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Anticancer Drugs
| Anticancer Drugs |
| Autore | O’Boyle Niamh M |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (214 p.) |
| Soggetto non controllato |
graphene oxide
indole androgens cyclooxygenase-2 cyclooxygenase-1 heteropolysaccharide drug conjugation drug delivery ellipticine chemical linker oesophageal cancer antiproliferative activity topoisomerase II ?-lactam DSD antibody topoisomerase inhibitors magnetic targeting cisplatin resistance steroidogenesis [18F]FDG PET/CT heterocyclic chemistry dehydroepiandrosterone antimitotic 3-vinylazetidin-2-ones glioblastoma and cancer therapy intestinal mucositis Combretastatin A-4 metabolism anti-cancer drugs maghemite COX-1 inhibitor anticancer CYP17A1 conjugate and hybrid drugs inflammation snticancer drugs P450c17 tumorigenesis cisplatin biomarker profiling cancer drug design tubulin cytochrome P450 5-fluorouracil prostate cancer abiraterone NCI screen radiation cancer immunotherapy microtubule targeted drugs cancer treatment resistance |
| ISBN | 3-03921-587-6 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910367753903321 |
O’Boyle Niamh M
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Clinical Utility of Applying PGx and Deprescribing-Based Decision Support in Polypharmacy : Future Perspectives
| Clinical Utility of Applying PGx and Deprescribing-Based Decision Support in Polypharmacy : Future Perspectives |
| Autore | Vermehren Charlotte |
| Pubbl/distr/stampa | Basel, : MDPI Books, 2022 |
| Descrizione fisica | 1 electronic resource (224 p.) |
| Soggetto topico |
Medicine
Pharmaceutical industries |
| Soggetto non controllato |
acute kidney injury
early biomarker plasma neutrophil gelatinase-associated lipocalin soluble urokinase plasminogen activator receptor medication optimization older patients emergency department multimorbidity polypharmacy potentially inappropriate medication use older adults prevalence determinants chronic outpatient 2019 Beers criteria Ethiopia pharmacogenomics persons with diabetes drug–drug interactions drug–gene interactions cytochrome P450 SLCO1B1 drug interaction checkers adverse drug reactions pharmacogenetics personalized medicine phenprocoumon DOACs bleeding thromboembolism HLA drug hypersensitivity abacavir allopurinol flucloxacillin antiepileptic drugs cost-effectiveness shared medication record medication reconciliation drug information service hospital pharmacy service electronic prescribing electronic medical record clinical pharmacist CYP2D6 CYP2D7P CYP2D8P copy number variation CNV genotyping 5’nuclease assay HRM high resolution melting drug metabolization extracellular vesicles exosomes microvesicles pharmacogene expression medication review deprescriptions quality of life aged aged, 80 and over nursing homes deprescribing medication-based risk score health outcomes cytochromes CYP1A2 adverse drug reaction antipsychotics olanzapine clozapine loxapine children youth digital decision-support health services research general practice process evaluation antidepressants utility population-based appropriateness medication adherence digital health |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Clinical Utility of Applying PGx and Deprescribing-Based Decision Support in Polypharmacy |
| Record Nr. | UNINA-9910595072903321 |
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Vermehren Charlotte
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| Basel, : MDPI Books, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0
| Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0 |
| Autore | Dansette Patrick M |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (286 p.) |
| Soggetto topico | Research & information: general |
| Soggetto non controllato |
Antibiotics
Bacillus biosynthetic gene clusters comparative analysis cytochrome P450 monooxygenase Mycobacterium P450 diversity percentage P450 profiling secondary metabolites NADPH-cytochrome P450 reductase (CPR) microsomal cytochrome P450 (CYP) Cytochrome b5 (CYB5) protein dynamics electron-transfer (ET) protein–protein interaction cytochromes P450 CYP3A4 active site access channels cavities boundaries minimal cost paths CYP139A1 genome data mining host metabolism Mycobacterium tuberculosis polyketides tuberculosis cryptococcus cryptococcus neoformans CYP51 fungal pathogens genome data-mining human pathogens CYP diversity analysis tremellomycetes trichosporon mechanism-based inhibitor crystal structure CYP4 genes genetic polymorphisms 20-HETE fatty acid arachidonic acid SNPs molecular functionality metabolism lamellar ichthyosis Bietti’s crystalline dystrophy cytochrome P450 isoform membrane protein protein-membrane interactions enzyme substrate specificity mutagenesis molecular dynamics simulation Sogatella furcifera sulfoxaflor transcriptome RNA interference CYP2C8 polymorphisms reactive oxygen species paclitaxel cytochrome P450 reductase electron transfer extracellular vesicles exosomes extrahepatic tissues plasma circulatory CYPs CYP450 drug metabolism precision Cardio-Oncology precision medicine systems medicine cytochromes P450 monooxygenases Cyanobacteria gene-cluster diversity percentage mathematical formula phylogenetic analysis Streptomyces cytochrome P450 monooxygenases terpenes P450 blooming non-ribosomal peptides cytochrome P450 monooxygenenases CYP128A1 Mycobacterium tuberculosis H37Rv molecular dynamic simulations azole drugs menaquinone |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Cytochromes P450 |
| Record Nr. | UNINA-9910557761103321 |
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Dansette Patrick M
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Drug metabolism, pharmacokinetics and bioanalysis / / special issue editors, Hye Suk Lee, Kwang-Hyeon Liu
| Drug metabolism, pharmacokinetics and bioanalysis / / special issue editors, Hye Suk Lee, Kwang-Hyeon Liu |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (230 p.) |
| Disciplina | 615.1 |
| Soggetto topico | Drugs - Metabolism |
| Soggetto non controllato |
human liver microsomes
alcohol addiction UGT ultra-high-pressure liquid chromatography adalimumab procainamide LC-MS/MS DA-9805 paeonol LC-QTOF-MS/MS YRA-1909 chlorogenic acid immunoprecipitation Eurycoma longifolia CYP caffeic acid rat pharmaceutical excipient Korean red ginseng extract Stauntonia hexaphylla leaf extract bioanalysis HPLC-MS/MS B6 eurycomanone bioavailability drying technology GB3 diclofenac 129-Glatm1Kul/J aglycone caffeic acid O-glucuronides organic anion transporting polypeptide protein precipitation metabolic stability Fabry disease biopharmaceuticals imperatorin neochlorogenic acid gastric ulcer saikosaponin a hair anthraquinone acetyl tributyl citrate pharmacokinetics brain distribution mematine ethyl glucuronide pharmacokinetic loxoprofen liquid chromatography-quadrupole TOF MS glucuronidation esomeprazole metformin cytochrome P450 glycoside AUDIT score protein stability efficacy LC-HR/MS cryptochlorogenic acid aceclofenac drug interaction liquid chromatography-tandem mass spectrometry Osthenol plasma N-acetylprocainamide diabetes |
| ISBN | 3-03897-917-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346664803321 |
| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Drug Metabolism/Transport and Pharmacokinetics
| Drug Metabolism/Transport and Pharmacokinetics |
| Autore | Song Im-Sook |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (232 p.) |
| Soggetto topico |
Medicine
Pharmaceutical industries |
| Soggetto non controllato |
tofacitinib
dose-dependent pharmacokinetics hepatic and intestinal first-pass effect rats catalposide in vitro human metabolism UDP-glucuronosyltransferase sulfotransferase carboxylesterase celecoxib drug–drug interaction fluorescence HPLC metabolism repaglinide HSG4112 anti-obesity agent stereoselectivity pharmacokinetics compound K protopanaxadiol (PPD) biliary excretion intestinal metabolism Carthamus tinctorius extract notoginseng total saponins comparative pharmacokinetic study large volume direct injection compatibility mechanism mertansine human hepatocytes cytochrome P450 UDP-glucuronosyltransferases sodium-glucose cotransporter 2 (SGLT2) inhibitors DWP16001 kidney distribution inhibition mode diabetes transporter-enzyme interplay influx transporter efflux transporter physiologically based pharmacokinetic model cytochrome P450 enzymes tiropramide healthy Korean subjects modeling population pharmacokinetic quercetin breast cancer resistance protein inhibitor prazosin sulfasalazine kinetic analysis food–drug interactions Caco-2 EpiIntestinal first-pass P-gp BCRP drug transporter CYP3A4 oral availability automatization drug absorption drug dosing head-and-neck cancer real-time measurements taxanes tissue engineering UHPLC-MS/MS metformin verapamil drug interaction organic cation transporter 2 renal excretion acute renal failure gentamicin cisplatin hepatic CYP3A1(23) creatinine clearance renal clearance nonrenal clearance |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557607703321 |
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Song Im-Sook
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Drug-Drug Interactions
| Drug-Drug Interactions |
| Autore | Kim Dong Hyun |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (242 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
tadalafil
ticagrelor drug-drug interaction pharmacokinetics plasma concentration CYP3A4 Loxoprofen CYP3A Dexamethasone Ketoconazole CYP2D6 O-desmethyltramadol physiologically-based pharmacokinetics tramadol (‒)-sophoranone CYP2C9 potent inhibition in vitro in vivo drug interaction low permeability high plasma protein binding biflavonoid cytochrome P450 drug interactions selamariscina A uridine 5′-diphosphoglucuronosyl transferase tissue-specific systemic exposure P-glycoprotein (P-gp) organic anion transporting polypeptide 1A2 (OATP1A2) Rumex acetosa fexofenadine chronic kidney disease drug–drug interactions polypharmacy adverse drug reactions Lexicomp subset analysis signal detection algorithms spontaneous reporting systems mechanism-based inhibition competitive inhibition non-competitive inhibition substrate inhibitor cytochromes P450 OATP1B1 OATP1B3 tyrosine kinase inhibitors drug-drug interactions migraine lasmiditan gepants monoclonal antibodies CYP1A1 CYP1A2 drug–drug interaction expression metabolism regulation drug transporter ubiquitination ixazomib DDI computational prediction in silico QSAR drug metabolism ADME CYP metabolic DDI P450 1A2 2B6 2C19 2C8 2C9 2D6 3A4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557666403321 |
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Kim Dong Hyun
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Kidney Inflammation, Injury and Regeneration
| Kidney Inflammation, Injury and Regeneration |
| Autore | Koch Benjamin |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (496 p.) |
| Soggetto non controllato |
microRNAs
transcription ischemia/reperfusion injury DSS-colitis kidney inflammation therapeutics targets CXCL13 glomerulus interleukin-6 rhabdomyolysis IgA nephropathy CREB Regulated Transcriptional Coactivators (CRTC) slit diaphragm injury xanthine oxidase Salt Inducible Kinase (SIK) acute and chronic kidney disease therapeutic target KIT-IgA score G-protein-coupled bile acid receptor (TGR5) lysophosphatidic acid glomerular injury IL-18 mesenchymal stem cells Taiwan acute kidney injury renal ischemia-reperfusion long non-coding RNA fibrosis acute kidney failure diabetic kidney diseases chronic kidney disease lncRNA LPS-binding protein endotoxemia-induced oliguric kidney injury dapagliflozin cPLA2 and COX-2 NLRP3 inflammasome CmklR1 haem chronic kidney injury omega-3 fatty acid noninvasive inflammation regulated necrosis GLP-1 receptor agonists miRNA AKI SGLT2 inhibitors diabetic kidney disease extracellular vesicles podocin type IV collagen epithelial cells nephrin 2-kidney-1-clip renal fibrosis papilla diagnostics necrosis non-coding RNAs podocyte Thy1.1 nephritis KIT assay oxidative stress conditioned medium C-reactive protein pericyte myofibroblast Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-?B) endotoxemia modifier gene polymorphism renal stem cells kidney polyploidization Class IIa Histone Deacetylases (HDAC) 2k1c molecular signaling proximal tubule arachidonic acid empagliflozin tubular injury signaling cascade signal transduction inflammatory maker niches biomarkers renal progenitors type V collagen cyclooxygenase focal segmental glomerulosclerosis inflammatory bowel disease (IBD) chronic kidney disease (CKD) allograft rejection renovascular hypertension genotype molecular mechanisms ROS prediction glomerular filtration barrier (GFB) alport syndrome scattered tubular cells long non-coding RNAs renal inflammation lysophosphatidic acid receptor cAMP Regulatory Element Binding Protein (CREB) Farnesiferol B differentiation mesenchymal stromal cells modified-MSCs kidney transplantation polyunsaturated fatty acids apoptosis type I collagen diabetes mellitus natural products lipoxygenase stem cell T cell-mediated rejection exosomes renal injury obese kidney fibrosis kidney injury cytotoxicity mesenchymal stem cell pigment nephropathy mesodermal stem cell ischemia-reperfusion cytochrome P450 renal cell carcinoma hematuria B-cell attracting chemokine microRNA chemerin glomerular basement membrane glomerular damage renal tubular cells kidney proximal tubule exosome hypertension diabetic nephropathy |
| ISBN | 3-03928-539-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910404091203321 |
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Koch Benjamin
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| MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular Mechanisms of Leaf Morphogenesis
| Molecular Mechanisms of Leaf Morphogenesis |
| Autore | Koyama Tomotsugu |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (164 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences Botany & plant sciences |
| Soggetto non controllato |
apical meristems
Class I KNOX genes compound leaves determinacy Dryopteridaceae ferns leaf development pinna development shoot development Nepenthes carnivorous plants UPLC-qToF-MS metabolomics tissue specificity cheminformatics CIN-like TCP transcription factors regulation light high temperature microRNA319 BRAHMA TIE1 transcriptional repressors TEAR1 E3 ligases Leaf angle Phytohormones crop yield BR Crosstalk Class I KNOX Elaphoglossum fronds leaf diversity leaf evolution and development megaphyll Riccia fluitans liverwort adaptation terrestrialization transformation sexual induction shoot meristem embryogenesis stem cell boundary transcription factor cytochrome P450 CUC STM LAS BLR KNAT6 KLU CYP78A5 ASYMMETRIC LEAVES2 AS2/LOB domain adaxial–abaxial polarity ETTIN/AUXIN RESPONSE FACTOR3 (ETT/ARF3) AS2 body nucleolus gene body methylation ribosomal DNA (rDNA) adaptive significance of insect galls gall-inducing insects gall formation mechanism insect effectors |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557615603321 |
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Koyama Tomotsugu
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Mycotoxins in Feed and Food Chain : Present Status and Future Concerns
| Mycotoxins in Feed and Food Chain : Present Status and Future Concerns |
| Autore | Rossi Filippo |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (224 p.) |
| Soggetto topico |
Humanities
Social interaction |
| Soggetto non controllato |
Atlantic salmon
zebrafish liquid chromatography high-resolution mass spectrometry mycotoxins phytoestrogens plant-based feed rice sterigmatocystin STC deoxynivalenol DON growing season azoxystrobin fungicide Fumonisins Fusarium spp food contamination health issues secondary metabolites Aflatoxins binding food safety biocontrol food discipline ergot alkaloids ergochromes secalonic acid cereals tetrahydroxanthones Claviceps aflatoxin mycotoxin black soldier fly BSFL Hermetia illucens S9 fraction cytochrome P450 metabolic conversion enzyme induction Alternaria mycotoxins combinatory effects combined toxicity co-occurrence bioactive compounds fungi phaseolinone LC/MS soybean charcoal rot disease root infection mechanism Fusarium species toxigenic profile mycotoxin migration sweet pepper fungal disease fumonisin human exposure maize products botryodiplodin root toxicity Macrophomina phaseolina hydroponic culture AMF1 infant formulae estimated daily intake carcinogenic risk index Monterrey (Mexico) T-2 toxin HT-2 toxin deoxynivalenol (DON) enniatin B (EnnB) size sorting unprocessed cereals |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Mycotoxins in Feed and Food Chain |
| Record Nr. | UNINA-9910557299203321 |
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Rossi Filippo
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Sulfur-Containing Marine Bioactives
| Sulfur-Containing Marine Bioactives |
| Autore | Palumbo Anna |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (140 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
propylene glycol alginate sodium sulfate
angiogenesis invasion FGF2 MMP-2 MMP-9 fucoidan fucan age-related macular degeneration VEGF oxidative stress Laminaria hyperborea brown seaweed extracts proliferation molecular weight retinal pigment epithelium thiopeptide antibiotic screening structure elucidation natural products rare actinobacteria carbohydrate sulfotransferase carrageenan cytochrome P450 galactose-6 sulfurylase red alga reproduction stages WD 40 sulfavants adjuvant immunomodulatory activity colloid aggregates algae antioxidant diatoms light nitric oxide ovothiol biofouling marine coatings anti-settlement chemical synthesis sulfated gallic acid eco-friendly Tetraselmis suecica autotrophic culture heterotrophic culture exopolysaccharides antioxidant capacity cytotoxic effects on tumor cells |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557113603321 |
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Palumbo Anna
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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