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Functionally Relevant Macromolecular Interactions of Disordered Proteins
| Functionally Relevant Macromolecular Interactions of Disordered Proteins |
| Autore | Simon Istvan |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 online resource (520 p.) |
| Soggetto topico |
Biology, life sciences
Research and information: general |
| Soggetto non controllato |
aggregation
CABS model co-evolution coarse-grained conformational plasticity copper binding correlated mutations decision tree based artificial neural network dehydron differentially regulated genes disorder-to-order regions disordered protein disordered protein platform DNA conformational landscape DNA-protein interactions drug discovery drugs dual threshold eIF4E epiproteome evolution evolutionary couplings extracellular FG-Nups fluorescence anisotropy folding functional analysis gene ontology analysis histone lysine methyltransferase homodimer HOTAIR hydration hydrogen bond immune inter-subunit interaction interaction surface intrinsic disorder intrinsic disorder prediction intrinsically disorder proteins intrinsically disordered intrinsically disordered protein intrinsically disordered proteins intrinsically disordered proteins (IDPs) intrinsically disordered region ion pair leukemia lncRNA MC simulations MEG3 membrane-less organelle meta strategy Microarray MLL proteins MLL4 molecular machines molecular recognition feature molten globule mutual synergistic folding N-terminal prion protein neurodegenerative disease neurodegenerative diseases Nuclear pore complex oligomer p300 HAT acetylation p53 phosphorylation physiological homeostasis plant virus post-translational modification post-translational modifications potyvirus prion disease mutations protein protein aggregation protein conformation protein hydrodynamics protein intrinsic disorder protein stability protein structure protein thermostability protein-protein interaction protein-RNA interactions residue co-variation residue contact network ribosomal protein RIN4 RNA binding RNA sequencing salt bridges secretion sequential DNA bending significance voting smFRET solvent-accessible surface area Sox2 sequential DNA loading spectroscopy stabilization center statistical force fields stress response structural disorder structural domain Tau fibrillation temperature response transcription factor dosage transcription factors transcriptome unstructured proteins VPg wide-line 1H NMR |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557509403321 |
Simon Istvan
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular Mechanism of Alzheimer's Disease / Ian Macreadie
| Molecular Mechanism of Alzheimer's Disease / Ian Macreadie |
| Autore | Macreadie Ian |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (228 p.) |
| Soggetto topico | Biology, life sciences |
| Soggetto non controllato |
HOTAIR
neurosciences sleep disturbance positron emission tomography (PET) vitamin B complex neurodegeneration Tau miR-15/107 default-mode network complement receptor 1 neuronal differentiation epigenetics brain glucose metabolism oligomerization genetic risk A?O receptors prion ryanodine receptor type 3 diabetes complement cognitive behavioral therapy for insomnia cognitive function epigenome-wide association study Alzheimer’s disease calcium signaling ?-secretase tau Prolyl isomerases NEAT1 complement C3b/C4b receptor proteostasis amyloid beta yeast slow-wave sleep amyloid ? nutrition 4 protein aggregation apolipoprotein E dementia MALAT1 inositol 1 lncRNAs molecular biology methylenetetrahydrofolate reductase MTHFR gene 5-trisphosphate receptor CR1 density miR-34c aggregation heat shock protein dendritic spine S-adenosylmethionine beta amyloid ion channel inflammation sleep fragmentation cystathionine-?-lyase CTH gene DNA methylation heat shock response microglia drug target discovery amyloid-? oligomer therapy CR1 length polymorphism methylome APOE gene ubiquitin magnetic resonance imaging (MRI) neuronal degeneration type 2 diabetes Pin1 mild cognitive impairment dairy products endoplasmic reticulum oxidative stress Hispanics CDK5R1 |
| ISBN |
9783039214082
303921408X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910367750403321 |
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Macreadie Ian
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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