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Drug Metabolism/Transport and Pharmacokinetics
| Drug Metabolism/Transport and Pharmacokinetics |
| Autore | Song Im-Sook |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (232 p.) |
| Soggetto topico |
Manufacturing industries
Medicine and Nursing |
| Soggetto non controllato |
acute renal failure
anti-obesity agent automatization BCRP biliary excretion breast cancer resistance protein Caco-2 carboxylesterase Carthamus tinctorius extract catalposide celecoxib cisplatin comparative pharmacokinetic study compatibility mechanism compound K creatinine clearance CYP3A4 cytochrome P450 cytochrome P450 enzymes diabetes dose-dependent pharmacokinetics drug absorption drug dosing drug interaction drug transporter drug-drug interaction DWP16001 efflux transporter EpiIntestinal first-pass fluorescence food-drug interactions gentamicin head-and-neck cancer healthy Korean subjects hepatic and intestinal first-pass effect hepatic CYP3A1(23) HPLC HSG4112 human hepatocytes in vitro human metabolism influx transporter inhibition mode inhibitor intestinal metabolism kidney distribution kinetic analysis large volume direct injection mertansine metabolism metformin modeling nonrenal clearance notoginseng total saponins oral availability organic cation transporter 2 P-gp pharmacokinetics physiologically based pharmacokinetic model population pharmacokinetic prazosin protopanaxadiol (PPD) quercetin rats real-time measurements renal clearance renal excretion repaglinide sodium-glucose cotransporter 2 (SGLT2) inhibitors stereoselectivity sulfasalazine sulfotransferase taxanes tiropramide tissue engineering tofacitinib transporter-enzyme interplay UDP-glucuronosyltransferase UDP-glucuronosyltransferases UHPLC-MS/MS verapamil |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557607703321 |
Song Im-Sook
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Ionic Liquids and Deep Eutectic Solvents for Application in Pharmaceutics
| Ionic Liquids and Deep Eutectic Solvents for Application in Pharmaceutics |
| Autore | Branco Luis Cobra |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (154 p.) |
| Soggetto topico | Technology: general issues |
| Soggetto non controllato |
Active Pharmaceutical Ingredients
active pharmaceutical ingredients as organic salts and ionic liquids (API-OSILs) active pharmaceutical ingredients-ionic liquids and organic salts (API-OSILs) alendronic acid antibiotics anticancer drugs anticrystal engineering API-OSILs benzocaine biocompatible chemical ciprofloxacin deep eutectic mixtures drug absorption drug delivery fluoroquinolones ionic liquid ionic liquids ketoprofen lipid formulation classification system lipid-based formulation lipophilic salt local anesthetics lumefantrine mechanochemistry microemulsion n/a non-steroidal anti-inflammatory drugs (NSAIDs) norfloxacin penicillin G and amoxicillin hydrolysate derivatives permeation enhancer physical polymorphism poorly water-soluble drug procaine resistant bacteria SEDDS sensitive bacteria synergy tetracaine transdermal transdermal drug delivery system Transdermal drug delivery systems |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557780303321 |
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Branco Luis Cobra
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Organs-on-chips
| Organs-on-chips |
| Autore | Tung Yi-Chung |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 online resource (262 p.) |
| Soggetto topico | History of engineering and technology |
| Soggetto non controllato |
3D cell culture
3D cell culture system angiogenesis barrier permeability beating force bio-mechanical property biomechanics biomimetic oxidation cardiac 3D tissue cell cell culture compression drug absorption drug efficacy drug hepatotoxicity drug metabolism endothelial cell activation epithelial-endothelial interface fluoroelastomer functional neuron imaging high-throughput screening human induced pluripotent Stem cell-derived cardiomyocytes (hiPS-CM) image-based screening integrated pump ischemia/reperfusion injury lattice light-sheet microscopy liver-on-a-chip lung epithelial cell mechanical cue membranes MEMS microfabrication microfluidic device microfluidics multi-culture n/a nanogrooves neuronal cell networks neuronal cells neuronal guidance organ-on-a-chip organ-on-a-chip (OOC) organ-on-chip organ-on-chips organoid organs-on-chips paracellular/transcellular transport passive delivery PDMS SH-SY5Y cells shear flow shear stress silicon spheroid array strain stress stretch surfactant protein syringe pump thrombolysis tissue engineering trans-epithelial electrical resistance vacuum chuck vascularization vascularized tumor model vessel branching |
| ISBN | 3-03928-918-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910404077903321 |
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Tung Yi-Chung
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| MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Polymers Enhancing Bioavailability in Drug Delivery
| Polymers Enhancing Bioavailability in Drug Delivery |
| Autore | Fernandes Ana Isabel |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (260 p.) |
| Soggetto topico |
Medicine
Pharmaceutical industries |
| Soggetto non controllato |
cystic fibrosis
Pseudomonas aeruginosa liposomes efflux pump inhibitor PABN aminoglycosides macrolides poloxamer thiourea thiolation mucoadhesion drug release in vivo analysis in vitro dissolution studies S-propargyl-cysteine poly(lactic acid) endogenous hydrogen sulfide water-in-oil-in-water rheumatoid arthritis chitosan drug delivery drug absorption intestinal assimilation oral bioavailability nanoemulsions micelles SEDDS zeta potential sustained release albumin nanoparticle MPT0B291 high-pressure homogenizer histone deacetylase calix[8]arenes silibinin inclusion complexes PEGylation cytotoxicity oromucosal films sodium alginate nanoparticle drug carriers digoxin zein heart failure polymer-liposome complexes Pluronic®-poly(acrylic acid) Pluronic®-poly(N,N-dimethylaminoethyl methacrylate) stimuli-responsive intelligent drug delivery systems liposome polymer long circulation polymer-lipid conjugates targeting stimulus-responsive antibody affinity cyclodextrin protein therapeutics sustained drug delivery Nitric oxide hydrogel wound dressing chronic wounds glycyrrhetinic acid Soluplus® solid dispersions anti-inflammatory biosafety bioavailability |
| ISBN | 3-0365-5683-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910637795003321 |
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Fernandes Ana Isabel
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Regional Intestinal Drug Absorption : Biopharmaceutics and Drug Formulation
| Regional Intestinal Drug Absorption : Biopharmaceutics and Drug Formulation |
| Autore | Gonzalez-Alvarez Maria Isabel |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (238 p.) |
| Soggetto topico |
Manufacturing industries
Medicine and Nursing |
| Soggetto non controllato |
absorption-modifying excipients
BCS class IV drugs BCS drugs bioequivalence biomimetic membrane biopharmaceutics biopharmaceutics classification system Biopharmaceutics Classification System clinical studies colon absorption combined zero- and first-order absorption controlled release drug product DDI disintegration dissolution dissolution test drug absorption drug permeability drug solubility drug solubility/dissolution drug-drug interactions energy intake enteric-coated first-order absorption first-pass effect Franz cell Franz-PAMPA furosemide gastrointestinal gastrointestinal hormone GastroPlus hierarchical support vector regression (HSVR) human colon carcinoma cell layer (Caco-2) ibuprofen ICH in silico modeling in situ perfusion in vitro in vitro in vivo extrapolations intestinal absorption intestinal perfusion intestinal permeability IVIVE location-dependent absorption manometry mechanistic modeling microdevices mucoadhesion nutrient absorption nutrient digestion obesity oral absorption oral drug delivery oral peptide delivery passive drug transport PBBM PBPK permeation enhancers pharmaceutical development pharmacokinetics Phoenix WinNonlin physiologically-based pharmacokinetic (PBPK) modeling postprandial glycaemia pravastatin quality control region of the gut regional intestinal permeability regional/segmental-dependent permeability and absorption route-dependent intestinal metabolism segmental-dependent intestinal permeability segregated flow intestinal model (SFM) shape traditional model (TM) transit compartment absorption model type 2 diabetes zero-order absorption |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Regional Intestinal Drug Absorption |
| Record Nr. | UNINA-9910566462603321 |
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Gonzalez-Alvarez Maria Isabel
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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