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ABC Transporters in Human Diseases
| ABC Transporters in Human Diseases |
| Autore | Falguières Thomas |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (494 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
ABC transporters
drug action regulatory extension regulatory insertion mechanism of action MRP1 MRP4 breast cancer proliferation migration invasion cAMP ABCG2 ABCB1 blood-brain barrier PET Alzheimer's disease beta-amyloid tariquidar erlotinib ABCG5 ABCG8 ATP-binding cassette transporter cholesterol polar relay sitosterolemia 5' untranslated region cis-acting elements ABCA subfamily bioinformatics ABC transporter therapy response disease-free survival next-generation sequencing competitive allele-specific PCR P-glycoprotein amyloid-beta neuron SK-N-SH gene therapy AAV PFIC BSEP ABCB11 bile salts intrahepatic cholestasis chaperones PFIC2 BRIC ATP-binding cassette transporter A1 (ABCA1) cholesterol homeostasis reverse cholesterol transport HDL-C dyslipidemia type 2 diabetes microparticles ABCG2 genotype clinico-genetic analysis ethnic specificity genetic variations precision medicine rare variant Roma serum uric acid SUA-lowering therapy urate transporter bile secretion ABCB4 ABCC2 ABCG5/G8 molecular partners phytosterol xenosterol atherosclerosis gall stone ABC transporter ABC (ATP-binding cassette) transporters multidrug resistance transport trafficking urate mutations polymorphisms ABCC6 TNAP NT5E Pseudoxanthoma elasticum (PXE) cancer membrane protein functional divergence calcification pseudoxanthoma elasticum generalized arterial calcification of infancy pyrophosphate therapies ABCA7 phagocytosis Aβ peptides yeast multidrug transporter anticancer antifungal resistance mechanism peroxisome adrenoleukodystrophy fatty acids gout early-onset gout hyperuricemia uric acid BCRP single nucleotide polymorphism SNP homology modeling substrate-binding site cellular ATP efflux mutagenesis intracellular traffic MDR3 phosphatidylcholine RAB GTPase taxol drug transport |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910674029103321 |
Falguières Thomas
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Amyloid-beta clearance in Alzheimer's disease [[electronic resource] /] / topic editors: Robert A. Marr and Eliezer Masliah
| Amyloid-beta clearance in Alzheimer's disease [[electronic resource] /] / topic editors: Robert A. Marr and Eliezer Masliah |
| Autore | Robert Marr |
| Pubbl/distr/stampa | Frontiers Media SA, 2015 |
| Descrizione fisica | 1 online resource (111 pages) : illustrations; digital, PDF file(s) |
| Disciplina | 616.831 |
| Collana |
Frontiers research topics
Frontiers in aging neuroscience |
| Soggetto topico |
Alzheimer's disease
Alzheimer's disease - Pathogenesis Alzheimer's disease - Molecular aspects Neurosciences |
| Soggetto non controllato |
amyloid-beta
Signal Transduction Proteases LDL receptors Clearance Alzheimer's disease |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910136278803321 |
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Robert Marr
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| Frontiers Media SA, 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Neuroprotection: Rescue from Neuronal Death in the Brain
| Neuroprotection: Rescue from Neuronal Death in the Brain |
| Autore | Lee Bae Hwan |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (408 p.) |
| Soggetto topico | Research & information: general |
| Soggetto non controllato |
global cerebral ischemia
amiloride sodium-hydrogen exchanger-1 zinc neuronal death neuroprotection neurodegenerative disorder choline acetyltransferase (ChAT) trimethyltin (TMT) bean phosphatidylserine (Bean-PS) brain-derived neurotrophic factor moderate hypoxia physical exercise psychomotor function reaction time cortisol catecholamines nitrite endotheline-1 lactate pyridoxine deficiency ischemia gerbil homocysteine cell death glia neurogenesis N-acetyl-l-cysteine transient receptor potential melastatin 2 neurodegeneration Alzheimer's disease metabolic disease adiponectin insulin antioxidants stroke preventive gene therapy adenoviral vector VEGF GDNF NCAM human umbilical cord blood mononuclear cells antioxidant brain neurodegenerative disease oxidative stress PGC-1α vascular endothelial growth factor vascular endothelial growth factor receptor 2 PI3K/AKT MEK/ERK status epilepticus hippocampus middle cerebral artery occlusion reperfusion injury lipid emulsion excitotoxicity apoptosis GPR4 receptor MPP+ Parkinson's disease CRISPR/cas9 ischemic stroke blood brain barrier nanoparticle-based drug delivery brain targeting BDNF miRNAs synaptic plasticity depression glioblastoma astrocytes astrocytic networks connexin 43 calcium activity neural injury nimodipine subarachnoid haemorrhage acid-sensing ion channels oxygen-glucose deprivation liver growth factor inflammation microglia Tg2576 transgenic mice amyloid-beta oculomotor system trophic factors motoneurons axotomy amyotrophic lateral sclerosis electroneutral transport cation-chloride cotransporters KCCs NKCCs WNK-SPAK/OSR1 ascorbic acid aging organotypic hippocampal slice culture |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Neuroprotection |
| Record Nr. | UNINA-9910557716703321 |
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Lee Bae Hwan
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Systems Analytics and Integration of Big Omics Data
| Systems Analytics and Integration of Big Omics Data |
| Autore | Hardiman Gary |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (202 p.) |
| Soggetto non controllato |
precision medicine informatics
drug sensitivity chromatin modification cell lines biocuration neurodegeneration multivariate analysis artificial intelligence epigenetics missing data sequencing clinical data class imbalance integrative analytics algorithm development for network integration deep phenotype non-omics data feature selection Gene Ontology miRNA-gene expression networks omics data plot visualization Alzheimer's disease tissue classification epidemiological data proteomic analysis genotype RNA expression indirect effect multi-omics dementia multiomics integration data integration phenomics network topology analysis challenges transcriptome enrichment analysis regulatory genomics scalability heterogeneous data systemic lupus erythematosus database microtubule-associated protein tau disease variants genomics joint modeling distance correlation annotation phenotype direct effect curse of dimensionality gene-environment interactions logic forest machine learning KEGG pathways multivariate causal mediation amyloid-beta bioinformatics pipelines support vector machine pharmacogenomics candidate genes tissue-specific expressed genes cognitive impairment causal inference |
| ISBN | 3-03928-745-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910404089603321 |
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Hardiman Gary
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| MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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