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Fibroblast Growth Factor Receptor (FGFR) Signaling Pathway in Tumor
| Fibroblast Growth Factor Receptor (FGFR) Signaling Pathway in Tumor |
| Autore | Holzmann Klaus |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (276 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
FGFR4
FGF19 gene regulation cancer signaling anticancer FRS2 FGFR NVP-BGJ398 LY2874455 sarcoma cancer-associated fibroblasts GPER breast cancer estrogen FGFR1 FGF2 optogenetics ERK AKT receptor kinase neurite outgrowth HEK293 PC12 fibroblast growth factor receptors signaling receptor cross-talk coreceptor membrane proteins FGFR2 ERK1/2 phosphorylation serine negative feedback loop cancer prognosis HCC inhibitors FGF fibroblast growth factor autocrine signaling skin melanoma squamous and basal cell carcinoma seborrheic keratosis targeted therapy resistance structure kinase inhibitor gastric cancer monoclonal antibody small molecule FGFR2c autophagy keratinocyte MTOR JNK1 review malignant glioma brain cancer astrocytoma Sprouty proteins FGF-mediated signaling tumor suppressor tumor promoter malignant pleural mesothelioma overall survival immunohistochemistry infigratinib sensitivity FGF8 FGF18 adenocarcinoma of the esophagogastric junction neoadjuvant therapy |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Fibroblast Growth Factor Receptor |
| Record Nr. | UNINA-9910557898903321 |
Holzmann Klaus
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Mitochondria in Health and Diseases
| Mitochondria in Health and Diseases |
| Autore | Javadov Sabzali |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (434 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
hypoglycemia
sodium dichloroacetate pyruvate dehydrogenase kinase pyruvate dehydrogenase oxidative stress neuron death cholangiocellular carcinoma mitochondria energy metabolism oxidative phosphorylation 4-HNE DRP1 ERK1/2 hippocampus JNK mitochondrial dynamics PKA protein phosphatases TUNEL DDE high-fat diet mitochondrial UCP2 ROS antioxidant system uncoupling protein mitochondria: energy metabolism lipid handling fatty acid oxidation potassium channel reactive oxygen species antioxidants life span aging BKCa channels pravastatin gemfibrozil liver colon mitochondrial function cyclosporin A mitochondria calcium buffering mitochondria bioenergetics mitochondria permeability transition pore inorganic phosphate hepatic fibrogenesis HtrA2/Omi reactive oxygen species stress mitochondrial homeostasis complex I (CI) deficiency metabolome and proteome profiling reactive oxygen species (ROS) respirasome assembly electron tunneling (ET) perilipin 5 lipid droplet H9c2 cardiomyoblasts adenine nucleotide translocase respiratory supercomplexes ETC complexes dentate granule cell epilepsy hyperforin LONP1 neuroprotection pilocarpine seizure siRNA cardioprotection mitochondrial permeability transition pores mitochondrial connexin 43 cardiolipin iron overload hepcidin transferrin ferritin ZIP inflammation mtDNA mitochondrial dysfunction muscle aging physical performance LHON Siberian population ancient mutation specific genetic background apoptosis human amniotic membrane mitochondrial cell death BAX BCL-2 tensile strength mitochondrial gene expression mtDNA transcription mtRNA post-transcriptional mtRNA processing dsRNA innate immunity interferon response amino acid neurotransmitter cerebellar amino acid metabolism hypoxia 2-oxoglutarate dehydrogenase tricarboxylic acid cycle heart cytoskeletal proteins mitochondrial interactions plectin tubulin beta signaling GW9662 ischemia reperfusion injury Langendorff myocardial pioglitazone redox state rosiglitazone TZD uncoupling ADP/ATP carrier KmADP dextran morphology cardiomyocytes telomere length telomerase activity development regeneration intranuclear mitochondria healthy cells electron and confocal microscopy signaling pathways ion homeostasis human diseases |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557577203321 |
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Javadov Sabzali
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Mitogen Activated Protein Kinases : Functions in Signal Transduction and Human Diseases
| Mitogen Activated Protein Kinases : Functions in Signal Transduction and Human Diseases |
| Autore | Tikkanen Ritva |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (276 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
Rabdosia inflexa
inflammation gastric ulcer cytokines MAPK NF-κB extracellular signal-regulated kinases 1/2 hyperoxia bronchopulmonary dysplasia HPAECs angiogenesis cell cycle SIRT1 oxidative stress psoriasis antimicrobial peptide cecropin A tight junction protein MEK/ERK signaling porcine intestinal epithelial cell extracellular signal-regulated kinase 5 (ERK5) Kv4.2 PC12 cells infantile myofibromatosis receptor tyrosine kinases platelet-derived growth factor receptor protein kinase inhibitors sunitinib erlotinib FR180204 U0126 targeted therapy apoptosis ERK1/2 JNKs mitochondrial dysfunction neurodegeneration neuro-inflammation p38 MAPKs Parkinson's disease mitogen-activated protein kinases (MAPKs) MAPK kinetics osteoclast differentiation bone remodeling DAPK ERK p38 JNK mitogen-activated protein kinase pathway (MAPK pathway) protein tyrosine phosphatase interacting protein 51 (PTPIP51) protein-protein interaction (PPI) cancer signaling SR CR Compatibility T2DM metabolic profiling MAPK/PI3K/Akt signaling pathway reactive oxygen species PTPN6 SRC DOK4 MKK4 MKK7 p53 DUSP1 SIRT2 atherosclerosis aortic valve sclerosis aortic valve stenosis naphthalimide-metal complex conjugates N-heterocyclic carbene mitochondria ROS p38 MAPK cancer FGF-induced signaling FRS2 phosphorylation downregulation |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Mitogen Activated Protein Kinases |
| Record Nr. | UNINA-9910557405603321 |
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Tikkanen Ritva
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Targeting STAT3 and STAT5 in Cancer
| Targeting STAT3 and STAT5 in Cancer |
| Autore | Moriggl Richard |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (578 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
multiple myeloma
STAT3 S3I-1757 nanoparticle CD38 siRNA/RNAi polyethylenimine PEI lipopolyplex siRNA delivery glioma glioblastoma STAT5 AKT ERK1/2 prolactin androgens prostate cancer knockout escape mechanisms stem/progenitor cells cell hierarchy cancer CD4+ T cells CD8+ T cells myeloid cells immune check point hepatitis C virus (HCV) cirrhosis hepatocellular carcinoma (HCC) endoplasmic reticulum (ER) stress oxidative stress (OS) unfolded protein response (UPR) microRNA-122 (miR-122) nuclear factor erythroid 2-related factor 2 (NRF2) signal transducer and activator of transcription 3 (STAT3) hepatocyte nuclear factor 4 alpha (HNF4A) solid cancers cell cycle apoptosis inflammation mitochondria stemness tumor suppression melanoma autoimmune disease immunotherapy tumor-immune cell interactions breast cancer PD-L1 M2 macrophages NK cells STAT3 inhibitor XIII hedging transaction costs dynamic programming risk management post-decision state variable cancer progression cancer-stem cell cytokine therapy resistance metastasis immunosuppression tumor microenvironment proliferation tyrosine kinase 2 JAK family of protein tyrosine kinases signal transducer and activator of transcription cytokine receptor signaling gain-of-function mutation tumorigenesis ADAM17 interleukin-6 trans-signaling epidermal growth factor receptor (EGF-R) shedding metalloprotease tumor necrosis factor alpha (TNFα) inflammation associated cancer colon cancer lung cancer SH2 domain mutations autosomal-dominant hyper IgE syndrome inflammatory hepatocellular adenomas T-cell large granular lymphocytic leukemia T-cell prolymphocytic leukemia growth hormone insensitivity syndrome nuclear pore complex nuclear transport receptors nucleocytoplasmic shuttling targeting tumor-associated macrophages adoptive T cell therapy immune suppression STAT transcription factors JAK STAT T-PLL T-cell leukemia meta-analysis STAT5B signaling small-molecule inhibitors cancer models companion animals comparative oncology pharmacological inhibitor STAT5 signaling chemotherapy resistance myeloid leukemia heat shock proteins chaperones stabilization targeted therapy ovarian cancer hematopoietic cancers therapeutic targeting pharmacological inhibitors mTOR Bone Marrow Failure Syndromes lymphocytes lymphoma T-cells RHOA NGS MPN JAK2 V617F neoplastic stem cells |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557623503321 |
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Moriggl Richard
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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