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Advances in Multiple Sclerosis Research-Series I
| Advances in Multiple Sclerosis Research-Series I |
| Autore | Matsoukas John |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (334 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
multiple sclerosis
inflammation oxidative biomarker sample size autoimmune encephalitis plasma exchange autoimmunity immunotherapeutics clinical outcomes major depression bupropion S-adenosylmethionine vitamin D3 yoga craniopharyngioma fractionated stereotactic radiation treatments sphenoid sinusitis cranial nerve-VI palsy autoimmune diseases immune thrombocytopenic purpura alemtuzumab antibodies against GluR3 peptide cognitive impairment diagnosis neuropsychological assessment short intracortical inhibition intracortical facilitation fampridine walking disability TSPAN32 tetraspanins cellular immunity memory T cells tDCS neuroimaging positron emission tomography cerebral blood flow probiotics Streptococcus thermophilus ST285 MBP83–99 peptide mannan immune modulation agonist peptide gut microbiome gut–brain axis metagenomics disease-modifying treatments MS vaccine immunomodulation carriers B cell receptor delivery methods immunotherapy monoclonal antibodies T cell receptor tolerance diagnostic markers immunoglobulins kappa free light chains antigen-specific immunotherapies tolerogenic vaccines tolerance induction central nervous system myelin peptides myelin basic protei proteolipid protein myelin oligodendrocyte glycoprotein nanotechnology drug delivery nanosystems lipids polymers vaccines nanoparticles antigen-specific immunotherapy experimental autoimmune encephalomyelitis neurodegeneration chloroquine EAE dendritic cells microglia astrocytes oligodendrocytes conformational analysis peptides altered peptide ligands NMR spectroscopy NOE-constraints molecular dynamic trimolecular complex Multiple Sclerosis early-onset adult-onset Human Leucocyte Antigens immunogenetics clinical phenotype clinical outcome therapeutics antibody detection ELISA multivalency N-glucosylated peptide epitopes peptide conjugation MOG35-55 Graphite/SiO2 electrode voltammetry HPLC MS drugs |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557385403321 |
Matsoukas John
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Advances in the Treatment of Renal Cell Carcinoma
| Advances in the Treatment of Renal Cell Carcinoma |
| Autore | Reynolds Paul |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (221 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
renal cell carcinoma
autophagy hydroxychloroquine chloroquine ROC-325 cysteine cathepsins cysteine cathepsin inhibitors lysosome renal cancer metastatic renal cell carcinoma immune-based combination therapies network meta-analysis PD-L1 predictive biomarker treatment TKIs mRCC biomarkers soluble factors immunotherapy renal cell carcinoma (RCC) sunitib resistance artesunate (ART) Traditional Chinese Medicine (TCM) growth inhibition ferroptosis reactive oxygen species (ROS) clear cell renal cell carcinoma ccRCC RCC kidney cancer evolution evolutionary trajectory metastatic second line therapy renal cell cancer immune checkpoint inhibitors tyrosine kinase inhibitors individualization genomic signature transcriptomic analysis |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557615503321 |
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Reynolds Paul
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Bioactive Phytochemicals in Health and Disease
| Bioactive Phytochemicals in Health and Disease |
| Autore | Iriti Marcello |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (264 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
quercetin
nervous system molecular signals pharmacological potential cognitive impairment micronuclei radioprotectors radiation effects melanoma PNT2 B16F10 cells Ulmus parvifolia wound healing matrix metalloproteinase transforming growth factor skin rejuvenation kaempferol naringin orientin rutin vitexin chlorogenic acid citric acid malic acid quinic acid rosmarinic acid curcumin nanocurcumin neurological disorders nanocarriers liposomes cancer diet flavonoids food supplements hormesis phytoestrogens sulforaphane resveratrol cardiovascular disease nanomedicine liposome nanoformulation RNA-dependent RNA polymerase remdesivir chloroquine SARS-CoV-2 COVID-19 spike glycoproteins Acorus calamus ethnomedicinal phytochemistry toxicity pharmacological action clinical trial neuroprotective neurological metabolic application kurarinone coronavirus HCoV-OC43 autophagy infection MRC-5 cell LC3 p62/SQSTM1 protein |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557389003321 |
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Iriti Marcello
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Botulinum Neurotoxins and Nervous System : Future Challenges for Novel Indications
| Botulinum Neurotoxins and Nervous System : Future Challenges for Novel Indications |
| Autore | Luvisetto Siro |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (368 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
botulinum toxin
limb tremors muscle selection biological effect various cell types neurotransmitter dermatology novel indication botulinum neurotoxin masticatory system maxillofacial bone dental occlusion orthognathic surgery sialorrhoea drooling salivary glands swallowing eccrine glands onabotulinumtoxin A incobotulinumtoxin A botulinum neurotoxins botulinum neurotoxin serotype A heavy chain botulinum neurotoxin serotype a heavy chain (BoNT/A HC) spinal cord injury (SCI) nerve regeneration growth associated protein 43 (GAP-43) superior cervical ganglion 10 (SCG10) neuronal processes neural regeneration Schwann cells glia spinal cord immunohistochemistry allodynia weight bearing sciatic static index walking track analysis itch SNARE VAMP mast cells compound 48/80 chloroquine spasticity botulinum toxin type A appropriate treatment Therapeutic Index pruritus antipruritic clinical experimental BoNT/A astroglia interleukins microglia TLR2 TLR4 Snap-23 pain cerebral palsy botulinum toxin A complex regional pain syndrome lumbar sympathetic ganglion block chronic pelvic pain overactive detrusor vaginism temporomandibular joint dislocation lateral pterygoid muscle botulinum toxin therapy synaptic transmission SNAP-25 epilepsy Parkinson's disease neurotransmission blockade electrical activity prion disease new indications formulation delivery refractory chronic migraine tension headache medication overuse headache prophylactic treatment XEOMIN® BTX central neuropathic pain spinal cord injury post-stroke shoulder pain mouse test Clostridium tetani botulinum antitoxin food safety abobotulinumtoxinA upper limb spasticity post-stroke early use ONTIME clinical trial human urodynamics botulinum neurotoxin-A basal ganglia interspecies differences in motor behavior mouse rat interneurons hand tremor treatment electromyography kinematics essential tremor dystonic tremor tremor movement disorders Botulinum toxin upper limb biomechanics joint biomechanics diagnostic guidance clinical decision support spastic paresis electrical stimulation stroke management rehabilitation hand |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Botulinum Neurotoxins and Nervous System |
| Record Nr. | UNINA-9910557109003321 |
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Luvisetto Siro
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Lysosomal Storage Disorders: Molecular Basis and Therapeutic Approaches
| Lysosomal Storage Disorders: Molecular Basis and Therapeutic Approaches |
| Autore | Moro Enrico |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (301 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
mucopolysaccharidosis IIIB
quantitative proteomics NAGLU lysosomes Gaucher disease bone involvement enzyme replacement therapy substrate reduction therapy Osteoimmunology RANK/RANKL Osteopontin MIP-1β mucolipidosis II sortilin TGF-beta cathepsin D Fabry disease alpha-galactosidase A endocytosis lysosome IGF2R/M6P clathrin chloroquine lysosomal diseases precision medicine pharmacological chaperones gene therapy Pompe disease lysosomal targeting autophagy muscle satellite cells rhGAA glycogen lysosomal α-glucosidase GAA biomarker Gaucher Disease Wnt/β-catenin Dkk1 Wnt3a iPSC neuronopathy Krabbe disease Twitcher mouse psychosine visual system visual cortex astrogliosis mucopolysaccharidosis type I Hurler syndrome hematopoietic stem cell transplantations animal models experimental therapies axon guidance lysosomal storage disorders neuronal circuit α-galactosidase A A4GALT globotriaosylceramide (Gb3) globotriaosyl-sphingosine (lysoGb3) pharmacological chaperone therapy exosomes endocytic pathways neurodegenerative disease Parkinson disease lysosomal storage disorder viral vectors newborn screening variant interpretation second tier test tandem mass spectrometry lyso-Gb3 dried blood spot GLA gene globotriaosylsphingosine biomarkers |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Lysosomal Storage Disorders |
| Record Nr. | UNINA-9910557545503321 |
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Moro Enrico
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery II
| Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery II |
| Autore | Spetea Mariana |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (260 p.) |
| Soggetto topico |
Research & information: general
Chemistry |
| Soggetto non controllato |
thiazole
piperazine tail-clip hot-plate acetic acid-induced writhing test opioid prodynorphin epigenetics transcription human brain morphine dosing behavior locomotor activity tolerance µ-opioid receptor DAMGO SR-17018 buprenorphine nalbuphine kappa opioid receptor agonist pruritis scratching mice TAT-HIV cholestasis chloroquine deoxycholic acid analgesic δ opioid receptor G-protein-biased agonist opioid peptide rubiscolins µ-opioid analgesics angiotensin receptors chronic pain neuropathic pain delta opioid receptor inverse agonist irreversible antagonist non-competitive antagonist molecular pharmacology free fatty acid receptors lipids opioid receptor colitis chemotype high-throughput screen allosteric modulation beta-arrestin molecular dynamics opioid receptors β-amino acids peptide synthesis receptor binding studies functional assay nociceptin/orphanin FQ receptor NOP receptor ligands nociceptin N/OFQ analgesia GPCR HS-731 peripheral opioid agonist binding selectivity molecular docking molecular dynamics simulations fluorescence cross-correlation spectroscopy (FCCS) G protein-coupled receptor (GPCR) serotonin |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Opioids and Their Receptors |
| Record Nr. | UNINA-9910576875203321 |
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Spetea Mariana
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Therapeutic Potential of Plant Secondary Metabolites in the Treatment of Diseases and Drug Development
| Therapeutic Potential of Plant Secondary Metabolites in the Treatment of Diseases and Drug Development |
| Autore | Drašar Pavel B |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (334 p.) |
| Soggetto topico |
Technology: general issues
Chemical engineering |
| Soggetto non controllato |
Cannabis sativa (Cannabis)
cannabinoids tetrahydrocannabinol (THC) cannabidiol (CBD) cannabinoid receptors (CB1 and CB2) Papaver somniferum (opium poppy) secondary metabolites ursolic acid NSCLC tumorsphere EGFR STAT3 MMP2 PD-L1 MAFLD tanshinone IIA phytochemical lipogenesis lipid accumulation LXRα malaria quinine chloroquine artemisinin onchocerciasis ivermectin moxidectin cancer vincristine vinblastine anabolic diabetes Duchenne muscular dystrophy β-ecdysone ecdysteroid ecdysterone Mas1 osteoporosis sarcopenia COVID-19 cardiometabolic diseases respiratory diseases natural product SARS-CoV-2 lung cancer United States Food and Drug Administration-approved drug natural remedy triterpenoid molecular ribbon Huisgen 1,3-dipolar cycloaddition amide bond multifunctional PEG3 derivative antimicrobial activity anti-HIV activity cytotoxicity supramolecular self-assembly phytocannabinoids cannabichromene thermos-TRPs TRPA1 α,α-dimethylheptyl effect betulinic acid BODIPY bevirimat cell-cycle fluorescent microscopy maturation inhibitor capsaicinoids endocannabinoidome microbiota overweight obesity food intake lipidomics metabolism alkaloids membrane fusion viral fusion inhibitor antiviral therapy curcumin cancer cells bioavailability curcumin derivatives curcumin analogues curcumin delivery systems natural product synthesis lignans inflammation NF-κB inhibition |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910580203103321 |
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Drašar Pavel B
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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