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Advances in Antifungal Development: Discovery of New Drugs and Drug Repurposing
| Advances in Antifungal Development: Discovery of New Drugs and Drug Repurposing |
| Autore | Kim Jong Heon |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (282 p.) |
| Soggetto topico |
Biology, life sciences
Research & information: general |
| Soggetto non controllato |
3-phenyl-1H-indazole
Acanthamoeba Acanthamoeba keratitis acetylsalicylic acid (ASA, aspirin) all-trans retinoic acid anticandidal activity antifungal antifungal drugs antifungals Aspergillus spp azole azoles beta-glucan biological synthesis candida Candida candida albicans Candida auris Candida spp candidosis canesten CAP64 capsule cell integrity cell lysis cell separation cell wall clotrimazole Cryptococcus cyst cytokinesis dermatophytes drug drug delivery systems drug design drug discovery drug repurposing drug targets echinocandin drugs echinocandin resistance echinocandins emerging fungi Felis catus fission yeast Fks resistance hot spots free-living ameba fungi Galleria mellonella model host-directed drug therapy hydrazones indazole invasive aspergillosis treatment invasive fungal infections isavuconazonium sulfate Malassezia spp marine membrane potential (ΔΨM) microbiology multidrug resistance mycology myconanotechnology mycosis n/a nanoparticles natural products new targets onychomycosis photodynamic treatment photosensitiser polycations polyenes pyrazole quinones repositioning resistance retinoids septation sporotrichosis synergy therapeutic alternatives ultrastructure vaginal health vaginitis viral infections vulvovaginal yeast infection yeasts zoonoses β(1,3)-D-glucan synthase |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Advances in Antifungal Development |
| Record Nr. | UNINA-9910585935503321 |
Kim Jong Heon
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Anticancer Inhibitors
| Anticancer Inhibitors |
| Autore | Fantacuzzi Marialuigia |
| Pubbl/distr/stampa | Basel, : MDPI Books, 2022 |
| Descrizione fisica | 1 electronic resource (216 p.) |
| Soggetto topico |
Research & information: general
Chemistry |
| Soggetto non controllato |
breast cancer
tamoxifen LY294002 synergism apoptosis cell cycle tea (Camellia sinensis) flowers BTFS A2780/CP70 ovarian cancer cells S phase cell cycle arrest nicotinamide phosphoribosyltransferase NAD+ biosynthesis inhibitor azacyclohexane anticancer drug drug design enthalpy effect NSCLC Cathepsin K cell proliferation cell migration cell invasion mTOR isatin-hydrazones cytotoxicity CDK2 inhibitor ATP competitive inhibitor ADME analysis receptor tyrosine kinases protein-protein interactions protein engineering directed evolution angiogenesis binding affinity agonistic activity saponins phytochemicals tea (Camellia sinensis) flower ovarian cancer autophagy ZMYND8 tumorigenesis epigenetic regulation pro-oncogenic effects tumor suppression tacrine-coumarin derivatives DNA topoisomerases I, II lung carcinoma cells A549 chemotherapy prodrug drug targeting overexpressed enzymes ADC ADEPT GDEPT LEAPT PROTAC cyclin-dependent kinase cancer resistance small molecule inhibitors PROTACs statins pancreatic cancer DNA microarray pitavastatin cerivastatin simvastatin fluvastatin atorvastatin pravastatin HMG-CoA reductase inhibitors |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910595069203321 |
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Fantacuzzi Marialuigia
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| Basel, : MDPI Books, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Antimicrobial Peptides Aka Host Defense Peptides – From Basic Research to Therapy
| Antimicrobial Peptides Aka Host Defense Peptides – From Basic Research to Therapy |
| Autore | Petrlova Jitka |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (226 p.) |
| Soggetto topico |
Research & information: general
Chemistry |
| Soggetto non controllato |
ECP
AMPs infection murine model Gram-negative bacteria LPS host defense peptides monocytes neutrophils neutrophil–monocyte interaction extracellular traps host defense peptide innate immunity NF-κB poly I:C toll-like receptor 3 mucus of Cornu aspersum peptide fraction MW < 10 kDa Escherichia coli NBIMCC 8785 SEM fluorescence and digital assays antibacterial effect oral cavity human cathelicidin antimicrobial peptides immunomodulation oncolytic peptides cancer membrane integrity bulky non-nature amino acid DAMPs drug design antimicrobial peptidomimetic hydrogel-based system hyaluronic acid anti-infective activity skin infections antimicrobial peptide expression intein self-cleavage cecropin-like apolipoprotein E host defense aggregation body fluid AMP interaction network chemical barrier cationic antimicrobial peptides length dependent activity antimicrobial activity hemolysis vesicle leakage solid-state 31P-, 15N- and 19F-NMR β-stranded peptides β-sheets structure and orientation of peptides in membranes |
| ISBN | 3-0365-5820-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910639991103321 |
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Petrlova Jitka
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Chemoinformatics Approaches to Structure- and Ligand-Based Drug Design
| Chemoinformatics Approaches to Structure- and Ligand-Based Drug Design |
| Autore | Andricopulo Adriano D |
| Pubbl/distr/stampa | Frontiers Media SA, 2019 |
| Descrizione fisica | 1 online resource (415 p.) |
| Collana | Frontiers Research Topics |
| Soggetto topico |
Pharmacology
Science: general issues |
| Soggetto non controllato |
chemoinformatics
Computational Chemistry drug design molecular docking molecular dynamics Molecular modeling QSAR QSPR Virtual Screening |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557666603321 |
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Andricopulo Adriano D
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| Frontiers Media SA, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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From Peptide and Protein Toxins to Ion Channel Structure/Function and Drug Design
| From Peptide and Protein Toxins to Ion Channel Structure/Function and Drug Design |
| Autore | Tsetlin Victor I |
| Pubbl/distr/stampa | Frontiers Media SA, 2020 |
| Descrizione fisica | 1 online resource (135 p.) |
| Soggetto topico |
Pharmacology
Science: general issues |
| Soggetto non controllato |
Cys-loop receptors
drug design nicotinic receptors receptor complexes Three-finger Ly6 proteins Voltage-gated ion channels α-conotoxins |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557564203321 |
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Tsetlin Victor I
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| Frontiers Media SA, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Intrinsically Disordered Proteins and Chronic Diseases
| Intrinsically Disordered Proteins and Chronic Diseases |
| Autore | Kulkarni Prakash |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (224 p.) |
| Soggetto topico | Research & information: general |
| Soggetto non controllato |
binding mechanism
coactivators conformational ensemble conformational plasticity COR15A depletion interaction diffusion disease-related proteins drug design dynamic configuration electrostatics entropic force extremely fuzzy complex free energy landscape functional segments fuzzy interactions gene regulation glucocorticoid receptor IDP intrinsic disordered protein intrinsically disordered intrinsically disordered protein intrinsically disordered proteins intrinsically disordered regions Kinase-inducible domain interacting domain kinetics Late embryogenesis abundant liquid-liquid phase separation low-complexity sequences membraneless organelles microtubule associated protein microtubules molecular dynamics molecular modelling mouse double minute 2 mouse double minute 4 n/a nuclear magnetic resonance Nuclear magnetic resonance optical tweezer order-disorder transition PAGE4 phosphomimetics phosphorylation protein complementation assays protein diffusion protein interaction protein structure prediction protein-protein interaction replica exchange molecular dynamics split-GFP reassembly subcellular location tau tau-microtubule association transactivation activity transient secondary structure Trifluoroethanol tumor protein p53 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557746903321 |
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Kulkarni Prakash
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Marine Bioactive Peptides : : Structure, Function, and Therapeutic Potential / / Tatiana V. Ovchinnikova
| Marine Bioactive Peptides : : Structure, Function, and Therapeutic Potential / / Tatiana V. Ovchinnikova |
| Autore | Ovchinnikova Tatiana V |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (442 p.) |
| Soggetto topico | Biology, life sciences |
| Soggetto non controllato |
cone snail
tilapia animal models BRICHOS domain recombinant peptide calcium absorption plastein reaction antioxidant activity endothelial dysfunction C3a lung cancer invertebrate immunity identification zinc bioavailability NA-inhibitory peptide nuclear magnetic resonance (NMR) review ACE-inhibitory activity intestinal absorption hairtail (Trichiurus japonicas) DU-145 cells peptide crustacean venom duct Kalloconus drug design molecular symmetry arenicin ?-helix APETx2 conotoxins functional diversity docking conotoxin neuraminidase angiotensin II polychaeta influenza virus phylogeny gene expression host defense peptide Perinereis aibuhitensis anti-diabetic activity conopeptides SHRs Chlorella pyrenoidosa protein hydrolysate (CPPH) metastasis Caco-2 cell monolayer Nrf2 caco-2 cells HUVEC PYP15 sea cucumber decapeptide cytotoxic arenicin-1 marine peptides cell proliferation Conus Conus ateralbus self-production of hydrogen peroxide antimicrobial activity molecular dynamics machine learning tachyplesins ion channels gut microbiota Anthopleura anjunae oligopeptide signaling pathways half-fin anchovy hydrolysates NF-?B Chlorella pyrenoidosa protein hydrolysate-calcium chelate (CPPH-Ca) antihypertensive effect QAGLSPVR antimicrobial peptides vasculogenic mimicry antibacterial ?-hairpin innate immunity transcriptome sequencing HIF-1? Gracilariopsis lemaneiformis function ACE-inhibitory peptide complement peptide-zinc complex structure-activity relationship multi-functional peptides cod skin adsorption Maillard reaction products molecular docking antibacterial peptide PI3K/AKT/mTOR signaling pathway Arenicola marina antimicrobial peptide Rana-box acid-sensing ion channel Neptunea arthritica cumingii apoptosis membrane damage proteolytic system toxin polyphemusins computational studies muscle oyster zinc-binding peptide abalone pain relief transport routes cytotoxicity dexamethasone cell death host?microbe relationship anti-LPS factor MMPs protein synthesis structure Pyropia yezoensis peptide cone snails chemical synthesis prostate cancer Ugr 9-1 myotube atrophy |
| ISBN |
9783039215331
3039215337 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910367750603321 |
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Ovchinnikova Tatiana V
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Marine Drug Research in China: Selected Papers from the 15-NASMD Conference
| Marine Drug Research in China: Selected Papers from the 15-NASMD Conference |
| Autore | Zhou Xuefeng |
| Descrizione fisica | 1 online resource (512 p.) |
| Soggetto topico | Medicine and Nursing |
| Soggetto non controllato |
absolute configuration
AChE inhibitory actinomycete actinomycin D actinomycin X2 adenosine monophosphate-activated protein kinase (AMPK) ADME ADMET adsorption kinetics and isotherms angiotensin-I-converting enzyme (ACE) peptide Antarctic krill (Euphausia superba) anti-glioma activity anti-inflammatory activity antiaging antibacterial antibacterial activity antibacterial properties anticancer antihyperlipidemic antimicrobial activity antimicrobial peptides antioxidant activity antitumor activity antitumor peptide apoptosis Arca inflata aromatic acids ascidian-derived fungus Aspergillus flavipes HN4-13 Aspergillus hiratsukae Aspergillus puniceus Aspergillus sclerotiorum Aspergillus sp Aspergillus terreus Aspergillus unguis biological activities butenolides butyrolactone I Caenorhabditis elegans calmodulin CDK4/6 chejuenlide chronic kidney disease clavipitacae cognitive dysfunction colorectal cancer coral-derived fungi cyclic pentapeptide cytotoxic activity cytotoxicity deep-sea actinomycetes deep-sea fungus deep-sea-derived fungus depsides depsidones Diaporthe sp drug design dyeing emodin enantiomers endothelin-1 (ET-1) enrichment eremophilane sesquiterpenoids flavonoid fluorescent properties food allergy fucoidan fucoxanthin galaxamide analogues genome mining geodin GSK3β-Nrf2-HO-1 signaling Hahella heterocornols IL-17 pathway insecticidal activity isoquinoline alkaloid LC-MS/MS Lecanicillium fusisporum lipodepsipeptide macroporous resin XAD-16 mangrove endophytic Pestalotiopsis mangrove-derived fungus MAPK signaling marine compounds marine fungi mechanism meroterpenoids metabolism methicillin-resistant Staphylococcus aureus microbial pigments microbiota microglial polarization mm-pbsa molecular docking molecular dynamics mutants NAFLD nasopharyngeal carcinoma neuroinflammation nitric oxide (NO) Nrf2 nuclear factor erythroid-2-related factor 2-mediated (Nrf2) Oceanapia osteoclast differentiation oxidative stress oxidized low-density lipoprotein oximes oyster pancreatic lipase PD-L1 Penicillium sp peptide peptidome Pestalotiopsis heterocornis pharmacokinetics pharmacophore construction pharmacophore modeling phycocyanin piericidins plasma prodiginine protein tyrosine phosphatase inhibitor pyranodipyran derivatives sclerotides Sdy-1 secondary metabolites semisynthesize sesquiterpene glycoside signaling pathway silk skipjack tuna (Katsuwonus pelamis) muscle soft-coral-derived fungus Sonneratia apetala sponge sponge-derived fungus stability Streptomyces parvulus tetramic acid derivatives Toll-like receptor 4-mediated (TLR4) transcriptome Trichoderma longibrachiatum tyrosyl DNA phosphodiesterase 1 inhibitory activities vascular endothelial cell virtual screening Wnt signaling xanthones β-catenin |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Marine Drug Research in China |
| Record Nr. | UNINA-9910595071903321 |
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Zhou Xuefeng
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| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Modeling and Simulation of Lipid Membranes
| Modeling and Simulation of Lipid Membranes |
| Autore | Marti Jordi |
| Pubbl/distr/stampa | Basel, : MDPI Books, 2022 |
| Descrizione fisica | 1 electronic resource (174 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences Biochemistry |
| Soggetto non controllato |
peptide
MD GUV LUV azo-amino acid KRas-4B mutation post-translational modification HVR anionic plasma membrane signaling cholesterol model membranes molecular dynamics calorimetry Schiff base imine benzimidazole 2,4-dihydroxybenzaldehyde neutron reflectometry X-ray reflectometry small-angle neutron scattering small-angle X-ray scattering molecular dynamics simulations scattering length density profile phospholipid membrane phosphatidylserine cancer cells MD simulation membrane permeability withaferin A withanone CAPE artepillin C membrane elasticity red blood cells hemodynamics hemorheology microfluidics benzothiadiazine derivatives drug design KCNE3 structural dynamics lipid bilayers molecular dynamics simulation membrane mimetic |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910595071503321 |
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Marti Jordi
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| Basel, : MDPI Books, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular Modeling in Drug Design
| Molecular Modeling in Drug Design |
| Autore | Wade Rebecca |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 online resource (220 p.) |
| Soggetto topico | Chemistry |
| Soggetto non controllato |
adenosine
adenosine receptor adenosine receptors adhesion aggregation all-atom molecular dynamics simulation allosterism Alzheimer's disease amyloid fibrils AR ligands artificial intelligence AutoGrid binding affinity biophenols boron cluster cosolvent molecular dynamics de novo design deep learning density-based clustering docking drug design drug discovery dynamic light scattering enzymatic assays EphA2-ephrin A1 extracellular loops FimH fragment screening grid maps human ecto-5?-nucleotidase hyperlipidemia in silico screening interaction energy ligand binding ligand-protofiber interactions mechanical stability metadynamics method development molecular docking molecular dynamics molecular dynamics simulation molecular modeling molecular recognition natural compounds neural networks PPI inhibition probe energies promiscuous mechanism property prediction protein protein interactions protein-peptide interactions proteins quantitative structure-activity relationship (QSAR) quantitative structure-property prediction (QSPR) rational drug design resultant dipole moment scoring function solvent effect squalene synthase (SQS) steered molecular dynamics structure-based drug design target-focused pharmacophore modeling Traditional Chinese Medicine turbidimetry virtual screening |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346839403321 |
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Wade Rebecca
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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