injury adverse drug reaction adverse drug reactions aged allopurinol antidepressants antiepileptic drugs antipsychotics appropriateness bleeding children chronic clinical pharmacist clozapine CNV copy number variation cost-effectiveness CYP1A2 CYP2D6 CYP2D7P CYP2D8P cytochrome P450 cytochromes deprescribing deprescriptions determinants digital decision-support digital health DOACs drug hypersensitivity drug information service drug interaction checkers drug metabolization drug-drug interactions drug-gene interactions early biomarker electronic medical record electronic prescribing emergency department Ethiopia exosomes extracellular vesicles flucloxacillin general practice genotyping health outcomes health services research high resolution melting HLA hospital pharmacy service HRM loxapine medication adherence medication optimization medication reconciliation medication review medication-based risk score microvesicles multimorbidity nursing homes olanzapine older adults older patients outpatient personalized medicine persons with diabetes pharmacogene expression pharmacogenetics pharmacogenomics phenprocoumon plasma neutrophil gelatinase-associated lipocalin polypharmacy population-based potentially inappropriate medication use prevalence process evaluation quality of life shared medication record SLCO1B1 soluble urokinase plasminogen activator receptor thromboembolism utility youth |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Clinical Utility of Applying PGx and Deprescribing-Based Decision Support in Polypharmacy |
| Record Nr. | UNINA-9910595072903321 |
Vermehren Charlotte
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Drug-Drug Interactions
| Drug-Drug Interactions |
| Autore | Kim Dong Hyun |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (242 p.) |
| Soggetto topico |
Biology, life sciences
Research & information: general |
| Soggetto non controllato |
(‒)-sophoranone
1A2 2B6 2C19 2C8 2C9 2D6 3A4 ADME adverse drug reactions biflavonoid chronic kidney disease competitive inhibition computational prediction CYP CYP1A1 CYP1A2 CYP2C9 CYP2D6 CYP3A CYP3A4 cytochrome P450 cytochromes P450 DDI Dexamethasone drug interaction drug interactions drug metabolism drug transporter drug-drug interaction drug-drug interactions expression fexofenadine gepants high plasma protein binding in silico in vitro in vivo inhibitor ixazomib Ketoconazole lasmiditan Lexicomp low permeability Loxoprofen mechanism-based inhibition metabolic DDI metabolism migraine monoclonal antibodies non-competitive inhibition O-desmethyltramadol OATP1B1 OATP1B3 organic anion transporting polypeptide 1A2 (OATP1A2) P-glycoprotein (P-gp) P450 pharmacokinetics physiologically-based pharmacokinetics plasma concentration polypharmacy potent inhibition QSAR regulation Rumex acetosa selamariscina A signal detection algorithms spontaneous reporting systems subset analysis substrate systemic exposure tadalafil ticagrelor tissue-specific tramadol tyrosine kinase inhibitors ubiquitination uridine 5'-diphosphoglucuronosyl transferase |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557666403321 |
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Kim Dong Hyun
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Regional Intestinal Drug Absorption : Biopharmaceutics and Drug Formulation
| Regional Intestinal Drug Absorption : Biopharmaceutics and Drug Formulation |
| Autore | Gonzalez-Alvarez Maria Isabel |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (238 p.) |
| Soggetto topico |
Manufacturing industries
Medicine and Nursing |
| Soggetto non controllato |
absorption-modifying excipients
BCS class IV drugs BCS drugs bioequivalence biomimetic membrane biopharmaceutics biopharmaceutics classification system Biopharmaceutics Classification System clinical studies colon absorption combined zero- and first-order absorption controlled release drug product DDI disintegration dissolution dissolution test drug absorption drug permeability drug solubility drug solubility/dissolution drug-drug interactions energy intake enteric-coated first-order absorption first-pass effect Franz cell Franz-PAMPA furosemide gastrointestinal gastrointestinal hormone GastroPlus hierarchical support vector regression (HSVR) human colon carcinoma cell layer (Caco-2) ibuprofen ICH in silico modeling in situ perfusion in vitro in vitro in vivo extrapolations intestinal absorption intestinal perfusion intestinal permeability IVIVE location-dependent absorption manometry mechanistic modeling microdevices mucoadhesion nutrient absorption nutrient digestion obesity oral absorption oral drug delivery oral peptide delivery passive drug transport PBBM PBPK permeation enhancers pharmaceutical development pharmacokinetics Phoenix WinNonlin physiologically-based pharmacokinetic (PBPK) modeling postprandial glycaemia pravastatin quality control region of the gut regional intestinal permeability regional/segmental-dependent permeability and absorption route-dependent intestinal metabolism segmental-dependent intestinal permeability segregated flow intestinal model (SFM) shape traditional model (TM) transit compartment absorption model type 2 diabetes zero-order absorption |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Regional Intestinal Drug Absorption |
| Record Nr. | UNINA-9910566462603321 |
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Gonzalez-Alvarez Maria Isabel
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Tuberculosis Drug Discovery and Development 2019
| Tuberculosis Drug Discovery and Development 2019 |
| Autore | Riccardi Giovanna |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 online resource (296 p.) |
| Soggetto topico |
Biology, life sciences
Research & information: general |
| Soggetto non controllato |
anti-TB drug pipeline
anti-virulence compounds antibiotic antimicrobial drug resistance (AMR) antimycobacterial antituberculosis agents artificial pneumothorax BCG bedaquiline biomarkers Carlo Forlanini caseum cell envelope clinical studies clinical trial CTVD delpazolid discovery DNA gyrase dormancy DprE1 inhibitor drug combination drug development drug discovery drug resistance drug-drug interactions EDCTP electron transport chain energy metabolism genomics granulomas host-directed therapy IAVI in vitro in vivo isoniazid lead generation lipidomics macozinone mechanism of action mechanisms of resistance metabolomics MID3 mode of action multi-drug resistance mutations mycobacteria mycobacterium Mycobacterium tuberculosis n/a oxidative phosphorylation pharmacodynamics pharmacokinetics phenotypic screening PknB PknG post-treatment sequelae privileged targets promiscuous targets proteomics pulmonary rehabilitation Q203 rifampin structure-based drug design surgery target target identification target-based drug design target-based screening TB TBVI toxicity transcriptomics tuberculosis tuberculosis treatment tuberculosis vaccines |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557627203321 |
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Riccardi Giovanna
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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