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ABC Transporters in Human Diseases
| ABC Transporters in Human Diseases |
| Autore | Falguières Thomas |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (494 p.) |
| Soggetto topico |
Biology, life sciences
Research & information: general |
| Soggetto non controllato |
5' untranslated region
AAV ABC ABC (ATP-binding cassette) transporters ABC transporter ABC transporters ABCA subfamily ABCA7 ABCB1 ABCB11 ABCB4 ABCC2 ABCC6 ABCG2 ABCG2 genotype ABCG5 ABCG5/G8 ABCG8 adrenoleukodystrophy Alzheimer's disease amyloid-beta anticancer antifungal resistance atherosclerosis ATP-binding cassette transporter ATP-binding cassette transporter A1 (ABCA1) Aβ peptides BCRP beta-amyloid bile salts bile secretion bioinformatics blood-brain barrier breast cancer BRIC BSEP calcification cAMP cancer cellular ATP efflux chaperones cholesterol cholesterol homeostasis cis-acting elements clinico-genetic analysis competitive allele-specific PCR disease-free survival drug action drug transport dyslipidemia early-onset gout erlotinib ethnic specificity fatty acids functional divergence gall stone gene therapy generalized arterial calcification of infancy genetic variations gout HDL-C homology modeling hyperuricemia intracellular traffic intrahepatic cholestasis invasion MDR3 mechanism mechanism of action membrane protein microparticles migration molecular partners MRP1 MRP4 multidrug resistance multidrug transporter mutagenesis mutations n/a neuron next-generation sequencing NT5E P-glycoprotein peroxisome PET PFIC PFIC2 phagocytosis phosphatidylcholine phytosterol polar relay polymorphisms precision medicine proliferation pseudoxanthoma elasticum Pseudoxanthoma elasticum (PXE) pyrophosphate RAB GTPase rare variant regulatory extension regulatory insertion reverse cholesterol transport Roma serum uric acid single nucleotide polymorphism sitosterolemia SK-N-SH SNP SUA-lowering therapy substrate-binding site tariquidar taxol therapies therapy response TNAP trafficking transport transporter type 2 diabetes urate urate transporter uric acid xenosterol yeast |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910674029103321 |
Falguières Thomas
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Anticancer Agents : Design, Synthesis and Evaluation
| Anticancer Agents : Design, Synthesis and Evaluation |
| Autore | Chen Qiao-Hong |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (606 p.) |
| Soggetto topico | Medicine and Nursing |
| Soggetto non controllato |
1,2,3-triazole
2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide 3,6-dibromocarbazole 4-(pyridin-4-yloxy)benzamide 5-bromoindole 5-fluorouracil ABCB1 (P-glycoprotein) actin ADME allene amides/esters androgen receptor anti-cancer activity anti-neuroinflammation anti-ovarian cancer anti-tumor anticancer anticancer activity anticancer agent anticancer agents anticancer compounds antimitotic agents antioxidant activity antiproliferative activity antiproliferative agent antitumor antitumor activity apalutamide apoptosis aromatase benzimidazole benzofuran-pyrazole benzofurans beta-lapachone bivalency breast cancer c-Met carbazole cell cycle chemical synthesis chemoresistance chrysin analogues colchiceine colchicine amide colchicine analogs colchicine sulfonamide colon cancer computational docking coumarin crystal structure cyanopyridone cytotoxic activity cytotoxic properties cytotoxicity darolutamide DFT study dihydroartemisinin dihydropyranoindole docking docking studies drug discovery drug resistance E-stereoselective enzalutamide enzyme inhibition estrone derivatives flavonoid flavonoids gemcitabine HDAC inhibitors HeLa HepG2 hydrates hydrazine IGF-1R IL-12 immune modulation indoleamine 2,3-dioxygenase inflammation inhibitor K562 kinase inhibitor MCF-7 MDM2-p53 interaction migration mimetics molecular simulation MOLT-4 multidrug resistance (MDR) reversal N-substituted pyrazoline nanoparticles natural product neuroblastoma NIH3T3 o-nitro-benzyl organosilicon compounds ortho-quinones ovarian cancer overcoming drug resistance P-glycoprotein P-MAPA PARP inhibitor PARP-1 inhibition phenylpyrazolopyrimidine photoactivatable protecting groups PI3Ks PI3Kα inhibitor PI3Kδ inhibitors polyvalency prodrug prostate cancer PROTACs protein degradation protein kinase protein-protein interactions Pyrazole pyrazolopyridine pyridotriazine quinazolin-4(3H)-one quinazolin-4(3H)-thione regioselective salinomycin Schiff base SILA-409 (Alis-409) SILA-421 (Alis-421) Src substituted pyridine synergy synthesis Talazoparib tanshione IIA taxoids thiazolidinone Thienopyrimidine thienopyrimidinone thiocolchicine thiopene thioxotriazopyridine TLR signaling topoisomerase II inhibitor triazolothiadiazine triple-negative breast cancer tryptophan metabolism tubulin inhibitors tumor specificity urea virtual screening xanthones yeast-based assays zampanolide βIII-tubulin |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Anticancer Agents |
| Record Nr. | UNINA-9910557129103321 |
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Chen Qiao-Hong
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Antitumor and Anti-HIV Agents from Natural Products
| Antitumor and Anti-HIV Agents from Natural Products |
| Autore | Nakagawa-Goto Kyoko |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 online resource (338 p.) |
| Soggetto topico | Research & information: general |
| Soggetto non controllato |
acute toxicity
allyl isothiocyanate Angelica dahurica anti-HIV antiangiogenic antioxidants antiproliferation antiproliferative activity antiretroviral agents antitumor activity apoptosis Artemisia absinthium L. aspidosperma-type benzyl isothiocyanate bladder cancer Bousigonia mekongensis BRAF inhibitor breast cancer butanolides caffeic acid cancer cancer multidrug resistance cancer stem cell Carpesium divaricatum cell cycle cell cycle arrest cervical cancer chemistry chemoprevention cisplatin coumarins curcumin analog cytotoxicity delcosine delpheline diterpenoid alkaloids DOTA drug development drug-drug interaction epithelial-to-mesenchymal transition essential oil flavonoids G2/M phase cell cycle arrest HaCaT cells HEF cell line hepatocellular carcinoma hepatoma cells Hernandia nymphaeifolia human tumor cell lines human tumor cells inflammation Ivalin kobusine lignan glycosides lipojesaconitine marine metabolites matrix metalloproteinase medicine melanoma melanoma and breast cancer cell line Mentha aquatica var. Kenting Water Mint metastasis mitochondria-mediated apoptosis monoterpenoid indole alkaloids natural agents natural phaeosphaeride A natural products NF-κB oral squamous cell carcinoma cells oxidative stress oxypeucedanin P-glycoprotein p53 phenethyl isothiocyanate phenolic acid pseudokobusine pterostilbene quercetin reactive oxygen species resveratrol SK-Hep-1 sulforaphane tamoxifen taxol total phenolic content transforming growth factor-β1 triterpenoids tubulin inhibitor tumor suppression two-stage skin carcinogenesis ursolic acid β-lapachone |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557504803321 |
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Nakagawa-Goto Kyoko
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Biological and Pharmacological Activity of Plant Natural Compounds
| Biological and Pharmacological Activity of Plant Natural Compounds |
| Autore | Pezzani Raffaele |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (296 p.) |
| Soggetto topico | Medicine and Nursing |
| Soggetto non controllato |
10-oxyderivatives of oleoside secoiridoids
acute inflammation Ageratina havanensis Amelanchier alnifolia Nutt anti-ageing anti-cancer activities anti-inflammatory anti-oxidant antibacterial antioxidant antioxidant potential behavioral disorders bioactive compounds biological activity Bromelia antiacantha Brosimum gaudichaudii cancer preventive carriers caspase-1 catechin colorectal cancer cytokine storm cytotoxicity depression doxorubicin EGCG epigallocatechin-3-gallate flavonoids flow cytometry forced swim test functional food Genipa americana granuloma green tea hesperidin Hibiscus acetosella histopathology human lung adenocarcinoma hyperuricemia IL-18 IL-1β immunological disorders immunopharmacology inflammation juglone KRAS lipopolysaccharide Mahonia aquifolium matrix metalloproteinases multifloroside muscle function n/a nanocrystals natural compounds natural products nephrotoxicity new-clean process extraction NLRP3 inflammasome nootkatone P-glycoprotein Pharbitis nil pharmacological activities pharmacological activity phenolic acids phenolic compound phenylpropanoids phytochemistry plant secondary metabolites plant side effects plants powders procalcitonin RA-3 structure-activity relationship Tabebuia impetiginosa Taheebo tail suspension test Talisia esculenta traditional uses triterpene UPLC UPLC-ESI-MS/MS zingerone |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557471303321 |
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Pezzani Raffaele
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Cytobiology of Human Prostate Cancer Cells and Its Clinical Applications
| Cytobiology of Human Prostate Cancer Cells and Its Clinical Applications |
| Autore | Ishii Kenichiro |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 online resource (184 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
abiraterone
AKR1C3 androgen deprivation therapy androgen receptor androgen receptor dependency androgen sensitivity animal model apoptosis autophagy cabazitaxel CAF castration resistant prostate cancer castration-resistant prostate cancer Caveolin-1 CCL2 CCL22 CCL5 chemotherapy CW069 cytokine diet docetaxel docetaxel resistance enzalutamide EPI-002 epigenetics fat fibroblast fibroblast growth factor fibroblast growth factor receptor fibroblast-dependent androgen receptor activation fibroblasts G1 cell cycle arrest high-fat diet hormone-naïve prostate cancer immune cells immunohistochemistry in vitro in vivo inflammation KIFC1 LSD1 migration mouse n/a obesity P-glycoprotein pirfenidone prostate cancer prostate-specific antigen radiotherapy resistance splice variant testosterone TGFβ1 time to PSA nadir tissue microarray TP53-regulated inhibitor of apoptosis 1 tumour microenvironment tumour stroma |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557116703321 |
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Ishii Kenichiro
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Drug Absorption Studies: In Situ, In Vitro and In Silico Models
| Drug Absorption Studies: In Situ, In Vitro and In Silico Models |
| Autore | Song Im-Sook |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (171 p.) |
| Soggetto topico |
Manufacturing industries
Medicine and Nursing |
| Soggetto non controllato |
acetaminophen-induced hepatotoxicity
amorphous solid dispersion BCS drug classification bioavailability biomedical drug breast cancer resistance protein candesartan Cilexetil catabolism disorder chitosan cinnarizine D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) dissolution profiles drug-phytochemical interaction endocytosis enoxaparin enzyme extra virgin olive oil hepatic metabolism hydrogel in vivo-in vitro correlation intestinal absorption intestinal permeability kinetics l-phenylalanine ammonia-lyase lipid-based drug delivery system lipid-polymer hybrid nanoparticles lipolysis lipolysis-permeation liver distribution LY335979 meloxicam metabolism microsphere mixed inhibition naftidrofuryl oxalate nanocrystals nasal administration non-sink condition oral oral mucositis P-glycoprotein permeability PermeaPad pH-modulation pharmaceutical availability phenolic compounds phenylketonuria poorly soluble drugs PVPK30 quercetin rebamipide repaglinide secoiridoids silymarin solubility solubility-permeability interplay solubilizer additive spray drying spray-drying unstirred water layer WK-X-34 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Drug Absorption Studies |
| Record Nr. | UNINA-9910557689203321 |
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Song Im-Sook
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular Computing and Bioinformatics / Xiangxiang Zeng, Quan Zou, Alfonso Rodríguez-Patón
| Molecular Computing and Bioinformatics / Xiangxiang Zeng, Quan Zou, Alfonso Rodríguez-Patón |
| Autore | Zeng Xiangxiang |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (390 p.) |
| Soggetto topico | Biotechnology |
| Soggetto non controllato |
systems biology
join graph hierarchical support vector regression transcription factor brain storm optimization heterogeneous information network embedding structural patterns gene fusion data Panax ginseng flowering plant geometric arithmetic index interspecies transmission iron-depleted drug discovery protein protein targeting recursively enumerable function Mycoplasma hominis environmental factor Alzheimer’s disease absorption angiogenesis classification self-organizing systems enzymatic numerical P system excretion atom-bond connectivity index molecular learning DNA coding phylogeny bone formation DCL1 line graph pseudo dinucleotide composition load balancing K2 efflux ratio osteogenesis distribution NanoString Technologies RAST server 8-bit adder/subtractor gene networks dihydrouridine structure information Cartesian product graph domain label stacking denoising auto-encoder DNA computing Stenotrophomonas maltophilia pattern classification stress causal direction learning machine learning adverse drug reaction prediction membrane computing support vector machine Brassica napus miRNA biogenesis identification of Chinese herbal medicines bio-inspired toxicity protein transduction domain RNA sequence information multiple interaction networks in silico protein complex drug low-dimensional representation gene coding protein amino acid mutation Bayesian causal model edge detection big data function prediction parallel computing resolution free Hamming distance cascade oligopeptide transporter DNA barcoding technology DNA strand displacement protein–protein interaction (PPI) biomedical text mining bioinformatics metabolism hypoxia-inducible factor-1? nucleotide physicochemical property Turing universality diabetes mellitus chaotic map multinetwork integration bacterial computing lignification penalized matrix decomposition ensemble classifier bacteria and plasmid system similarity network RNA secondary structure avian influenza virus evaluating driver partner image encryption siderophores meta-path-based proximity P-glycoprotein Tianhe-2 prostate cancer iron acquisition systems biochip technology gene susceptibility prioritization laccase DNA molecular computing microRNA clustering drug-target interaction prediction endoplasmic reticulum |
| ISBN |
9783039211968
303921196X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346836303321 |
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Zeng Xiangxiang
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Strategies to Improve Antineoplastic Activity of Drugs in Cancer Progression
| Strategies to Improve Antineoplastic Activity of Drugs in Cancer Progression |
| Autore | Stefanachi Angela |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (416 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
EGR-1
flavonoid (E)-5-((4-oxo-4H-chromen-3-yl)methyleneamino)-1-phenyl-1H-pyrazole-4-carbonitrile MDA-MB-231 MMP9 TNFα pancreatic ductal adenocarcinoma cyclodextrin inclusion complex phase solubility studies preformulation studies biphenylnicotinamide derivatives dual inhibitor EGFR VEGFR2 ligand-based pharmacophore molecular docking molecular dynamics leukemias doxorubicin inflammation drug delivery tumor targeting elastin-like polypeptide cell penetrating peptide matrix metalloproteinase doxorubicin resistance photosensitizer delivery system PAMAM dendrimer photodynamic therapy cytotoxicity phototoxicity colorectal adenocarcinoma dicarboximides chemical synthesis apoptosis kinases anticancer gene profiling SAR biomarkers colorectal cancer early detection examination liquid biopsy personalized medicine tumor treatment exosomes ctDNA CTC cytotoxic activity pyrazole derivatives MTT assay ADMET analysis single-crystal diffraction FTIR spectroscopy NMR spectroscopy thermogravimetric analysis acute myelogenous leukemia platelets microparticles γδ T cells immunotherapy tumor resistance combination therapy tumor microenvironment immune checkpoint inhibitor neuroblastoma molecular iodine cyclophosphamide xenografts metronomic therapy tamoxifen CYP2D6 MCF-7 Ishikawa cells SERM TNBC uterotrophic α-mangostin poly(amidoamine) dendrimer targeted drug delivery biotin targeting glioblastoma multiforme squamous cell carcinoma antiparasitic therapy diclofenac indomethacin oleanolic acid derivative conjugates NF-κB Nrf2 MAPKs PSN-1 cells reactive oxygen species glioblastoma brain tumor extracellular vesicles pancreatic cancer paclitaxel clathrin endocytosis sulforaphane nicotine metalloproteinase-9 gastric cancer cell invasion Arylquin 1 colon cancer tumor progression azelastine oxidative stress autophagy mitotic catastrophe chronic myeloid leukemia imatinib tyrosine kinase ketoconazole P-glycoprotein drug efflux transporter non-small-cell lung cancer cisplatin resistance aldehyde dehydrogenase isothiocyanates disulfiram epithelial to mesenchymal transition aminopeptidase N acetamidophenones Schiff bases semicarbazones thiosemicarbazones inhibition of proliferation |
| ISBN | 3-0365-5927-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910639990003321 |
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Stefanachi Angela
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Transmucosal Absorption Enhancers in the Drug Delivery Field
| Transmucosal Absorption Enhancers in the Drug Delivery Field |
| Autore | Maher Sam |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 online resource (406 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
absorption enhancement
absorption enhancer absorption enhancers absorption modifying excipients Aloe vera amino acid amphiphilic polymers and liposome antiepileptic drug antimicrobial peptide biocompatibility studies bioenhancer block copolymers brush border Caco-2 Caco-2 cells cationic functionalization cell-penetrating peptide cell-penetrating peptide (CPP) cervicovaginal tumors chitosan chitosan derivatives claudin clinical trial CNS disorders combined microsphere compound 48/80 confocal laser scanning microscopy cornea curcumin cyclodextrin cytochrome P450 drug absorption enhancer drug administration drug delivery efflux enterocyte epithelial permeability epithelial transport epithelium F-actin FITC-dextran formulation gel gemini surfactant GLP-1 hydrophobization imatinib in situ hydrogel in vivo studies insulin intestinal absorption intestinal delivery intestinal epithelial cells intestinal permeation enhancers KLAL man mast cell activator metabolism mucoadhesion mucoadhesiveness N-dodecyl-?-D-maltoside (DDM) nanocapsules nanocrystals nanomedicine nanoparticle nanoparticles nasal nasal delivery nasal formulation nasal permeability nasal vaccination nose to brain delivery nose to brain transport nose-to-brain ocular conditions ocular delivery ocular drug delivery ophthalmology oral delivery oral macromolecule delivery oral peptides osteoporosis P-glycoprotein penetration enhancer penetration enhancers permeability permeation enhancer permeation enhancers pharmacokinetic interaction pharmacokinetics PN159 polymeric micelles poorly absorbed drug preclinical PTH 1-34 pulmonary quaternization safety salcaprozate sodium sheep simulated intestinal fluid simvastatin small intestine sodium caprate sodium cholate (NaC) sugar-based surfactants teriparatide thermogel system tight junction tight junction modulator tight junctions transepithelial electrical resistance transferrin transmucosal drug delivery transmucosal permeation tryptophan vaccine adjuvant vaginal delivery whole leaf |
| ISBN | 3-03921-849-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910372785603321 |
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Maher Sam
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| MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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