Info
Advances in Antifungal Development: Discovery of New Drugs and Drug Repurposing
| Advances in Antifungal Development: Discovery of New Drugs and Drug Repurposing |
| Autore | Kim Jong Heon |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (282 p.) |
| Soggetto topico |
Biology, life sciences
Research & information: general |
| Soggetto non controllato |
3-phenyl-1H-indazole
Acanthamoeba Acanthamoeba keratitis acetylsalicylic acid (ASA, aspirin) all-trans retinoic acid anticandidal activity antifungal antifungal drugs antifungals Aspergillus spp azole azoles beta-glucan biological synthesis candida Candida candida albicans Candida auris Candida spp candidosis canesten CAP64 capsule cell integrity cell lysis cell separation cell wall clotrimazole Cryptococcus cyst cytokinesis dermatophytes drug drug delivery systems drug design drug discovery drug repurposing drug targets echinocandin drugs echinocandin resistance echinocandins emerging fungi Felis catus fission yeast Fks resistance hot spots free-living ameba fungi Galleria mellonella model host-directed drug therapy hydrazones indazole invasive aspergillosis treatment invasive fungal infections isavuconazonium sulfate Malassezia spp marine membrane potential (ΔΨM) microbiology multidrug resistance mycology myconanotechnology mycosis n/a nanoparticles natural products new targets onychomycosis photodynamic treatment photosensitiser polycations polyenes pyrazole quinones repositioning resistance retinoids septation sporotrichosis synergy therapeutic alternatives ultrastructure vaginal health vaginitis viral infections vulvovaginal yeast infection yeasts zoonoses β(1,3)-D-glucan synthase |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Advances in Antifungal Development |
| Record Nr. | UNINA-9910585935503321 |
Kim Jong Heon
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Computational and Experimental Approaches in Multi-Target Pharmacology
| Computational and Experimental Approaches in Multi-Target Pharmacology |
| Autore | Anastasio Thomas J |
| Pubbl/distr/stampa | Frontiers Media SA, 2017 |
| Descrizione fisica | 1 online resource (122 p.) |
| Collana | Frontiers Research Topics |
| Soggetto topico | Pharmacology |
| Soggetto non controllato |
computer modeling
drug combination drug discovery drug repurposing high throughput screening multidrug therapeutics multifactorial process polypharmacy synergy systems biology |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910261143503321 |
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Anastasio Thomas J
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| Frontiers Media SA, 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Computational Approaches: Drug Discovery and Design in Medicinal Chemistry and Bioinformatics
| Computational Approaches: Drug Discovery and Design in Medicinal Chemistry and Bioinformatics |
| Autore | Tutone Marco |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (387 p.) |
| Soggetto topico |
Chemistry
Research & information: general |
| Soggetto non controllato |
3CL-Pro
3D-QSAR acetylcholinesterase aging progression mechanism Alzheimer's disease aminophenylbenzamide antibody:antigen interactions antivirals binding free energies binding site binding space carbon nanotubes cholesterol computational biology consensus models COVID-19 COX-2 inhibitors deep learning diabetes docking simulations doxorubicin encapsulation drug delivery system drug discovery drug repositioning drug repositioning approaches drug repurposing drug resistance drug-resistance mutations dual mode of action dual-target lead discovery epitope binning epitope mapping epitope prediction FimH fingerprints gene expression signature genome-wide genetic and epigenetic network (GWGEN) glycoprotein D (gD) haeckelite defects HDACs hERG toxicity herpes simplex virus fusion proteins high-throughput virtual screening HIV-2 protease homology modeling hTSPO human dihydrofolate reductase immunoproteasome in silico induced structural deformations induced-fit docking inhibitors isoform-selective histone deacetylase inhibitors isomeric space ligand-based model machine learning main protease MD binding MD simulation metadynamics methotrexate molecular docking molecular dynamics molecular dynamics (MD) simulation molecular dynamics simulation molecular dynamics simulations molecular modeling MRP4 multi-modal multiple-molecule drug multiprotein inhibiting natural compounds multiscale multitargeting mutants Mycobacterium tuberculosis n/a natural compounds neurodegenerative disorders nicotinic acetylcholine receptor non-covalent inhibitors noncovalent interactions oxidative stress PF-00835231 pharmacophore model pharmacophore modeling PK11195 polypharmacology proteasome protein docking protein threading modeling proteomic signature RNA expression regulation SARS-CoV-2 skin aging SNPs sodium-glucose co-transporters 2 Src inhibitors Stone-Wales defects structural bioinformatics structural characterization systems medicine design tuberculosis urinary tract infections uropathogenic bacteria variants virtual screening |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Computational Approaches |
| Record Nr. | UNINA-9910557519403321 |
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Tutone Marco
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Converging Nanochemistry: From Disease Prevention to Diagnosis and Treatment
| Converging Nanochemistry: From Disease Prevention to Diagnosis and Treatment |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2023 |
| Descrizione fisica | 1 online resource (210 p.) |
| Soggetto topico | Technology: general issues |
| Soggetto non controllato |
Andes virus
antibody anticancer antiproliferation APN receptor apoptosis artificial intelligence bacterial nanocellulose biomarker particles biopanning cancer biomarker CDR randomization cell death chemoprevention colon cancer colorectal cancer conjugation strategy controlled drug delivery system covalent bonding drug development drug repurposing early detection electrochemical glycobiosensor encapsulation epidermal growth factor fungal pathogens genistein glycan in situ infectious disease inflammation MEK inhibitors miRNA molecular docking nanobody nanomaterial new therapeutic targets non-covalent bonding parasporin phage display protein modeling protein structure reactive oxygen species site-directed mutagenesis structural bioinformatics styrylquinolines surface modification synthetic library tumor necrosis factor vascular endothelial growth factor |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Converging Nanochemistry |
| Record Nr. | UNINA-9910743276003321 |
| MDPI - Multidisciplinary Digital Publishing Institute, 2023 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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In Silico Strategies for Prospective Drug Repositionings
| In Silico Strategies for Prospective Drug Repositionings |
| Autore | Udrescu Lucreția |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (288 p.) |
| Soggetto topico |
Medicine
Pharmaceutical industries |
| Soggetto non controllato |
COVID-19
drug repurposing topological data analysis persistent Betti function SARS-CoV-2 network-based pharmacology combination therapy nucleoside GS-441524 fluoxetine synergy antidepressant natural compounds QSAR molecular docking drug repositioning UK Biobank vaccine LC-2/ad cell line drug discovery docking MM-GBSA calculation molecular dynamics cytotoxicity assay GWAS multiple sclerosis oxidative stress repurposing ADME-Tox bioinformatics complex network analysis modularity clustering ATC code hidradenitis suppurativa acne inversa transcriptome proteome comorbid disorder biomarker signaling pathway druggable gene drug-repositioning MEK inhibitor MM/GBSA Glide docking MD simulation MM/PBSA single-cell RNA sequencing pulmonary fibrosis biological networks p38α MAPK allosteric inhibitors in silico screening computer-aided drug discovery network analysis psychiatric disorders medications psychiatry mental disorders toxoplasmosis Toxoplasma gondii in vitro screening drug targets drug-disease interaction target-disease interaction DPP4 inhibitors lipid rafts |
| ISBN | 3-0365-6133-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910639987703321 |
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Udrescu Lucreția
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Innovative Therapeutic and Vaccine Approaches against Respiratory Pathogens
| Innovative Therapeutic and Vaccine Approaches against Respiratory Pathogens |
| Autore | Chevalier Christophe |
| Pubbl/distr/stampa | Frontiers Media SA, 2020 |
| Descrizione fisica | 1 online resource (273 p.) |
| Soggetto topico |
Immunology
Medicine and Nursing |
| Soggetto non controllato |
adjuvant
antimicrobial peptide drug repurposing innovative delivery system respiratory pathogen therapeutics vaccine |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557482503321 |
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Chevalier Christophe
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| Frontiers Media SA, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Malignant Mesothelioma
| Malignant Mesothelioma |
| Autore | L. Pouliquen Daniel |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (328 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
asbestos
asbestos exposure BAP1 biomarkers cancer biomarkers cancer-specific mutations cancers carbon nanotubes carcinogenesis CDKN2A circulating tumor DNA dendritic cells DNA damage response DNA methylation DNA sequencing drug repurposing epigenome-wide analysis epithelioid extrapleural pneumonectomy fatty acid-binding protein FDG first line gene expression genomics Hippo pathway histotype immune therapy immunogenicity immunohistochemistry immunotherapy infiltrating immune cells inflammation interaction analysis laminin subunit beta-2 liquid biopsies lurbinectedin lymphocyte-to-monocyte ratio macrophage-capping protein malignant mesothelioma malignant pleural mesothelioma mesothelioma mesothelium meta-analysis metabolomics MPM MTAP mutation n/a network analysis NF2 oxidative stress PET-CT plasma pleural effusion pleural mesothelioma pleurectomy decortication predictive biomarker prognostic biomarker protein-protein interactions proteomics PTCH1 radiotherapy redox-sensitive factors sarcomatoid selenium-binding protein 1 SETD2 survival survival analysis systematic review systems biology targeted therapy therapy response tumor microenvironment tumor suppressor tumor-associated macrophages VATS WDPM well-differentiated papillary mesothelioma |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557359303321 |
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L. Pouliquen Daniel
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Mechanisms and Novel Therapeutic Approaches for Gynecologic Cancer
| Mechanisms and Novel Therapeutic Approaches for Gynecologic Cancer |
| Autore | Nakayama Naomi |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (258 p.) |
| Soggetto topico | Public health and preventive medicine |
| Soggetto non controllato |
adoptive immunotherapy
anti-angiogenic therapy aryl hydrocarbon receptor BEN (BANP, E5R and NAC1) domain biological planning biomarkers borderline ovarian tumors BRCA1 mutant ovarian cancer cancer progression CD44 cervical cancer cervical neoplasia chimeric antigen receptor clear cell carcinoma differentially expressed genes DNA damage response DNA mismatch repair (MMR) drug repurposing endometrial cancer endometrial carcinoma endometrioid endometrial cancer epithelial ovarian cancer epithelial ovarian cancers epithelial-mesenchymal transition exosome gene ontology gynecological cancer HDR brachytherapy human cytomegalovirus immune checkpoints inhibitors immune micro-environment immunohistochemistry immunosuppression in vivo dosimetry inflammation integrative analysis interventional radiotherapy isothermal titration calorimetry (ITC) liquid biopsy long-term survival melanoma treatment microsatellite instability miRNA mismatch repair deficiency MMR deficient (dMMR) n/a nanocarriers NK cells non-coding RNAs nucleus accumbens-associated protein 1 (NAC1) ovarian cancer p16 protein pGSK3β PLA2G7) platelet-activating factor acetylhydrolase (PAF-AH prognosis sequence-specific DNA-binding protein solution NMR structure somatic mutation targeted therapy testin vaginal melanoma vaginal-cuff brachytherapy vulvar melanoma Wnt signaling β-catenin |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910580209103321 |
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Nakayama Naomi
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Novel Anti-cancer Agents and Cellular Targets and Their Mechanism(s) of Action
| Novel Anti-cancer Agents and Cellular Targets and Their Mechanism(s) of Action |
| Autore | Allison Simon J |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (206 p.) |
| Soggetto topico |
History of engineering & technology
Technology: general issues |
| Soggetto non controllato |
5-FU resistance
8-hydroxydaidzein affibody drug conjugate (AffiDC) affibody molecule albumin binding domain angiogenesis anti-cancer agent anticancer drug apoptosis AQ4N autophagy B-lactam steroid alkylators BCR-ABL biomarker bioprecursor breast cancer BxPC-3 c-myc cancer hallmarks CCN1 colorectal cancer Connectivity Map CYP1A1 CYP1B1 CYP2W1 Cytochrome P450 DM1 drug repurposing duocarmycin EGFR tyrosine kinase inhibitor emtansine expression gene silencing Genomics of Drug Sensitivity in Cancer glioblastoma HepG2 Huh7 human epidermal growth factor receptor 3 (HER3) hybrid steroidal alkylating agents in vivo imaging invasion isatin sulfonamides K562 MAPK mesenchymal-amoeboid transition microtubule acetylation migration molecular docking n/a nanoparticles nanosystems NF-κB oncogene ovarian cancer phortress photon upconversion PLGA poly (ADP-ribose) polymerase inhibitors prodrug RNA interference siRNA synthetic lethality triple-negative breast cancer triplet-triplet annihilation |
| ISBN | 3-0365-5222-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Novel Anti-cancer Agents and Cellular Targets and Their Mechanism |
| Record Nr. | UNINA-9910619465503321 |
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Allison Simon J
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| MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Novel Treatment Strategies for Glioblastoma
| Novel Treatment Strategies for Glioblastoma |
| Autore | Stylli Stanley |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (268 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
angiopoietin (Ang)
anti-angiogenesis anticancer brain cancer brain tumor cancer stem cell cancer stem cell niche cancer stem cells cell cycle chimeric antigen receptor (CAR) T cells CK2 CRISPR/Cas9 CX-4945 de novo purine synthesis differentiation drug repurposing drug targets drug-inducible gene expression endothelial nitric oxide synthase (eNOS) GBM gene therapy glioblastoma glioblastoma (GB) glioblastoma multiforme glioma immune checkpoint inhibitors immunotherapy invadopodia invasion ion channels Mardepodect metabolic reprogramming metabolic treatment migration n/a nanomedicine nerve/glial antigen 2 new trial design newly diagnosed glioblastoma NG2 novel therapy one-carbon metabolism organoids P-bi-TAT P-m-TAT PEG personalized treatment pluripotent stem cells proliferation prolyl-oligopeptidase (POP) radiotherapy RAS recurrent glioblastoma Regorafenib renin-angiotensin system SRGAP2 stem cell targeted therapy temozolomide tetrac thyrointegrin αvβ3 TP53 transforming growth factor-β (TGF-β) triazole tetrac tumor antigens tumor microenvironment vaccine vascular endothelial growth factor (VEGF) viral vectors |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557363703321 |
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Stylli Stanley
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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