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Drug Metabolism/Transport and Pharmacokinetics
| Drug Metabolism/Transport and Pharmacokinetics |
| Autore | Song Im-Sook |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (232 p.) |
| Soggetto topico |
Medicine
Pharmaceutical industries |
| Soggetto non controllato |
tofacitinib
dose-dependent pharmacokinetics hepatic and intestinal first-pass effect rats catalposide in vitro human metabolism UDP-glucuronosyltransferase sulfotransferase carboxylesterase celecoxib drug–drug interaction fluorescence HPLC metabolism repaglinide HSG4112 anti-obesity agent stereoselectivity pharmacokinetics compound K protopanaxadiol (PPD) biliary excretion intestinal metabolism Carthamus tinctorius extract notoginseng total saponins comparative pharmacokinetic study large volume direct injection compatibility mechanism mertansine human hepatocytes cytochrome P450 UDP-glucuronosyltransferases sodium-glucose cotransporter 2 (SGLT2) inhibitors DWP16001 kidney distribution inhibition mode diabetes transporter-enzyme interplay influx transporter efflux transporter physiologically based pharmacokinetic model cytochrome P450 enzymes tiropramide healthy Korean subjects modeling population pharmacokinetic quercetin breast cancer resistance protein inhibitor prazosin sulfasalazine kinetic analysis food–drug interactions Caco-2 EpiIntestinal first-pass P-gp BCRP drug transporter CYP3A4 oral availability automatization drug absorption drug dosing head-and-neck cancer real-time measurements taxanes tissue engineering UHPLC-MS/MS metformin verapamil drug interaction organic cation transporter 2 renal excretion acute renal failure gentamicin cisplatin hepatic CYP3A1(23) creatinine clearance renal clearance nonrenal clearance |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557607703321 |
Song Im-Sook
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Osteoarthritis: From Molecular Pathways to Therapeutic Advances
| Osteoarthritis: From Molecular Pathways to Therapeutic Advances |
| Autore | Veronese Nicola |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (306 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
osteoarthritis
cartilage type II collagen matrix metalloproteinases MMP-13 regulation inhibitor NO synthase Interleukin-1β chondrocytes mitochondrial dysfunction mesenchimal stem cells chondrocytic commitment autophagy miRNAs hydrostatic pressure adipokines visfatin Wnt/β-catenin mechanical loading obesity microRNA oxidative stress vibrational spectroscopy near-infrared spectroscopy infrared spectroscopy Raman spectroscopy early diagnosis exercise physical activity nutraceuticals dietary supplements inflammation aging inflammaging osteochondral explant culture joint modelling pharmacological assay native tissue analysis hexosamine biosynthetic pathway cartilage trauma post-traumatic osteoarthritis O-GlcNAcylation glucosamine cell death therapy sex as a biological variable whole transcriptome sequencing molecules TGF-β SMAD2/3 signaling linker modifications meniscus proteomics MRM ECM celecoxib glucosamine sulfate chondroprotection NF-κB cytokines chemokines pathogenesis biomarker chondrocyte IL-1β IFNγ, IL-17 IL-4 RNA-Seq hypertrophy remodeling angiogenesis chondroitin collagen methylsulfonylmethane vitamin C vitamin D hyaluronic acid |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Osteoarthritis |
| Record Nr. | UNINA-9910566461503321 |
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Veronese Nicola
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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