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Appetite and Satiety Control-Gut Mechanisms
| Appetite and Satiety Control-Gut Mechanisms |
| Autore | Feinle-Bisset Christine |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (454 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
lixisenatide
intragastric meal retention energy intake type 2 diabetes obesity amino acid isoleucine chronic supplementation energy expenditure oral glucose tolerance test glycaemic control gastric emptying breath test endocannabinoid cannabinoid CB1 receptor gut-brain intestine western diet preference whey protein gastric emptying appetite lifecourse gut hormones hunger protein TAS2R5 TAS2R39 TAS2R14 agonist food intake GLP1 CCK PYY miniature pig pig model functional brain imaging molecular imaging vagal afferents single fiber recording insulin resistance GLP-1r gastric barostat scintigraphy meal ingestion postprandial responses hedonic sensations homeostatic sensations abdominal wall activity abdominal distension taste fat carbohydrate bariatric surgery GLP-1 ghrelin Roux-en-Y gastric bypass gastric band sleeve gastrectomy circadian gastrointestinal tract enteroendocrine cells chemosensory GIP nutrients hormones food ingestion digestion satiety digestive well-being functional gastrointestinal disorders postprandial symptoms brainstem vagus feeding gastrointestinal cue reactivity meal anticipation motivation nutrient preference flavor aversion bile acids TGR-5 FXR gastrointestinal hormones body weight gastric accommodation satiation CB1 receptor reward aging whey anorexia supplements sarcopenia nutrient sensing enteroendocrine cells (EECs) appetite regulation G-protein coupled receptors (GPCRs) bitter substances gastric motor function postprandial blood glucose preclinical studies human studies texture oro-sensory exposure sensory science cephalic responses brain areas brain stem weight management intestinal brake duodenal jejunal and ileal brake tastants circadian clock gastric bypass surgery microbiome hypothalamus |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557519503321 |
Feinle-Bisset Christine
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery
| Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery |
| Autore | Spetea Mariana |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (358 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
opioid receptors
neurokinin-1 receptor peptide synthesis receptor binding studies functional assay writhing test tolerance Leu-enkephalin beta-arrestin mu opioid receptor delta opioid receptor biased signaling DADLE ischemia plasma stability morphinan BNTX δ opioid receptor antagonist 1H-NMR experiments mechanism elucidation peripheral antinociception 14-methoxycodeine-6-O-sulfate codeine-6-O-sulfate opioid peptides and peptidomimetics DAMGO DALDA [Dmt1]DALDA KGOP01 binding molecular docking structure-activity relationships β2-amino acids β2-Homo-amino acids µ-opioid receptor opioid peptides TAPP racemic synthesis of β2-amino acids peripheral µ-opioid receptors analgesia peripheral analgesic tolerance dysbiosis opioid bifunctional ligands (−)-N-phenethylnorhydromorphone analogs [35S]GTPgammaS assay forskolin-induced cAMP accumulation assays β-arrestin recruitment assays MOR and DOR agonists respiratory depression bias factor molecular modeling & simulation δ opioid receptor NTI derivative sulfonamide inverse agonist neutral antagonist agonist opioids mu receptor opioid side effects biased agonism partial agonism zerumbone chronic constriction injury (CCI) allodynia hyperalgesia potassium channels over-the-counter drugs misuse abuse opioid drugs pharmacology codeine dihydrocodeine loperamide opioid peptide macrocyclic tetrapeptide multifunctional ligands kappa opioid receptor analgesics opioid liabilities μ opioid receptor receptor model biased ligands dependence pain therapy neonatal opioid withdrawal syndrome naltrexone 6β-naltrexol buprenorphine G-protein bias arrestin recruitment respiration mitragynine heteromer internalization primary hippocampal culture lysosomes µ opioid receptor molecular dynamics docking interaction fingerprints biased agonists SR-17018 PZM21 morphine fentanyl diphenethylamines design and synthesis partial agonist biased agonist antagonist binding affinity selectivity |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Opioids and Their Receptors |
| Record Nr. | UNINA-9910557108003321 |
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Spetea Mariana
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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