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Anticancer Agents : Design, Synthesis and Evaluation
| Anticancer Agents : Design, Synthesis and Evaluation |
| Autore | Chen Qiao-Hong |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (606 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
benzofurans
chemical synthesis cytotoxic properties HeLa MOLT-4 K562 anticancer anti-neuroinflammation coumarin dihydroartemisinin flavonoids allene E-stereoselective regioselective anti-cancer activity cyanopyridone substituted pyridine pyridotriazine pyrazolopyridine thioxotriazopyridine anticancer activity HepG2 antitumor activity computational docking MDM2-p53 interaction xanthones yeast-based assays estrone derivatives hydrazine N-substituted pyrazoline anti-ovarian cancer topoisomerase II inhibitor kinase inhibitor antiproliferative agent urea synthesis antiproliferative activity apoptosis indoleamine 2,3-dioxygenase inhibitor anti-tumor immune modulation tryptophan metabolism taxoids βIII-tubulin P-glycoprotein drug resistance thiopene thienopyrimidinone thiazolidinone breast cancer benzofuran–pyrazole nanoparticles cytotoxic activity PARP-1 inhibition 3,6-dibromocarbazole 5-bromoindole carbazole actin migration Thienopyrimidine Pyrazole PI3Kα inhibitor quinazolin-4(3H)-one quinazolin-4(3H)-thione Schiff base antioxidant activity DFT study ortho-quinones beta-lapachone tanshione IIA PI3Ks PI3Kδ inhibitors 2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide anticancer agents protein–protein interactions virtual screening mimetics drug discovery bivalency polyvalency antitumor cell cycle ovarian cancer P-MAPA IL-12 TLR signaling inflammation chemoresistance 4-(pyridin-4-yloxy)benzamide 1,2,3-triazole c-Met natural product anticancer agent zampanolide Talazoparib PARP inhibitor prodrug o-nitro-benzyl photoactivatable protecting groups salinomycin overcoming drug resistance tumor specificity synergy 5-fluorouracil gemcitabine amides/esters colchicine analogs thiocolchicine colchiceine antimitotic agents hydrates dihydropyranoindole HDAC inhibitors neuroblastoma aromatase MCF-7 NIH3T3 benzimidazole triazolothiadiazine docking ADME organosilicon compounds SILA-409 (Alis-409) SILA-421 (Alis-421) multidrug resistance (MDR) reversal ABCB1 (P-glycoprotein) colon cancer colchicine amide colchicine sulfonamide tubulin inhibitors docking studies crystal structure PROTACs protein degradation IGF-1R Src protein kinase phenylpyrazolopyrimidine enzyme inhibition molecular simulation androgen receptor prostate cancer enzalutamide apalutamide darolutamide triple-negative breast cancer cytotoxicity chrysin analogues flavonoid anticancer compounds |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Anticancer Agents |
| Record Nr. | UNINA-9910557129103321 |
Chen Qiao-Hong
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Drug-Drug Interactions
| Drug-Drug Interactions |
| Autore | Kim Dong Hyun |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (242 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
tadalafil
ticagrelor drug-drug interaction pharmacokinetics plasma concentration CYP3A4 Loxoprofen CYP3A Dexamethasone Ketoconazole CYP2D6 O-desmethyltramadol physiologically-based pharmacokinetics tramadol (‒)-sophoranone CYP2C9 potent inhibition in vitro in vivo drug interaction low permeability high plasma protein binding biflavonoid cytochrome P450 drug interactions selamariscina A uridine 5′-diphosphoglucuronosyl transferase tissue-specific systemic exposure P-glycoprotein (P-gp) organic anion transporting polypeptide 1A2 (OATP1A2) Rumex acetosa fexofenadine chronic kidney disease drug–drug interactions polypharmacy adverse drug reactions Lexicomp subset analysis signal detection algorithms spontaneous reporting systems mechanism-based inhibition competitive inhibition non-competitive inhibition substrate inhibitor cytochromes P450 OATP1B1 OATP1B3 tyrosine kinase inhibitors drug-drug interactions migraine lasmiditan gepants monoclonal antibodies CYP1A1 CYP1A2 drug–drug interaction expression metabolism regulation drug transporter ubiquitination ixazomib DDI computational prediction in silico QSAR drug metabolism ADME CYP metabolic DDI P450 1A2 2B6 2C19 2C8 2C9 2D6 3A4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557666403321 |
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Kim Dong Hyun
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Marine Drug Research in China: Selected Papers from the 15-NASMD Conference
| Marine Drug Research in China: Selected Papers from the 15-NASMD Conference |
| Autore | Zhou Xuefeng |
| Pubbl/distr/stampa | Basel, : MDPI Books, 2022 |
| Descrizione fisica | 1 electronic resource (512 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
Antarctic krill (Euphausia superba)
peptide antioxidant activity stability oyster plasma peptidome antimicrobial peptides cytotoxicity actinomycete piericidins absolute configuration Pestalotiopsis heterocornis heterocornols anti-inflammatory activity sponge-derived fungus sclerotides lipodepsipeptide Aspergillus sclerotiorum nasopharyngeal carcinoma AChE inhibitory vascular endothelial cell flavonoid oxidized low-density lipoprotein Nrf2 apoptosis butyrolactone I food allergy metabolism pharmacokinetics actinomycin X2 microbial pigments dyeing silk antibacterial properties PD-L1 virtual screening pharmacophore modeling ADME molecular dynamics xanthones ascidian-derived fungus Diaporthe sp anti-glioma activity antiaging Sonneratia apetala signaling pathway Caenorhabditis elegans mutants coral-derived fungi Aspergillus hiratsukae meroterpenoids antibacterial activity cytotoxic activity deep-sea-derived fungus Aspergillus puniceus isoquinoline alkaloid protein tyrosine phosphatase inhibitor antibacterial Aspergillus sp geodin semisynthesize insecticidal activity Arca inflata antitumor peptide MAPK signaling calmodulin colorectal cancer methicillin-resistant Staphylococcus aureus actinomycin D Streptomyces parvulus mechanism mangrove endophytic Pestalotiopsis Sdy-1 antitumor activity Wnt signaling β-catenin eremophilane sesquiterpenoids mangrove-derived fungus Penicillium sp Oceanapia sponge secondary metabolites biological activities drug design anticancer cyclic pentapeptide galaxamide analogues skipjack tuna (Katsuwonus pelamis) muscle angiotensin-I-converting enzyme (ACE) peptide molecular docking nitric oxide (NO) endothelin-1 (ET-1) Trichoderma longibrachiatum sesquiterpene glycoside antimicrobial activity marine fungi Aspergillus unguis depsides depsidones osteoclast differentiation soft-coral-derived fungus pyranodipyran derivatives tyrosyl DNA phosphodiesterase 1 inhibitory activities fluorescent properties butenolides enantiomers Aspergillus terreus pancreatic lipase NAFLD fucoxanthin adenosine monophosphate-activated protein kinase (AMPK) nuclear factor erythroid-2-related factor 2-mediated (Nrf2) Toll-like receptor 4-mediated (TLR4) Aspergillus flavipes HN4-13 emodin macroporous resin XAD-16 adsorption kinetics and isotherms enrichment tetramic acid derivatives deep-sea fungus clavipitacae Lecanicillium fusisporum chronic kidney disease fucoidan cognitive dysfunction neuroinflammation oxidative stress GSK3β-Nrf2-HO-1 signaling microglial polarization deep-sea actinomycetes aromatic acids oximes antihyperlipidemic phycocyanin microbiota transcriptome IL-17 pathway Hahella prodiginine chejuenlide genome mining LC-MS/MS CDK4/6 marine compounds pharmacophore construction ADMET mm-pbsa |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Marine Drug Research in China |
| Record Nr. | UNINA-9910595071903321 |
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Zhou Xuefeng
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| Basel, : MDPI Books, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Natural Additives in Food
| Natural Additives in Food |
| Autore | Barros Lillian |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (290 p.) |
| Soggetto topico | Technology: general issues |
| Soggetto non controllato |
trisodium citrate
microbial transglutaminase casein gels textural properties microstructures Urtica spp bioactive compounds antioxidant activity antimicrobial activity traditional medicine food industry animal breeding beta cyclodextrin ewe’s milk cheese Manchego lipids cholesterol anthocyanin natural extract tetraethyl orthosilicate black carrot black rice flour anthocyanins low gluten muffins added value products soymilk enzyme modified soymilk skim milk rennet induced gelation rheological properties egg yolk cholesterol extraction granules extraction anionic chelating biopolymers ADME absorption chlorophylls chlorophyllin green colorant zinc-chlorophylls copper-chlorophyll coloring foodstuff natural colorants food colors pomelo peel essential oil anti-oxidant anti-melanogenic B16 melanoma cell oxygen-containing sulfur flavor molecules β-carotene bis(2-methyl-3-furyl) disulfide (BMFDS) oxidation products beetroot betalains semi-preparative RP-HPLC in vitro human gastrointestinal digestion ex vivo colon fermentation antioxidant ability malonildialdehyde extra virgin olive oil leaf addition Tunisian varieties phenolics tocopherols Prunus spinosa L. fruit epicarp wild fruit valorization cyanidin 3-rutinoside peonidin 3-rutinoside heat and ultrasound assisted extraction response surface methodology Ocimum basilicum var. purpurascens leaves red rubin basil Heat-Assisted Extraction extraction optimization polyphenols tiger nut by-products solvent extraction horchata de chufa triple TOF-LC-MS-MS Caenorhabditis elegans antioxidants bergenin stress resistance lifespan Huntington uxi Endopleura uchi Allium cepa red cv Citrus limon pickling volatiles SPME chemometrics byproducts food additives antimicrobial antioxidant colorants texturizing agents foaming capacity and emulsifiers |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910580210003321 |
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Barros Lillian
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Novel Strategies in the Development of New Therapies, Drug Substances and Drug Carriers
| Novel Strategies in the Development of New Therapies, Drug Substances and Drug Carriers |
| Autore | Kutner Andrzej |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (450 p.) |
| Soggetto topico |
Research & information: general
Chemistry |
| Soggetto non controllato |
alpha-ketoglutarate
cell cycle apoptosis JNK cell migration cell invasion TGF-β VEGF glycoconjugates methotrexate cancer treatment glucose metabolism drug design and discovery anticancer drugs targeted therapy Warburg effect antidepressants pyrido[1,2-c]pyrimidines dual 5-HT1A/SERT activity drug design anticancer activity lung cancer resveratrol PRI-2191 vitamin D active substance delivery systems biomedical hydrogels active substance-controlled release genistein hydrogels for cosmetology hydrogels for dermatology transdermal active substance delivery systems histone deacetylase (HDAC) depression biomarker anti-depressant therapy human DNA topoisomerase cancer drug molecular docking synthesis fluorine vitamin D3 metabolite A-ring CD-ring side-chain nanoparticles molecular modeling oxidation mechanisms electrochemistry MALDI spectroscopic data cytotoxic study self-assembled monolayer gold electrode multimodal activity calcium-sensing receptor enantiomer calcimimetic calcilytic colon cancer stereospecificity HT-29 IL-8 inflammation cyclooxygenase 1,2,4-triazole pyridazinone SAR anti-inflammatory activity antioxidant activity ADME anticancer drug antimicrobial peptide (AMP) dermaseptin frog skin peptides LHRH prostate cancer Phyllomedusa bicolor therapeutic peptides copper (II) complexes thiourea cytotoxic activity proteome analysis antimicrobial activity major latex protein Chelidonium majus greater celandine defense-related proteins alkaloids cancer cells vitamin D receptor split luciferase-based biosensor CYP24A1-dependent metabolism CYP27B1 rickets genome editing vitamin D biology and action transcription ChIP-chip analysis distal enhancers histone H3 acetylation RNA polymerase II analogue actions at genes vitamin D hormone (1,25(OH)2D3) latex antiviral proteins antimicrobial compounds cytotoxicity drug discovery CRISPR/Cas9 tetrahydro-β-carbolines Plasmodium falciparum (P. falciparum) antimalarial antiparasitic agents hemolysis vitamin D analogs 25 vitamin D 24-hydroxylase CYP24A1 proliferation high-grade serous ovarian cancer cells gold Au(III) complex colorectal cancer organometallic cancer therapy metallodrugs |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910585938903321 |
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Kutner Andrzej
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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