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Paediatric Formulation: Design and Development
| Paediatric Formulation: Design and Development |
| Autore | Denora Nunzio |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (205 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
dasatinib
Duchenne muscular dystrophy cyclodextrin inclusion complex phase solubility studies paediatric age liquid formulation tumorspheres retinoblastoma topotecan penetration confocal microscopy poorly water soluble drug solubility enhancement grinding spray congealing neglected tropical diseases polymorph Norvir® ritonavir poorly soluble compound pediatric palatability assessment bioavailability flavor profile Interleukin-1 anakinra canakinumab innovative biotechnologies autoinflammatory disease Kawasaki disease systemic juvenile idiopathic arthritis personalized medicine child pediatrics neonates formulation product development formulation development oral parenteral topical inhaled intra nasal biopharmaceutics administration excipient NICU device medication error dosage form modified release drug delivery paediatric formulation development paediatric dosage forms chronic myeloid leukemia tyrosine kinase inhibitors pediatric age imatinib nilotinb ponatinib Orodispersible formulation pyrazinamide pediatric drug delivery tuberculosis design of experiments children edible films development design paediatric age-related palatable taste-masking acceptable |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Paediatric Formulation |
| Record Nr. | UNINA-9910557304003321 |
Denora Nunzio
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Regional Intestinal Drug Absorption : Biopharmaceutics and Drug Formulation
| Regional Intestinal Drug Absorption : Biopharmaceutics and Drug Formulation |
| Autore | Gonzalez-Alvarez Maria Isabel |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (238 p.) |
| Soggetto topico |
Medicine
Pharmaceutical industries |
| Soggetto non controllato |
bioequivalence
Biopharmaceutics Classification System in vitro dissolution test pravastatin oral absorption in silico modeling GastroPlus Phoenix WinNonlin pharmacokinetics clinical studies ibuprofen manometry gastrointestinal mechanistic modeling PBPK PBBM disintegration dissolution enteric-coated ICH quality control regional intestinal permeability permeation enhancers absorption-modifying excipients oral peptide delivery intestinal perfusion pharmaceutical development controlled release drug product biopharmaceutics classification system drug solubility drug permeability location-dependent absorption segregated flow intestinal model (SFM) traditional model (TM) route-dependent intestinal metabolism first-pass effect drug-drug interactions DDI in vitro in vivo extrapolations IVIVE zero-order absorption first-order absorption combined zero- and first-order absorption transit compartment absorption model in situ perfusion microdevices shape mucoadhesion colon absorption nutrient digestion nutrient absorption gastrointestinal hormone postprandial glycaemia energy intake region of the gut obesity type 2 diabetes Franz–PAMPA BCS drugs biomimetic membrane Franz cell passive drug transport BCS class IV drugs segmental-dependent intestinal permeability intestinal absorption oral drug delivery biopharmaceutics physiologically-based pharmacokinetic (PBPK) modeling furosemide intestinal permeability human colon carcinoma cell layer (Caco-2) hierarchical support vector regression (HSVR) drug absorption drug solubility/dissolution regional/segmental-dependent permeability and absorption |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Regional Intestinal Drug Absorption |
| Record Nr. | UNINA-9910566462603321 |
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Gonzalez-Alvarez Maria Isabel
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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