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Aging and health : a systems biology perspective / / volume editors, Anatoliy I. Yashin, S. Michal Jazwinski
Aging and health : a systems biology perspective / / volume editors, Anatoliy I. Yashin, S. Michal Jazwinski
Autore Yashin Anatoliy I
Pubbl/distr/stampa Karger, 2014
Descrizione fisica 1 online resource (208 p.)
Disciplina 612.6/7
Collana Interdisciplinary topics in gerontology
Soggetto topico Aging - Physiological aspects
Soggetto non controllato Medicine & Public Health
Gerontology
Geriatrics
Genetics
Bioinformatics
Genomics
Physiology
Medicine
ISBN 3-318-02730-8
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Introduction to the theory of aging networks / Witten, T.M. -- Applications to aging networks / Wimble, C., Witten, T.M. -- Computational systems biology for aging research / Auley, M.T., Mooney, K.M. -- How does the body know how old it is? Introducing the epigenetic clock hypothesis / Mitteldorf, J. -- The great evolutionary divide : two genomic systems biologies of aging / Rose, M.R., Cabral, I.G., Philips, M.A., Rutledge, G.A., Phung, K.H., Mueller, L.D., Greer, L.F. -- Development and aging : two opposite but complementary phenomena / Feltes, B.C., De Faria Poloni, J., Bonatto, D. -- Aging as a process of deficit accumulation : its utility and origin / Mitnitski, A., Rockwood, K. -- Low-grade systemic inflammation connects aging, metabolic syndrome and cardiovascular disease / Guarner, V., Rubio-Ruiz, M.E. -- Modulating mTOR in aging and health / Johnson, S.C., Sangesland, M., Kaeberlein, M., Rabinovitch, P. -- Melatonin and circadian oscillators in aging : a dynamic approach to the multiply connected players / Hardeland, R. -- Diet-microbiota-health interactions in older subjects : implications for healthy aging / Lynch, D.B., Jeffery, I.B., Cusack, S., O'Connor, E.M., O'Toole, P.W. -- Systems biology approaches in aging research / Chauhan, A., Liebal, U.W., Vera, J., Baltrusch, S., Junghanss, C., Tiedge, M., Fuellen, G., Wolkenhauer, O., Köhling, R. -- Conservative growth hormone/IGF-1 and mTOR signaling pathways as a target for aging and cancer prevention : do we really have an antiaging drug? / Anisimov, V.N.
Record Nr. UNINA-9910353342603321
Yashin Anatoliy I  
Karger, 2014
Materiale a stampa
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Algorithms in Bioinformatics [[electronic resource] ] : 4th International Workshop, WABI 2004, Bergen, Norway, September 17-21, 2004, Proceedings / / edited by Inge Jonassen, Junhyong Kim
Algorithms in Bioinformatics [[electronic resource] ] : 4th International Workshop, WABI 2004, Bergen, Norway, September 17-21, 2004, Proceedings / / edited by Inge Jonassen, Junhyong Kim
Edizione [1st ed. 2004.]
Pubbl/distr/stampa Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2004
Descrizione fisica 1 online resource (IX, 477 p.)
Disciplina 572.0285
Collana Lecture Notes in Bioinformatics
Soggetto topico Biochemistry
Computer programming
Algorithms
Computers
Data structures (Computer science)
Computer science—Mathematics
Biochemistry, general
Programming Techniques
Algorithm Analysis and Problem Complexity
Computation by Abstract Devices
Data Structures
Discrete Mathematics in Computer Science
Soggetto non controllato WABI
Algorithms
Bioinformatics
ISBN 3-540-30219-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Papers -- Reversing Gene Erosion – Reconstructing Ancestral Bacterial Genomes from Gene-Content and Order Data -- Reconstructing Ancestral Gene Orders Using Conserved Intervals -- Sorting by Reversals with Common Intervals -- A Polynomial-Time Algorithm for the Matching of Crossing Contact-Map Patterns -- A 1.5-Approximation Algorithm for Sorting by Transpositions and Transreversals -- Algorithms for Finding Maximal-Scoring Segment Sets -- Gapped Local Similarity Search with Provable Guarantees -- Monotone Scoring of Patterns with Mismatches -- Suboptimal Local Alignments Across Multiple Scoring Schemes -- A Faster Reliable Algorithm to Estimate the p-Value of the Multinomial llr Statistic -- Adding Hidden Nodes to Gene Networks -- Joint Analysis of DNA Copy Numbers and Gene Expression Levels -- Searching for Regulatory Elements of Alternative Splicing Events Using Phylogenetic Footprinting -- Supervised Learning-Aided Optimization of Expert-Driven Functional Protein Sequence Annotation -- Multiple Vector Seeds for Protein Alignment -- Solving the Protein Threading Problem by Lagrangian Relaxation -- Protein-Protein Interfaces: Recognition of Similar Spatial and Chemical Organizations -- ATDD: An Algorithmic Tool for Domain Discovery in Protein Sequences -- Local Search Heuristic for Rigid Protein Docking -- Sequence Database Compression for Peptide Identification from Tandem Mass Spectra -- Linear Reduction for Haplotype Inference -- A New Integer Programming Formulation for the Pure Parsimony Problem in Haplotype Analysis -- Fast Hare: A Fast Heuristic for Single Individual SNP Haplotype Reconstruction -- Approximation Algorithms for the Selection of Robust Tag SNPs -- The Minisatellite Transformation Problem Revisited: A Run Length Encoded Approach -- A Faster and More Space-Efficient Algorithm for Inferring Arc-Annotations of RNA Sequences Through Alignment -- New Algorithms for Multiple DNA Sequence Alignment -- Chaining Algorithms for Alignment of Draft Sequence -- Translation Initiation Sites Prediction with Mixture Gaussian Models -- Online Consensus and Agreement of Phylogenetic Trees -- Relation of Residues in the Variable Region of 16S rDNA Sequences and Their Relevance to Genus-Specificity -- Topological Rearrangements and Local Search Method for Tandem Duplication Trees -- Phylogenetic Super-networks from Partial Trees -- Genome Identification and Classification by Short Oligo Arrays -- Novel Tree Edit Operations for RNA Secondary Structure Comparison -- The Most Probable Labeling Problem in HMMs and Its Application to Bioinformatics -- Integrating Sample-Driven and Pattern-Driven Approaches in Motif Finding -- Finding Optimal Pairs of Patterns -- Finding Missing Patterns.
Record Nr. UNISA-996465434003316
Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2004
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Algorithms in Bioinformatics [[electronic resource] ] : 4th International Workshop, WABI 2004, Bergen, Norway, September 17-21, 2004, Proceedings / / edited by Inge Jonassen, Junhyong Kim
Algorithms in Bioinformatics [[electronic resource] ] : 4th International Workshop, WABI 2004, Bergen, Norway, September 17-21, 2004, Proceedings / / edited by Inge Jonassen, Junhyong Kim
Edizione [1st ed. 2004.]
Pubbl/distr/stampa Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2004
Descrizione fisica 1 online resource (IX, 477 p.)
Disciplina 572.0285
Collana Lecture Notes in Bioinformatics
Soggetto topico Biochemistry
Computer programming
Algorithms
Computers
Data structures (Computer science)
Computer science—Mathematics
Biochemistry, general
Programming Techniques
Algorithm Analysis and Problem Complexity
Computation by Abstract Devices
Data Structures
Discrete Mathematics in Computer Science
Soggetto non controllato WABI
Algorithms
Bioinformatics
ISBN 3-540-30219-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Papers -- Reversing Gene Erosion – Reconstructing Ancestral Bacterial Genomes from Gene-Content and Order Data -- Reconstructing Ancestral Gene Orders Using Conserved Intervals -- Sorting by Reversals with Common Intervals -- A Polynomial-Time Algorithm for the Matching of Crossing Contact-Map Patterns -- A 1.5-Approximation Algorithm for Sorting by Transpositions and Transreversals -- Algorithms for Finding Maximal-Scoring Segment Sets -- Gapped Local Similarity Search with Provable Guarantees -- Monotone Scoring of Patterns with Mismatches -- Suboptimal Local Alignments Across Multiple Scoring Schemes -- A Faster Reliable Algorithm to Estimate the p-Value of the Multinomial llr Statistic -- Adding Hidden Nodes to Gene Networks -- Joint Analysis of DNA Copy Numbers and Gene Expression Levels -- Searching for Regulatory Elements of Alternative Splicing Events Using Phylogenetic Footprinting -- Supervised Learning-Aided Optimization of Expert-Driven Functional Protein Sequence Annotation -- Multiple Vector Seeds for Protein Alignment -- Solving the Protein Threading Problem by Lagrangian Relaxation -- Protein-Protein Interfaces: Recognition of Similar Spatial and Chemical Organizations -- ATDD: An Algorithmic Tool for Domain Discovery in Protein Sequences -- Local Search Heuristic for Rigid Protein Docking -- Sequence Database Compression for Peptide Identification from Tandem Mass Spectra -- Linear Reduction for Haplotype Inference -- A New Integer Programming Formulation for the Pure Parsimony Problem in Haplotype Analysis -- Fast Hare: A Fast Heuristic for Single Individual SNP Haplotype Reconstruction -- Approximation Algorithms for the Selection of Robust Tag SNPs -- The Minisatellite Transformation Problem Revisited: A Run Length Encoded Approach -- A Faster and More Space-Efficient Algorithm for Inferring Arc-Annotations of RNA Sequences Through Alignment -- New Algorithms for Multiple DNA Sequence Alignment -- Chaining Algorithms for Alignment of Draft Sequence -- Translation Initiation Sites Prediction with Mixture Gaussian Models -- Online Consensus and Agreement of Phylogenetic Trees -- Relation of Residues in the Variable Region of 16S rDNA Sequences and Their Relevance to Genus-Specificity -- Topological Rearrangements and Local Search Method for Tandem Duplication Trees -- Phylogenetic Super-networks from Partial Trees -- Genome Identification and Classification by Short Oligo Arrays -- Novel Tree Edit Operations for RNA Secondary Structure Comparison -- The Most Probable Labeling Problem in HMMs and Its Application to Bioinformatics -- Integrating Sample-Driven and Pattern-Driven Approaches in Motif Finding -- Finding Optimal Pairs of Patterns -- Finding Missing Patterns.
Record Nr. UNINA-9910768471403321
Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2004
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Biocomputing 2010 - Proceedings of the Pacific Symposium
Biocomputing 2010 - Proceedings of the Pacific Symposium
Autore Russ B Altman
Pubbl/distr/stampa World Scientific Publishing Co, 2009
Descrizione fisica viii, 487 p. : ill. (some col.)
Disciplina 572.8
Altri autori (Persone) AltmanRuss
DunkerA. Keith <1943-> (Alan Keith)
HunterLawrence <1961->
Soggetto topico Bioinformatics
Genomics
Soggetto non controllato Protein Interactions
Metabolomics
Biocomputing
Computational Genetics
Ontology
Computational Proteomics
Bioinformatics
ISBN 1-282-76350-4
9786612763502
981-4295-29-9
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Computational challenges in comparative genomics. Session introduction / Bernard Moret ... [et al.]. Accurate taxonomic assignment of short pyrosequencing reads / José C. Clemente , Jesper Jansson, Gabriel Valiente. Benchmarking BLAST accuracy of genus/phyla classification of metagenomic reads / Steven D. Essinger, Gail L. Rosen. Guided genome halving : provably optimal solutions provide good insights into the preduplication ancestral genome of Saccharomyces cerevisiae / Haris Gavranovic, Eric Tannier. A practical algorithm for estimation of the maximum likelihood ancestral reconstruction error / Glenn Hickey, Mathieu Blanchette. Optimization methods for selecting founder populations for captive breeding of endangered species / Webb Miller ... [et al.] -- Computational studies of non-coding RNAs. Session introduction / Rolf Backofen ... [et al.]. RNA structural segmentation / Ivan Dotu ... [et al.]. RNAz 2.0 : improved noncoding RNA detection / Andreas R. Gruber ... [et al.]. Identification and classification of small RNAs in transcriptome sequence data / D. Langenberger ... [et al.]. Improvement of structure conservation index with centroid estimators / Yohei Okada, Kengo Sato, Yasubumi Sakakibara. Dynamic programming algorithms for RNA structure prediction with binding sites / Unyanee Poolsap, Yuki Kato, Tatsuya Akutsu. An algorithm for the energy barrier problem without pseudoknots and temporary arcs / Chris Thachuk ... [et al.] -- Dynamics of biological networks. Session introduction / Tanya Y. Berger-Wolf ... [et al.]. Local optimization for global alignment of protein interaction networks / Leonid Chindelevitch, Chung-Shou Liao, Bonnie Berger. Identification of coordinately dysregulated subnetworks in complex phenotypes / Salim A. Chowdhury, Mehmet Koyuturk. Subspace differential coexpression analysis : problem definition and a general approach / Gang Fang ... [et al.]. Estimation of protein and domain interactions in the switching motility system of Myxococcus xanthus ... [et al.]. Exploring biological network dynamics with ensembles of graph partitions / Saket Navlakha, Carl Kingsford. Geometric evolutionary dynamics of protein interaction networks / Natasa Przulj ... [et al.]. The steady states and dynamics of Urokinase-mediated plasmin activation / Lakshmi Venkatraman ... [et al.] -- Multi-resolution modeling of biological macromolecules. Session introduction / Samuel Flores ... [et al.]. Multi-resolution approach for interactively locating functionally linked ion binding sites by steering small molecules into electrostatic potential maps using a haptic device / Olivier Delalande ... [et al.]. Predicting RNA structure by multiple template homology modeling / Samuel C. Flores ... [et al.]. Constructing multi-resolution Markov State Models (MSMs) to elucidate RNA hairpin folding mechanisms / Xuhui Huang ... [et al.]. Multiscale dynamics of macromolecules using normal mode langevin / Jesus A. Izaguirre, Christopher R. Sweet, Vijay S. Pande. Insights into the intra-ring subunit order of TriC/CCT : structural and evolutionary analysis / Nir Kalisman, Michael Levitt. "Cross-graining :" Efficient multi-scale simulation via Markov state models / Peter Kasson, Vijay Pande. Toward understanding allosteric signaling mechanisms in the ATPase domain of molecular chaperones / Ying Liu, Ivet Bahar. 3D-blast : 3D protein structure alignment, comparison, and classification using spherical polar Fourier correlations / Lazaros Mavridis. David W. Ritchie. Structural prediction of protein-RNA interaction by computational docking with propensity-based statistical potentials / Laura Pérez-Cano ... [et al.] -- Personal genomics. Session introduction / Can Alkan ... [et al.]. Improving the prediction of pharmacogenes using text-derived gene-drug relationships / Yael Garten, Nicholas P. Tatonetti, Russ B. Altman. Finding unique filter sets in PLATO : a precursor to efficient interaction analysis in GWAS data / Benjamin J. Grady ... [et al.]. Enabling personal genomics with an explicit test of epistasis / Casey S. Greene ... [et al.]. Loss of post-translational modification sites in disease / Shuyan Li ... [et al.]. Detecting genome-wide haplotype polymorphism by combined use of mendelian constraints and local population structure / Xin Li, Yixuan Chen, Jing Li. Sequence Feature Variant Type (SFVT) analysis of the HLA genetic association in juvenile idiopathic arthritis / Glenys Thomson ... [et al.]. Cokgen : a software for the identification of rare copy number variation from SNP microarrays / Gökhan Yavas ... [et al.] -- Reverse engineering and synthesis of biomolecular systems. Session introduction / Gil Alterovitz ... [et al.]. Co-design in synthetic biology : a system-level analysis of the development of an environmental sensing device / David A. Ball ... [et al.]. Critical analysis of transcriptional and post-transcriptional regulatory networks in multiple myeloma / Marta Biasiolo ... [et al.]. A computational model of gene expression in an inducible synthetic circuit / Francesca Ceroni, Simone Furini, Silvio Cavalcanti. Retrovirus HTLV-1 gene circuit : a potential oscillator for eukaryotes / Alberto Corradin ... [et al.]. Emulsion based selection of T7 promoters of varying activity / Eric A. Davidson ... [et al.]. Clustering context-specific gene regulatory networks / Archana Ramesh ... [et al.]. Writing and compiling code into biochemistry / Adam Shea ... [et al.]. Synthesis of pharmacokinetic pathways through knowledge acquisition and automated reasoning / Luis Tari ... [et al.] -- Workshops. In silico biology / Richard Goldstein ... [et al.]. Genomic standards consortium workshop : Metagenomics, Metadata and Metaanalysis (M3) / Peter Sterk ... [et al.]. Extraction of genotype-phenotype-drug relationships from text : from entity recognition to bioinformatics application / Adrien Coulet ... [et al.].
Record Nr. UNINA-9910346696203321
Russ B Altman  
World Scientific Publishing Co, 2009
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Biocomputing 2011 [[electronic resource] ] : Proceedings of the Pacific Symposium
Biocomputing 2011 [[electronic resource] ] : Proceedings of the Pacific Symposium
Autore Altman Russ
Pubbl/distr/stampa Singapore, : World Scientific Publishing Company, 2010
Descrizione fisica 1 online resource (500 p.)
Disciplina 574.0151
Altri autori (Persone) DunkerA. Keith <1943-> (Alan Keith)
HunterLawrence <1961->
Soggetto topico Biology -- Computer simulation -- Congresses
Biology -- Mathematical models -- Congresses
Molecular biology -- Computer simulation -- Congresses
Molecular biology -- Mathematical models -- Congresses
Soggetto non controllato Protein Interactions
Metabolomics
Biocomputing
Computational Genetics
Ontology
Computational Proteomics
Bioinformatics
ISBN 1-283-14526-X
9786613145260
981-4335-05-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto PREFACE; CONTENTS; INTEGRATIVE -OMICS FOR TRANSLATIONAL SCIENCE; TOWARDS INTEGRATIVE GENE PRIORITIZATION IN ALZHEIMER'S DISEASE; SYSTEMS BIOLOGY ANALYSES OF GENE EXPRESSION AND GENOME WIDEASSOCIATION STUDY DATA IN OBSTRUCTIVE SLEEP APNEA; FINDING MOST LIKELY HAPLOTYPES IN GENERAL PEDIGREESTHROUGH PARALLEL SEARCH WITH DYNAMIC LOAD BALANCING; DYNAMIC, MULTI-LEVEL NETWORK MODELS OF CLINICAL TRIALS; MINING FUNCTIONALLY RELEVANT GENE SETS FOR ANALYZINGPHYSIOLOGICALLY NOVEL CLINICAL EXPRESSION DATA; GENOTYPE PHENOTYPE MAPPING IN RNA VIRUSES - DISJUNCTIVENORMAL FORM LEARNING
GENOME-WIDE ASSOCIATION MAPPING AND RARE ALLELES: FROMPOPULATION GENOMICS TO PERSONALIZED MEDICINEAN APPLICATION AND EMPIRICAL COMPARISON OF STATISTICAL ANALYSISMETHODS FOR ASSOCIATING RARE VARIANTS TO A COMPLEX PHENOTYPE; HAPLOTYPE PHASING BY MULTI-ASSEMBLY OF SHAREDHAPLOTYPES: PHASE-DEPENDENT INTERACTIONS BETWEEN RARE VARIANTS; AN EVALUATION OF POWER TO DETECT LOW-FREQUENCY VARIANTASSOCIATIONS USING ALLELE-MATCHING TESTS THAT ACCOUNTFOR UNCERTAINTY; PENALIZED REGRESSION FOR GENOME-WIDE ASSOCIATIONSCREENING OF SEQUENCE DATA; MICROBIOME STUDIES: PSB 2011 SPECIAL SESSION INTRODUCTION
ESTIMATING THE NUMBER OF SPECIES WITH CATCHALLA FRAMEWORK FOR ANALYSIS OF METAGENOMIC SEQUENCING DATA; VISUALIZATION AND STATISTICAL COMPARISONS OF MICROBIALCOMMUNITIES USING R PACKAGES ON PHYLOCHIP DATA; HUMAN MICROBIOME VISUALIZATION USING 3D TECHNOLOGY; COMPARING BACTERIAL COMMUNITIES INFERRED FROM 16S rRNA GENE SEQUENCING AND SHOTGUN METAGENOMICS; MULTI-SCALE MODELLING OF BIOSYSTEMS: FROM MOLECULAR TOMESOCALE; COMPUTATIONAL GENERATION INHIBITOR-BOUND CONFORMERS OF P38 MAPKINASE AND COMPARISON WITH EXPERIMENTS
MOLECULAR DYNAMICS SIMULATIONS OF THE FULL TRIPLE HELICALREGION OF COLLAGEN TYPE I PROVIDE AN ATOMIC SCALE VIEW OF THEPROTEIN'S REGIONAL HETEROGENEITYSTRUCTURAL INSIGHTS INTO PRE-TRANSLOCATION RIBOSOME MOTIONS; NEW CONFORMATIONAL SEARCH METHOD USING GENETICALGORITHM AND KNOT THEORY FOR PROTEINS; PERSONAL GENOMICS; THE REFERENCE HUMAN GENOME DEMONSTRATES HIGH RISK OF TYPE 1DIABETES AND OTHER DISORDERS; MATCHING CANCER GENOMES TO ESTABLISHED CELL LINESFOR PERSONALIZED ONCOLOGY
USE OF BIOLOGICAL KNOWLEDGE TO INFORM THE ANALYSIS OF GENE-GENEINTERACTIONS INVOLVED IN MODULATING VIROLOGIC FAILURE WITHEFAVIRENZ-CONTAINING TREATMENT REGIMENS IN ART-NAÏVE ACTG CLINICALTRIALS PARTICVISUAL INTEGRATION OF RESULTS FROM A LARGE DNA BIOBANK (BIOVU)USING SYNTHESIS-VIEW; MULTIVARIATE ANALYSIS OF REGULATORY SNPS: EMPOWERING PERSONALGENOMICS BY CONSIDERING CIS-EPISTASIS AND HETEROGENEITY; HAPLOTYPE INFERENCE FROM SHORT SEQUENCE READS USING APOPULATION GENEALOGICAL HISTORY MODEL; REVERSE ENGINEERING AND SYNTHESIS OF BIOMOLECULAR SYSTEMS; BINARY COUNTING WITH CHEMICAL REACTIONS
DEFINING THE PLAYERS IN HIGHER-ORDER NETWORKS: PREDICTIVE MODELINGFOR REVERSE ENGINEERING FUNCTIONAL INFLUENCE NETWORKS
Record Nr. UNINA-9910346695803321
Altman Russ  
Singapore, : World Scientific Publishing Company, 2010
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Biocomputing 2018 - Proceedings Of The Pacific Symposium
Biocomputing 2018 - Proceedings Of The Pacific Symposium
Autore Altman Russ B
Pubbl/distr/stampa World Scientific Publishing Co, 2017
Descrizione fisica 1 online resource (649 pages)
Altri autori (Persone) DunkerA. Keith <1943-> (Alan Keith)
HunterLawrence <1961->
RitchieMarylyn D
MurrayTiffany A
KleinTeri E
Soggetto non controllato Protein Interactions
Metabolomics
Biocomputing
Computational Genetics
Ontology
Computational Proteomics
Bioinformatics
ISBN 981-323-553-5
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Altri titoli varianti Biocomputing 2018
Record Nr. UNINA-9910346695003321
Altman Russ B  
World Scientific Publishing Co, 2017
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Biocomputing 2019 - Proceedings Of The Pacific Symposium
Biocomputing 2019 - Proceedings Of The Pacific Symposium
Autore Altman Russ B
Pubbl/distr/stampa World Scientific Publishing Co, 2018
Descrizione fisica 1 online resource (471 pages)
Altri autori (Persone) DunkerA. Keith <1943-> (Alan Keith)
HunterLawrence <1961->
RitchieMarylyn D
MurrayTiffany A
KleinTeri E
Soggetto non controllato Protein Interactions
Metabolomics
Biocomputing
Computational Genetics
Ontology
Computational Proteomics
Bioinformatics
ISBN 981-327-982-6
981-327-981-8
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Intro -- Preface -- PATTERN RECOGNITION IN BIOMEDICAL DATA: CHALLENGES IN PUTTING BIG DATA TO WORK -- Session introduction -- Introduction -- References -- Learning Contextual Hierarchical Structure of Medical Concepts with Poincairé Embeddings to Clarify Phenotypes -- 1. Introduction -- 2. Methods -- 2.1. Source Code -- 2.2. Data Source -- 2.3. Data Selection and Preprocessing -- 2.3.1. Reference ICD9 Example -- 2.3.2. Real Member Analyses -- 2.4. Poincaré Embeddings -- 2.5. Processing and Evaluating Embeddings -- 3. Results -- 3.1. ICD9 Hierarchy Evaluation -- 3.2. Poincaré Embeddings on 10 Million Members -- 3.3. Comparison with Euclidean Embeddings -- 3.4. Cohort Specific Embeddings -- 4. Discussion and Conclusion -- 5. Acknowledgments -- References -- The Effectiveness of Multitask Learning for Phenotyping with Electronic Health Records Data -- 1. Introduction -- 2. Background -- 2.1. Multitask nets -- 3. Methods -- 3.1. Dataset Construction and Design -- 3.2. Experimental Design -- 4. Experiments and Results -- 4.1. When Does Multitask Learning Improve Performance? -- 4.2. Relationship Between Performance and Number of Tasks -- 4.3. Comparison with Logistic Regression Baseline -- 4.4. Interaction between Phenotype Prevalence and Complexity -- 5. Limitations -- 6. Conclusion -- Acknowledgments -- References -- ODAL: A one-shot distributed algorithm to perform logistic regressions on electronic health records data from multiple clinical sites -- 1. Introduction -- 1.1. Integrate evidence from multiple clinical sites -- 1.2. Distributed Computing -- 2. Material and Method -- 2.1. Clinical Cohort and Motivating Problem -- 2.2. Algorithm -- 2.3. Simulation Design -- 3. Results -- 3.1. Simulation Results -- 3.2. Fetal Loss Prediction via ODAL -- 4. Discussion -- References.
PVC Detection Using a Convolutional Autoencoder and Random Forest Classifier -- 1. Introduction -- 2. Methods -- 2.1. Data Set and Implementation -- 2.2. Proposed PVC Detection Method -- 2.2.1. Feature Extraction -- 2.2.2. Classification -- 3. Results -- 3.1. Full Database Evaluation -- 3.2. Timing Disturbance Evaluation -- 3.3. Cross-Patient Training Evaluation -- 3.4. Estimated Parameters and Convergence -- 4. Discussion -- References -- Removing Confounding Factors Associated Weights in Deep Neural Networks Improves the Prediction Accuracy for Healthcare Applications -- 1. Introduction -- 2. Related Work -- 3. Confounder Filtering (CF) Method -- 3.1. Overview -- 3.2. Method -- 3.3. Availability -- 4. Experiments -- 4.1. lung adenocarcinoma prediction -- 4.1.1. Data -- 4.1.2. Results -- 4.2. Segmentation on right ventricle(RV) of Heart -- 4.2.1. Data -- 4.2.2. Results -- 4.3. Students' confusion status prediction -- 4.3.1. Data -- 4.3.2. Results -- 4.4. Brain tumor prediction -- 4.4.1. Data -- 4.4.2. Results -- 4.5. Analyses of the method behaviors -- 5. Conclusion -- 6. Acknowledgement -- References -- DeepDom: Predicting protein domain boundary from sequence alone using stacked bidirectional LSTM -- 1. Introduction -- 2. METHODS -- 2.1 Data Set Preparation -- 2.2 Input Encoding -- 2.3 Model Architecture -- 2.4 Evaluation criteria -- 3. RESULTS AND DISCUSSION -- 3.1 Parameter configuration experiments on test data -- 3.2 Comparison with Other Domain Boundary Predictors -- 3.2.1 Free modeling targets from CASP 9 -- 3.2.2 Multi-domain targets from CASP 9 -- 3.2.3 Discontinuous domain target from CASP 8 -- 4. CONCLUSION -- 5. ACKNOWLEDGEMENTS -- REFERENCES -- Res2s2aM: Deep residual network-based model for identifying functional noncoding SNPs in trait-associated regions -- 1. Introduction -- 2. Background theory.
3. Dataset for training and testing -- 3.1. Source databases -- 3.2. Dataset generation -- 4. Methods -- 4.1. ResNet architecture in our model -- 4.2. Tandem inputs of forward- and reverse-strand sequences -- 4.3. Biallelic high-level network structure -- 4.4. Incorporating HaploReg SNP annotation features -- 4.5. Training of models -- 5. Results -- 6. Conclusions and discussion -- Acknowledgements -- References -- DNA Steganalysis Using Deep Recurrent Neural Networks -- 1. Introduction -- 2. Background -- 2.1. Notations -- 2.2. Hiding Messages -- 2.3. Determination of Message-Hiding Regions -- 3. Methods -- 3.1. Proposed DNA Steganalysis Principle -- 3.2. Proposed Steganalysis RNN Model -- 4. Results -- 4.1. Dataset -- 4.2. Input Representation -- 4.3. Model Training -- 4.4. Evaluation Procedure -- 4.5. Performance Comparison -- 5. Discussion -- Acknowledgments -- References -- Bi-directional Recurrent Neural Network Models for Geographic Location Extraction in Biomedical Literature -- 1. Introduction -- 2. Related Work -- 3. Methods -- 3.1. Toponym Detection -- 3.1.1. Recurrent Neural Networks -- 3.1.2. LSTM -- 3.1.3. Other Gated RNN Architectures -- 3.1.4. Hyperparameter search and optimization -- 3.2. Toponym Disambiguation -- 3.2.1. Building Geonames Index -- 3.2.2. Searching Geonames Index -- 4. Results and Discussion -- 4.1. Toponym Disambiguation -- 4.2. Toponym Resolution -- 5. Limitations and Future Work -- 6. Conclusion -- Acknowledgments -- Funding -- References -- Automatic Human-like Mining and Constructing Reliable Genetic Association Database with Deep Reinforcement Learning -- 1. Introduction -- 2. Related Work -- 3. Method -- 3.1. Model Framework -- 3.2. Deep Reinforcement Learning for Organizing Actions -- 3.3. Preprocessing and Name Entity Recognition with UMLS -- 3.4. Bidirectional LSTM for Relation Classification.
3.5. Algorithm -- 3.6. Implementation Specification -- 4. Experiments -- 4.1. Data -- 4.2. Evaluation -- 4.3. Results -- 4.3.1. Improved Reliability -- 4.3.2. Robustness in Real-world Situations -- 4.3.3. Number of Articles Read -- 5. Conclusions and Future Work -- 6. Acknowledgement -- References -- Estimating classification accuracy in positive-unlabeled learning: characterization and correction strategies -- 1. Introduction -- 2. Methods -- 2.1. Performance measures: definitions and estimation -- 2.2. Positive-unlabeled setting -- 2.3. Performance measure correction -- 3. Experiments and Results -- 3.1. A case study -- 3.2. Data sets -- 3.3. Experimental protocols -- 3.4. Results -- 4. Conclusions -- Acknowledgements -- References -- PLATYPUS: A Multiple-View Learning Predictive Framework for Cancer Drug Sensitivity Prediction -- 1. Introduction -- 2. System and methods -- 2.1. Data -- 2.2. Single views and co-training -- 2.3. Maximizing agreement across views through label assignment -- 3. Results -- 3.1. Preliminary experiments to optimize PLATYPUS performance -- 3.2. Predicting drug sensitivity in cell lines -- 3.3. Key features from PLATYPUS models -- 4. Conclusions -- Acknowledgments -- References -- Computational KIR copy number discovery reveals interaction between inhibitory receptor burden and survival -- 1. Introduction -- 2. Materials and Methods -- 2.1 Data collection -- 2.2 K-mer selection -- 2.3 NGS pipeline and k-mer extraction -- 2.4 Data cleaning -- 2.5 Normalization of k-mer frequencies -- 2.6 Copy number segregation and cutoff selection -- 2.7 Validation of copy number -- 2.8 Survival analysis -- 2.9 Additional immune analysis -- 3. Results and Discussions -- 3.1 Establishing unique k-mers -- 3.2 Varying coverage of KIR region by exome capture kit -- 3.3 Inference of KIR copy number -- 3.4 Population variation of the KIR region.
3.5 KIR inhibitory gene burden correlates with survival in cervical and uterine cancer -- 5. Conclusions -- 6. Acknowledgements -- 7. Supplementary Material -- References -- Exploring microRNA Regulation of Cancer with Context-Aware Deep Cancer Classifier -- 1. Introduction -- 2. Data -- 2.1. Preprocessing -- 3. Deep Cancer Classifier -- 3.1. Training & -- testing -- 3.2. Parameter tuning -- 3.3. Feature importance -- 4. Results and Discussion -- 4.1. Model selection -- 4.2. Classifier performance -- 4.3. Comparison with other methods -- 4.4. Feature importance -- 5. Conclusion -- References -- Implementing and Evaluating A Gaussian Mixture Framework for Identifying Gene Function from TnSeq Data -- 1. Introduction -- 1.1. TnSeq Motivation and Background -- 1.2. Motivation and New Methods -- 2. Methods -- 2.1. TnSeq Experimental Data -- 2.2. Mixture framework -- 2.3. Classification methods -- 2.3.1. Novel method - EM -- 2.3.2. Current method - t-statistic -- 2.3.3. Bayesian hierarchical model -- 2.3.4. Data partitioning for the Bayesian model -- 2.4. Simulation -- 2.5. Real data -- 3. Results -- 3.1.1. Classification rate -- 3.1.2. False positive rate -- 3.1.3. Positive classification rate -- 3.1.4. Cross entropy -- 3.2. Simulation Results -- 3.3. Comparisons on real data -- 3.4. Software -- 4. Discussion -- References -- SNPs2ChIP: Latent Factors of ChIP-seq to infer functions of non-coding SNPs -- 1. Introduction -- 2. Results -- 2.1. SNPs2ChIP analysis framework overview -- 2.2. Batch normalization of heterogeneous epigenetic features -- 2.3. Latent factor discovery and their biological characterization -- 2.4. SNPs2ChIP identifies relevant functions of the non-coding genome -- 2.4.1. Genome-wide SNPs coverage of the reference datasets -- 2.4.2. Non-coding GWAS SNPs of systemic lupus erythematosus -- 2.4.3. ChIP-seq peaks for vitamin D receptors.
2.5. Robustness Analysis in the latent factor identification.
Altri titoli varianti Biocomputing 2019
Biocomputing 2019:Proceedings of the Pacific Symposium:Pacific Symposium on Biocomputing 2019
Record Nr. UNINA-9910349464803321
Altman Russ B  
World Scientific Publishing Co, 2018
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Biocomputing 2021 - Proceedings Of The Pacific Symposium
Biocomputing 2021 - Proceedings Of The Pacific Symposium
Autore Altman Russ B
Pubbl/distr/stampa World Scientific Publishing Co, 2020
Descrizione fisica 1 online resource (372 pages)
Altri autori (Persone) DunkerA. Keith <1943-> (Alan Keith)
HunterLawrence <1961->
RitchieMarylyn D
MurrayTiffany A
KleinTeri E
Soggetto non controllato Protein Interactions
Metabolomics
Biocomputing
Computational Genetics
Ontology
Computational Proteomics
Bioinformatics
ISBN 981-12-3270-9
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Intro -- Contents -- Preface -- ACHIEVING TRUSTWORTHY BIOMEDICAL DATA -- Session Introduction: Achieving Trustworthy Biomedical Data Solutions -- 1. Introduction -- 2. Preserving Privacy and Explaining Decisions of Artificial Intelligence -- 3. Sharing Genomic and Health Records -- 4. Deploying Digital Health Solutions -- 5. Crowdsourcing Healthcare -- 6. Considering the Bioethics -- 7. Anticipating the Future -- References -- Selection of Trustworthy Crowd Workers for Telemedical Diagnosis of Pediatric Autism Spectrum Disorder -- 1. Introduction -- 2. Methods -- 2.1. Clinically representative videos -- 2.2. Crowdsourcing task for Microworkers -- 2.3. Classifier to evaluate performance -- 2.4. Metrics evaluated -- 2.5. Prediction of crowd worker performance from metrics -- 3. Results -- 3.1. Correlation between metrics and probability of the correct class -- 3.2. Regression prediction of the mean probability of the correct class -- 4. Discussion and Future Work -- 5. Conclusion -- 6. Acknowledgments -- References -- Differential Privacy Protection Against Membership Inference Attack on Machine Learning for Genomic Data -- 1. Introduction -- 2. Related Work -- 3. Methods -- 3.1. Membership inference attack (MIA) -- 3.2. Di erential privacy (DP) -- 4. Experimental Setup -- 4.1. Dataset -- 4.2. Implementation of target models -- 4.3. Implementation of DP -- 4.4. Implementation of MIA -- 4.5. Evaluation metrics -- 5. Results -- 5.1. Vulnerability of target model against MIA without DP protection -- 5.2. Impact of privacy budget on the target model accuracy -- 5.3. E ectiveness of DP against MIA -- 5.4. E ect of model sparsity -- 6. Conclusion -- References -- Making Compassionate Use More Useful: Using Real-World Data, Real-World Evidence and Digital Twins to Supplement or Supplant Randomized Controlled Trials -- 1. Introduction.
1.1 Compassionate use -- 1.2 Compassionate use during the pandemic -- 1.3 What is an RCT? -- 1.3 EA data and NDAs -- 2. Real-World Information -- 2.1 Real-world data in trials -- 2.2 Real-world data and real-world evidence -- 2.2 Real-world limitations -- 3.0 Making RWD Work -- 3.1 Digital twins -- 4.0 Conclusions -- References -- ADVANCED METHODS FOR BIG DATA ANALYTICS IN WOMEN'S HEALTH -- Session Introduction: Advanced Methods for Big Data Analytics in Women's Health -- 1. Introduction -- 2. Session Summary -- 2.1. Full-length papers -- 3. Discussion -- References -- Intimate Partner Violence and Injury Prediction from Radiology Reports -- 1. Introduction -- 2. Related Work -- 2.1. Intimate partner violence -- 2.2. Clinical prediction -- 2.3. Natural language processing -- 3. Dataset -- 3.1. IPV patient selection -- 3.2. Control group selection -- 3.3. Injury labels -- 3.4. Data cleaning -- 3.5. Demographic data -- 4. Methodology -- 4.1. Experiment setup -- 4.2. Models -- 4.3. Evaluation -- 4.3.1. Prediction and predictive features -- 4.3.2. Error analysis -- 4.3.3. Report-program date gap -- 5. Results -- 5.1. IPV and injury prediction and predictive features -- 5.2. Error analysis -- 5.3. Report-program date gap -- 6. Discussion and conclusion -- References -- Not All C-sections Are the Same: Investigating Emergency vs. Elective C-section deliveries as an Adverse Pregnancy Outcome -- 1. Background and Significance -- 2. Methods -- 2.1. Dataset characteristics -- 2.2. Identification of delivery outcomes -- 2.2.1. Cesarean section deliveries -- 2.2.2. Preterm birth, stillbirth, and multiple birth deliveries -- 2.3. Integration of data from encounter records -- 2.4. Generalized regression models -- 3. Results -- 3.1. Utilization of cesarean section codes -- 3.2. Admission types recorded in encounter records.
3.3. Age distribution by delivery admit type -- 3.4. Number of deliveries by weekday and admit type -- 4. Generalized regression model -- 4.1. Surgical Incision Type for C-section and Effect on Emergency Admission -- 5. Discussion -- References -- Co-occurrence Patterns of Intimate Partner Violence -- 1. Introduction -- 2. Materials and Methods -- 2.1. Description of Data and Pre-Processing -- 2.2. Co-Occurrence of Violence Types -- 2.3. Co-Occurrence Network of Individual Violence Items -- 2.4. Radial Visualization -- 2.5. Clustering of Survivors and Identification of Subgroups -- 2.6. Health Problems and Trauma Symptoms -- 3. Results -- 4. Discussion -- 5. Acknowledgments -- References -- BIOCOMPUTING AND AI FOR INFECTIOUS DISEASE MODELLING AND THERAPEUTICS -- Session Introduction: AI for Infectious Disease Modelling and Therapeutics -- 1. Background -- 2. Introduction -- 3. Social Media and COVID-19 -- 4. Biomedical literature and COVID-19 plus neglected tropical diseases -- 5. Genomics and HCV -- 6. Protein intrinsically disordered regions and SARS-CoV-2 -- 7. Protein-protein interactions and SARS-CoV-2 -- References -- Characterization of Anonymous Physician Perspectives on COVID-19 Using Social Media Data -- 1. Introduction -- 2. Methods -- 2.1. Data Collection -- 2.2. N-gram Frequency Measures -- 2.3. Sentiment Analysis -- 3. Results -- 3.1. Frequency of terms and n-grams -- 3.2. Sentiment analysis -- 3.3. Sentiments of tweets containing specific terms -- 4. Discussion and Conclusion -- 5. Acknowledgments -- References -- Semantic Changepoint Detection for Finding Potentially Novel Research Publications -- 1. Introduction -- 2. Methods -- 2.1. Data collection and general procedures -- 2.2. Title and abstract entropies -- 2.3. Bayesian changepoint analysis -- 2.4. Differential word clouds -- 2.5. Title and abstract embeddings.
2.6. Semantic novelty -- 2.6.1. Strategy T1: Novel paper detection based on semantic distance -- 2.6.2. Strategy T2: Detection of novel papers that may constitute a trend -- 2.6.3. Strategy Y1: Detection of a group of novel papers based on their mean vector -- 2.6.4. Strategy Y2: Proportion of novel papers -- 3. Results and Discussion -- 4. Conclusions -- 5. Supplementary Information -- 6. Acknowledgements -- References -- TreeFix-TP: Phylogenetic Error-Correction for Infectious Disease Transmission Network Inference -- 1. Background -- 2. Methods -- 2.1. Minimizing inter-host transmissions -- 2.2. Description of TreeFix-TP -- 2.3. Evaluation using simulated data sets -- 2.3.1. Data set generation -- 2.3.2. Evaluating reconstruction accuracy -- 3. Results -- 3.1. Phylogenetic error correction results -- 3.2. Source recovery in HCV outbreaks -- 3.3. Running time and scalability -- 4. Discussion and Conclusions -- Acknowledgments -- Authors' Contributions -- Supplementary Material -- References -- SARS-CoV-2 Drug Discovery based on Intrinsically Disordered Regions -- 1. Introduction -- 2. Methods -- 2.1. Molecular docking -- 2.1.1. Data collection -- 2.1.2. Data preprocessing -- 2.1.3. Target file generation -- 2.1.4. Flexible docking -- 2.1.5. Ensemble docking -- 2.2. Statistical model -- 2.2.1. Chemprop -- 2.2.2. Data and training -- 3. Results -- 3.1. Interaction modelling -- 3.2. Activity prediction -- 4. Conclusion -- 5. Acknowledgements -- References -- Feasibility of the Vaccine Development for SARS-CoV-2 and Other Viruses Using the Shell Disorder Analysis -- 1. Introduction -- 1.1. SARS-COV-2 Vaccine -- 1.2. Shell disorder analysis of HIV and other viruses -- 1.3. Spinoff projects including coronaviruses: Shell disorder and modes of transmission -- 1.4. Yet another spinoff: Correlations between the inner shell disorder and virulence.
2. Results -- 2.1. Clustering of CoV based mainly on NPID -- 2.2 Outer shell disorder is an indicator for the presence or absence of effective vaccines -- 2.3. A disordered outer shell provides an immune evasion tactic: Viral shapeshifting -- 2.4. SARS-CoV-2: Exceptionally hard shell (low MPID) associated with burrowing animals and buried feces -- 2.5. Behavior of the animal hosts matters in the evolutions of the viruses: EIAV vs. HIV -- 2.6. Feasibility of developing attenuated vaccine strains for SARS-CoV-2 -- 3. Discussion -- 3.1. Links between respiratory transmission, N (Inner shell) disorder, and virulence: Viral load in body fluids vs. vital organs -- 3.2. Greater disorder in the inner shell proteins provide means for the more efficient replication of viral particles -- 3.3 Two modes of immune evasion: "Trojan Horse" (inner shell disorder) and "viral shapeshifting" (outer shell disorder) -- 3.4. FIV, HIV-1 and HIV-2: Similarities and differences -- 3.5. FIV vaccine enigma: Questionable efficacy -- 4. Conclusions -- 4.1. Development of the SARS-CoV-2 vaccine is feasible and vaccine strains can be found in nature -- 5. Materials and Methods -- References -- Protein Sequence Models for Prediction and Comparative Analysis of the SARS-CoV-2−Human Interactome -- 1. Introduction -- 2. Methods -- 2.1. Generalized Additive Models with interactions (GA2M) -- 3. Gold Standard Interaction Datasets -- 3.1. Dealing with the lack of negative examples -- 3.2. Features -- 4. Experiments -- 4.1. TAPE: Transformer based model for protein sequences -- 5. Results -- 5.1. Prediction performance and validation of predicted interactions -- 5.2. Enrichment analysis of predicted human binding partners -- 6. Discussion -- 6.1. Visualizing the virus-human interactions -- 6.2. Highly ranked sequence features -- 6.3. Structural analysis -- 7. Prior Work -- 8. Conclusion.
9. Acknowledgements.
Altri titoli varianti Biocomputing 2021
Record Nr. UNINA-9910433229003321
Altman Russ B  
World Scientific Publishing Co, 2020
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Bioimage Data Analysis Workflows [[electronic resource] /] / edited by Kota Miura, Nataša Sladoje
Bioimage Data Analysis Workflows [[electronic resource] /] / edited by Kota Miura, Nataša Sladoje
Autore Miura Kota
Edizione [1st ed. 2020.]
Pubbl/distr/stampa Cham, : Springer Nature, 2020
Descrizione fisica 1 online resource (170)
Disciplina 610.28
Collana Learning Materials in Biosciences
Soggetto topico Biomedical engineering
Cell biology
Bioinformatics
Biology—Technique
Systems biology
Biological systems
Biomedical Engineering/Biotechnology
Cell Biology
Computational Biology/Bioinformatics
Biological Techniques
Systems Biology
Soggetto non controllato Medicine
Biomedical engineering
Cell biology
Bioinformatics
Biology—Technique
Systems biology
Biological systems
ISBN 3-030-22386-8
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Workflows and Components of Bioimage Analysis -- Measurements of Intensity Dynamics at the Periphery of the Nucleus -- 3D Quantitative Colocalisation Analysis -- The NEMO Dots Assembly: Single-Particle Tracking and Analysis -- Introduction to MATLAB: Image Analysis & Brownian Motion -- Resolving the process of Clathrin Mediated Endocytosis Using Correlative Light & Electron Microscopy (CLEM).
Record Nr. UNINA-9910367258203321
Miura Kota  
Cham, : Springer Nature, 2020
Materiale a stampa
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Bloodstain Pattern Analysis in Crime Scenarios / Kacper Choromanski
Bloodstain Pattern Analysis in Crime Scenarios / Kacper Choromanski
Autore Choromanski, Kacper
Pubbl/distr/stampa Singapore, : Springer, 2020
Descrizione fisica x, 65 p. : ill. ; 24 cm
Soggetto topico 00A79 (77-XX) - Physics [MSC 2020]
00-XX - General and overarching topics; collections [MSC 2020]
Soggetto non controllato Autopsy
Bioinformatics
Crime Scenes
Criminal Analysis
Criminal Law
DNA Fingerprinting
Digital Reconstruction
Findings
Forensic Investigation
Homicide
Suicide
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Titolo uniforme
Record Nr. UNICAMPANIA-VAN0233807
Choromanski, Kacper  
Singapore, : Springer, 2020
Materiale a stampa
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