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ABC Transporters in Human Diseases
| ABC Transporters in Human Diseases |
| Autore | Falguières Thomas |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (494 p.) |
| Soggetto topico |
Biology, life sciences
Research & information: general |
| Soggetto non controllato |
5' untranslated region
AAV ABC ABC (ATP-binding cassette) transporters ABC transporter ABC transporters ABCA subfamily ABCA7 ABCB1 ABCB11 ABCB4 ABCC2 ABCC6 ABCG2 ABCG2 genotype ABCG5 ABCG5/G8 ABCG8 adrenoleukodystrophy Alzheimer's disease amyloid-beta anticancer antifungal resistance atherosclerosis ATP-binding cassette transporter ATP-binding cassette transporter A1 (ABCA1) Aβ peptides BCRP beta-amyloid bile salts bile secretion bioinformatics blood-brain barrier breast cancer BRIC BSEP calcification cAMP cancer cellular ATP efflux chaperones cholesterol cholesterol homeostasis cis-acting elements clinico-genetic analysis competitive allele-specific PCR disease-free survival drug action drug transport dyslipidemia early-onset gout erlotinib ethnic specificity fatty acids functional divergence gall stone gene therapy generalized arterial calcification of infancy genetic variations gout HDL-C homology modeling hyperuricemia intracellular traffic intrahepatic cholestasis invasion MDR3 mechanism mechanism of action membrane protein microparticles migration molecular partners MRP1 MRP4 multidrug resistance multidrug transporter mutagenesis mutations n/a neuron next-generation sequencing NT5E P-glycoprotein peroxisome PET PFIC PFIC2 phagocytosis phosphatidylcholine phytosterol polar relay polymorphisms precision medicine proliferation pseudoxanthoma elasticum Pseudoxanthoma elasticum (PXE) pyrophosphate RAB GTPase rare variant regulatory extension regulatory insertion reverse cholesterol transport Roma serum uric acid single nucleotide polymorphism sitosterolemia SK-N-SH SNP SUA-lowering therapy substrate-binding site tariquidar taxol therapies therapy response TNAP trafficking transport transporter type 2 diabetes urate urate transporter uric acid xenosterol yeast |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910674029103321 |
Falguières Thomas
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Adipose-Derived Stromal/Stem Cells
| Adipose-Derived Stromal/Stem Cells |
| Autore | Baer Patrick C |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 online resource (286 p.) |
| Soggetto topico | Medicine and Nursing |
| Soggetto non controllato |
3D cell culture
adipocytes adipogenesis adiponectin adipose derived mesenchymal cells adipose derived stem cells adipose tissue adipose tissue-derived mesenchymal stromal/stem cells (ASCs) adipose-derived mesenchymal stem cells adipose-derived stem cells adipose-derived stromal cells adipose-derived stromal/stem cells ageing angiogenesis ankylosing spondylitis Ataxia telangiectasia Atm bio imaging bioluminescence biomaterials breast cancer cell differentiation characterization chondrogenesis collagen I colony forming unit-fibroblast conditioned medium cytokines cytomegalovirus differentiation discoidin domain-containing receptor epigenetic memory equine metabolic syndrome extracellular vesicles fat fetal bovine serum Histogel human adipose-derived stem cells human platelet lysate INF-γ integrins JAK/STAT pathway lipomas lipopolysaccharide MAPK pathway mesenchymal stem cell mesenchymal stem cells mesenchymal stromal cell mesenchymal stromal cells mesenchymal stromal/stem cells metabolic monitoring metformin migration n/a osteogenesis perineural invasion perirenal phenotype primary cilium prolonged culture protein interactions qRT-PCR regenerative medicine secretion secretory potential signaling pathway sonic hedgehog signaling spheroid culture stem cell proliferation stem cells stimulation subcutaneous fat systemic lupus erythematosus systemic sclerosis T-cells tissue of origin TLR tracking tumor microenvironment valproic acid volatile organic compounds |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557113303321 |
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Baer Patrick C
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Advanced Computational Methods for Oncological Image Analysis
| Advanced Computational Methods for Oncological Image Analysis |
| Autore | Rundo Leonardo |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (262 p.) |
| Soggetto topico | Medicine and Nursing |
| Soggetto non controllato |
3D-CNN
bone scintigraphy brain MRI image brain tumor brain tumor segmentation BRATS dataset breast cancer breast cancer detection breast cancer diagnosis breast imaging breast mass classification clutter rejection computer-aided detection contrast source inversion dataset partition deep learning dimensionality reduction ensemble classification ensemble method false positives reduction feature selection image reconstruction imaging biomarkers immunotherapy incoherent imaging interferometric optical fibers k-means clustering Kolmogorov-Smirnov hypothesis test machine learning magnetic resonance imaging mammography Mask R-CNN mass detection mass segmentation medical imaging melanoma detection microwave imaging MRgFUS n/a performance metrics principal component analysis prostate cancer proton resonance frequency shift radiomics RBF neural networks referenceless thermometry region growing risk assessment segmentation self-attention semisupervised classification shallow machine learning skull stripping statistical inference survey temperature variations texture transfer learning tumor region U-Net unsupervised machine learning Wisconsin Breast Cancer Dataset |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557353503321 |
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Rundo Leonardo
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Advanced Nanomaterials in Biomedical Application
| Advanced Nanomaterials in Biomedical Application |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2023 |
| Descrizione fisica | 1 online resource (360 p.) |
| Soggetto topico | Technology: general issues |
| Soggetto non controllato |
active targeting
adjuvants amino functionalization anti-inflammatory antibacterial effect antimicrobial antimicrobial activity bacillus subtilis bioactive glass nanoparticles biocompatibility bone regeneration breast cancer Candida albicans cell labelling cell tracking cell uptake chlorhexidine cisplatin colorimetric discrimination compressive strength controlled drug delivery coronaviruses CXC chemokine receptor 4 diagnostic nanoparticles drug delivery drug delivery systems dual-crosslinked hydrogel electrospun fibrous materials Escherichia coli fluorination FMD virus-like particles giant polyoxometalate glass ionomer cements glioblastoma glycol chitosan graphene oxide graphene oxide composites hemin HPV capsid protein hypochromic of molybdate clusters immune responses infection inflammation intestinal epithelial permeability linkers liposome magnetic nanoparticles microhardness mucus layers multidrug-resistant bacteria n/a nano-emulsion nanomaterials nanomedicine nanoparticles nanosilica nanotubes opposite color response oral drug delivery systems osmoregulatory peptide osteoimmunomodulation osteosarcoma passive targeting phenolic acid platinum-based drug platinum(IV) conjugates PLGA nanoparticles poly-3-hydroxybutyrate polyethylene glycol polyethyleneimine RNA interference silver nanoparticles squalane stem cell homing strength and elasticity targeted drug delivery targeting nanoparticles vaccines β-glucan |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910743281603321 |
| MDPI - Multidisciplinary Digital Publishing Institute, 2023 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Alzheimer Conundrum : Entanglements of Dementia and Aging / / Margaret Lock
| The Alzheimer Conundrum : Entanglements of Dementia and Aging / / Margaret Lock |
| Autore | Lock Margaret M. |
| Edizione | [Course Book] |
| Pubbl/distr/stampa | Princeton : , : Princeton University Press, , 2016 |
| Descrizione fisica | 1 online resource (323 p.) |
| Disciplina | 362.1968/31 |
| Soggetto topico |
Older people - Mental health
Brain - Aging - Molecular aspects Alzheimer's disease - Age factors |
| Soggetto non controllato |
APOE
Alois Alzheimer Alzheimer disease Alzheimer enterprise Alzheimer genetics Alzheimer prevention Alzheimer world Alzheimer's disease DNA samples DNA GWAS Huntington disease aging population aging populations aging societies amyloid cascade hypothesis amyloid cascade process behavioral changes biomarkers biosociality breast cancer clinical diagnosis clinical settings control samples dementia diagnosis divination early-onset environmental variables epidemiological research epidemiology epigenetics ethnographic research expert knowledge family practice settings gene function genes genetic testing geneticization genome-wide association studies genomics global economy late-onset localization theory medical publications memory clinics memory loss micro-medical management mild cognitive impairment molecular approach molecular biologists molecularization neuritic amyloid plaques neurofibrillary tangles neuroimaging prevention prodromal public health research throughput technology |
| ISBN |
0-691-16847-4
1-4008-4846-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Acknowledgments -- Orientations -- Making and remaking Alzheimer disease -- Striving to standardize Alzheimer disease -- Paths to Alzheimer prevention -- Embodied risk made visible -- Alzheimer genes: biomarkers of prediction and prevention -- Genome-wide association studies: back to the future -- Living with embodied omens -- Chance untamed and the return of fate -- Transcending entrenched tensions -- Portraits from the mind -- Notes -- Bibliography -- Index. |
| Record Nr. | UNINA-9910790678703321 |
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Lock Margaret M.
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| Princeton : , : Princeton University Press, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Anticancer Agents : Design, Synthesis and Evaluation
| Anticancer Agents : Design, Synthesis and Evaluation |
| Autore | Chen Qiao-Hong |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (606 p.) |
| Soggetto topico | Medicine and Nursing |
| Soggetto non controllato |
1,2,3-triazole
2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide 3,6-dibromocarbazole 4-(pyridin-4-yloxy)benzamide 5-bromoindole 5-fluorouracil ABCB1 (P-glycoprotein) actin ADME allene amides/esters androgen receptor anti-cancer activity anti-neuroinflammation anti-ovarian cancer anti-tumor anticancer anticancer activity anticancer agent anticancer agents anticancer compounds antimitotic agents antioxidant activity antiproliferative activity antiproliferative agent antitumor antitumor activity apalutamide apoptosis aromatase benzimidazole benzofuran-pyrazole benzofurans beta-lapachone bivalency breast cancer c-Met carbazole cell cycle chemical synthesis chemoresistance chrysin analogues colchiceine colchicine amide colchicine analogs colchicine sulfonamide colon cancer computational docking coumarin crystal structure cyanopyridone cytotoxic activity cytotoxic properties cytotoxicity darolutamide DFT study dihydroartemisinin dihydropyranoindole docking docking studies drug discovery drug resistance E-stereoselective enzalutamide enzyme inhibition estrone derivatives flavonoid flavonoids gemcitabine HDAC inhibitors HeLa HepG2 hydrates hydrazine IGF-1R IL-12 immune modulation indoleamine 2,3-dioxygenase inflammation inhibitor K562 kinase inhibitor MCF-7 MDM2-p53 interaction migration mimetics molecular simulation MOLT-4 multidrug resistance (MDR) reversal N-substituted pyrazoline nanoparticles natural product neuroblastoma NIH3T3 o-nitro-benzyl organosilicon compounds ortho-quinones ovarian cancer overcoming drug resistance P-glycoprotein P-MAPA PARP inhibitor PARP-1 inhibition phenylpyrazolopyrimidine photoactivatable protecting groups PI3Ks PI3Kα inhibitor PI3Kδ inhibitors polyvalency prodrug prostate cancer PROTACs protein degradation protein kinase protein-protein interactions Pyrazole pyrazolopyridine pyridotriazine quinazolin-4(3H)-one quinazolin-4(3H)-thione regioselective salinomycin Schiff base SILA-409 (Alis-409) SILA-421 (Alis-421) Src substituted pyridine synergy synthesis Talazoparib tanshione IIA taxoids thiazolidinone Thienopyrimidine thienopyrimidinone thiocolchicine thiopene thioxotriazopyridine TLR signaling topoisomerase II inhibitor triazolothiadiazine triple-negative breast cancer tryptophan metabolism tubulin inhibitors tumor specificity urea virtual screening xanthones yeast-based assays zampanolide βIII-tubulin |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Anticancer Agents |
| Record Nr. | UNINA-9910557129103321 |
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Chen Qiao-Hong
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Anticancer Drugs 2021
| Anticancer Drugs 2021 |
| Autore | Meegan Mary J |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (594 p.) |
| Soggetto topico |
Chemistry
Research & information: general |
| Soggetto non controllato |
1,2,3-triazole
1,3,4-oxadiazole 3-amino-4'-guanidino 3,4'-bis-guanidino 5-fluoruracil 7-deaza-4'-thioadenosine derivatives acetamide adamantane ADC (antibody-drug conjugate) age alkylated anticancer anticancer activity anticancer agents apoptosis apoptosis induction aromatase inhibitor Bcl-2 inhibitors benzenesulfonamides benzimidazole BRAF breast cancer cancer cancer cell viability cancer vaccine CAR (chimeric antigen receptor) cardiotoxicity carvedilol cell cycle analysis chalcone chalcones colony formation combretastatin A-4 concentration-guided dosing covalent binding CovDock cumulative dose cyclophosphamide cytotoxic activity cytotoxic agents cytotoxicity designed multiple ligand diphenyl ether DNA fragmentation docking doxazosin drug efflux dual inhibitors dual-targeting molecule EGFR ELISA enantioselective synthesis entrectinib exportin-1 gastric adenocarcinoma generic product H1299 HDAC inhibitors HER2 heterocyclic compound histopathology HL-60 HT-29 cells hybrid compounds hybrid molecule hydrazide derivatives imidazoles Imiquimod immunotherapy in vitro in vivo indazole Indole-based analogues inflammation interleukin-6 intramolecular hydrogen bond isolation kidney larotrectinib letrozole MD simulations MDA-MB-231 cells mechanism prediction miR-21 mitoxantrone model informed dosing MTT cytotoxic assay MUC1 MUC16 mucin multi-kinase inhibitor multidrug resistance n/a NaMSA nitrogen scaffolds NTRK nucleoside oxidative stress patent review pemetrexed phenstatin phenyl pyridyl ether physiologically based pharmacokinetics protein kinase inhibitors resin acid solid/lipid nanoparticles sorafenib STAT inhibitors synthesis TDP1 testis thieno[2,3-d][1,2,3]triazine thiourea thymidylate synthase tissue-agnostic Toll-Like Receptor toxicity Trk Trk fusion trypan blue assay tryptophanol tubulin polymerisation inhibitor tumor spheroids tyrosil-DNA-phosphodiesterase 1 urinary bladder USFDA xanthone |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910576874303321 |
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Meegan Mary J
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Anticancer Inhibitors
| Anticancer Inhibitors |
| Autore | Fantacuzzi Marialuigia |
| Pubbl/distr/stampa | Basel, : MDPI Books, 2022 |
| Descrizione fisica | 1 electronic resource (216 p.) |
| Soggetto topico |
Research & information: general
Chemistry |
| Soggetto non controllato |
breast cancer
tamoxifen LY294002 synergism apoptosis cell cycle tea (Camellia sinensis) flowers BTFS A2780/CP70 ovarian cancer cells S phase cell cycle arrest nicotinamide phosphoribosyltransferase NAD+ biosynthesis inhibitor azacyclohexane anticancer drug drug design enthalpy effect NSCLC Cathepsin K cell proliferation cell migration cell invasion mTOR isatin-hydrazones cytotoxicity CDK2 inhibitor ATP competitive inhibitor ADME analysis receptor tyrosine kinases protein-protein interactions protein engineering directed evolution angiogenesis binding affinity agonistic activity saponins phytochemicals tea (Camellia sinensis) flower ovarian cancer autophagy ZMYND8 tumorigenesis epigenetic regulation pro-oncogenic effects tumor suppression tacrine-coumarin derivatives DNA topoisomerases I, II lung carcinoma cells A549 chemotherapy prodrug drug targeting overexpressed enzymes ADC ADEPT GDEPT LEAPT PROTAC cyclin-dependent kinase cancer resistance small molecule inhibitors PROTACs statins pancreatic cancer DNA microarray pitavastatin cerivastatin simvastatin fluvastatin atorvastatin pravastatin HMG-CoA reductase inhibitors |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910595069203321 |
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Fantacuzzi Marialuigia
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| Basel, : MDPI Books, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Anticancer Properties of Natural and Derivative Products
| Anticancer Properties of Natural and Derivative Products |
| Autore | Lupiáñez José Antonio |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (312 p.) |
| Soggetto topico | Research and information: general |
| Soggetto non controllato |
1,3-dipolar cycloaddition
3-hydroxy-β-ionone actin cytoskeleton Adenosma bracteosum AKT/PI3K signaling pathway anti-cancer anti-inflammatory agent anti-proliferative activity anticancer activity anticancer agent antioxidant antioxidant activity antioxidant enzymes apoptosis autophagy betulin glycoconjugates betulinic acid bioactive compounds breast cancer cancer caspase-3 Caveolin-1 cell cycle cell line chemoprevention chemotherapy click chemistry complementary medicine cytotoxicity danthron DNA DPPH Elaeagnus angustifolia emodin EMT extract GC-MS gingival fibroblasts glioblastoma (GBM) grapes hepatocellular carcinoma (HCC) human hepatocarcinoma HepG2 cells hypericin in vivo interaction isolated compounds lactucopicrin (LCTP) lung metastases maslinic acid medicinal mushrooms melanoma metabolites migration activity Moringa oleifera n/a natural compounds natural extract natural photosensitive compounds natural product NF-κB Olea europaea L. oleanolic acid oral cancer oxidative stress p62/SQSM1 photodynamic therapy photosensitiser Pogostemon cablin (PPa extract) proliferation quinizarin rhodamine B ROS level ROS levels squamous cell carcinoma synergism temozolomide (TMZ) therapeutic triglyceride tormentic acid total flavonoid content total phenolic content triterpenoic acid uvaol wine xenograft study |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557370303321 |
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Lupiáñez José Antonio
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Antitumor and Anti-HIV Agents from Natural Products
| Antitumor and Anti-HIV Agents from Natural Products |
| Autore | Nakagawa-Goto Kyoko |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 online resource (338 p.) |
| Soggetto topico | Research & information: general |
| Soggetto non controllato |
acute toxicity
allyl isothiocyanate Angelica dahurica anti-HIV antiangiogenic antioxidants antiproliferation antiproliferative activity antiretroviral agents antitumor activity apoptosis Artemisia absinthium L. aspidosperma-type benzyl isothiocyanate bladder cancer Bousigonia mekongensis BRAF inhibitor breast cancer butanolides caffeic acid cancer cancer multidrug resistance cancer stem cell Carpesium divaricatum cell cycle cell cycle arrest cervical cancer chemistry chemoprevention cisplatin coumarins curcumin analog cytotoxicity delcosine delpheline diterpenoid alkaloids DOTA drug development drug-drug interaction epithelial-to-mesenchymal transition essential oil flavonoids G2/M phase cell cycle arrest HaCaT cells HEF cell line hepatocellular carcinoma hepatoma cells Hernandia nymphaeifolia human tumor cell lines human tumor cells inflammation Ivalin kobusine lignan glycosides lipojesaconitine marine metabolites matrix metalloproteinase medicine melanoma melanoma and breast cancer cell line Mentha aquatica var. Kenting Water Mint metastasis mitochondria-mediated apoptosis monoterpenoid indole alkaloids natural agents natural phaeosphaeride A natural products NF-κB oral squamous cell carcinoma cells oxidative stress oxypeucedanin P-glycoprotein p53 phenethyl isothiocyanate phenolic acid pseudokobusine pterostilbene quercetin reactive oxygen species resveratrol SK-Hep-1 sulforaphane tamoxifen taxol total phenolic content transforming growth factor-β1 triterpenoids tubulin inhibitor tumor suppression two-stage skin carcinogenesis ursolic acid β-lapachone |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557504803321 |
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Nakagawa-Goto Kyoko
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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