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A Themed Issue in Honor of Professor Raphael Mechoulam: The Father of Cannabinoid and Endocannabinoid Research
| A Themed Issue in Honor of Professor Raphael Mechoulam: The Father of Cannabinoid and Endocannabinoid Research |
| Autore | Maccarrone Mauro |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (236 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences Biochemistry |
| Soggetto non controllato |
cannabinoid
MRI-1867 hybrid ligand CB1 receptor antagonist iNOS inhibitor rimonabant intracerebroventricular administration alcohol craving two-bottle paradigm drinking in the dark N-acyltransferase anandamide endocannabinoid phospholipase A2 cannabichromene cannabidiolic acid cannabidivarin cannabidivarinic acid phytocannabinoids tetrahydrocannabivarin 4'-fluoro-cannabidiol cannabinoid tetrad elevated plus maze catalepsy marble bury HUF-101 equilibrative nucleoside transporter CB1 biased signaling functional selectivity G-protein β-arrestin cannabigerol anti-inflammatory obesity cannabinoid receptor 2 (CB2R) microglia inflammaging memory lipofuscin aminoalkylindole allodynia antinociception cannabinoid receptor CP55940 JWH-018 K2 pravadoline spice WIN55212-2 type 1 cannabinoid receptor CB1 cholesterol hippocampus frontal cortex synaptosomes rescue model anti-CB1 antibody cannabinoids GPR55 receptors VCE-006.1 chromenopyrazole Parkinson's disease 6-hydroxydopamine lipopolysaccharide amyotrophic lateral sclerosis mSOD1 mice TDP-43 transgenic mice PPARs gut microbiome intestine ghrelin LEAP2 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Themed Issue in Honor of Professor Raphael Mechoulam |
| Record Nr. | UNINA-9910566470103321 |
Maccarrone Mauro
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Monitoring endogenous GPCRs: lessons for drug design
| Monitoring endogenous GPCRs: lessons for drug design |
| Autore | Dominique Massotte |
| Pubbl/distr/stampa | Frontiers Media SA, 2015 |
| Descrizione fisica | 1 electronic resource (134 p.) |
| Collana | Frontiers Research Topics |
| Soggetto non controllato |
opioid receptors
G protein coupled receptors CGamP mice FLIM fluorescent knock-in mice receptor heteromerization Endogenous receptors cannabinoid receptors biased signaling Opiate tolerance |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Monitoring endogenous GPCRs |
| Record Nr. | UNINA-9910137094503321 |
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Dominique Massotte
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| Frontiers Media SA, 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery
| Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery |
| Autore | Spetea Mariana |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (358 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
opioid receptors
neurokinin-1 receptor peptide synthesis receptor binding studies functional assay writhing test tolerance Leu-enkephalin beta-arrestin mu opioid receptor delta opioid receptor biased signaling DADLE ischemia plasma stability morphinan BNTX δ opioid receptor antagonist 1H-NMR experiments mechanism elucidation peripheral antinociception 14-methoxycodeine-6-O-sulfate codeine-6-O-sulfate opioid peptides and peptidomimetics DAMGO DALDA [Dmt1]DALDA KGOP01 binding molecular docking structure-activity relationships β2-amino acids β2-Homo-amino acids µ-opioid receptor opioid peptides TAPP racemic synthesis of β2-amino acids peripheral µ-opioid receptors analgesia peripheral analgesic tolerance dysbiosis opioid bifunctional ligands (−)-N-phenethylnorhydromorphone analogs [35S]GTPgammaS assay forskolin-induced cAMP accumulation assays β-arrestin recruitment assays MOR and DOR agonists respiratory depression bias factor molecular modeling & simulation δ opioid receptor NTI derivative sulfonamide inverse agonist neutral antagonist agonist opioids mu receptor opioid side effects biased agonism partial agonism zerumbone chronic constriction injury (CCI) allodynia hyperalgesia potassium channels over-the-counter drugs misuse abuse opioid drugs pharmacology codeine dihydrocodeine loperamide opioid peptide macrocyclic tetrapeptide multifunctional ligands kappa opioid receptor analgesics opioid liabilities μ opioid receptor receptor model biased ligands dependence pain therapy neonatal opioid withdrawal syndrome naltrexone 6β-naltrexol buprenorphine G-protein bias arrestin recruitment respiration mitragynine heteromer internalization primary hippocampal culture lysosomes µ opioid receptor molecular dynamics docking interaction fingerprints biased agonists SR-17018 PZM21 morphine fentanyl diphenethylamines design and synthesis partial agonist biased agonist antagonist binding affinity selectivity |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Opioids and Their Receptors |
| Record Nr. | UNINA-9910557108003321 |
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Spetea Mariana
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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