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Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery
| Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery |
| Autore | Spetea Mariana |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (358 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
opioid receptors
neurokinin-1 receptor peptide synthesis receptor binding studies functional assay writhing test tolerance Leu-enkephalin beta-arrestin mu opioid receptor delta opioid receptor biased signaling DADLE ischemia plasma stability morphinan BNTX δ opioid receptor antagonist 1H-NMR experiments mechanism elucidation peripheral antinociception 14-methoxycodeine-6-O-sulfate codeine-6-O-sulfate opioid peptides and peptidomimetics DAMGO DALDA [Dmt1]DALDA KGOP01 binding molecular docking structure-activity relationships β2-amino acids β2-Homo-amino acids µ-opioid receptor opioid peptides TAPP racemic synthesis of β2-amino acids peripheral µ-opioid receptors analgesia peripheral analgesic tolerance dysbiosis opioid bifunctional ligands (−)-N-phenethylnorhydromorphone analogs [35S]GTPgammaS assay forskolin-induced cAMP accumulation assays β-arrestin recruitment assays MOR and DOR agonists respiratory depression bias factor molecular modeling & simulation δ opioid receptor NTI derivative sulfonamide inverse agonist neutral antagonist agonist opioids mu receptor opioid side effects biased agonism partial agonism zerumbone chronic constriction injury (CCI) allodynia hyperalgesia potassium channels over-the-counter drugs misuse abuse opioid drugs pharmacology codeine dihydrocodeine loperamide opioid peptide macrocyclic tetrapeptide multifunctional ligands kappa opioid receptor analgesics opioid liabilities μ opioid receptor receptor model biased ligands dependence pain therapy neonatal opioid withdrawal syndrome naltrexone 6β-naltrexol buprenorphine G-protein bias arrestin recruitment respiration mitragynine heteromer internalization primary hippocampal culture lysosomes µ opioid receptor molecular dynamics docking interaction fingerprints biased agonists SR-17018 PZM21 morphine fentanyl diphenethylamines design and synthesis partial agonist biased agonist antagonist binding affinity selectivity |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Opioids and Their Receptors |
| Record Nr. | UNINA-9910557108003321 |
Spetea Mariana
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Recent Advances in Minimally Invasive Surgery
| Recent Advances in Minimally Invasive Surgery |
| Autore | Biebl Matthias |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (414 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
ovarian cancer
laparoscopy minimally invasive surgery survival mortality platelet-rich plasma (PRP) thin endometrium hysteroscopy robotic surgery sexuality laparoscopic hysterectomy learning curve quality of life counseling patient-doctor-relationship body donors surgical education clinical anatomy live surgery events neuropelveology LION procedure genital nerves stimulation chronic pelvic pain esophagectomy esophageal cancer Ivor-Lewis procedure health-related quality of life cervical cancer robotic radical hysterectomy recurrence rate surgery artificial intelligence machine learning augmented reality hysterectomy NOTES minimally invasive systematic review meta-analysis pediatric surgery fetal surgery single-incision surgery surgical techniques surgical devices open surgery endoscopy endoscopic surgery cysts of the canal of Nuck Nuck hydrocele hydrocelectomy TAPP Lichtenstein colorectal liver metastases laparoscopic liver surgery minimal invasive surgery general anesthesia anesthetics perioperative care laparoscopic surgery endometrial cancer lymphadenectomy embryology sentinel lymph node mapping indocyanine green PMMR technical aspects rectal cancer mesorectal transanal laparoscopic local recurrence conversion rate minimally invasive surgical procedures radiotherapy ovarian neoplasms endometrial neoplasms uterine cervical neoplasms vaginal neoplasms vulvar neoplasms survival analysis video feedback video modeling gynecology surgical training pelvitrainer prolapse pelvic floor native tissue pectopexy robotic assisted surgery pancreatic surgery pancreaticoduodenectomy pelvic floor repair laparoscopic repair vaginal repair mesh use VATS pain postoperative pain control thoracic surgery lung cancer intercostal catheter opioid regional anaesthesia hepatectomy single-port laparoscopy radiofrequency pre-coagulation endometriosis endometrioma surgery ovarian reserve anti-Müllerian hormone spontaneous pregnancy robotic liver resection da Vinci intraoperative imaging hepatocellular cancer real-life imaging hepatic metastasis COVID-19 sars-cov-2 surgical performance 3D printing skill assessment snorkel mask malabsorption Roux-en-Y gastric bypass one-anastomosis gastric bypass SADI-S biliopancreatic diversion weight regain hepatocellular carcinoma cholangiocarcinoma risk score pelvic compartments embryologic development oncologic surgery pelvic lymphonodectomy topographic anatomy autonomic pelvic nerves uterine cancer prostate cancer diaphragmatic hernia liver resection hernia repair mesh enterothorax |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557467203321 |
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Biebl Matthias
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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