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Challenges and Advances in Tuberculosis and Mycobacterial Lung Diseases
| Challenges and Advances in Tuberculosis and Mycobacterial Lung Diseases |
| Autore | Szturmowicz Monika |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (140 p.) |
| Soggetto topico | Public health & preventive medicine |
| Soggetto non controllato |
Gordonia bronchialis
microbiological diagnostics respiratory infection Mycobacterium tuberculosis drug resistance XDR-tuberculosis household TB transmission tuberculous pericarditis extrapulmonary tuberculosis pericarditis constrictive pericarditis tuberculosis abscess scrofula head and neck epiglottis larynx airway mycobacteria surgical drainage FluoroType MTBDR molecular isoniazid rifampin bacillus Calmette-Guerin bladder cancer immunotherapy BCGosis BCG pulmonary infection severe respiratory insufficiency nontuberculous mycobacterium lung cancer surgery nontuberculous mycobacteria cystic fibrosis chest computed tomography Beijing-TB Beijing-like genotype Mycobacterium chimaera nontuberculous mycobacterial disease silicosis extracorporeal membrane oxygenation COVID-19 pandemic spoligotyping Poland human immunodeficiency virus acquired immunodeficiency syndrome chest imaging rapidly growing mycobacteria antimicrobial resistance broth microdilution minimal inhibitory concentration (MIC) |
| ISBN | 3-0365-5492-0 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910637783103321 |
Szturmowicz Monika
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Computational Approaches: Drug Discovery and Design in Medicinal Chemistry and Bioinformatics
| Computational Approaches: Drug Discovery and Design in Medicinal Chemistry and Bioinformatics |
| Autore | Tutone Marco |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (387 p.) |
| Soggetto topico |
Research & information: general
Chemistry |
| Soggetto non controllato |
3D-QSAR
pharmacophore modeling ligand-based model HDACs isoform-selective histone deacetylase inhibitors aminophenylbenzamide hERG toxicity drug discovery fingerprints machine learning deep learning gene expression signature drug repositioning approaches RNA expression regulation high-throughput virtual screening dual-target lead discovery neurodegenerative disorders Alzheimer's disease dual mode of action multi-modal nicotinic acetylcholine receptor acetylcholinesterase molecular docking methotrexate drug resistance human dihydrofolate reductase virtual screening molecular dynamics simulation epitope binning epitope mapping epitope prediction antibody:antigen interactions protein docking glycoprotein D (gD) herpes simplex virus fusion proteins Src inhibitors pharmacophore model molecular dynamics simulations in silico COX-2 inhibitors molecular modeling sodium-glucose co-transporters 2 FimH uropathogenic bacteria urinary tract infections diabetes drug-resistance mutations HIV-2 protease structural characterization induced structural deformations SARS-CoV-2 COVID-19 multiprotein inhibiting natural compounds MD simulation 3CL-Pro antivirals docking simulations drug repurposing consensus models binding space isomeric space MRP4 SNPs variants protein threading modeling molecular dynamics binding site hTSPO PK11195 cholesterol homology modeling molecular dynamics (MD) simulation carbon nanotubes Stone-Wales defects haeckelite defects doxorubicin encapsulation drug delivery system binding free energies noncovalent interactions main protease mutants inhibitors PF-00835231 Mycobacterium tuberculosis tuberculosis proteasome natural compounds multiscale multitargeting polypharmacology computational biology drug repositioning structural bioinformatics proteomic signature skin aging oxidative stress aging progression mechanism genome-wide genetic and epigenetic network (GWGEN) systems medicine design multiple-molecule drug immunoproteasome non-covalent inhibitors MD binding metadynamics induced-fit docking |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Computational Approaches |
| Record Nr. | UNINA-9910557519403321 |
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Tutone Marco
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0
| Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0 |
| Autore | Dansette Patrick M |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (286 p.) |
| Soggetto topico | Research & information: general |
| Soggetto non controllato |
Antibiotics
Bacillus biosynthetic gene clusters comparative analysis cytochrome P450 monooxygenase Mycobacterium P450 diversity percentage P450 profiling secondary metabolites NADPH-cytochrome P450 reductase (CPR) microsomal cytochrome P450 (CYP) Cytochrome b5 (CYB5) protein dynamics electron-transfer (ET) protein–protein interaction cytochromes P450 CYP3A4 active site access channels cavities boundaries minimal cost paths CYP139A1 genome data mining host metabolism Mycobacterium tuberculosis polyketides tuberculosis cryptococcus cryptococcus neoformans CYP51 fungal pathogens genome data-mining human pathogens CYP diversity analysis tremellomycetes trichosporon mechanism-based inhibitor crystal structure CYP4 genes genetic polymorphisms 20-HETE fatty acid arachidonic acid SNPs molecular functionality metabolism lamellar ichthyosis Bietti’s crystalline dystrophy cytochrome P450 isoform membrane protein protein-membrane interactions enzyme substrate specificity mutagenesis molecular dynamics simulation Sogatella furcifera sulfoxaflor transcriptome RNA interference CYP2C8 polymorphisms reactive oxygen species paclitaxel cytochrome P450 reductase electron transfer extracellular vesicles exosomes extrahepatic tissues plasma circulatory CYPs CYP450 drug metabolism precision Cardio-Oncology precision medicine systems medicine cytochromes P450 monooxygenases Cyanobacteria gene-cluster diversity percentage mathematical formula phylogenetic analysis Streptomyces cytochrome P450 monooxygenases terpenes P450 blooming non-ribosomal peptides cytochrome P450 monooxygenenases CYP128A1 Mycobacterium tuberculosis H37Rv molecular dynamic simulations azole drugs menaquinone |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Cytochromes P450 |
| Record Nr. | UNINA-9910557761103321 |
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Dansette Patrick M
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Five Years of Separations : Feature Paper 2018
| Five Years of Separations : Feature Paper 2018 |
| Autore | Samanidou Victoria |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (152 p.) |
| Soggetto topico | Research & information: general |
| Soggetto non controllato |
recycled diatomaceous earth
solid phase microextraction polycyclic aromatic hydrocarbons gas chromatography-mass spectrometry antibody-drug conjugate biopharmaceutical cytotoxicity hydrophobicity micellar electrokinetic chromatography tandem mass spectrometry linear ion trap glycolipid diacyltrehalose Mycobacterium tuberculosis bisphosphonates risedronate zoledronate tiludronate ZIC-HILIC PDA quantitation tablets ionic liquid stationary phase gas chromatography chromatographic selectivity alkylated polycyclic aromatic hydrocarbons (alkylated PAHs) diphenylamine gunshot residues hands dry cotton swab in-tube solid-phase extraction capillary liquid chromatography SEM-EDX thyroid dissolution liquid chromatography-mass spectrometry membrane filtration-treatment membrane type-operation membrane fouling mechanism tannery industrial wastewater vibratory shear-enhanced process (VSEP) tricyclic antidepressants (TCAs) sample treatment biological fluids UV filters matrix solid-phase dispersion μ-MSPD miniaturized extraction technique GC–MS/MS cosmetic analysis personal care products fragrance allergens preservatives plasticizers synthetic musks |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Five Years of Separations |
| Record Nr. | UNINA-9910557299503321 |
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Samanidou Victoria
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Host-Directed Therapies for Tuberculosis
| Host-Directed Therapies for Tuberculosis |
| Autore | Venketaraman Vishwanath |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (120 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
Mycobacterium tuberculosis
host-directed therapies immune responses tuberculosis lung cancer misdiagnosis invasive procedure revising antiplatelet aspirin immunomodulation survival Taiwan latent infection pulmonary rabbit iron supplementation pathology immune response gene expression Perls’ stain autophagy M. tb BCG vaccination immune exhaustion glutathione cytokines granulomas type 2 diabetes co-morbidities co-infections inflammation redox imbalance antioxidants |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557602603321 |
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Venketaraman Vishwanath
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Microbial modulation of host apoptosis and pyroptosis / / topic editors: Yongqun He and Amal O. Amer
| Microbial modulation of host apoptosis and pyroptosis / / topic editors: Yongqun He and Amal O. Amer |
| Autore | Amal O. Amer |
| Pubbl/distr/stampa | Frontiers Media SA, 2014 |
| Descrizione fisica | 1 online resource (109 pages) : illustrations; digital, PDF file(s) |
| Collana | Frontiers Research Topics |
| Soggetto topico |
Cytology
Biology Health & Biological Sciences |
| Soggetto non controllato |
microbial infection
pyroptosis Mycobacterium tuberculosis bacterial exploitation of apoptosis Brucella Infectious Disease Inflammasome Legionella programmed cell death Apoptosis |
| ISBN | 9782889192809 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910137207203321 |
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Amal O. Amer
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| Frontiers Media SA, 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Mycobacterium tuberculosis Pathogenesis, Infection Prevention and Treatment
| Mycobacterium tuberculosis Pathogenesis, Infection Prevention and Treatment |
| Autore | Ferraris Davide Maria |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (128 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
Mycobacterium tuberculosis
line probe assay second-line drugs drug resistance XDR-TB MDR-TB omics analysis TB treatment system analysis Beijing B0/W148 Mycobacterium smegmatis imidazo[1,2-b][1,2,4,5]tetrazine MmpS5-MmpL5 efflux drug discovery tuberculosis immune activation HLA-DR CD38 treatment response Mycobacterium macrophage apoptosis effector cytokine microRNA Beijing genotype Central Asia Outbreak murine infection model Virulence pre-XDR-TB Mycobacterium avium unique metabolic pathways subtractive genomics drug target uncharacterized proteins BM-MSCs Mtb bone-homing stem cell niche latent tuberculosis relapse liposomes M. tuberculosis host-pathogen interactions immune response antitubercular drug discovery antitubercular treatments IL-18 IL-18BP IL-18R gene expression |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557291103321 |
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Ferraris Davide Maria
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Protein-Ligand Interactions: Target Identification and Drug Discovery
| Protein-Ligand Interactions: Target Identification and Drug Discovery |
| Autore | Altieri Fabio |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (184 p.) |
| Soggetto topico |
Research & information: general
Chemistry |
| Soggetto non controllato |
serum half-life extension
fatty acid conjugation FcRn-mediated recycling serum albumin translocator protein (TSPO) CoCl2 mitochondrial membrane potential reactive oxygen species (ROS) cell viability cell death lung cancer cell line acetylcholinesterase amyloid beta aggregation neuroprotection molecular docking multi-target drug structure–activity relationship brassicasterol phytosterols HSV Mycobacterium tuberculosis HSV-1 DNA polymerase HSV-1 TK human CDK2 ACE UDP-galactopyranose mutase heat shock protein 70 Hsp70 piperine fluorescence spectroscopy molecular dynamics molecular biophysics GADD45β MKK7 multiple myeloma protein-ligand interaction STD-NMR sigma receptors sigma ligands cancer SIGMAR1 PGRMC1 TMEM97 NCI60 COMPARE analysis membrane lipid-protein interaction lipid signalling kinase regulation phosphatidylinositols molecular docking simulation target identification small-molecule derivatives of salicylanilide drug discovery drug development thyroid diseases endocrine disruptor compound human umbilical artery vascular homeostasis |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti |
Protein—Ligand Interactions
Protein-Ligand Interactions Protein–Ligand Interactions |
| Record Nr. | UNINA-9910557497703321 |
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Altieri Fabio
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Tuberculosis Drug Discovery and Development 2019
| Tuberculosis Drug Discovery and Development 2019 |
| Autore | Riccardi Giovanna |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (296 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
mycobacteria
tuberculosis multi-drug resistance drug discovery promiscuous targets Mycobacterium tuberculosis rifampin isoniazid mechanisms of resistance mutations granulomas caseum cell envelope dormancy delpazolid macozinone DprE1 inhibitor clinical studies discovery mode of action drug resistance toxicity target energy metabolism electron transport chain oxidative phosphorylation bedaquiline Q203 MID3 pharmacokinetics pharmacodynamics drug-drug interactions in vitro in vivo drug development tuberculosis treatment biomarkers drug combination clinical trial BCG tuberculosis vaccines TBVI EDCTP IAVI CTVD host-directed therapy anti-virulence compounds TB post-treatment sequelae surgery pulmonary rehabilitation Carlo Forlanini artificial pneumothorax structure-based drug design target-based drug design PknB PknG DNA gyrase antibiotic mycobacterium genomics transcriptomics proteomics metabolomics lipidomics target identification mechanism of action antimicrobial drug resistance (AMR) target-based screening phenotypic screening antituberculosis agents antimycobacterial anti-TB drug pipeline privileged targets lead generation |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557627203321 |
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Riccardi Giovanna
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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