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Antitumoral Properties of Natural Products
| Antitumoral Properties of Natural Products |
| Autore | Fabiani Roberto |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (344 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
cytotoxic activity
NCI-60 cancer cell line pristimerin Salacia crassifolia Celastraceae Brazilian Cerrado biome Salacia elliptica Cheiloclinium cognatum Plenckia populnea Aspergillus fumigatus Cordyceps sinensis isochromanes chiral resolution ECD calculation cytotoxicity coronarin D JNK osteosarcoma Zeylenone gastric cancer invasion migration apoptosis anti-cancer agents anthraquinones glycosyltransferase Dendrobium officinale structure elucidation anti-tumor activity plantation mode AR Ganoderma tsugae lipogenesis prostate cancer SREBP-1 ursolic acid betulinic acid triterpenoids necrotic quercetin quercetagetin patuletin lichen secondary metabolites tumidulin stemness potential colorectal cancer cells oncogene transcriptional regulation neferine FAK/S6K1 autophagy human neuroblastoma cells natural yellow Monascus pigments water-soluble antioxidation MCF-7 cells phloretin cell proliferation inflammation glucose uptake Catalpa speciosa Taxus cuspidata Magnolia acuminata phenols antioxidants anticancer Colocasia esculenta food bioactive tarin stable nanocapsules entrapment efficiency no-toxicity preclinical tests antitumoral activity chemotherapeutic adjuvant grape leaves ASE TP Antioxidant activities Antiproliferative pro-apoptotic effects Gene expression Nutraceuticals Cucurbitacin B gefitinib-resistant NSCLC EGFR lysosomal degradation CIP2A zerumbone cancer NF-κB IL-6/JAK2/STAT3 Akt FOXO1 multiple myeloma quality control naringenin flavonoids traditional preparation cancer stem cells phytochemicals plant-derived foods fruit vegetable cell signaling Artemisia absinthium endoplasmic reticulum stress mitochondrial-dependent pathway melanoma bee venom melittin temozolomide AKT MAPK antrodin C mTOR metabolic stability capsazepine inflammatory diseases ROS TRPV1 PI3K/AKT/mTOR CLE-10 LC3 MDA-MB-231 lactoferrin hydrolysate copper manganese gastric cancer cells anti-cancer activity molecular mechanism natural product alkaloids cephalotaxine protein synthesis inhibition antiproliferation agents folk medicine DLD-1 cells doxorubicin chemotherapy drug resistance CrataBL glioblastoma mesenchymal stem cells microenvironment plant lectin protease inhibitor cryptolepine neocryptolepine isocryptolepine antiproliferative activity structure activity relationships Licochalcone A ATM-Chk2 13-ethylberberine mitochondrial ROS RT-R breast cancer cells diallyl disulfide PI3K/Akt/mTOR pathway Pulsatilla saponin D SB365 glioblastoma multiforme autophagic flux inhibition lysosomal membrane permeabilization mitochondrial membrane potential CLEFMA p38 proanthocyanins TNF-α lung adenocarcinoma natural compounds cervical cancer cell cycle arrest dicentrine metastasis glioma semi-synthetic derivative ingenol Euphorbia tirucalli protein kinase C seaweed porphyran carrageenan anti-cancer natural products |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557419703321 |
Fabiani Roberto
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Antitumoral Properties of Natural Products : Volume 2
| Antitumoral Properties of Natural Products : Volume 2 |
| Autore | Fabiani Roberto |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (300 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
cytotoxic activity
NCI-60 cancer cell line pristimerin Salacia crassifolia Celastraceae Brazilian Cerrado biome Salacia elliptica Cheiloclinium cognatum Plenckia populnea Aspergillus fumigatus Cordyceps sinensis isochromanes chiral resolution ECD calculation cytotoxicity coronarin D JNK osteosarcoma Zeylenone gastric cancer invasion migration apoptosis anti-cancer agents anthraquinones glycosyltransferase Dendrobium officinale structure elucidation anti-tumor activity plantation mode AR Ganoderma tsugae lipogenesis prostate cancer SREBP-1 ursolic acid betulinic acid triterpenoids necrotic quercetin quercetagetin patuletin lichen secondary metabolites tumidulin stemness potential colorectal cancer cells oncogene transcriptional regulation neferine FAK/S6K1 autophagy human neuroblastoma cells natural yellow Monascus pigments water-soluble antioxidation MCF-7 cells phloretin cell proliferation inflammation glucose uptake Catalpa speciosa Taxus cuspidata Magnolia acuminata phenols antioxidants anticancer Colocasia esculenta food bioactive tarin stable nanocapsules entrapment efficiency no-toxicity preclinical tests antitumoral activity chemotherapeutic adjuvant grape leaves ASE TP Antioxidant activities Antiproliferative pro-apoptotic effects Gene expression Nutraceuticals Cucurbitacin B gefitinib-resistant NSCLC EGFR lysosomal degradation CIP2A zerumbone cancer NF-κB IL-6/JAK2/STAT3 Akt FOXO1 multiple myeloma quality control naringenin flavonoids traditional preparation cancer stem cells phytochemicals plant-derived foods fruit vegetable cell signaling Artemisia absinthium endoplasmic reticulum stress mitochondrial-dependent pathway melanoma bee venom melittin temozolomide AKT MAPK antrodin C mTOR metabolic stability capsazepine inflammatory diseases ROS TRPV1 PI3K/AKT/mTOR CLE-10 LC3 MDA-MB-231 lactoferrin hydrolysate copper manganese gastric cancer cells anti-cancer activity molecular mechanism natural product alkaloids cephalotaxine protein synthesis inhibition antiproliferation agents folk medicine DLD-1 cells doxorubicin chemotherapy drug resistance CrataBL glioblastoma mesenchymal stem cells microenvironment plant lectin protease inhibitor cryptolepine neocryptolepine isocryptolepine antiproliferative activity structure activity relationships Licochalcone A ATM-Chk2 13-ethylberberine mitochondrial ROS RT-R breast cancer cells diallyl disulfide PI3K/Akt/mTOR pathway Pulsatilla saponin D SB365 glioblastoma multiforme autophagic flux inhibition lysosomal membrane permeabilization mitochondrial membrane potential CLEFMA p38 proanthocyanins TNF-α lung adenocarcinoma natural compounds cervical cancer cell cycle arrest dicentrine metastasis glioma semi-synthetic derivative ingenol Euphorbia tirucalli protein kinase C seaweed porphyran carrageenan anti-cancer natural products |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Antitumoral Properties of Natural Products |
| Record Nr. | UNINA-9910557531303321 |
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Fabiani Roberto
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug Delivery of siRNA Therapeutics
| Drug Delivery of siRNA Therapeutics |
| Autore | Lamberti Gaetano |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (288 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
oligonucleotide delivery
light-activated release intracellular release liposome indocyanine green drug co-delivery methotrexate siRNA antitumor effect mixed micelles targeted delivery system cationic liposome folate folate receptor cationic cholesterol derivative siRNA delivery gene knockdown tumor-targeting VEGFA VEGFR1 endoglin peptide angiogenesis gene silencing migration proliferation endothelial cells RNAi therapeutics amphiphilic dendrons PAMAM dendrimers self-assembling nanovectors covalent dendrimers NABDs liposomes clinical trials drug delivery nanoparticle carbonate apatite ERBB2 AKT breast cancer ovarian cancer polymer lipid delivery poly(ethylene) imine PEI RNA tyrosine-modification tumor xenograft magnetic nanoparticle iron oxide BCL2 BIRC5/survivin oral cancer aptamers cancer nanoparticles STAT6 polyaspartamide pegylation polyamine polyplexes asthma |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557498903321 |
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Lamberti Gaetano
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Fibroblast Growth Factor Receptor (FGFR) Signaling Pathway in Tumor
| Fibroblast Growth Factor Receptor (FGFR) Signaling Pathway in Tumor |
| Autore | Holzmann Klaus |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (276 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
FGFR4
FGF19 gene regulation cancer signaling anticancer FRS2 FGFR NVP-BGJ398 LY2874455 sarcoma cancer-associated fibroblasts GPER breast cancer estrogen FGFR1 FGF2 optogenetics ERK AKT receptor kinase neurite outgrowth HEK293 PC12 fibroblast growth factor receptors signaling receptor cross-talk coreceptor membrane proteins FGFR2 ERK1/2 phosphorylation serine negative feedback loop cancer prognosis HCC inhibitors FGF fibroblast growth factor autocrine signaling skin melanoma squamous and basal cell carcinoma seborrheic keratosis targeted therapy resistance structure kinase inhibitor gastric cancer monoclonal antibody small molecule FGFR2c autophagy keratinocyte MTOR JNK1 review malignant glioma brain cancer astrocytoma Sprouty proteins FGF-mediated signaling tumor suppressor tumor promoter malignant pleural mesothelioma overall survival immunohistochemistry infigratinib sensitivity FGF8 FGF18 adenocarcinoma of the esophagogastric junction neoadjuvant therapy |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Fibroblast Growth Factor Receptor |
| Record Nr. | UNINA-9910557898903321 |
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Holzmann Klaus
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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mTOR in Human Diseases
| mTOR in Human Diseases |
| Autore | Dormond Olivier |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (480 p.) |
| Soggetto non controllato |
primary cilia
neurodegeneration nutrient sensor PI3K transcriptomics phosphorylation metabolic reprogramming autophagy Alzheimer's disease rapalogs liver angiogenesis mTOR complex MBSCs advanced biliary tract cancers Medulloblastoma epithelial to mesenchymal transition AMPK p70S6K lipid metabolism thyroid cancer sodium iodide symporter (NIS)/SLC5A5 male fertility anesthesia illumina mTOR inhibitor miRNA Hutchinson-Gilford progeria syndrome (HGPS) eIFs Emery-Dreifuss muscular dystrophy (EDMD) glucose AKT oral cavity squamous cell carcinoma (OSCC) glucose and lipid metabolism cellular signaling aging tumor microenvironment rapamycin leukemia chloral hydrate rapalogues schizophrenia T-cell acute lymphoblastic leukemia senescence lamin A/C neurotoxicity neurodevelopment inhibitor methamphetamine pulmonary fibrosis mTOR mTOR inhibitors combination therapy proteolysis fluid shear stress tumour cachexia biomarkers synapse gluconeogenesis mTOR signal pathway Sertoli cells immunosenescence miRNome protein aggregation senolytics metabolism NGS mTORC2 mTORC1 metabolic diseases IonTorrent apoptosis dopamine receptor nocodazole microenvironment everolimus acute myeloid leukemia immunotherapy spermatogenesis bone remodeling signalling targeted therapy ageing therapy NVP-BEZ235 fructose physical activity laminopathies MC3T3-E1 cells cell signaling microRNA cancer lipolysis melatonin Parkinson's disease |
| ISBN | 3-03921-061-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346684303321 |
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Dormond Olivier
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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New Prognostic and Predictive Markers in Cancer Progression
| New Prognostic and Predictive Markers in Cancer Progression |
| Autore | Costantini Susan |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (294 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
MSI2
OSCC oral cancer musashi 2 prognosis N-cadherin EMT breast cancer new metastasis eribulin blood biomarker bladder cancer immune checkpoint inhibitor CD8+ T effector cells microRNA biomarkers head and neck cancer laryngeal cancer prediction metastasis lifestyle habit chemo-/radio resistance therapeutic target AKT AR castration-resistant prostate cancer (CRPC) MAPK mTOR PI3K prostate cancer therapeutic resistance WNT miRNA melanoma melanoma resistance to MAPK/MEK inhibitors resistance to immune checkpoint inhibitors TNBC BRCA1/2 HRR PDL1 TILs PI3KCA PTEN CTCs CSC pancreatic cancer K-RAS oncogene oncogene dependency targeted therapies genomic mutations transcriptomics metabolomics selenoproteins cancer HUB nodes major histocompatibility complex (MHC) human leukocyte antigen (HLA) antigen processing machinery (APM) molecules carcinogenesis tumor predisposition cancer immunotherapy pheochromocytoma paraganglioma head and neck neoplasms head and neck tumors genetic syndromes mutations hyperglycemia cardioncology nivolumab cytokines cardiotoxicity acetyltransferase cancer prognosis NAA10 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557794803321 |
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Costantini Susan
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases
| Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases |
| Autore | Kwok Hang Fai |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (180 p.) |
| Soggetto topico |
Humanities
Social interaction |
| Soggetto non controllato |
DAPK1
SUMO SENP protein degradation post-translational modification amphibian Bowman-Birk inhibitor Tat peptide molecular cloning antifungal drug design protease inhibitor natural-based compound anticancer therapy lung cancer survivin apoptosis STAT3 colorectal cancer orientin cell cycle arrest Bcl-2 family proteins Astragalus membranaceus insulin PI3K AKT PPARγ PDX-1 Petasites japonicus Asteraceae lignan anti-inflammation NO PGE2 iNOS COX-2 molecular docking peptides kynurenines binding affinity μ-opioid receptor pharmacophore G-protein activation fucoidan PLGA docetaxel drug delivery system anticancer therapy/cancer treatment hIAPP amyloidogenesis insulin granules endoplasmic reticulum anionic lipids F23R variant β-sheet transitions β-cell cytotoxicity unfolded protein response pomegranate punicalagin tannins gingiva fibroblasts antioxidant wound healing branched-chain fatty acids Conidiobolus heterosporus peroxisome proliferator-activated receptor α lipid metabolism fatty acid oxidation hepatocyte |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557607403321 |
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Kwok Hang Fai
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Role of Natural Bioactive Compounds in the Rise and Fall of Cancers : Volume 2
| Role of Natural Bioactive Compounds in the Rise and Fall of Cancers : Volume 2 |
| Autore | Luparello Claudio |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (318 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
berberine
signaling pathways oncogenic cascades TRAIL microRNAs cancer therapy colon cancer cells ethanol Nrf2 HO-1 ER stress autophagy MMPs formononetin cancer preclinical models cell signaling angiogenesis nobiletin colorectal cancer chemoprevention bioactivities experimental therapeutics HDAC multiple myeloma oleacein breast cancer persistent organic pollutants breast cancer risk breast cancer prognostic systematic review carrageenan invasion metastasis RacGAP1 radiotherapy marine sponge natural product anticancer drug oral cancer inhibition phytochemicals small organic agents Piper eriopodon, alkenylphenols human cancer cells cell death apoptosis caspase-independent cell death XIAP antagonists XIAP-BIR3 domain Calocedrus formosana lung cancer yatein cell-cycle arrest xenograft isorhamnetin G2/M arrest ROS AMPK pancreatic cancer epigallocatechin-3-gallate (EGCG) gemcitabine glycolysis phosphofructokinase natural polyphenols anticancer activities molecular mechanisms Streptomyces mangrove anti-proliferative colon cancer epithelial mesenchymal transition inflammation malignant cancer natural anti-inflammatory compounds pro-resolving lipids anticancer drugs flavonoids natural compounds Xenopus laevis AOM/DSS model melanoma cells nicotine α9-nAChR PD-L1 STAT3 gigantol AKT JAK/STAT cancer stem cell tumor maintenance tumor density proteomics honokiol anticancer mechanism signalling pathway uterine sarcoma fucoidan isobolography colchicine alkaloid mesoporous silica nanoparticles targeted delivery system PD-1 immune checkpoint inhibitor and cancer immunotherapy glucose transport drugs innate immunity β-glucans nutrition immunotherapy estrogen estrogen receptor alpha polyphenols daidzein daidzein metabolites paclitaxel breast cancer cells obesity renin-angiotensin system eicosapentaenoic acid adipocyte inflammation olive leaf extract oleuropein Seahorse analysis cancer metabolism glycolytic markers Malva pseudolavatera Webb & Berthel acute myeloid leukemia reactive oxygen species brain cancer gliomas schwannomas malignant tumors of the peripheral nerve sheath (MPNST) neurofibromas bioavailability nanoparticle-based delivery systems natural bioactive compound gallic acid EGFR signaling p53 EGCG non-coding RNAs anti-cancer drug NSCLC EGFR TKI FASN inhibitors resistance |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Role of Natural Bioactive Compounds in the Rise and Fall of Cancers |
| Record Nr. | UNINA-9910557476303321 |
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Luparello Claudio
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Targeting STAT3 and STAT5 in Cancer
| Targeting STAT3 and STAT5 in Cancer |
| Autore | Moriggl Richard |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (578 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
multiple myeloma
STAT3 S3I-1757 nanoparticle CD38 siRNA/RNAi polyethylenimine PEI lipopolyplex siRNA delivery glioma glioblastoma STAT5 AKT ERK1/2 prolactin androgens prostate cancer knockout escape mechanisms stem/progenitor cells cell hierarchy cancer CD4+ T cells CD8+ T cells myeloid cells immune check point hepatitis C virus (HCV) cirrhosis hepatocellular carcinoma (HCC) endoplasmic reticulum (ER) stress oxidative stress (OS) unfolded protein response (UPR) microRNA-122 (miR-122) nuclear factor erythroid 2-related factor 2 (NRF2) signal transducer and activator of transcription 3 (STAT3) hepatocyte nuclear factor 4 alpha (HNF4A) solid cancers cell cycle apoptosis inflammation mitochondria stemness tumor suppression melanoma autoimmune disease immunotherapy tumor-immune cell interactions breast cancer PD-L1 M2 macrophages NK cells STAT3 inhibitor XIII hedging transaction costs dynamic programming risk management post-decision state variable cancer progression cancer-stem cell cytokine therapy resistance metastasis immunosuppression tumor microenvironment proliferation tyrosine kinase 2 JAK family of protein tyrosine kinases signal transducer and activator of transcription cytokine receptor signaling gain-of-function mutation tumorigenesis ADAM17 interleukin-6 trans-signaling epidermal growth factor receptor (EGF-R) shedding metalloprotease tumor necrosis factor alpha (TNFα) inflammation associated cancer colon cancer lung cancer SH2 domain mutations autosomal-dominant hyper IgE syndrome inflammatory hepatocellular adenomas T-cell large granular lymphocytic leukemia T-cell prolymphocytic leukemia growth hormone insensitivity syndrome nuclear pore complex nuclear transport receptors nucleocytoplasmic shuttling targeting tumor-associated macrophages adoptive T cell therapy immune suppression STAT transcription factors JAK STAT T-PLL T-cell leukemia meta-analysis STAT5B signaling small-molecule inhibitors cancer models companion animals comparative oncology pharmacological inhibitor STAT5 signaling chemotherapy resistance myeloid leukemia heat shock proteins chaperones stabilization targeted therapy ovarian cancer hematopoietic cancers therapeutic targeting pharmacological inhibitors mTOR Bone Marrow Failure Syndromes lymphocytes lymphoma T-cells RHOA NGS MPN JAK2 V617F neoplastic stem cells |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557623503321 |
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Moriggl Richard
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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