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Drug Metabolism/Transport and Pharmacokinetics
| Drug Metabolism/Transport and Pharmacokinetics |
| Autore | Song Im-Sook |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (232 p.) |
| Soggetto topico |
Medicine
Pharmaceutical industries |
| Soggetto non controllato |
tofacitinib
dose-dependent pharmacokinetics hepatic and intestinal first-pass effect rats catalposide in vitro human metabolism UDP-glucuronosyltransferase sulfotransferase carboxylesterase celecoxib drug–drug interaction fluorescence HPLC metabolism repaglinide HSG4112 anti-obesity agent stereoselectivity pharmacokinetics compound K protopanaxadiol (PPD) biliary excretion intestinal metabolism Carthamus tinctorius extract notoginseng total saponins comparative pharmacokinetic study large volume direct injection compatibility mechanism mertansine human hepatocytes cytochrome P450 UDP-glucuronosyltransferases sodium-glucose cotransporter 2 (SGLT2) inhibitors DWP16001 kidney distribution inhibition mode diabetes transporter-enzyme interplay influx transporter efflux transporter physiologically based pharmacokinetic model cytochrome P450 enzymes tiropramide healthy Korean subjects modeling population pharmacokinetic quercetin breast cancer resistance protein inhibitor prazosin sulfasalazine kinetic analysis food–drug interactions Caco-2 EpiIntestinal first-pass P-gp BCRP drug transporter CYP3A4 oral availability automatization drug absorption drug dosing head-and-neck cancer real-time measurements taxanes tissue engineering UHPLC-MS/MS metformin verapamil drug interaction organic cation transporter 2 renal excretion acute renal failure gentamicin cisplatin hepatic CYP3A1(23) creatinine clearance renal clearance nonrenal clearance |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557607703321 |
Song Im-Sook
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Ionic Liquids and Deep Eutectic Solvents for Application in Pharmaceutics
| Ionic Liquids and Deep Eutectic Solvents for Application in Pharmaceutics |
| Autore | Branco Luis Cobra |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (154 p.) |
| Soggetto topico | Technology: general issues |
| Soggetto non controllato |
ionic liquids
transdermal synergy permeation enhancer chemical physical Transdermal drug delivery systems ionic liquid lipophilic salt drug delivery drug absorption poorly water-soluble drug lumefantrine lipid-based formulation SEDDS lipid formulation classification system active pharmaceutical ingredients-ionic liquids and organic salts (API-OSILs) penicillin G and amoxicillin hydrolysate derivatives sensitive bacteria resistant bacteria alendronic acid Active Pharmaceutical Ingredients API-OSILs anticancer drugs deep eutectic mixtures ketoprofen non-steroidal anti-inflammatory drugs (NSAIDs) local anesthetics procaine benzocaine tetracaine anticrystal engineering mechanochemistry biocompatible transdermal drug delivery system microemulsion active pharmaceutical ingredients as organic salts and ionic liquids (API-OSILs) antibiotics ciprofloxacin fluoroquinolones norfloxacin polymorphism |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557780303321 |
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Branco Luis Cobra
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Organs-on-chips
| Organs-on-chips |
| Autore | Tung Yi-Chung |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (262 p.) |
| Soggetto non controllato |
tissue engineering
microfluidic device ischemia/reperfusion injury syringe pump liver-on-a-chip vacuum chuck epithelial-endothelial interface vessel branching organs-on-chips nanogrooves passive delivery functional neuron imaging organ-on-a-chip lung epithelial cell MEMS drug absorption strain 3D cell culture system mechanical cue multi-culture angiogenesis high-throughput screening fluoroelastomer membranes cell culture paracellular/transcellular transport beating force microfabrication drug hepatotoxicity biomimetic oxidation compression microfluidics surfactant protein PDMS neuronal cell networks neuronal guidance trans-epithelial electrical resistance spheroid array organ-on-a-chip (OOC) biomechanics cell organ-on-chips organ-on-chip stretch shear stress shear flow image-based screening drug metabolism vascularization human induced pluripotent Stem cell-derived cardiomyocytes (hiPS-CM) stress barrier permeability bio-mechanical property cardiac 3D tissue endothelial cell activation organoid silicon lattice light-sheet microscopy integrated pump SH-SY5Y cells thrombolysis 3D cell culture neuronal cells drug efficacy vascularized tumor model |
| ISBN | 3-03928-918-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910404077903321 |
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Tung Yi-Chung
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| MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Polymers Enhancing Bioavailability in Drug Delivery
| Polymers Enhancing Bioavailability in Drug Delivery |
| Autore | Fernandes Ana Isabel |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (260 p.) |
| Soggetto topico |
Medicine
Pharmaceutical industries |
| Soggetto non controllato |
cystic fibrosis
Pseudomonas aeruginosa liposomes efflux pump inhibitor PABN aminoglycosides macrolides poloxamer thiourea thiolation mucoadhesion drug release in vivo analysis in vitro dissolution studies S-propargyl-cysteine poly(lactic acid) endogenous hydrogen sulfide water-in-oil-in-water rheumatoid arthritis chitosan drug delivery drug absorption intestinal assimilation oral bioavailability nanoemulsions micelles SEDDS zeta potential sustained release albumin nanoparticle MPT0B291 high-pressure homogenizer histone deacetylase calix[8]arenes silibinin inclusion complexes PEGylation cytotoxicity oromucosal films sodium alginate nanoparticle drug carriers digoxin zein heart failure polymer-liposome complexes Pluronic®-poly(acrylic acid) Pluronic®-poly(N,N-dimethylaminoethyl methacrylate) stimuli-responsive intelligent drug delivery systems liposome polymer long circulation polymer-lipid conjugates targeting stimulus-responsive antibody affinity cyclodextrin protein therapeutics sustained drug delivery Nitric oxide hydrogel wound dressing chronic wounds glycyrrhetinic acid Soluplus® solid dispersions anti-inflammatory biosafety bioavailability |
| ISBN | 3-0365-5683-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910637795003321 |
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Fernandes Ana Isabel
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Regional Intestinal Drug Absorption : Biopharmaceutics and Drug Formulation
| Regional Intestinal Drug Absorption : Biopharmaceutics and Drug Formulation |
| Autore | Gonzalez-Alvarez Maria Isabel |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (238 p.) |
| Soggetto topico |
Medicine
Pharmaceutical industries |
| Soggetto non controllato |
bioequivalence
Biopharmaceutics Classification System in vitro dissolution test pravastatin oral absorption in silico modeling GastroPlus Phoenix WinNonlin pharmacokinetics clinical studies ibuprofen manometry gastrointestinal mechanistic modeling PBPK PBBM disintegration dissolution enteric-coated ICH quality control regional intestinal permeability permeation enhancers absorption-modifying excipients oral peptide delivery intestinal perfusion pharmaceutical development controlled release drug product biopharmaceutics classification system drug solubility drug permeability location-dependent absorption segregated flow intestinal model (SFM) traditional model (TM) route-dependent intestinal metabolism first-pass effect drug-drug interactions DDI in vitro in vivo extrapolations IVIVE zero-order absorption first-order absorption combined zero- and first-order absorption transit compartment absorption model in situ perfusion microdevices shape mucoadhesion colon absorption nutrient digestion nutrient absorption gastrointestinal hormone postprandial glycaemia energy intake region of the gut obesity type 2 diabetes Franz–PAMPA BCS drugs biomimetic membrane Franz cell passive drug transport BCS class IV drugs segmental-dependent intestinal permeability intestinal absorption oral drug delivery biopharmaceutics physiologically-based pharmacokinetic (PBPK) modeling furosemide intestinal permeability human colon carcinoma cell layer (Caco-2) hierarchical support vector regression (HSVR) drug absorption drug solubility/dissolution regional/segmental-dependent permeability and absorption |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Regional Intestinal Drug Absorption |
| Record Nr. | UNINA-9910566462603321 |
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Gonzalez-Alvarez Maria Isabel
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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