Advances and Novel Treatment Options in Metastatic Melanoma |
Autore | Facchiano Antonio |
Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
Descrizione fisica | 1 electronic resource (528 p.) |
Soggetto topico | Medicine |
Soggetto non controllato |
melanoma
invasion WNT5A MARCKS phosphorylation MANS peptide nanoparticles cell therapy tumor microenvironment sex/gender sex-hormones immunity microRNAs immunotherapy BRAF-mutant melanoma BRAF inhibitor mechanism of action targeted therapy tumour microenvironment plasmacytoid dendritic cells lactate dehydrogenase TLR interferon CXCL10 TPC2 HIPPO SOCE metastasis essential oils angiogenesis apoptosis uveal melanoma (UM) metastatic uveal melanoma (mUM) prognostication adjuvant therapy metastatic therapy metastatic dormancy liver-directed-therapies targeted-therapy combined therapy protein tyrosine phosphatase PTPs inhibitors melanoma immune infiltrate BRAF inhibitors microenvironment resistance therapy therapeutic resistance exosomes extracellular vesicles diagnosis prognosis ctDNA liquid biopsy prediction patient stratification BRAF arthralgia rheumatoid arthritis carbonic anhydrase hedgehog cyclopamine small molecules acetazolamide motility metalloproteinases FAK cancer mucosal melanoma nivolumab pembrolizumab ipilimumab radiotherapy cholinergic system acetylcholine muscarinic receptors nicotinic receptors melanoma metastasis ShcD adaptor protein amoeboid motility Rac1 DOCK4 melanoma PDX target therapy cancer stem cells slow cycling phenotype drug resistance OXPHOS lipid metabolism cancer associated fibroblast melanomagenesis biomarkers checkpoint inhibitor PD-1 melanoma markers cytokines machine learning Support Vector Machine principal component analysis BCL2L10 STAT3 cytotoxicity survival ABT-737 Bcl-2 family ML258 HuR MITF metastases siRNA |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910557612103321 |
Facchiano Antonio | ||
Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Anticancer Agents : Design, Synthesis and Evaluation |
Autore | Chen Qiao-Hong |
Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
Descrizione fisica | 1 electronic resource (606 p.) |
Soggetto topico | Medicine |
Soggetto non controllato |
benzofurans
chemical synthesis cytotoxic properties HeLa MOLT-4 K562 anticancer anti-neuroinflammation coumarin dihydroartemisinin flavonoids allene E-stereoselective regioselective anti-cancer activity cyanopyridone substituted pyridine pyridotriazine pyrazolopyridine thioxotriazopyridine anticancer activity HepG2 antitumor activity computational docking MDM2-p53 interaction xanthones yeast-based assays estrone derivatives hydrazine N-substituted pyrazoline anti-ovarian cancer topoisomerase II inhibitor kinase inhibitor antiproliferative agent urea synthesis antiproliferative activity apoptosis indoleamine 2,3-dioxygenase inhibitor anti-tumor immune modulation tryptophan metabolism taxoids βIII-tubulin P-glycoprotein drug resistance thiopene thienopyrimidinone thiazolidinone breast cancer benzofuran–pyrazole nanoparticles cytotoxic activity PARP-1 inhibition 3,6-dibromocarbazole 5-bromoindole carbazole actin migration Thienopyrimidine Pyrazole PI3Kα inhibitor quinazolin-4(3H)-one quinazolin-4(3H)-thione Schiff base antioxidant activity DFT study ortho-quinones beta-lapachone tanshione IIA PI3Ks PI3Kδ inhibitors 2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide anticancer agents protein–protein interactions virtual screening mimetics drug discovery bivalency polyvalency antitumor cell cycle ovarian cancer P-MAPA IL-12 TLR signaling inflammation chemoresistance 4-(pyridin-4-yloxy)benzamide 1,2,3-triazole c-Met natural product anticancer agent zampanolide Talazoparib PARP inhibitor prodrug o-nitro-benzyl photoactivatable protecting groups salinomycin overcoming drug resistance tumor specificity synergy 5-fluorouracil gemcitabine amides/esters colchicine analogs thiocolchicine colchiceine antimitotic agents hydrates dihydropyranoindole HDAC inhibitors neuroblastoma aromatase MCF-7 NIH3T3 benzimidazole triazolothiadiazine docking ADME organosilicon compounds SILA-409 (Alis-409) SILA-421 (Alis-421) multidrug resistance (MDR) reversal ABCB1 (P-glycoprotein) colon cancer colchicine amide colchicine sulfonamide tubulin inhibitors docking studies crystal structure PROTACs protein degradation IGF-1R Src protein kinase phenylpyrazolopyrimidine enzyme inhibition molecular simulation androgen receptor prostate cancer enzalutamide apalutamide darolutamide triple-negative breast cancer cytotoxicity chrysin analogues flavonoid anticancer compounds |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Altri titoli varianti | Anticancer Agents |
Record Nr. | UNINA-9910557129103321 |
Chen Qiao-Hong | ||
Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Antimicrobial Resistance and Virulence - 2nd Volume |
Autore | Oliveira Manuela |
Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
Descrizione fisica | 1 electronic resource (156 p.) |
Soggetto topico |
Research & information: general
Biology, life sciences Microbiology (non-medical) |
Soggetto non controllato |
biocide
antibiotic resistance cross-resistance aminoglycoside adaptation biofilm pyruvate cycle mastitis staphylococci virulence factors genes antimicrobial resistance infant newborn bacteremia Gram-negative bacteria drug resistance microbial mortality microcosm Aeromonas climate change temperature pH water Acinetobacter baumannii virulence whole-genome sequencing international high-risk clones genomic epidemiology dogs Escherichia coli ESBL CTX-M-15 CTX-M-1 CTX-M-32 CTX-M-55 CTX-M-14 qAmpC CMY-2 camel domestic milk virulence genes extended-spectrum β-lactamases biofilm formation Pseudomonas aeruginosa carbapenem resistance KPC-2 plasmid diabetic foot infections Staphylococcus aureus subinhibitory concentrations virulence-related genes |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910566473203321 |
Oliveira Manuela | ||
Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Antitumoral Properties of Natural Products |
Autore | Fabiani Roberto |
Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
Descrizione fisica | 1 electronic resource (344 p.) |
Soggetto topico |
Research & information: general
Biology, life sciences |
Soggetto non controllato |
cytotoxic activity
NCI-60 cancer cell line pristimerin Salacia crassifolia Celastraceae Brazilian Cerrado biome Salacia elliptica Cheiloclinium cognatum Plenckia populnea Aspergillus fumigatus Cordyceps sinensis isochromanes chiral resolution ECD calculation cytotoxicity coronarin D JNK osteosarcoma Zeylenone gastric cancer invasion migration apoptosis anti-cancer agents anthraquinones glycosyltransferase Dendrobium officinale structure elucidation anti-tumor activity plantation mode AR Ganoderma tsugae lipogenesis prostate cancer SREBP-1 ursolic acid betulinic acid triterpenoids necrotic quercetin quercetagetin patuletin lichen secondary metabolites tumidulin stemness potential colorectal cancer cells oncogene transcriptional regulation neferine FAK/S6K1 autophagy human neuroblastoma cells natural yellow Monascus pigments water-soluble antioxidation MCF-7 cells phloretin cell proliferation inflammation glucose uptake Catalpa speciosa Taxus cuspidata Magnolia acuminata phenols antioxidants anticancer Colocasia esculenta food bioactive tarin stable nanocapsules entrapment efficiency no-toxicity preclinical tests antitumoral activity chemotherapeutic adjuvant grape leaves ASE TP Antioxidant activities Antiproliferative pro-apoptotic effects Gene expression Nutraceuticals Cucurbitacin B gefitinib-resistant NSCLC EGFR lysosomal degradation CIP2A zerumbone cancer NF-κB IL-6/JAK2/STAT3 Akt FOXO1 multiple myeloma quality control naringenin flavonoids traditional preparation cancer stem cells phytochemicals plant-derived foods fruit vegetable cell signaling Artemisia absinthium endoplasmic reticulum stress mitochondrial-dependent pathway melanoma bee venom melittin temozolomide AKT MAPK antrodin C mTOR metabolic stability capsazepine inflammatory diseases ROS TRPV1 PI3K/AKT/mTOR CLE-10 LC3 MDA-MB-231 lactoferrin hydrolysate copper manganese gastric cancer cells anti-cancer activity molecular mechanism natural product alkaloids cephalotaxine protein synthesis inhibition antiproliferation agents folk medicine DLD-1 cells doxorubicin chemotherapy drug resistance CrataBL glioblastoma mesenchymal stem cells microenvironment plant lectin protease inhibitor cryptolepine neocryptolepine isocryptolepine antiproliferative activity structure activity relationships Licochalcone A ATM-Chk2 13-ethylberberine mitochondrial ROS RT-R breast cancer cells diallyl disulfide PI3K/Akt/mTOR pathway Pulsatilla saponin D SB365 glioblastoma multiforme autophagic flux inhibition lysosomal membrane permeabilization mitochondrial membrane potential CLEFMA p38 proanthocyanins TNF-α lung adenocarcinoma natural compounds cervical cancer cell cycle arrest dicentrine metastasis glioma semi-synthetic derivative ingenol Euphorbia tirucalli protein kinase C seaweed porphyran carrageenan anti-cancer natural products |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910557419703321 |
Fabiani Roberto | ||
Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Antitumoral Properties of Natural Products : Volume 2 |
Autore | Fabiani Roberto |
Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
Descrizione fisica | 1 electronic resource (300 p.) |
Soggetto topico |
Research & information: general
Biology, life sciences |
Soggetto non controllato |
cytotoxic activity
NCI-60 cancer cell line pristimerin Salacia crassifolia Celastraceae Brazilian Cerrado biome Salacia elliptica Cheiloclinium cognatum Plenckia populnea Aspergillus fumigatus Cordyceps sinensis isochromanes chiral resolution ECD calculation cytotoxicity coronarin D JNK osteosarcoma Zeylenone gastric cancer invasion migration apoptosis anti-cancer agents anthraquinones glycosyltransferase Dendrobium officinale structure elucidation anti-tumor activity plantation mode AR Ganoderma tsugae lipogenesis prostate cancer SREBP-1 ursolic acid betulinic acid triterpenoids necrotic quercetin quercetagetin patuletin lichen secondary metabolites tumidulin stemness potential colorectal cancer cells oncogene transcriptional regulation neferine FAK/S6K1 autophagy human neuroblastoma cells natural yellow Monascus pigments water-soluble antioxidation MCF-7 cells phloretin cell proliferation inflammation glucose uptake Catalpa speciosa Taxus cuspidata Magnolia acuminata phenols antioxidants anticancer Colocasia esculenta food bioactive tarin stable nanocapsules entrapment efficiency no-toxicity preclinical tests antitumoral activity chemotherapeutic adjuvant grape leaves ASE TP Antioxidant activities Antiproliferative pro-apoptotic effects Gene expression Nutraceuticals Cucurbitacin B gefitinib-resistant NSCLC EGFR lysosomal degradation CIP2A zerumbone cancer NF-κB IL-6/JAK2/STAT3 Akt FOXO1 multiple myeloma quality control naringenin flavonoids traditional preparation cancer stem cells phytochemicals plant-derived foods fruit vegetable cell signaling Artemisia absinthium endoplasmic reticulum stress mitochondrial-dependent pathway melanoma bee venom melittin temozolomide AKT MAPK antrodin C mTOR metabolic stability capsazepine inflammatory diseases ROS TRPV1 PI3K/AKT/mTOR CLE-10 LC3 MDA-MB-231 lactoferrin hydrolysate copper manganese gastric cancer cells anti-cancer activity molecular mechanism natural product alkaloids cephalotaxine protein synthesis inhibition antiproliferation agents folk medicine DLD-1 cells doxorubicin chemotherapy drug resistance CrataBL glioblastoma mesenchymal stem cells microenvironment plant lectin protease inhibitor cryptolepine neocryptolepine isocryptolepine antiproliferative activity structure activity relationships Licochalcone A ATM-Chk2 13-ethylberberine mitochondrial ROS RT-R breast cancer cells diallyl disulfide PI3K/Akt/mTOR pathway Pulsatilla saponin D SB365 glioblastoma multiforme autophagic flux inhibition lysosomal membrane permeabilization mitochondrial membrane potential CLEFMA p38 proanthocyanins TNF-α lung adenocarcinoma natural compounds cervical cancer cell cycle arrest dicentrine metastasis glioma semi-synthetic derivative ingenol Euphorbia tirucalli protein kinase C seaweed porphyran carrageenan anti-cancer natural products |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Altri titoli varianti | Antitumoral Properties of Natural Products |
Record Nr. | UNINA-9910557531303321 |
Fabiani Roberto | ||
Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Application of Bioinformatics in Cancers |
Autore | Brenner J. Chad |
Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
Descrizione fisica | 1 electronic resource (418 p.) |
Soggetto non controllato |
cancer treatment
extreme learning independent prognostic power AID/APOBEC HP gene inactivation biomarkers biomarker discovery chemotherapy artificial intelligence epigenetics comorbidity score denoising autoencoders protein single-biomarkers gene signature extraction high-throughput analysis concatenated deep feature feature selection differential gene expression analysis colorectal cancer ovarian cancer multiple-biomarkers gefitinib cancer biomarkers classification cancer biomarker mutation hierarchical clustering analysis HNSCC cell-free DNA network analysis drug resistance hTERT variable selection KRAS mutation single-cell sequencing network target skin cutaneous melanoma telomeres Neoantigen Prediction datasets clinical/environmental factors StAR PD-L1 miRNA circulating tumor DNA (ctDNA) false discovery rate predictive model Computational Immunology brain metastases observed survival interval next generation sequencing brain machine learning cancer prognosis copy number aberration mutable motif steroidogenic enzymes tumor mortality tumor microenvironment somatic mutation transcriptional signatures omics profiles mitochondrial metabolism Bufadienolide-like chemicals cancer-related pathways intratumor heterogeneity estrogen locoregionally advanced RNA feature extraction and interpretation treatment de-escalation activation induced deaminase knockoffs R package copy number variation gene loss biomarkers cancer CRISPR overall survival histopathological imaging self-organizing map Network Analysis oral cancer biostatistics firehose Bioinformatics tool alternative splicing biomarkers diseases genes histopathological imaging features imaging TCGA decision support systems The Cancer Genome Atlas molecular subtypes molecular mechanism omics curative surgery network pharmacology methylation bioinformatics neurological disorders precision medicine cancer modeling miRNAs breast cancer detection functional analysis biomarker signature anti-cancer hormone sensitive cancers deep learning DNA sequence profile pancreatic cancer telomerase Monte Carlo mixture of normal distributions survival analysis tumor infiltrating lymphocytes curation pathophysiology GEO DataSets head and neck cancer gene expression analysis erlotinib meta-analysis traditional Chinese medicine breast cancer TCGA mining breast cancer prognosis microarray DNA interaction health strengthening herb cancer genomic instability |
ISBN | 3-03921-789-5 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910367743403321 |
Brenner J. Chad | ||
MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Bioinformatics and Machine Learning for Cancer Biology |
Autore | Wan Shibiao |
Pubbl/distr/stampa | Basel, : MDPI Books, 2022 |
Descrizione fisica | 1 electronic resource (196 p.) |
Soggetto topico |
Research & information: general
Biology, life sciences |
Soggetto non controllato |
tumor mutational burden
DNA damage repair genes immunotherapy biomarker biomedical informatics breast cancer estrogen receptor alpha persistent organic pollutants drug-drug interaction networks molecular docking NGS ctDNA VAF liquid biopsy filtering variant calling DEGs diagnosis ovarian cancer PUS7 RMGs CPA4 bladder urothelial carcinoma immune cells T cell exhaustion checkpoint architectural distortion image processing depth-wise convolutional neural network mammography bladder cancer Annexin family survival analysis prognostic signature therapeutic target R Shiny application RNA-seq proteomics multi-omics analysis T-cell acute lymphoblastic leukemia CCLE sitagliptin thyroid cancer (THCA) papillary thyroid cancer (PTCa) thyroidectomy metastasis drug resistance biomarker identification transcriptomics machine learning prediction variable selection major histocompatibility complex bidirectional long short-term memory neural network deep learning cancer incidence mortality modeling forecasting Google Trends Romania ARIMA TBATS NNAR |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910595077403321 |
Wan Shibiao | ||
Basel, : MDPI Books, 2022 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Candida albicans A Major Fungal Pathogen of Humans |
Autore | Richardson Jonathan |
Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
Descrizione fisica | 1 electronic resource (182 p.) |
Soggetto topico |
Research & information: general
Biology, life sciences Microbiology (non-medical) |
Soggetto non controllato |
Candida albicans
acridine antifungal topoisomerase inhibitor candidiasis 1,3,4-oxadiazole drug discovery antifungal agents drug resistance toxicity biofilm invasive Candida infections invasive fungal infections antifungal prophylaxis newborns surgery neonatal surgery multivalency anti-adhesion glycoconjugates glycomimetics Candida C. albicans XCL1 metamorphic protein fold-switching protein antifungal peptide polymorphism hyphal morphogenesis hyphal activation signal transduction pathways cell cycle regulation sphingolipids myriocin fungal infections epigenetic yeast chromatin hyphae human fungal pathogen nutrient sensing amino acid metabolism proline catabolism mitochondria SPS-sensor nitrogen catabolite repression glucose repression immunometabolism metabolism macrophages epithelial cells glycolysis glucose moonlighting proteins |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910580211203321 |
Richardson Jonathan | ||
Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Carbon Ligands : From Fundamental Aspects to Applications |
Autore | Canac Yves |
Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
Descrizione fisica | 1 electronic resource (311 p.) |
Soggetto topico | Research & information: general |
Soggetto non controllato |
carbenes
ylides DFT calculations electronic structure catalysis ligands structure-activity relationship NHC nanoparticle calixarene palladium catalyst Suzuki-Miyaura reaction amino-acids water carbon ligand amide negative charge phosphonium ylide oxide pincer metathesis ruthenium nitro catalysts NHC ligands olefins selenonium ylides selenonium salts chirality stereogenic selenium atom asymmetric synthesis optical resolution reactivity malaria Plasmodium falciparum gold NHC-ligands hybrid molecules drug resistance N-heterocyclic carbene platinum metal complexes 195Pt NMR N-heterocyclic carbenes imidazole spectroscopy X-ray mercury(II) complex T-shaped carbodiphosphorane phosphorus ylides pincer ligands coordination chemistry Cu(I) complex photoluminescence titanium hafnium copolymerization of epoxide with CO2 density functional theory natural bond orbitals aromaticity ion pairs alkali metals tropylidenyl ions cyclooctatetraene ions rhodium electron paramagnetic resonance (EPR) spectroscopy density functional theory (DFT) electrochemistry carbone complexes carbido complexes transition metal complexes chemical bonding pincer ligand macrocycle lithium potassium intramolecular C-H activation dehydrogenation carbone ligand germylene coordination ylide |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Altri titoli varianti | Carbon Ligands |
Record Nr. | UNINA-9910557372703321 |
Canac Yves | ||
Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Challenges and Advances in Tuberculosis and Mycobacterial Lung Diseases |
Autore | Szturmowicz Monika |
Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
Descrizione fisica | 1 electronic resource (140 p.) |
Soggetto topico | Public health & preventive medicine |
Soggetto non controllato |
Gordonia bronchialis
microbiological diagnostics respiratory infection Mycobacterium tuberculosis drug resistance XDR-tuberculosis household TB transmission tuberculous pericarditis extrapulmonary tuberculosis pericarditis constrictive pericarditis tuberculosis abscess scrofula head and neck epiglottis larynx airway mycobacteria surgical drainage FluoroType MTBDR molecular isoniazid rifampin bacillus Calmette-Guerin bladder cancer immunotherapy BCGosis BCG pulmonary infection severe respiratory insufficiency nontuberculous mycobacterium lung cancer surgery nontuberculous mycobacteria cystic fibrosis chest computed tomography Beijing-TB Beijing-like genotype Mycobacterium chimaera nontuberculous mycobacterial disease silicosis extracorporeal membrane oxygenation COVID-19 pandemic spoligotyping Poland human immunodeficiency virus acquired immunodeficiency syndrome chest imaging rapidly growing mycobacteria antimicrobial resistance broth microdilution minimal inhibitory concentration (MIC) |
ISBN | 3-0365-5492-0 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910637783103321 |
Szturmowicz Monika | ||
Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|