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Functionally Relevant Macromolecular Interactions of Disordered Proteins
| Functionally Relevant Macromolecular Interactions of Disordered Proteins |
| Autore | Simon Istvan |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (520 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
intrinsically disordered proteins
epiproteome disordered protein platform molecular recognition feature post-translational modifications physiological homeostasis stress response RIN4 p53 molecular machines intrinsically disordered protein membrane-less organelle neurodegenerative disease p300 HAT acetylation post-translational modification protein aggregation Tau fibrillation intrinsically disorder proteins disorder-to-order regions protein–RNA interactions unstructured proteins conformational plasticity disordered protein folding ribosomal protein spectroscopy protein stability temperature response protein thermostability salt bridges meta strategy dual threshold significance voting decision tree based artificial neural network protein intrinsic disorder intrinsic disorder intrinsic disorder prediction intrinsically disordered region protein conformation transcriptome RNA sequencing Microarray differentially regulated genes gene ontology analysis functional analysis intrinsically disordered structural disorder correlated mutations co-evolution evolutionary couplings residue co-variation interaction surface residue contact network dehydron homodimer hydrogen bond inter-subunit interaction ion pair mutual synergistic folding solvent-accessible surface area stabilization center MLL proteins MLL4 lncRNA HOTAIR MEG3 leukemia histone lysine methyltransferase RNA binding protein hydration wide-line 1H NMR secretion immune extracellular protein-protein interaction structural domain evolution transcription factors DNA-protein interactions Sox2 sequential DNA loading smFRET DNA conformational landscape sequential DNA bending transcription factor dosage oligomer N-terminal prion protein copper binding prion disease mutations Nuclear pore complex FG-Nups phosphorylation coarse-grained CABS model MC simulations statistical force fields protein structure intrinsically disordered proteins (IDPs) neurodegenerative diseases aggregation drugs drug discovery plant virus eIF4E VPg potyvirus molten globule fluorescence anisotropy protein hydrodynamics |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557509403321 |
Simon Istvan
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular Mechanism of Alzheimer's Disease
| Molecular Mechanism of Alzheimer's Disease |
| Autore | Macreadie Ian |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (228 p.) |
| Soggetto non controllato |
HOTAIR
neurosciences sleep disturbance positron emission tomography (PET) vitamin B complex neurodegeneration Tau miR-15/107 default-mode network complement receptor 1 neuronal differentiation epigenetics brain glucose metabolism oligomerization genetic risk A?O receptors prion ryanodine receptor type 3 diabetes complement cognitive behavioral therapy for insomnia cognitive function epigenome-wide association study Alzheimer’s disease calcium signaling ?-secretase tau Prolyl isomerases NEAT1 complement C3b/C4b receptor proteostasis amyloid beta yeast slow-wave sleep amyloid ? nutrition 4 protein aggregation apolipoprotein E dementia MALAT1 inositol 1 lncRNAs molecular biology methylenetetrahydrofolate reductase MTHFR gene 5-trisphosphate receptor CR1 density miR-34c aggregation heat shock protein dendritic spine S-adenosylmethionine beta amyloid ion channel inflammation sleep fragmentation cystathionine-?-lyase CTH gene DNA methylation heat shock response microglia drug target discovery amyloid-? oligomer therapy CR1 length polymorphism methylome APOE gene ubiquitin magnetic resonance imaging (MRI) neuronal degeneration type 2 diabetes Pin1 mild cognitive impairment dairy products endoplasmic reticulum oxidative stress Hispanics CDK5R1 |
| ISBN | 3-03921-408-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910367750403321 |
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Macreadie Ian
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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