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Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches
| Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches |
| Autore | Jeon Byeong Hwa |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (368 p.) |
| Soggetto topico |
Technology: general issues
Biotechnology |
| Soggetto non controllato |
endothelial cells
oxidative stress inflammageing endothelial dysfunction aldehyde dehydrogenase-2 cardiovascular disease neurovascular disease vascular inflammation APE1/Ref-1 cardiovascular diseases subcellular localization serological biomarkers atherosclerosis aerobic exercise PCSK9 LOX-1 insulin resistance macrophage polarity serum γ-glutamyltransferase essential hypertension cardiovascular risk factors angiogenesis nargenicin A1 compound 9 VEGF VEGFR2 HIF-1α electronegative low-density lipoprotein LDL(-) L5 LDL oxidized LDL oxLDL ADMA arginine arginine paradox BH4 blood pressure COVID-19 dietary supplements endothelium eNOS uncoupling heart failure hypertension L-arginine myocardial infarction NADPH nitric oxide peripheral artery disease ApoE knockout mouse atorvastatin VCAM-1 galectin-3 neutrophil/lymphocyte ratio electronegative LDL LDL(−) lectin-like oxLDL receptor-1 dyslipidemia chronic venous insufficiency prolyl oligopeptidase (POP) inflammation endothelial disfunction lung disease endothelial to mesenchymal transition pulmonary hypertension pulmonary fibrosis metformin diabetes CV risk hyperglycemia glycated lipoproteins glycated LDL glycated HDL endothelial cell dysfunction molecular mechanisms epigenetic factors therapeutic approaches vasoactive factors EndoMT TGF-β epigenetics endothelial cell glycolysis metabolism pathological angiogenesis tumor microenvironment MRI (magnetic resonance imaging) high-fat diets plaque burden low-level laser therapy phototherapy vascular disease healing ischemia vascular calcification chronic kidney disease CKD uremic toxins hyperphosphatemia vascular smooth muscle cells VSMCs macrophages |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Endothelial Dysfunction |
| Record Nr. | UNINA-9910566471803321 |
Jeon Byeong Hwa
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Strategies to Improve Antineoplastic Activity of Drugs in Cancer Progression
| Strategies to Improve Antineoplastic Activity of Drugs in Cancer Progression |
| Autore | Stefanachi Angela |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (416 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
EGR-1
flavonoid (E)-5-((4-oxo-4H-chromen-3-yl)methyleneamino)-1-phenyl-1H-pyrazole-4-carbonitrile MDA-MB-231 MMP9 TNFα pancreatic ductal adenocarcinoma cyclodextrin inclusion complex phase solubility studies preformulation studies biphenylnicotinamide derivatives dual inhibitor EGFR VEGFR2 ligand-based pharmacophore molecular docking molecular dynamics leukemias doxorubicin inflammation drug delivery tumor targeting elastin-like polypeptide cell penetrating peptide matrix metalloproteinase doxorubicin resistance photosensitizer delivery system PAMAM dendrimer photodynamic therapy cytotoxicity phototoxicity colorectal adenocarcinoma dicarboximides chemical synthesis apoptosis kinases anticancer gene profiling SAR biomarkers colorectal cancer early detection examination liquid biopsy personalized medicine tumor treatment exosomes ctDNA CTC cytotoxic activity pyrazole derivatives MTT assay ADMET analysis single-crystal diffraction FTIR spectroscopy NMR spectroscopy thermogravimetric analysis acute myelogenous leukemia platelets microparticles γδ T cells immunotherapy tumor resistance combination therapy tumor microenvironment immune checkpoint inhibitor neuroblastoma molecular iodine cyclophosphamide xenografts metronomic therapy tamoxifen CYP2D6 MCF-7 Ishikawa cells SERM TNBC uterotrophic α-mangostin poly(amidoamine) dendrimer targeted drug delivery biotin targeting glioblastoma multiforme squamous cell carcinoma antiparasitic therapy diclofenac indomethacin oleanolic acid derivative conjugates NF-κB Nrf2 MAPKs PSN-1 cells reactive oxygen species glioblastoma brain tumor extracellular vesicles pancreatic cancer paclitaxel clathrin endocytosis sulforaphane nicotine metalloproteinase-9 gastric cancer cell invasion Arylquin 1 colon cancer tumor progression azelastine oxidative stress autophagy mitotic catastrophe chronic myeloid leukemia imatinib tyrosine kinase ketoconazole P-glycoprotein drug efflux transporter non-small-cell lung cancer cisplatin resistance aldehyde dehydrogenase isothiocyanates disulfiram epithelial to mesenchymal transition aminopeptidase N acetamidophenones Schiff bases semicarbazones thiosemicarbazones inhibition of proliferation |
| ISBN | 3-0365-5927-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910639990003321 |
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Stefanachi Angela
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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