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ABC Transporters in Human Diseases
| ABC Transporters in Human Diseases |
| Autore | Falguières Thomas |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (494 p.) |
| Soggetto topico |
Biology, life sciences
Research & information: general |
| Soggetto non controllato |
5' untranslated region
AAV ABC ABC (ATP-binding cassette) transporters ABC transporter ABC transporters ABCA subfamily ABCA7 ABCB1 ABCB11 ABCB4 ABCC2 ABCC6 ABCG2 ABCG2 genotype ABCG5 ABCG5/G8 ABCG8 adrenoleukodystrophy Alzheimer's disease amyloid-beta anticancer antifungal resistance atherosclerosis ATP-binding cassette transporter ATP-binding cassette transporter A1 (ABCA1) Aβ peptides BCRP beta-amyloid bile salts bile secretion bioinformatics blood-brain barrier breast cancer BRIC BSEP calcification cAMP cancer cellular ATP efflux chaperones cholesterol cholesterol homeostasis cis-acting elements clinico-genetic analysis competitive allele-specific PCR disease-free survival drug action drug transport dyslipidemia early-onset gout erlotinib ethnic specificity fatty acids functional divergence gall stone gene therapy generalized arterial calcification of infancy genetic variations gout HDL-C homology modeling hyperuricemia intracellular traffic intrahepatic cholestasis invasion MDR3 mechanism mechanism of action membrane protein microparticles migration molecular partners MRP1 MRP4 multidrug resistance multidrug transporter mutagenesis mutations n/a neuron next-generation sequencing NT5E P-glycoprotein peroxisome PET PFIC PFIC2 phagocytosis phosphatidylcholine phytosterol polar relay polymorphisms precision medicine proliferation pseudoxanthoma elasticum Pseudoxanthoma elasticum (PXE) pyrophosphate RAB GTPase rare variant regulatory extension regulatory insertion reverse cholesterol transport Roma serum uric acid single nucleotide polymorphism sitosterolemia SK-N-SH SNP SUA-lowering therapy substrate-binding site tariquidar taxol therapies therapy response TNAP trafficking transport transporter type 2 diabetes urate urate transporter uric acid xenosterol yeast |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910674029103321 |
Falguières Thomas
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Amyloid-beta clearance in Alzheimer's disease [[electronic resource] /] / topic editors: Robert A. Marr and Eliezer Masliah
| Amyloid-beta clearance in Alzheimer's disease [[electronic resource] /] / topic editors: Robert A. Marr and Eliezer Masliah |
| Autore | Robert Marr |
| Pubbl/distr/stampa | Frontiers Media SA, 2015 |
| Descrizione fisica | 1 online resource (111 pages) : illustrations; digital, PDF file(s) |
| Disciplina | 616.831 |
| Collana |
Frontiers research topics
Frontiers in aging neuroscience |
| Soggetto topico |
Alzheimer's disease
Alzheimer's disease - Pathogenesis Alzheimer's disease - Molecular aspects Neurosciences |
| Soggetto non controllato |
amyloid-beta
Signal Transduction Proteases LDL receptors Clearance Alzheimer's disease |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910136278803321 |
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Robert Marr
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| Frontiers Media SA, 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Neuroprotection: Rescue from Neuronal Death in the Brain
| Neuroprotection: Rescue from Neuronal Death in the Brain |
| Autore | Lee Bae Hwan |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (408 p.) |
| Soggetto topico | Research & information: general |
| Soggetto non controllato |
acid-sensing ion channels
adenoviral vector adiponectin aging Alzheimer's disease amiloride amyloid-beta amyotrophic lateral sclerosis antioxidant antioxidants apoptosis ascorbic acid astrocytes astrocytic networks axotomy BDNF bean phosphatidylserine (Bean-PS) blood brain barrier brain brain targeting brain-derived neurotrophic factor calcium activity catecholamines cation-chloride cotransporters cell death choline acetyltransferase (ChAT) connexin 43 cortisol CRISPR/cas9 depression electroneutral transport endotheline-1 excitotoxicity GDNF gerbil glia glioblastoma global cerebral ischemia GPR4 receptor hippocampus homocysteine human umbilical cord blood mononuclear cells inflammation insulin ischemia ischemic stroke KCCs lactate lipid emulsion liver growth factor MEK/ERK metabolic disease microglia middle cerebral artery occlusion miRNAs moderate hypoxia motoneurons MPP+ N-acetyl-l-cysteine n/a nanoparticle-based drug delivery NCAM neural injury neurodegeneration neurodegenerative disease neurodegenerative disorder neurogenesis neuronal death neuroprotection nimodipine nitrite NKCCs oculomotor system organotypic hippocampal slice culture oxidative stress oxygen-glucose deprivation Parkinson's disease PGC-1α physical exercise PI3K/AKT preventive gene therapy psychomotor function pyridoxine deficiency reaction time reperfusion injury sodium-hydrogen exchanger-1 status epilepticus stroke subarachnoid haemorrhage synaptic plasticity Tg2576 transgenic mice transient receptor potential melastatin 2 trimethyltin (TMT) trophic factors vascular endothelial growth factor vascular endothelial growth factor receptor 2 VEGF WNK-SPAK/OSR1 zinc |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Neuroprotection |
| Record Nr. | UNINA-9910557716703321 |
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Lee Bae Hwan
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Systems Analytics and Integration of Big Omics Data
| Systems Analytics and Integration of Big Omics Data |
| Autore | Hardiman Gary |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 online resource (202 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
algorithm development for network integration
Alzheimer's disease amyloid-beta annotation artificial intelligence biocuration bioinformatics pipelines candidate genes causal inference cell lines challenges chromatin modification class imbalance clinical data cognitive impairment curse of dimensionality data integration database deep phenotype dementia direct effect disease variants distance correlation drug sensitivity enrichment analysis epidemiological data epigenetics feature selection Gene Ontology gene-environment interactions genomics genotype heterogeneous data indirect effect integrative analytics joint modeling KEGG pathways logic forest machine learning microtubule-associated protein tau miRNA-gene expression networks missing data multi-omics multiomics integration multivariate analysis multivariate causal mediation n/a network topology analysis neurodegeneration non-omics data omics data pharmacogenomics phenomics phenotype plot visualization precision medicine informatics proteomic analysis regulatory genomics RNA expression scalability sequencing support vector machine systemic lupus erythematosus tissue classification tissue-specific expressed genes transcriptome |
| ISBN | 3-03928-745-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910404089603321 |
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Hardiman Gary
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| MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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