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Advances and Novel Treatment Options in Metastatic Melanoma
| Advances and Novel Treatment Options in Metastatic Melanoma |
| Autore | Facchiano Antonio |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (528 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
melanoma
invasion WNT5A MARCKS phosphorylation MANS peptide nanoparticles cell therapy tumor microenvironment sex/gender sex-hormones immunity microRNAs immunotherapy BRAF-mutant melanoma BRAF inhibitor mechanism of action targeted therapy tumour microenvironment plasmacytoid dendritic cells lactate dehydrogenase TLR interferon CXCL10 TPC2 HIPPO SOCE metastasis essential oils angiogenesis apoptosis uveal melanoma (UM) metastatic uveal melanoma (mUM) prognostication adjuvant therapy metastatic therapy metastatic dormancy liver-directed-therapies targeted-therapy combined therapy protein tyrosine phosphatase PTPs inhibitors melanoma immune infiltrate BRAF inhibitors microenvironment resistance therapy therapeutic resistance exosomes extracellular vesicles diagnosis prognosis ctDNA liquid biopsy prediction patient stratification BRAF arthralgia rheumatoid arthritis carbonic anhydrase hedgehog cyclopamine small molecules acetazolamide motility metalloproteinases FAK cancer mucosal melanoma nivolumab pembrolizumab ipilimumab radiotherapy cholinergic system acetylcholine muscarinic receptors nicotinic receptors melanoma metastasis ShcD adaptor protein amoeboid motility Rac1 DOCK4 melanoma PDX target therapy cancer stem cells slow cycling phenotype drug resistance OXPHOS lipid metabolism cancer associated fibroblast melanomagenesis biomarkers checkpoint inhibitor PD-1 melanoma markers cytokines machine learning Support Vector Machine principal component analysis BCL2L10 STAT3 cytotoxicity survival ABT-737 Bcl-2 family ML258 HuR MITF metastases siRNA |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557612103321 |
Facchiano Antonio
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Catalyzed Synthesis of Natural Products
| Catalyzed Synthesis of Natural Products |
| Autore | Díez David |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (82 p.) |
| Soggetto non controllato |
structured phosphatidylcholine
carvone immobilized lipases trimyristin 3-hydroxyoxindole green chemistry structural revision anticancer triterpenoid organocatalysis natural products epoxidation benzimidazole total synthesis zinc Antrodia cinnamomea aminocatalysis epoxide asymmetric organocatalysis mandelamides STAT3 asymmetric catalysis Psychrobacillus isatin chiral ?-hydroxyamide interesterification proline phaeosphaeride B biotransformation phaeosphaeride A myristic acid egg-yolk phosphatidylcholine acidolysis antcin K deep eutectic solvents |
| ISBN | 3-03921-949-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910367737103321 |
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Díez David
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Classification of Lymphomas and Hematological Neoplasia in the Era of Genomic Research : A Themed Issue in Honor of Dr. Elaine S. Jaffe
| Classification of Lymphomas and Hematological Neoplasia in the Era of Genomic Research : A Themed Issue in Honor of Dr. Elaine S. Jaffe |
| Autore | Nicolae Alina |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (252 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
lymphomas in PLWH
KSHV/HHV8 EBV lymphoma classification management cART HLX HOXB9 NFIB PBX1 STAT3 TLX2 autoimmune hemolytic anemia cold agglutinin B-cell lymphoproliferative disorder lymphomagenesis methylation histone modification indolent T-cell NK-cell lymphoproliferative disorder gastrointestinal tract genetics cell of origin T follicular helper cells TFH lymphoma angioimmunoblastic T-cell lymphoma follicular T-cell lymphoma peripheral T-cell lymphoma of T-follicular helper immunophenotype peripheral T-cell lymphoma primary cutaneous B-cell lymphoma primary cutaneous marginal zone B-cell lymphoma primary cutaneous follicle centre lymphoma primary cutaneous diffuse large B-cell lymphoma, leg-type primary cutaneous diffuse large B-cell lymphoma, not otherwise specified intravascular B-cell lymphoma EBV+ mucocutaneous ulcer Burkitt lymphoma epidemiology Plasmodium falciparum Epstein Barr virus registry studies multimodal cancer non-Hodgkin lymphoma HIV/AIDS follicular lymphoma in situ follicular neoplasia FL transformation FL in young patients diffuse large B-cell lymphoma NOS high grade B-cell lymphoma lymphoma gene expression profiling tumor microenvironment diagnostics centrocytic lymphoma intermediate lymphocytic lymphoma Jaffe mantle cell lymphoma mantle zone lymphoma cyclin D1 lymphomas people living with HIV tumor prevention in people living with HIV KSHV BCL2 rearrangement genetic alterations histological transformation targeted therapies transformed follicular lymphoma lymphoproliferative neoplasms of uncertain biological significance monoclonal B-cell lymphocytosis “in situ” follicular neoplasia “in situ” mantle cell neoplasia atypical germinal centers large B-cell lymphoma with IRF4 rearrangement “in situ” high-grade B lymphomas Hodgkin lymphoma |
| ISBN | 3-0365-5744-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Classification of Lymphomas and Hematological Neoplasia in the Era of Genomic Research |
| Record Nr. | UNINA-9910637783903321 |
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Nicolae Alina
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Curcumin in Health and Disease
| Curcumin in Health and Disease |
| Autore | Bachmeier Beatrice |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (274 p.) |
| Soggetto non controllato |
minerals
cancer treatment chitosan neurodegeneration antioxidant activity senescence tumor proliferation nanoparticles antimicrobial agents oxidative metabolites drug discovery Akt/mTOR signaling micronutrients ulcerative colitis transmission electron microscopy metabolic reprogramming curcumin death receptor chaperone-mediated autophagy wound healing brain ischemia autophagy Alzheimer's disease genes transthyretin inflammatory bowel disease cellular pathway centrifugal partition chromatography nutrition amyloid Curcuma longa protein aggregation supportive care IL-17 senolytics complementary medicine macronutrients structure activity relationship gastroprotection Zingiberaceae anti-inflamation TLC bioautography microbiota glioblastoma multiforme amyloidosis SHMT2 antioxidants silica apoptosis reflux esophagitis gastric ulcer TLC-MS anti-cancer anticancer ImageJ anti-tumor delivery system wound Helicobacter pylori direct protein binding protein misfolding tumor growth diet Crohn's disease hydrostatic counter-current chromatography ageing renal cell cancer gastric cancer amino-acids STAT3 mechanism of action inflamm-aging mitophagy necrotizing enterocolitis cell cycling vitamins turmeric tuber cancer tau protein |
| ISBN | 3-03921-450-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910367753703321 |
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Bachmeier Beatrice
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Drug delivery technology development in Canada / / special issue editors, Kishor M. Wasan, Ildiko Badea
| Drug delivery technology development in Canada / / special issue editors, Kishor M. Wasan, Ildiko Badea |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (352 p.) |
| Disciplina | 615.1/900971 |
| Soggetto topico | Drug Delivery Systems - Canada |
| Soggetto non controllato |
encapsulation
biodistribution pharmaceutics targeted therapies gambogic acid GE11 peptide formulation and dosage form development transient modulation ROESY NMR spectroscopy bioaccessibility polymeric micelle pharmacological Inhibitors of HIF-1 and STAT3 nanoparticles Vitamin D drug discovery EGFR-targeted therapy translational research clinical trials doxorubicin dissolution drug development permeation enhancers Canada plant primary central nervous system lymphomas photostabilizers head and neck squamous cell carcinoma mouse models drug delivery systems melphalan hypoxia-induced chemoresistance skin virus circadian clock child friendly formulation adenanthin co-delivery canola oil deodorizer distillate Metaplex innovation controlled drug delivery nifedipine radiolabeling amphotericin B biological barriers blood-brain barrier (BBB) biologicals lipid nanoparticles oral formulation phytosterols medical devices chronotherapy oral cationic gemini surfactant route of administration drug delivery intra-arterial chemotherapy developing world sustained delivery water miscible solvents combination therapy antibodies throughput magnetic fields liposomes medulloblastoma drug-resistant melanoma rosmarinic acid topical formulation TNO gastrointestinal model gastrointestinal simulator malignant gliomas transdermal drug delivery oral delivery precision medicine 3D spheroid flavonoids staurosporine DOX-Vit D loading gradients bacteriophage phospholipid complex triggered drug release HIF-1 phage display pharmacokinetics emulsion quercetin cisplatin parasitic infections remote loading HAV6 cadherin peptide blood-brain barrier inclusion complex tocopherols STAT3 ultrasound liposome fungal infections magnetic resonance imaging (MRI) MG63 model orange juice radiation cancer mefloquine small molecules |
| ISBN | 3-03928-005-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910367736503321 |
| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Marine Bioactive Natural Product Studies—A Southern Hemisphere Perspective
| Marine Bioactive Natural Product Studies—A Southern Hemisphere Perspective |
| Autore | Urban Sylvia |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (142 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
Sinularia
Alcyoniidae anticancer activity lobane cembrane diterpene conotoxins ShK toxin ion channels docking molecular dynamics potential of mean force free energy perturbation bioactivity biosynthesis brominated secondary metabolites choline ester indole sea cucumber viscera saponins mass spectrometry MALDI ESI HPCPC triterpene glycosides structure elucidation bioactive compounds marine invertebrate Echinodermata holothurian Cnemidocarpa stolonifera taurine amide PC3 cell line immunofluorescence assay thiaplidiaquinone Aplidium ascidian thiazinoquinone apoptosis Jurkat cytotoxicity malaria farnesyltransferase synthesis thiaplakortone regioisomer tricyclic natural product scaffold X-ray crystal Plasmodium falciparum antiplasmodial cephalostatin mandelalide methicillin resistant Staphylococcus aureus MRSA PK bisindole alkaloids salternamide A (SA) HIF-1α PI3K/Akt/mTOR p42/p44 MAPK STAT3 cell death |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557573903321 |
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Urban Sylvia
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Marine Compounds and Cancer 2020
| Marine Compounds and Cancer 2020 |
| Autore | Honecker Friedemann |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (480 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
apoptosis
fucoidan hepatocellular carcinoma reactive oxygen species 3-alkylpyridinium polymers nicotine nicotinic acetylcholine receptor non-small cell lung carcinoma melanoma sinulariolide proteomic mitochondria caspase cascade marine fungus sediment anthranilic acid Penicillium paneum cytotoxicity dibromotyrosine mitochondrial dysfunction oxidative stress topoisomerase epigonal organ bonnethead shark Jurkat tumor cell line hippuristanol PEL AP-1 STAT3 Akt colorectal cancer marine mollusc brominated indoles shrimp chemoprevention fatty acids carotenoids cancer nanoparticle osteosarcoma lung metastasis elisidepsin lipid rafts hydroxylated lipids fatty acid 2-hydroxylase cooperative binding membrane permeabilization marine organisms polysaccharides anticancer anticarcinogenic mechanisms of action fumigaclavine C anti-proliferation mitochondrial pathway anti-cancer anti-proliferative carotenoid cell cycle arrest fucoxanthin azoxymethane bioactive natural product isatin in vivo model Marthasterias glacialis L. palmitic acid ER-stress CHOP Antibody Drug Conjugates (ADCs) marine antitumor agents clinical trials approved antitumor agents AD0157 angiogenesis marine drug pyrrolidinedione secondary metabolites cancer preventive chemopreventive trabectedin plitidepsin tumor-associated macrophages tumor microenvironment preclinical anticancer immunity antiangiogenesis fascaplysin cyclin-dependent kinase small cell lung cancer camptothecin poly(ADP-ribose)-polymerase inhibitor breast cancer seaweed therapeutic compounds autophagy marine drugs autophagy inhibitors autophagy inducers macrolide programmed cell death energy stress araguspongine C c-Met HER2 gemcitabine pazopanib phase I safety soft tissue sarcoma pachastrissamine jaspine B carbocyclic analogue sphingosine kinase inhibitor molecular modeling ET-743 DNA minor groove binder soft tissue sarcoma chemotherapy bis (2,3-dibromo-4,5-dihydroxy-phenyl)-methane (BDDPM) anti-metastatic activity cell adhesion β1-integrin FAK BEL-7402 cell triterpene glycosides sea cucumbers antitumor activities arrest of cell cycle antibacterial marangucyclines deep-sea Streptomyces sp. SCSIO 11594 LS-1 SNU-C5/5-FU TGF-β signaling carcinoembryonic antigen kalkitoxin Moorea producens mitochondria toxin VEGF angiogenesis inhibitor hypoxia-inducible factor-1 HIF-1 Lyngbya majuscula marine metabolites SZ-685C nonfunctioning pituitary adenomas Ecklonia cava phlorotannins dieckol migration sipholenol A ABC transporter multidrug resistance P-gp/ABCB1 BCRP/ABCG2 MRP1/ABCC1 marine natural products glioblastoma xyloketal B proliferation TRPM7 marine compound ribosomal protein genes snoRNA FAU RPS30 SNORA62 evolution Porifera Penicillium brevicompactum Brevianamide Mycochromenic acid derivative antifouling Caribbean sponge plakortide endoperoxide leukemia multi-drug resistant leukemia Sarcophyton ehrenbergi soft coral terpenes cembranoids cytotoxic activity molecular docking uveal melanoma oxidative stress virtual screening Topo I inhibitor low toxic natural product Ulva fasciata selenium-containing polysaccharide-protein complex pseudopterosin NF-κB p65 inflammation cytokine release IL-6 TNFα MCP-1 glucocorticoid receptor paulomycins Micromonospora antitumor Cantabrian Sea-derived actinobacteria puupehenones sponges antiangiogenic antitumoral porifera/sponge cancer genes molecular oncology bromophenol molecular mechanisms cell cycle PI3K/Akt p38/ERK ROS human lung cancer glycosaminoglycans antiproliferative heparan sulphate gliotoxin NSCLC adriamycin resistance Sepia ink polysaccharides antitumour chemosensitization anticoagulation sea anemone drug discovery endothelial cells RGD motif kunitz type inhibitor prostate cancer antioxidant natural marine compounds marine biotechnology microalgae marine sponges Aeroplysinin Isofistularin pheochromocytoma and paraganglioma metastasis cancer progression cell adhesion molecules integrin β1 hypoxia phycocyanin non-small cell lung cancer NF-κB signaling marine-derived drugs bioanalysis chromatography manzamine A epithelial-mesenchymal transition lung cancer circulating tumor cells signal transduction cisplatin Lampetra morii buccal gland cystatin F anti-angiogenesis cystatin superfamily Antimicrobial peptide (AMP) Tilapia piscidin 4 (TP4) non-small cell lung cancer (NSCLC) itampolin A FBDD p38α novel inhibitor tetracenomycin X cyclin D1 proteasomal degradation p38 c-JUN λ-carrageenan heparanase anticoagulant depolymerisation cell migration Aspergillus naphthopyrones endophytic fungus Leathesia nana mangrove-derived actinomycete ansamycins divergolides apoptosis-inducing activity actinomycin EMT invasion low molecular weight fucoidan extract N-Ras neuroblastoma-rat sarcoma Cancer programmed cell death-ligand 1 programmed cell death-ligand 2 human sarcoma cell line (HT1080 cells) human normal diploid fibroblast (TIG-1 cells) chimera chemical conjugation anticancer agent hybridization α9-nicotinic acetylcholine receptors (nAChRs) breast cancer cells αO-conotoxin GeXIVA targeted therapy gorgonian Leptogorgia humulane sesquiterpenoids anticancer activity 12-deacetyl-12-epi-scalaradial HeLa cells Nur77 MAPK/ERK pathway Mycalin A C15 acetogenins synthetic analogues antiproliferative activity A375 and HeLa cell lines polyoxygenated steroids sponge Haliclona gracilis Thalassia testudinum thalassiolin B polyphenols CYP1A1 benzo[a]pyrene JNK1/2 natural products synergism A549 cells cytoskeleton P2X7 receptor pollution anti-angiogenic gene expression HSP90 inhibitor |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557339303321 |
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Honecker Friedemann
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Marine Natural Products as Anticancer Agents
| Marine Natural Products as Anticancer Agents |
| Autore | Alves Celso |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (150 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
alga
marine-derived fungus Penicillium chrysogenum polyketide hydroxyphenylacetic acid cytotoxicity flaccidoxide-13-acetate hepatocellular carcinoma invasion migration epithelial-mesenchymal transition prostate cancer astaxanthin STAT3 proliferation colony formation apoptosis Sarcophyton digitatum biscembranoid-type metabolites inflammatory factor production LPS-stimulated murine macrophage Ehlich's tumor P. purpurogenum antitumor meroterpenoids inflammation T47D BT20 pontin mutp53 cancer stem cells Oct4 Nanog siRNA secondary metabolites epigenome epigenetic signaling bioactive compounds cancer therapy marine species environment total synthesis natural product nannocystin anti-cancer gram-scale aplysinopsin analogs indole alkaloids marine source chronic myeloid leukemia BH3 mimetics |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557595603321 |
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Alves Celso
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases
| Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases |
| Autore | Kwok Hang Fai |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (180 p.) |
| Soggetto topico |
Humanities
Social interaction |
| Soggetto non controllato |
DAPK1
SUMO SENP protein degradation post-translational modification amphibian Bowman-Birk inhibitor Tat peptide molecular cloning antifungal drug design protease inhibitor natural-based compound anticancer therapy lung cancer survivin apoptosis STAT3 colorectal cancer orientin cell cycle arrest Bcl-2 family proteins Astragalus membranaceus insulin PI3K AKT PPARγ PDX-1 Petasites japonicus Asteraceae lignan anti-inflammation NO PGE2 iNOS COX-2 molecular docking peptides kynurenines binding affinity μ-opioid receptor pharmacophore G-protein activation fucoidan PLGA docetaxel drug delivery system anticancer therapy/cancer treatment hIAPP amyloidogenesis insulin granules endoplasmic reticulum anionic lipids F23R variant β-sheet transitions β-cell cytotoxicity unfolded protein response pomegranate punicalagin tannins gingiva fibroblasts antioxidant wound healing branched-chain fatty acids Conidiobolus heterosporus peroxisome proliferator-activated receptor α lipid metabolism fatty acid oxidation hepatocyte |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557607403321 |
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Kwok Hang Fai
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Pleiotropic Action of Selenium in the Prevention and Treatment of Cancer, and Related Diseases
| Pleiotropic Action of Selenium in the Prevention and Treatment of Cancer, and Related Diseases |
| Autore | Rustum Youcef M |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (166 p.) |
| Soggetto non controllato |
isoselenourea
malignant chemotherapeutics epigenetics antitumor activity methylseleninic acid mTOR inhibitors tumor heterogeneity hypoxia ER stress melanoma EMT lipid peroxidation immune evasion hypoxia-inducible factors (HIFs) selenium-binding protein 1 glutathione DNA damage hSP56 apoptosis tocopherol anticancer viability SELENBP1 selenium clear-cell renal cell carcinoma microRNAs SBP1 entosis PD-L1 miRNA cancer stem cells cell plasticity disease clear cell renal cell carcinoma HIF head and neck cancer selenium species VEGF STAT3 hypoxia-inducible factor methylselenocysteine anticancer agent Se-containing nanoparticles DNA damage and repair radiation seleno-l-methionine cancer tumor microenvironment methylselenoesters |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346851003321 |
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Rustum Youcef M
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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