Info
- Utilizzare la checkbox di selezione a fianco di ciascun documento per attivare le funzionalità di stampa, invio email, download nei formati disponibili del (i) record.
The EBMT Handbook [[electronic resource] ] : Hematopoietic Stem Cell Transplantation and Cellular Therapies / / edited by Enric Carreras, Carlo Dufour, Mohamad Mohty, Nicolaus Kröger
| The EBMT Handbook [[electronic resource] ] : Hematopoietic Stem Cell Transplantation and Cellular Therapies / / edited by Enric Carreras, Carlo Dufour, Mohamad Mohty, Nicolaus Kröger |
| Autore | Carreras Enric |
| Edizione | [7th ed. 2019.] |
| Pubbl/distr/stampa | Cham, : Springer Nature, 2019 |
| Descrizione fisica | 1 online resource (XL, 702 p. 56 illus., 38 illus. in color.) |
| Disciplina | 616.15 |
| Soggetto topico |
Hematology
Surgical transplantation Blood transfusion Pediatric surgery Surgical oncology Hematopoietic Stem Cell Transplantation Leukemia - therapy |
| Soggetto non controllato |
Medicine
Hematology Surgical transplantation Blood transfusion Pediatric surgery Surgical oncology |
| ISBN | 3-030-02278-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Part 1. Introduction -- 1. HSCT: Historical perspective -- 2. The EBMT: History, present and future -- 3. The role of unrelated donor registries in HSCT -- 4. The HSCT Unit -- 5. JACIE accreditation of HSCT programs -- 6. Statistical methods in HSCT and Cellular Therapies -- Part 2. Biological aspects -- 7. Biological properties of HSC: scientific basis for HSCT -- 8. Biological properties of cells other than HSC -- 9. Histocompatibility -- 10. Clinical & biological concepts for mastering Immune reconstitution after HSCT: towards practical guidelines and greater harmonization -- Part 3. Methodology and clinical aspects -- 11. Evaluation and counselling of candidates -- 12. Donor selection for adults and pediatrics -- 13. Conditioning -- 14. Bone marrow harvesting for HSCT -- 15. Mobilization and collection of HSC -- 16. Collection of HSC in children -- 17. Processing, cryopreserving, and controlling the quality of HSCs -- 18. Procurement and management of cord blood -- 19. Graft manipulation -- 20. Documentation of engraftment and chimerism after HSCT -- 21. Short and long-term controls after HSCT -- Part 4. General management of the patient -- 22. Vascular access -- 23. Transfusion support -- 24. Nutritional support -- 25. GVHD prophylaxis (immunosuppression) -- 26. Management ATG (SIRS) -- 27. Infections control and isolation procedures -- 28. General management of the patient; Specific aspects of children -- 29. Vaccinations -- 30. Psychological morbidity and support -- 31. Clinical relevant drug interactions in HSCT -- 32. Role of nursing in HSCT -- 33. Ethical issues in HSCT -- 34. Quality of life assessment after HSCT for pediatric and adults -- Part 5. HSCT complications and management -- 35. Neutropenic fever -- 36. Bacterial infections -- 37. Invasive fungal infections -- 38. Viral infections -- 39. Other life-threatening infections -- 40. Bleeding and thrombotic complications -- 41. Graft failure -- 42. Early complications of endothelial origin -- 43. Acute Graft-versus-Host Disease -- 44. Chronic Graft-versus-Host Disease -- 45. Post-transplant lymphoproliferative syndromes -- 46. Iron overload -- 47. Secondary neoplasia (other than PTLPS) -- Part 6. Specific organ complications -- 48. Ocular and oral complications -- 49. Hepatic complications -- 50. Gastrointestinal complications -- 51. Hemorrhagic cystitis and renal dysfunction -- 52. Non-infectious pulmonary complications -- 53. Neurological complications -- 54. Skin, hair and musculoskeletal complications -- 55. Cardiovascular diseases and metabolic syndrome -- 56. Endocrine disorders, fertility and sexual health -- Part 7. Prevention and management of relapse -- 57. Monitoring MRD in ALL and AML -- 58. Preventing/treating relapse with drugs -- 59. Delayed transfer of immune cells, or the art of Donor Lymphocyte Infusion -- 60. Cellular therapy with engineered T cells, efficacy and side effects -- 61. Mechanisms of Immune resistance -- 62. Regulatory Aspects of ATMP versus minimally manipulated immune cells -- Part 8. Specific modalities of HSCT and management -- 63. At-home HSCT -- 64. Umbilical cord blood transplantation in children and adults -- 65. Haploidentical HSCT -- 66. Photopheresis in adults and pediatrics -- 67. Overweight and obese patients -- 68. HSCT in elderly patients -- Part 9. Indications and results -- 69. Acute Myeloid Leukemia in adults -- 70. Acute Myeloid Leukemia in children -- 71. Acute Lymphoblastic Leukemia in adults -- 72. Acute lymphoblastic leukemia in children and adolescents -- 73. Myelodysplastic syndromes -- 74. Pediatric MDS including Refractory Cytopenia and Juvenile Myelomonocytic Leukemia -- 75. Myelodysplastic/myeloproliferative neoplasms -- 76. Myeloproliferative neoplasms -- 77. Severe aplastic anemia and PNH -- 78. Fanconi anemia and other hereditary Bone Marrow Failure syndromes -- 79. Hemoglobinopathies (Sickle Cell Disease and Thalassemia) -- 80. Multiple myeloma -- 81. Systemic light chain amyloidosis -- 82. POEMS syndrome and disease produced by other monoclonal immunoglobulins -- 83. Follicular lymphoma -- 84. Chronic lymphocytic leukemia -- 85. Diffuse large B cell lymphoma -- 86. Mantle cell lymphoma -- 87. Other T- and B-aggressive lymphomas and lymphomas associated to HIV -- 88. Classical Hodgkin’s lymphoma -- 89. Primary immunodeficiencies -- 90. Inborn error of metabolism and osteopetrosis -- 91. Autoimmune disease -- 92. Solid tumors. |
| Record Nr. | UNINA-9910337530503321 |
Carreras Enric
|
||
| Cham, : Springer Nature, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Euthanasia : Experiences and Insights of Belgian Doctors and Nurses
| Euthanasia : Experiences and Insights of Belgian Doctors and Nurses |
| Autore | Devos Timothy |
| Pubbl/distr/stampa | Springer Nature, 2021 |
| Descrizione fisica | 1 online resource (124 pages) |
| Soggetto topico |
Eutanàsia
Ètica mèdica Ètica en infermeria |
| Soggetto genere / forma | Llibres electrònics |
| Soggetto non controllato |
Palliative Medicine
Hematology Oncology Bioethics Nursing Ethics Psychiatry Palliative Care Internal Medicine Moral Philosophy and Applied Ethics Medical Ethics Critical views Therapeutic obstinacy Meaning of life Slippery slope Experiences from daily practice Open Access Haematology Nursing Medical ethics & professional conduct |
| ISBN | 3-030-56795-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Foreword 1 -- Foreword 2 -- The Failure to Present "the Full Story" -- Range of Disciplines and Experiential Knowledge -- Issues Raised by Legalized Euthanasia -- Expansion and Normalization Through Giving Priority to Autonomy -- Suicide and Social Contagion -- Euthanasia is Incompatible with Palliative Care -- Loving Accompaniment Until Natural Death -- The "Mystery of Death" -- Conclusion -- Contents -- About the Authors -- About the Editor -- 1: The Slippery Slope Syndrome -- 1.1 The Decriminalization of Euthanasia -- 1.2 Ignorance About Palliative Care -- 1.3 The Trivialization of Euthanasia -- 1.4 A Perverted Sense of Duty -- 1.5 Suffering and Silence -- 1.6 The Economic Context -- 1.7 Euthanasia in the Psychiatric Context -- 1.8 After Euthanasia -- 1.9 The Euthanasia of Minors -- 1.10 The Euthanasia of Remorse -- References -- 2: The Doctor Turned into an Instrument -- 2.1 The Therapeutic Alliance -- 3: When Conscience Wavers. Some Reflections on the Normalization of Euthanasia in Belgium -- 3.1 The Embarrassment of the Law -- 3.2 Euthanasia: Medical Act or Transgression? -- 3.3 Euthanasia as Transgression -- 3.4 Between Law and Conscience: Euthanasia and Moral Integrity -- 3.5 Conclusion -- References -- 4: Euthanasia for Unbearable Psychological Suffering -- 4.1 What Does the Law Say? -- 4.2 A Lack of Prospect of Improvement of the Medical Situation -- 4.3 Incurable Disorder -- 4.4 Persistent and Unbearable Psychological Suffering -- 4.5 What Is Empathy? -- 4.6 Decision-Making Capacity -- 4.7 Conclusion -- 4.8 The Long and the Short of Mrs. Jeanine's Story -- References -- 5: People Facing the Question of Euthanasia: Patients, Family and Friends, Healthcare Workers -- 5.1 Personal Suffering -- 5.2 Physical Suffering -- 5.3 Psychological Suffering -- 5.4 Emotional and Relational Suffering.
5.5 Existential and Spiritual Suffering -- 5.6 How Can One Respond to a Request for Euthanasia? -- 5.7 The Reaction of Family and Friends to a Request for Euthanasia -- 5.8 How Can the Medical Staff Act or React to a Request for Euthanasia? -- References -- 6: Surrendering to or Inducing Death: Artificial Feeding as Paradigm -- 6.1 Framework of this Reflective Study -- 6.1.1 Case #1-Madame B. 73 Years Old -- 6.1.2 Case #2-Madame F. 90 Years Old -- 6.1.3 Case #3-Madame J. 68 Years Old -- 6.2 Why Use Feeding Tubes? What Criteria Prevailed? How Efficient Are they? How Did we Come to Adopt these Protocols? -- 6.3 First Approach of the Ethical Question -- 6.4 Distinguishing between Ordinary and Extraordinary -- 6.5 Three Levels of Ethical Judgment -- 6.6 Madame B. or the "Disproportioned Deemed Ordinary" -- 6.7 Madame F. or the "Proportionate Turned Doubtful (Optional) and Deemed Extraordinary" -- 6.8 Conclusion -- References -- 7: The Meaning of Suffering or the Meaning of Life Despite Suffering -- 7.1 Viktor Frankl: The Question of Meaning at the Heart of Medicine -- 7.2 How Can We Apply Viktor Frankl's Theories to Helping Patients? -- 7.2.1 First Pathway: Accomplishment Through Love -- 7.2.2 Second Pathway: Accomplishment Through a Meaningful Life -- 7.2.3 Third Pathway: Knowing How to Deal with Suffering -- 7.3 What Happens in a Country Where Euthanasia Has Been Decriminalised? -- References -- 8: Resisting -- 8.1 The Request for Euthanasia -- 8.2 Family Pressure -- 8.3 Explaining Euthanasia -- 8.4 The Trap of 'Integrated' Palliative Care -- 8.5 Sedation: Misunderstandings and Confusion -- 8.6 Palliative Care: A Hospital Paradigm -- 8.7 Contradiction and Ambiguity -- Reference -- 9: Behind the Scenes of Euthanasia -- 9.1 Distress of the Healthcare Worker -- 9.2 Euthanasia: A 'De-Humanising' Act. 9.3 When Conscience Competes Against Law and Bureaucracy -- 9.4 Euthanasia, a Stage in Accepting One's Illness -- 9.5 Euthanasia as a Wake-Up Call from Indifference -- 9.6 Sedation: Palliative Practise or Hypocrisy? -- 9.7 When Trust Meets Professional Integrity -- Correction to: When Conscience Wavers. Some Reflections on the Normalization of Euthanasia in Belgium -- Correction to: T. Devos (ed.), Euthanasia: Searching for the Full Story, https://doi.org/10.1007/978-3-030-56795-8 -- Postface -- Brief List of Health-Care Terms for the Non-specialist. |
| Altri titoli varianti | Euthanasia |
| Record Nr. | UNINA-9910473449503321 |
|
Devos Timothy
|
||
| Springer Nature, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Experimental hematology
| Experimental hematology |
| Pubbl/distr/stampa | New York, : Elsevier |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
Hematology, Experimental
Stem cells - Research Hematology Radiation - Physiological effect Radioactivity - Safety measures Stem cells Research Stem Cells Hématologie Rayonnement - Effets physiologiques Radioactivité - Sécurité - Mesures Hématologie expérimentale Cellules souches - Recherche Cellules souches Recherche research (function) 44.86 haematology Hematologie |
| Soggetto genere / forma |
Periodical
Periodicals. |
| Soggetto non controllato | Hematology |
| ISSN | 1873-2399 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996214261803316 |
| New York, : Elsevier | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Experimental hematology
| Experimental hematology |
| Pubbl/distr/stampa | New York, : Elsevier |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
Hematology, Experimental
Stem cells - Research Hematology Radiation - Physiological effect Radioactivity - Safety measures Stem cells Research Stem Cells Hématologie Rayonnement - Effets physiologiques Radioactivité - Sécurité - Mesures Hématologie expérimentale Cellules souches - Recherche Cellules souches Recherche research (function) 44.86 haematology Hematologie |
| Soggetto genere / forma |
Periodical
Periodicals. |
| Soggetto non controllato | Hematology |
| ISSN | 1873-2399 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910142891503321 |
| New York, : Elsevier | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Hematology
| Hematology |
| Pubbl/distr/stampa | Washington, DC, : American Society of Hematology |
| Disciplina | 616 |
| Soggetto topico |
Hematology
Blood - Diseases Hematologic Diseases |
| Soggetto genere / forma |
Congress.
Conference papers and proceedings. Periodicals. |
| Soggetto non controllato | Hematology |
| ISSN | 1520-4383 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996214975303316 |
| Washington, DC, : American Society of Hematology | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Hemomath : The Mathematics of Blood / Antonio Fasano, Adélia Sequeira
| Hemomath : The Mathematics of Blood / Antonio Fasano, Adélia Sequeira |
| Autore | Fasano, Antonio |
| Pubbl/distr/stampa | Cham, : Springer, 2017 |
| Descrizione fisica | xvii, 340 p. : ill. ; 24 cm |
| Altri autori (Persone) | Sequeira, Adélia |
| Soggetto topico |
92-XX - Biology and other natural sciences [MSC 2020]
76Zxx - Biological fluid mechanics [MSC 2020] 92C35 - Physiological flow [MSC 2020] |
| Soggetto non controllato |
Biomathematics
Dialysis Hematology Hemorheology Nephrology |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Titolo uniforme | |
| Record Nr. | UNICAMPANIA-VAN0123995 |
|
Fasano, Antonio
|
||
| Cham, : Springer, 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Vanvitelli | ||
| ||
Hemomath : The Mathematics of Blood / Antonio Fasano, Adélia Sequeira
| Hemomath : The Mathematics of Blood / Antonio Fasano, Adélia Sequeira |
| Autore | Fasano, Antonio |
| Pubbl/distr/stampa | Cham, : Springer, 2017 |
| Descrizione fisica | xvii, 340 p. : ill. ; 24 cm |
| Altri autori (Persone) | Sequeira, Adélia |
| Soggetto topico |
76Zxx - Biological fluid mechanics [MSC 2020]
92-XX - Biology and other natural sciences [MSC 2020] 92C35 - Physiological flow [MSC 2020] |
| Soggetto non controllato |
Biomathematics
Dialysis Hematology Hemorheology Nephrology |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Titolo uniforme | |
| Record Nr. | UNICAMPANIA-VAN00123995 |
|
Fasano, Antonio
|
||
| Cham, : Springer, 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Vanvitelli | ||
| ||
Quality Management and Accreditation in Hematopoietic Stem Cell Transplantation and Cellular Therapy : The JACIE Guide
| Quality Management and Accreditation in Hematopoietic Stem Cell Transplantation and Cellular Therapy : The JACIE Guide |
| Autore | Aljurf M. D (Mahmoud Deeb) |
| Pubbl/distr/stampa | Springer Nature, 2021 |
| Descrizione fisica | 1 online resource (189 pages) |
| Altri autori (Persone) |
SnowdenJohn A
HaydenPatrick (Consultant haematologist) OrchardKim H McGrathEoin |
| Soggetto topico |
Haematology
Oncology |
| Soggetto non controllato |
Hematology
Oncology Blood Transfusion Medicine Internal Medicine outcome analysis structural indicators process indicators Hematopoietic Stem Cell Transplantation Quality Management Audits Qualification and Validation Personnel Requirements Performance Measurement Tracking and Traceability Adverse Events Quality Management Plan Accreditation Data Management Training Risk Management JACIE Haematology |
| ISBN | 3-030-64492-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Introduction -- Contents -- Contributors -- Chapter 1: Quality and Standards for Haematopoietic Stem Cells Transplantation Programs -- Quality -- Standards -- Impact -- Conclusion -- References -- Chapter 2: Development of Organizational Quality Management System -- References -- Chapter 3: Document Development, Implementation, Review, Archive, and Disposal -- General -- Start -- Workflow -- Responsibilities -- Duplication of Requirements Between Different Quality Systems -- ICT Systems and Paper Documents -- Education and Document Management -- JACIE on Document Management -- Chapter 4: Audits -- General Concepts -- Definition and Purpose -- Scope -- Types of Audits -- Auditor Requirements -- How to Perform Internal Audit: The Steps of an Internal Audit -- Audit Calendar -- Audit Plan -- Conducting the Audit -- Closing -- Audit Report -- Actions -- Communication of the Result of Internal Audits -- References -- Chapter 5: Qualification and Validation -- Glossary -- Validation Process (Fig. 5.2) -- Example of Documents and Registration Forms for Validation -- Validation Master Plan (VMP) -- Validation Study -- References -- Chapter 6: Outcome Analysis -- What Is Outcome Analysis? -- Standards -- Collecting Data -- Establishing Outcome Analysis for Novel Applications -- Reviewing Data -- References -- Further Reading -- Chapter 7: Personnel Requirements Including Job Descriptions -- Introductıon -- Organisational Structure and Organisational Chart -- Key Personnel -- Personnel Competency -- Responsibility and Task Awareness -- Use of Effective Communication -- Job Descriptions -- Personnel File -- Conclusion -- References -- Chapter 8: Third-Party Agreements -- Gentlemen's Agreement -- Memoranda of Understanding (MoU) [1] -- Contract/Commercial Agreement (Fig. 8.2) -- Service-Level Agreements (SLAs) -- Technical Agreement.
Third-Party Agreement -- Quick Checklist [2] -- Communication Is Critical [3] (Fig. 8.4) -- References -- Chapter 9: Performance Measurement -- Definitions for Healthcare Performance Measurement -- Measure Development Life Cycle -- Measure Development Process -- Bringing It All Together -- Performance Score -- Goals for Measure Development in SCT Program -- SCT Program Performance Measure -- Performance Measurement and KPI -- The Value of Dashboards for Metrics or KPI -- Dashboard Basics for Quality (Table 9.4) -- Challenges HCT Programs Can Embrace -- Examples of Quality KPI for Clinical SCT Program (Table 9.5) -- KPI Administrative Focus Areas -- Conclusion -- References -- Chapter 10: Tracking and Traceability -- Introduction -- Information Environment -- Donation Identification -- Combining Donation and Product Information -- References -- Chapter 11: Adverse Events and Corrective and Preventive Actions -- Definitions of What to Report -- Investigation, Analysis -- Corrective, Preventive Action -- Biological Product Deviations (BPD) -- References -- Chapter 12: Process Indicators -- Introduction, Definitions, and Example -- Process Definitions -- Process Controls -- Process Indicators -- Selection, Definition, and Range -- Persons Responsible for the Measure and Timing -- Indicator's Table -- Actions -- Other Indicators -- Indicators Within Time -- Communication -- References -- Chapter 13: Writing a Quality Management Plan -- Introduction -- QMP Structure -- HCT Programme Description -- Organizational Structure - Roles and Responsibilities -- Key Personnel - Qualifications, Training, and Competency -- Document Control -- Key Performance Data and Outcome Analysis -- Audits -- The Management of Products with Positive Microbial Culture Results -- The Management of Occurrences -- Traceability -- Business Continuity Policy. Qualification and Validation -- General Principles -- Quality Risk Management -- Obtaining Feedback -- Tools for Continuous Quality Improvement -- Other Aspects -- References -- Chapter 14: The Accreditation Process -- Why Seek Accreditation? -- Where to Start? -- Phases of the Accreditation Process -- Pre-inspection Phase -- Application Form -- Self-Assessment Standards Checklist -- Pre-inspection Documentation -- Inspection Phase -- Post-inspection Phase -- Plan the Post-accreditation Period -- Key Agents -- References -- Chapter 15: Data Management -- Data Management -- Conclusion -- References -- Chapter 16: Maintaining the Quality Management Program -- General -- The Setup of the Quality Manual -- Work Area -- Material and Supplies -- Hygiene -- Education -- Documentation -- Changes -- Validation -- Information and Communications Technology (ICT) -- Meetings -- Outcome -- Risk Assessments -- Audits -- Chapter 17: Training Programme -- Types of Education -- Orientation Training -- Initial Training -- Continuous Education -- Training Methods -- Theoretical Education -- Practical Training -- Rotation Training -- Conferences -- Case Training -- Online Training -- Standard Operating Procedure (SOP) Training -- Unplanned Training -- Trainer Qualifications -- Determination of Training Needs -- Documentation of Training -- Training Evaluation -- Conclusion -- References -- Chapter 18: Risk Management -- Defining Risk in Cell Therapy -- The Quality Risk Management Process -- Risk Assessment -- Risk Control -- Risk Review -- Risk Communication -- Stakeholders Involved in Risk Management -- Illustrative Examples of Specific Applications -- Related vs. Unrelated Donors -- Processing of Cell Therapy Products -- Patients -- Final Remarks -- References. Correction to: Quality Management and Accreditation in Hematopoietic Stem Cell Transplantation and Cellular Therapy -- Correction to: -- Index. |
| Record Nr. | UNINA-9910473450803321 |
|
Aljurf M. D (Mahmoud Deeb)
|
||
| Springer Nature, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Role of neutrophils in disease pathogenesis
| Role of neutrophils in disease pathogenesis |
| Autore | Maitham Abbas Khajah |
| Pubbl/distr/stampa | IntechOpen, 2017 |
| Descrizione fisica | 1 online resource (182 pages) |
| Disciplina | 616 |
| Soggetto topico | MEDICAL / Hematology |
| Soggetto non controllato |
Medicine
Hematology Hemorheology Health Sciences |
| ISBN |
953-51-4800-1
953-51-3196-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910251430103321 |
|
Maitham Abbas Khajah
|
||
| IntechOpen, 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||