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Anticancer Agents : Design, Synthesis and Evaluation
| Anticancer Agents : Design, Synthesis and Evaluation |
| Autore | Chen Qiao-Hong |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (606 p.) |
| Soggetto topico | Medicine and Nursing |
| Soggetto non controllato |
1,2,3-triazole
2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide 3,6-dibromocarbazole 4-(pyridin-4-yloxy)benzamide 5-bromoindole 5-fluorouracil ABCB1 (P-glycoprotein) actin ADME allene amides/esters androgen receptor anti-cancer activity anti-neuroinflammation anti-ovarian cancer anti-tumor anticancer anticancer activity anticancer agent anticancer agents anticancer compounds antimitotic agents antioxidant activity antiproliferative activity antiproliferative agent antitumor antitumor activity apalutamide apoptosis aromatase benzimidazole benzofuran-pyrazole benzofurans beta-lapachone bivalency breast cancer c-Met carbazole cell cycle chemical synthesis chemoresistance chrysin analogues colchiceine colchicine amide colchicine analogs colchicine sulfonamide colon cancer computational docking coumarin crystal structure cyanopyridone cytotoxic activity cytotoxic properties cytotoxicity darolutamide DFT study dihydroartemisinin dihydropyranoindole docking docking studies drug discovery drug resistance E-stereoselective enzalutamide enzyme inhibition estrone derivatives flavonoid flavonoids gemcitabine HDAC inhibitors HeLa HepG2 hydrates hydrazine IGF-1R IL-12 immune modulation indoleamine 2,3-dioxygenase inflammation inhibitor K562 kinase inhibitor MCF-7 MDM2-p53 interaction migration mimetics molecular simulation MOLT-4 multidrug resistance (MDR) reversal N-substituted pyrazoline nanoparticles natural product neuroblastoma NIH3T3 o-nitro-benzyl organosilicon compounds ortho-quinones ovarian cancer overcoming drug resistance P-glycoprotein P-MAPA PARP inhibitor PARP-1 inhibition phenylpyrazolopyrimidine photoactivatable protecting groups PI3Ks PI3Kα inhibitor PI3Kδ inhibitors polyvalency prodrug prostate cancer PROTACs protein degradation protein kinase protein-protein interactions Pyrazole pyrazolopyridine pyridotriazine quinazolin-4(3H)-one quinazolin-4(3H)-thione regioselective salinomycin Schiff base SILA-409 (Alis-409) SILA-421 (Alis-421) Src substituted pyridine synergy synthesis Talazoparib tanshione IIA taxoids thiazolidinone Thienopyrimidine thienopyrimidinone thiocolchicine thiopene thioxotriazopyridine TLR signaling topoisomerase II inhibitor triazolothiadiazine triple-negative breast cancer tryptophan metabolism tubulin inhibitors tumor specificity urea virtual screening xanthones yeast-based assays zampanolide βIII-tubulin |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Anticancer Agents |
| Record Nr. | UNINA-9910557129103321 |
Chen Qiao-Hong
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Anticancer Drugs 2021
| Anticancer Drugs 2021 |
| Autore | Meegan Mary J |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (594 p.) |
| Soggetto topico |
Chemistry
Research & information: general |
| Soggetto non controllato |
1,2,3-triazole
1,3,4-oxadiazole 3-amino-4'-guanidino 3,4'-bis-guanidino 5-fluoruracil 7-deaza-4'-thioadenosine derivatives acetamide adamantane ADC (antibody-drug conjugate) age alkylated anticancer anticancer activity anticancer agents apoptosis apoptosis induction aromatase inhibitor Bcl-2 inhibitors benzenesulfonamides benzimidazole BRAF breast cancer cancer cancer cell viability cancer vaccine CAR (chimeric antigen receptor) cardiotoxicity carvedilol cell cycle analysis chalcone chalcones colony formation combretastatin A-4 concentration-guided dosing covalent binding CovDock cumulative dose cyclophosphamide cytotoxic activity cytotoxic agents cytotoxicity designed multiple ligand diphenyl ether DNA fragmentation docking doxazosin drug efflux dual inhibitors dual-targeting molecule EGFR ELISA enantioselective synthesis entrectinib exportin-1 gastric adenocarcinoma generic product H1299 HDAC inhibitors HER2 heterocyclic compound histopathology HL-60 HT-29 cells hybrid compounds hybrid molecule hydrazide derivatives imidazoles Imiquimod immunotherapy in vitro in vivo indazole Indole-based analogues inflammation interleukin-6 intramolecular hydrogen bond isolation kidney larotrectinib letrozole MD simulations MDA-MB-231 cells mechanism prediction miR-21 mitoxantrone model informed dosing MTT cytotoxic assay MUC1 MUC16 mucin multi-kinase inhibitor multidrug resistance n/a NaMSA nitrogen scaffolds NTRK nucleoside oxidative stress patent review pemetrexed phenstatin phenyl pyridyl ether physiologically based pharmacokinetics protein kinase inhibitors resin acid solid/lipid nanoparticles sorafenib STAT inhibitors synthesis TDP1 testis thieno[2,3-d][1,2,3]triazine thiourea thymidylate synthase tissue-agnostic Toll-Like Receptor toxicity Trk Trk fusion trypan blue assay tryptophanol tubulin polymerisation inhibitor tumor spheroids tyrosil-DNA-phosphodiesterase 1 urinary bladder USFDA xanthone |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910576874303321 |
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Meegan Mary J
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Bioactive Natural Products from the Red Sea
| Bioactive Natural Products from the Red Sea |
| Autore | Rateb Mostafa |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (152 p.) |
| Soggetto topico | Research & information: general |
| Soggetto non controllato |
Actinokineospora
Alternaria androgen receptor anti-inflammatory antibacterial antibiofilm antimalarial antimicrobial antimicrobial activities Aspergillus falconensis azaphilones bioactivity biodiversity ceramide cerebroside co-cultivation co-culture cytotoxic cytotoxic activity diketopiperazine alkaloids DNA gyrase docking docking studies Epicoccum epicotripeptin ergosterol derivative halogenated 3-phenylpropanoic acid derivatives LC-HRESIMS marine actinomycetes marine metagenomics marine natural products marine organisms metabolic analysis metabolomics n/a neuroprotective NF-κB inhibition OSMAC phenazine phragamide pyruvate kinase Red Sea Red Sea sponges Rhodococcus seagrass Sinularia polydactyla soft coral sponge-associated actinomycetes steroids Streptomyces coelicolor LY001 structural determinations Stylissa carteri Thalassodendron ciliatum X-ray diffraction |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557540903321 |
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Rateb Mostafa
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Cholinesterase Research
| Cholinesterase Research |
| Autore | Korabecny Jan |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (223 p.) |
| Soggetto topico | Medicine and Nursing |
| Soggetto non controllato |
acetylcholinesterase
acetylcholinesterase inhibitor acetylcholinesterase inhibitors alkaloids Alzheimer disease Alzheimer's disease Amaryllidaceae antioxidants behavior blood-brain barrier crossing bone healing butyrylcholinesterase butyrylcholinesterase inhibitors carltonine A-C catalysis cholinesterase dementia docking docking studies donepezil fluorene hemostasis hydrolysis in silico in vitro inhibition MD simulations molecular dynamics molecular modeling molecular modelling molecular recognition multi-target directed ligands N-methyl-d-aspartate receptor n/a Narcissus pseudonarcissus cv. Carlton neutron scattering nutraceuticals organophosphates organophosphorus organophosphorus nerve agents osmotic stress osseointegration oxime pharmacodynamics phytochemicals reactivation reactivation process reactivators slow-binding inhibition transition state analog ventilation zebrafish |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557764703321 |
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Korabecny Jan
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Coumarin and Its Derivatives
| Coumarin and Its Derivatives |
| Autore | Matos Maria João |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (406 p.) |
| Soggetto topico |
Biology, life sciences
Research & information: general |
| Soggetto non controllato |
3-aroylcoumarines
4-hydroxy-7-methoxycoumarin 4-hydroxycoumarin 6'-(4-biphenyl)-β-iso-cinchonine acenocoumarol adenosine receptors analytical methods anti-HIV antibacterial activity anticancer activity anticoagulation antiplatelet activity apoptosis autophagy benzopyrones benzyl 2,3-butadienoate binding affinity bioactivity biological applications biosynthesis biotransformation calanolide A calanolides Calophyllaceae Calophyllum chalcocoumarin chalcone chalepensin chalepin charge transfer cholinesterase inhibition cholinesterases Chromobacterium violaceum complementary therapies constitutive androstane receptor coumarin coumarin dyes coumarin3-carboxamides coumarins COX Crohn's disease curcumin curcumin-coumarin hybrids dihydrocoumarin-fused dihydropyranones direct laser write docking docking simulation drug discovery dye-sensitized solar cells electrophilic compounds Escherichia coli esculetin esculin ethynylaryl ferulenol five-membered aromatic heterocycles fluorescent probes free radical polymerization furan glutathione glycyrol Glycyrrhiza uralensis human monoamine oxidases hydroxyl-modified coumarin imidazole immunoproteasome impedance aggregometry in silico studies in silico tools inflammation inflammatory bowel disease intestinal inflammation isocoumarin kinetics LED liquiritigenin macrophage MAO-B MAPK mechanical valve model plant molecular dynamics monoamine oxidase inhibition n/a natural genetic variation natural products neurodegenerative diseases neuroprotection NF-κB non-nucleoside reverse transcriptase inhibitors (NNRTIs) non-peptidic osthole oxazole oxidative stress photocomposites photophysical plant-derived molecules polyphenols pseudocalanolides psoralen core pyranocoumarins pyrazole pyrrole QS inhibitors quorum sensing reverse transcriptase Ruta chalepensis Rutaceae scavenging activity scoparone selenophen simple coumarins sorafenib structural annotation thermal and structural characterization thiadiazole thiazole thieno [3,2-b] thiophene thiophene time in therapeutic range triazole ulcerative colitis umbelliferone warfarin warhead scan Yin Chen Hao |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557577003321 |
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Matos Maria João
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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In Silico Strategies for Prospective Drug Repositionings
| In Silico Strategies for Prospective Drug Repositionings |
| Autore | Udrescu Lucreția |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (288 p.) |
| Soggetto topico |
Medicine
Pharmaceutical industries |
| Soggetto non controllato |
COVID-19
drug repurposing topological data analysis persistent Betti function SARS-CoV-2 network-based pharmacology combination therapy nucleoside GS-441524 fluoxetine synergy antidepressant natural compounds QSAR molecular docking drug repositioning UK Biobank vaccine LC-2/ad cell line drug discovery docking MM-GBSA calculation molecular dynamics cytotoxicity assay GWAS multiple sclerosis oxidative stress repurposing ADME-Tox bioinformatics complex network analysis modularity clustering ATC code hidradenitis suppurativa acne inversa transcriptome proteome comorbid disorder biomarker signaling pathway druggable gene drug-repositioning MEK inhibitor MM/GBSA Glide docking MD simulation MM/PBSA single-cell RNA sequencing pulmonary fibrosis biological networks p38α MAPK allosteric inhibitors in silico screening computer-aided drug discovery network analysis psychiatric disorders medications psychiatry mental disorders toxoplasmosis Toxoplasma gondii in vitro screening drug targets drug-disease interaction target-disease interaction DPP4 inhibitors lipid rafts |
| ISBN | 3-0365-6133-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910639987703321 |
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Udrescu Lucreția
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Marine Bioactive Natural Product Studies-A Southern Hemisphere Perspective
| Marine Bioactive Natural Product Studies-A Southern Hemisphere Perspective |
| Autore | Urban Sylvia |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 online resource (142 p.) |
| Soggetto topico | Medicine and Nursing |
| Soggetto non controllato |
Alcyoniidae
anticancer activity antiplasmodial Aplidium apoptosis ascidian bioactive compounds bioactivity biosynthesis bisindole alkaloids brominated secondary metabolites cell death cembrane cephalostatin choline ester Cnemidocarpa stolonifera conotoxins crystal cytotoxicity diterpene docking Echinodermata ESI farnesyltransferase free energy perturbation HIF-1α holothurian HPCPC immunofluorescence assay indole ion channels Jurkat lobane malaria MALDI mandelalide marine invertebrate mass spectrometry methicillin resistant Staphylococcus aureus molecular dynamics MRSA PK natural product scaffold p42/p44 MAPK PC3 cell line PI3K/Akt/mTOR Plasmodium falciparum potential of mean force regioisomer salternamide A (SA) saponins sea cucumber ShK toxin Sinularia STAT3 structure elucidation synthesis taurine amide thiaplakortone thiaplidiaquinone thiazinoquinone tricyclic triterpene glycosides viscera X-ray |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557573903321 |
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Urban Sylvia
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Marine Bioactive Peptides : : Structure, Function, and Therapeutic Potential / / Tatiana V. Ovchinnikova
| Marine Bioactive Peptides : : Structure, Function, and Therapeutic Potential / / Tatiana V. Ovchinnikova |
| Autore | Ovchinnikova Tatiana V |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (442 p.) |
| Soggetto topico | Biology, life sciences |
| Soggetto non controllato |
cone snail
tilapia animal models BRICHOS domain recombinant peptide calcium absorption plastein reaction antioxidant activity endothelial dysfunction C3a lung cancer invertebrate immunity identification zinc bioavailability NA-inhibitory peptide nuclear magnetic resonance (NMR) review ACE-inhibitory activity intestinal absorption hairtail (Trichiurus japonicas) DU-145 cells peptide crustacean venom duct Kalloconus drug design molecular symmetry arenicin ?-helix APETx2 conotoxins functional diversity docking conotoxin neuraminidase angiotensin II polychaeta influenza virus phylogeny gene expression host defense peptide Perinereis aibuhitensis anti-diabetic activity conopeptides SHRs Chlorella pyrenoidosa protein hydrolysate (CPPH) metastasis Caco-2 cell monolayer Nrf2 caco-2 cells HUVEC PYP15 sea cucumber decapeptide cytotoxic arenicin-1 marine peptides cell proliferation Conus Conus ateralbus self-production of hydrogen peroxide antimicrobial activity molecular dynamics machine learning tachyplesins ion channels gut microbiota Anthopleura anjunae oligopeptide signaling pathways half-fin anchovy hydrolysates NF-?B Chlorella pyrenoidosa protein hydrolysate-calcium chelate (CPPH-Ca) antihypertensive effect QAGLSPVR antimicrobial peptides vasculogenic mimicry antibacterial ?-hairpin innate immunity transcriptome sequencing HIF-1? Gracilariopsis lemaneiformis function ACE-inhibitory peptide complement peptide-zinc complex structure-activity relationship multi-functional peptides cod skin adsorption Maillard reaction products molecular docking antibacterial peptide PI3K/AKT/mTOR signaling pathway Arenicola marina antimicrobial peptide Rana-box acid-sensing ion channel Neptunea arthritica cumingii apoptosis membrane damage proteolytic system toxin polyphemusins computational studies muscle oyster zinc-binding peptide abalone pain relief transport routes cytotoxicity dexamethasone cell death host?microbe relationship anti-LPS factor MMPs protein synthesis structure Pyropia yezoensis peptide cone snails chemical synthesis prostate cancer Ugr 9-1 myotube atrophy |
| ISBN |
9783039215331
3039215337 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910367750603321 |
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Ovchinnikova Tatiana V
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Marine Microbial Diversity as Source of Bioactive Compounds
| Marine Microbial Diversity as Source of Bioactive Compounds |
| Autore | Shaaban Khaled A |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (182 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
actinomycetia
alkaloids antibacterial activity antimicrobial activity antiviral bioactivity biological activities calcium influx Chlorella co-culture cytotoxicity deep-sea-derived viridicatol dereplication diversity docking enzymes food allergy indole-diterpenoids intestinal barrier isoquinolinequinones Leizhou Peninsula lipases mangrove soil mansouramycins marine microbes marine-derived fungus marine-derived Streptomyces sp mast cell metabolomics tools microorganism molecular dynamic simulations molecular modeling n/a natural products Penicillium sp polyketides SARS-CoV-2 sea cucumber secondary metabolites structural diversity sulfated polysaccharides trioxacarcins X-ray single crystal |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910595068803321 |
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Shaaban Khaled A
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Microbial Secondary Metabolites and Biotechnology
| Microbial Secondary Metabolites and Biotechnology |
| Autore | Fouillaud Mireille |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (464 p.) |
| Soggetto topico |
Biology, life sciences
Microbiology (non-medical) Research & information: general |
| Soggetto non controllato |
6-pentyl-α-pyrone
acridone actinomycetes Actinomycetes adsorption ammonium angucycline anthelminthic drugs antibacterial antibiofilm antibiosis antibiotic resistance anticancer antifungal action antimicrobial antinematode compound antioxidant antiproliferative activity aquayamycin Aurantiochytrium sp autophagy inducer azaphilone Bacillus bacteriocin bio-pigments bioactive properties bioactivity biofilms biological activities biomass bioproduction bioremediation biosynthesis biosynthetic pathway biotechnology Box-Behnken experimental design Caenorhabditis elegans Candida albicans carnosic acid catalase activation cation-exchange resin CDK7 inhibition cell viability cell wall-deficiency COD corn stover Corynebacterium glutamicum Covid-19 cryptic culture conditions Curvularia papendorfii cyanobacteria cyclic peptides degradation discoloration distillery waste water docking Docosahexaenoic acid (DHA) elastase inhibition electrochemical analysis endophytic fungi extraction fermentation fermentation by-products fungal pigments fungi Fungi Fyn kinase inhibition genome-scale model global pigment market glycosyltransferase GNPS Gordonia Gram-negative bacterium greener extraction gut bacteria heteroploidy human coronavirus HCoV 229E industrial applications insect iron kheiric acid lactic acid fermentation Lactococcus lactis Lake Baikal LC-HRESIMS maize industry wastewater marine bacteria marine biofilm marine environment marine epiphytic bacteria marine fungi mealworm medium compositions metabolic engineering microbial biotechnology microbial natural products Micromonospora microorganisms molasses spent wash molecular dynamic simulation Mpro MRSA mutant gdhA P. multocida B:2 mutant strain mycolic acid N-functionalized amines N-methylanthranilate N-threonyl-rubropunctamin natural colors natural products Nocardia novel compound discovery optimization OSMAC parasitic nematode Pediococcus acidilactici PA204 perspectives photosynthesis phytopathogens pigments plant growth-promoting bacteria plant pathogenic fungi polyhydroxyacid polyunsaturated fatty acids (PUFAs) PP-R production propolis proteins protoplast fusion Pseudomonas aeruginosa NEJ01R pyocyanin quinazoline alkaloid drugs quorum sensing red pigments redox metabolite removal response surface analysis response surface modeling Rhodobacter capsulatus S. aureus Saccharomyces cerevisiae flor yeast SARS-CoV-2 Scopalina hapalia screening second fermentation secondary metabolites Serratia sp Serratiochelin A Serratiochelin C sesquiterpene production siderophore simultaneous saccharification and fermentation sirtuin 1 activation sparkling wine sponges Staphylococcus sp Streptomyces submerged fermentation sugarcane sustainable production of quinoline precursors synergy synthetic biology systems biology Talaromyces Talaromyces albobiverticillius 30548 terpenoids textiles therapeutic insights transcriptome Trichoderma tyrosinase inhibition valorization vinasse Xanthomonas campestris pv. campestris yeasts β-caryophyllene |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910566472403321 |
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Fouillaud Mireille
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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