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Innate Immunity Pathways in Autoimmune Diseases
| Innate Immunity Pathways in Autoimmune Diseases |
| Autore | Zouali Moncef |
| Pubbl/distr/stampa | Frontiers Media SA, 2019 |
| Descrizione fisica | 1 electronic resource (124 p.) |
| Soggetto topico |
Medicine
Immunology |
| Soggetto non controllato |
toll-like receptor
dendritic cells innate-like B cells extracellular vesicle semaphorin lupus arthritis calcium-dependent peptidyl-arginine deiminase |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557702903321 |
Zouali Moncef
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| Frontiers Media SA, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Matrix Metalloproteinase
| Matrix Metalloproteinase |
| Autore | Ågren Magnus S |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (262 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
hemagglutinin-B
transwell co-cultures matrix metalloproteinases TNF-α matrix metalloproteinase peritoneal mesothelial cell gastric cancer metastatic dissemination MT4-MMP cancer diseases aggrecan aggrecanase ADAMTS cartilage arthritis MMP-2 MMP-9 inhibitor allodynia caspase-3 neuropathic pain dorsal root ganglion spinal nerve ligation tuberculosis tuberculous meningitis HIV-TB-associated IRIS extracellular matrix breakdown adult pediatric lung central nervous system matrix-metalloproteinase monocytes inflammation phagocytosis apoptosis blood sampling anticoagulants high-molecular-weight heparin IL-16 sICAM-1 IL-8 T cells a disintegrin and metalloproteinase EMMPRIN CD147 ectodomain shedding MMPs PTMs glycosylation phosphorylation glycosaminoglycans interleukin IL-6 IL-11 trans-signaling metalloproteases ADAM MMP meprin matrix metalloproteinases (MMPs) protease signaling invasion chemokine cytokine proteomics interferon Agkistrodon venom metalloproteinase fibrinogen antithrombotic metabolomics extracellular matrix cytokines proteinases interstitial collagens wound healing |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557717203321 |
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Ågren Magnus S
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Peptides for Health Benefits 2019 : Volume 2
| Peptides for Health Benefits 2019 : Volume 2 |
| Autore | Hernández-Ledesma Blanca |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (342 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
antihypertensive peptides
functional food food-derived fermentation Chlorella sorokiniana in silico BIOPEP-UWM database proteomics bioactive peptides nano liquid chromatography tandem mass spectrometry (nanoLC-nanoESI MS/MS) apolipoprotein E amyloid fibrils Alzheimer's disease Αβ oligomer amyloid Aβ peptide glioma platelets antiproliferative assay conjugation docetaxel doxorubicin extra domain B fibronectin Fmoc/tBu peptide-drug conjugate prostate cancer solid-phase synthesis targeting acrylamide enteric nervous system galanin pig stomach formyl peptide receptors ligands diseases polymicrobial biofilms intragenic antimicrobial peptide Hs02 Pseudomonas aeruginosa Staphylococcus aureus osteostatin arthritis inflammation immune response cartilage destruction bone erosion collagen hydrolysis enzyme molecular weight sheepskin NF-κB dry-cured pork ham angiotensin I converting enzyme endothelial dysfunction molecular blind docking Lactoferricin B (Lfcin B) Histatin-5 antimicrobial peptides (AMPs) antifungal activity proteome microarray synergy temporin MRSA antimicrobial peptide human keratinocytes pseudin-2 antisepsis, peptide antibiotics neurotensin asthma T cells In situ tetramer staining MHC tetramer antigen-specific confocal microscopy fresh tissue velvet antler alcalase hydrolysate antioxidant peptide protection ability oxidative stress Crassostrea angulata pidotimod CXCR3 monocyte migration PI3K/Akt pathway T cell immunomodulant host defense peptides membrane activity copper piscidins Clostridioides difficile prolactin-releasing peptide GPR10 RF-amide peptides food intake regulation energy expenditure neuroprotection signaling gender differences dyslipidemia obesity hyperglycemia pulmonary emphysema endothelial progenitor cells angiogenic precursor cells pegylated glucagon-like peptide 1 and endothelial regeneration miiuy croaker (Miichthys miiuy) swim bladder FPYLRH antioxidant activity cytoprotective effect antimicrobial peptides antimicrobial resistance AMP identification and design biosynthesis mode of action physico-chemical properties therapeutic potential insects Cecropins Cec-analogs MDR infectious diseases airway inflammation non-atopic asthma hybrid peptide pro-inflammatory cytokines sPLA2 MDA database proteolysis SMILES code foods nutrition chronic diseases nutraceuticals peptide vaccine immune checkpoint inhibitor humanized mouse cancer antigen immune suppression vasoactive intestinal peptide VPAC1 receptor VPAC2 receptor rheumatic diseases inflammatory bowel disease central nervous system diseases type 1 diabetes Sjögren's syndrome biomarkers human antimicrobial peptides defensins cathelicidins anti-inflammatory pro-inflammatory peptide combinatorial library library design screening mutagenesis prolyl-hydroxyproline (Pro-Hyp) hydroxyprolyl-glycine (Hyp-Gly) collagen peptide fibroblasts fetal bovine serum (FBS) AMD CNV VEGFR1 multimeric peptides oral delivery colorectal cancer cancer stem cells chemoprevention bioactive peptide lunasin ACE-inhibitory activity whey peptides molecular docking hypertension antibiotic resistance cystic fibrosis cryptides anti-biofilm peptides synergistic effects |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Peptides for Health Benefits 2019 |
| Record Nr. | UNINA-9910557492903321 |
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Hernández-Ledesma Blanca
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Peptides for Health Benefits 2019 : Volume 1
| Peptides for Health Benefits 2019 : Volume 1 |
| Autore | Hernández-Ledesma Blanca |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (340 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
antihypertensive peptides
functional food food-derived fermentation Chlorella sorokiniana in silico BIOPEP-UWM database proteomics bioactive peptides nano liquid chromatography tandem mass spectrometry (nanoLC-nanoESI MS/MS) apolipoprotein E amyloid fibrils Alzheimer's disease Αβ oligomer amyloid Aβ peptide glioma platelets antiproliferative assay conjugation docetaxel doxorubicin extra domain B fibronectin Fmoc/tBu peptide-drug conjugate prostate cancer solid-phase synthesis targeting acrylamide enteric nervous system galanin pig stomach formyl peptide receptors ligands diseases polymicrobial biofilms intragenic antimicrobial peptide Hs02 Pseudomonas aeruginosa Staphylococcus aureus osteostatin arthritis inflammation immune response cartilage destruction bone erosion collagen hydrolysis enzyme molecular weight sheepskin NF-κB dry-cured pork ham angiotensin I converting enzyme endothelial dysfunction molecular blind docking Lactoferricin B (Lfcin B) Histatin-5 antimicrobial peptides (AMPs) antifungal activity proteome microarray synergy temporin MRSA antimicrobial peptide human keratinocytes pseudin-2 antisepsis, peptide antibiotics neurotensin asthma T cells In situ tetramer staining MHC tetramer antigen-specific confocal microscopy fresh tissue velvet antler alcalase hydrolysate antioxidant peptide protection ability oxidative stress Crassostrea angulata pidotimod CXCR3 monocyte migration PI3K/Akt pathway T cell immunomodulant host defense peptides membrane activity copper piscidins Clostridioides difficile prolactin-releasing peptide GPR10 RF-amide peptides food intake regulation energy expenditure neuroprotection signaling gender differences dyslipidemia obesity hyperglycemia pulmonary emphysema endothelial progenitor cells angiogenic precursor cells pegylated glucagon-like peptide 1 and endothelial regeneration miiuy croaker (Miichthys miiuy) swim bladder FPYLRH antioxidant activity cytoprotective effect antimicrobial peptides antimicrobial resistance AMP identification and design biosynthesis mode of action physico-chemical properties therapeutic potential insects Cecropins Cec-analogs MDR infectious diseases airway inflammation non-atopic asthma hybrid peptide pro-inflammatory cytokines sPLA2 MDA database proteolysis SMILES code foods nutrition chronic diseases nutraceuticals peptide vaccine immune checkpoint inhibitor humanized mouse cancer antigen immune suppression vasoactive intestinal peptide VPAC1 receptor VPAC2 receptor rheumatic diseases inflammatory bowel disease central nervous system diseases type 1 diabetes Sjögren's syndrome biomarkers human antimicrobial peptides defensins cathelicidins anti-inflammatory pro-inflammatory peptide combinatorial library library design screening mutagenesis prolyl-hydroxyproline (Pro-Hyp) hydroxyprolyl-glycine (Hyp-Gly) collagen peptide fibroblasts fetal bovine serum (FBS) AMD CNV VEGFR1 multimeric peptides oral delivery colorectal cancer cancer stem cells chemoprevention bioactive peptide lunasin ACE-inhibitory activity whey peptides molecular docking hypertension antibiotic resistance cystic fibrosis cryptides anti-biofilm peptides synergistic effects |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Peptides for Health Benefits 2019 |
| Record Nr. | UNINA-9910557631703321 |
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Hernández-Ledesma Blanca
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Plant Natural Products for Human Health
| Plant Natural Products for Human Health |
| Autore | Zhang Hongjie |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (514 p.) |
| Soggetto non controllato |
PhGs
bitter orange immunomodulator A549 cells bergapten triptolide BMP/Smad phytochemicals antioxidant enzymes kumquat MTT assay HepaRG cells human health nanoparticles dendritic cells drug discovery biofilm catechin antitubercular activity Panax notoginseng saponins animals mouse-hair growth A? curcumin WNT/?-catenin copaiba AD Plasmodium parasites traditional medicine procyanidin A2 PET inhibition rheumatoid arthritis cannabinoid type 1 receptor iridoids inflammatory bowel disease acute liver injury human-hair-follicle dermal papilla cells Neuroprotective dihydromyricetin AMPK thromboembolism ginseng drug design and development endoplasmic reticulum stress mitogen-activated protein kinase Nrf2 prenylated flavonoids inflammation preclinical studies plants dietary supplements Glycyrrhiza uralensis aspirin Tripterygium wilfordii P. eryngii reperfusion ethnopharmacology glucans innovation hpatoprotection hinokitiol phytocannabinoid antistaphylococcal activity Shh/Gli green tea sesquiterpenoids adjuvant-induced arthritis yuzu hepatotoxicity p53/Bax Keap1 nuclear factor-kappaB oxidative stress pharmacokinetic study cinnamamides toxicity APAP Astragali Radix computational softwares plant natural product onion anti-malaria activity lipogenesis bleeding time diterpenoids Penthorum chinense Pursh myocardial hypertrophy automation adjuvant grapefruit melanoma cell essential oil sweet orange Amadori rearrangement compounds heme oxygenase global health calorie restriction bergamot liposomes EGCG celastrol herb–drug interactions cannabigerol anti-inflammation OH· free radical molecular targets gluconeogenesis microbiome SIRT1 fucoidan heart PC12 cells acetaminophen omics time-kill assay arthritis lychee seed bioinformatics structure–activity relationship precision medicine orange petitgrain immune modulation antiproliferation flavonoids scoulerine oleoresin triterpenic acids Cannabis sativa NAFLD biological activity differentiation oxygen consumption rate mitochondrial bioenergetics neroli apoptosis targeted delivery platelet activation protein kinase heat-process hepatic steatosis hyperglycemia natural products lemon genistein neuroinflammation astragaloside IV cytoxicity flavonoid paracetamol medicinal plants insulin resistance resveratrol mandarin garlic TGF-? morin hydrate sirtuin 3 MMPs gomisin N lime Ziziphus jujuba antifungal activity ischemia migration caspases small molecules |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346688103321 |
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Zhang Hongjie
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The queen of fats [[electronic resource] ] : why omega-3s were removed from the Western diet and what we can do to replace them / / Susan Allport
| The queen of fats [[electronic resource] ] : why omega-3s were removed from the Western diet and what we can do to replace them / / Susan Allport |
| Autore | Allport Susan |
| Pubbl/distr/stampa | Berkeley, CA ; ; London, : University of California Press, 2006 |
| Descrizione fisica | 1 online resource (233 p.) |
| Disciplina | 612.397 |
| Collana | California studies in food and culture |
| Soggetto topico |
Essential fatty acids in human nutrition
Omega-3 fatty acids - Health aspects Omega-3 fatty acids - Research - History |
| Soggetto non controllato |
africa
america arthritis brain function california cancer commercial food processing diet and nutrition eating fats fats fatty acids food and culture food industry food nutrition food science greenland health and wellness health nuts health healthy fats heart disease inflammatory diseases israel metabolic disorders metabolism nonfiction nutrients obesity omega 3 fats omega 3s popular science vital nutrients western diets western nutrition |
| ISBN |
1-282-36039-6
9786612360398 0-520-94132-2 1-60129-394-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Front matter -- Contents -- 1. What's for Dinner? -- 2. A Trip to Greenland -- 3. How the Omegas Got Their Name -- 4. Monsieur Cholesterol -- 5. Fishy Fats -- 6. Tree Lard and Cow Oil -- 7. The Chemist in the Kitchen -- 8. Out of Africa . . . -- 9. . . . and into the Membrane -- 10. Where Have All the Omega-3s Gone? -- 11. The Speed of Life -- 12. Putting Omega-3s Back into Your Food Supply -- 13. The Proof Is in the Pudding -- Time Line -- Glossary -- Notes -- Acknowledgments -- Index |
| Record Nr. | UNINA-9910784410203321 |
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Allport Susan
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| Berkeley, CA ; ; London, : University of California Press, 2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The queen of fats [[electronic resource] ] : why omega-3s were removed from the Western diet and what we can do to replace them / / Susan Allport
| The queen of fats [[electronic resource] ] : why omega-3s were removed from the Western diet and what we can do to replace them / / Susan Allport |
| Autore | Allport Susan |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Berkeley, CA ; ; London, : University of California Press, 2006 |
| Descrizione fisica | 1 online resource (233 p.) |
| Disciplina | 612.397 |
| Collana | California studies in food and culture |
| Soggetto topico |
Essential fatty acids in human nutrition
Omega-3 fatty acids - Health aspects Omega-3 fatty acids - Research - History |
| Soggetto non controllato |
africa
america arthritis brain function california cancer commercial food processing diet and nutrition eating fats fats fatty acids food and culture food industry food nutrition food science greenland health and wellness health nuts health healthy fats heart disease inflammatory diseases israel metabolic disorders metabolism nonfiction nutrients obesity omega 3 fats omega 3s popular science vital nutrients western diets western nutrition |
| ISBN |
1-282-36039-6
9786612360398 0-520-94132-2 1-60129-394-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Front matter -- Contents -- 1. What's for Dinner? -- 2. A Trip to Greenland -- 3. How the Omegas Got Their Name -- 4. Monsieur Cholesterol -- 5. Fishy Fats -- 6. Tree Lard and Cow Oil -- 7. The Chemist in the Kitchen -- 8. Out of Africa . . . -- 9. . . . and into the Membrane -- 10. Where Have All the Omega-3s Gone? -- 11. The Speed of Life -- 12. Putting Omega-3s Back into Your Food Supply -- 13. The Proof Is in the Pudding -- Time Line -- Glossary -- Notes -- Acknowledgments -- Index |
| Record Nr. | UNINA-9910823943403321 |
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Allport Susan
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| Berkeley, CA ; ; London, : University of California Press, 2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Research of Pathogenesis and Novel Therapeutics in Arthritis
| Research of Pathogenesis and Novel Therapeutics in Arthritis |
| Autore | Tang Chih-Hsin |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (366 p.) |
| Soggetto non controllato |
receptor activator of nuclear factor ?B
infliximab tripterine triptolide osteoblast tumor necrosis factor-alpha synovial cell anti-arthritis biosimilars Epstein-Barr virus cytokines SOX9 parathyroid hormone nitric oxide rat etanercept angiogenesis glycosylation mitogen activated protein kinase Th9 lymphocytes rheumatoid arthritis IL-6 clodronate bone erosion mesenchymal stem cells collagen-induced arthritis biological gene expression inflammatory arthritis osteoarthritis fraxinellone nuclear factor kappa B messenger RNA inflammation miRNA disease-modifying adipokines WNT glycoprotein 42 miR-199a-5p proliferation next-generation sequencing collagen osteoarthritis (OA) experimental arthritis bone morphogenetic protein TNF-? computational modeling basic research osteoclast therapeutics certolizumab pegol chondrocytes progenitor cells adjuvant arthritis adalimumab triterpenoid sclareol TNF? fibroblast growth factor 2 antibodies osteoblasts molecular pathology Th17 immunology obesity visfatin articular cartilage autoimmune biomarkers celastrol MAPK disease pathways IL1? arthritis bioinformatics anticitrullinated peptide antibodies drug delivery system antagonists shared epitope pathology SMA- and MAD-related protein small-molecule inhibitor transforming growth factor ? mice golimumab spinal fusion antirheumatic drug early osteoarthritis stem cell rheumatoid factor therapeutic antibody bisphosphonate osteoclastogenesis interleukin spondyloarthropathies clinical translation therapy Traditional Chinese medicine chemokines structure cell signaling microRNA |
| ISBN | 3-03897-066-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346843303321 |
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Tang Chih-Hsin
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Systemic Autoinflammatory Diseases-Clinical Rheumatic Challenges
| Systemic Autoinflammatory Diseases-Clinical Rheumatic Challenges |
| Autore | Feist Eugen |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (266 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
gout
febuxostat colchicine hepatotoxicity prophylaxis myositis inflammatory idiopathic myopathy dysphagia aspiration pneumonia immunoglobulin G4-related orbital disease (IgG4-ROD) orbital lymphoma (OL) computed tomography (CT) Hounsfield unit imaging autoinflammation arthritis CAPS FCAS MWS CINCA NOMID hearing loss urticarial-like rash autoinflammatory disease anti-IL-1 treatment rheumatoid arthritis synovitis neoplasms edema inflammation new genetic variant monogenic autoinflammatory syndrome diagnostic delay anakinra damage index genetic inheritance personalized therapy Interleukin-1 autoinflammatory diseases FMF coronavirus SARS-CoV-2 antibody response adult-onset Still's disease autoinflammatory disorder systemic-onset juvenile idiopathic arthritis haemophagocytic lymphohistiocytosis macrophage activation syndrome IFN-γ JAK inhibitor proliferation DNA damage repair γH2AX PBMCs T lymphocytes proteasome autoimmune proteasome-associated autoinflammatory syndrome therapy IL-1 inhibitors NGS SURF spondyloarthritis human leukocyte antigen undifferentiated enthesitis and/or arthritis ASAS classification criteria clinical management canakinumab cytokines |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557349503321 |
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Feist Eugen
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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When walking fails [[electronic resource] ] : mobility problems of adults with chronic conditions / / Lisa I. Iezzoni
| When walking fails [[electronic resource] ] : mobility problems of adults with chronic conditions / / Lisa I. Iezzoni |
| Autore | Iezzoni Lisa I |
| Pubbl/distr/stampa | Berkeley, : University of California Press |
| Descrizione fisica | 1 online resource (385 p.) |
| Disciplina | 362.4/3/0973 |
| Collana | California/Milbank books on health and the public |
| Soggetto topico |
Movement disorders
Chronic diseases - Complications |
| Soggetto non controllato |
american adults
arthritis back problems chronic conditions chronic health conditions diabetes disabling conditions emotional conditions health care system health policy healthy society heart disease improve mobility lung disease medicine mobility difficulties mobility problems nonfiction personal experiences physical disabilities policymakers public health quality of life social relationships societal issues textbooks walking |
| ISBN |
1-59875-002-X
9786612762901 0-520-93712-0 1-282-76290-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Front matter -- Contents -- Illustrations and Tables -- Foreword -- Acknowledgments -- Preface -- 1. Mobility Limits -- 2. Who Has Mobility Difficulties -- 3. Sensations of Walking -- 4. Society's Views of Walking -- 5. How People Feel about Their Difficulty Walking -- 6. At Home-with Family and Friends -- 7. Outside Home-at Work and in Communities -- 8. People Talking to Their Physicians -- 9. Physicians Talking to Their Patients -- 10. Physical and Occupational Therapy and Other Approaches -- 11. Ambulation Aids -- 12. Wheeled Mobility -- 13. Who Will Pay? -- 14. What Will Be Paid For? -- 15. Final Thoughts -- Appendix 1. Familiar Interviewees -- Appendix 2. Selected Resources -- Notes -- References -- Index |
| Altri titoli varianti | Mobility problems of adults with chronic conditions |
| Record Nr. | UNINA-9910783292003321 |
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Iezzoni Lisa I
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| Berkeley, : University of California Press | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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