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Drug design of zinc-enzyme inhibitors [[electronic resource] ] : functional, structural, and disease applications / / edited by Claudiu T. Supuran, Jean-Yves Winum
| Drug design of zinc-enzyme inhibitors [[electronic resource] ] : functional, structural, and disease applications / / edited by Claudiu T. Supuran, Jean-Yves Winum |
| Pubbl/distr/stampa | Hoboken, NJ, : John Wiley & Sons, c2009 |
| Descrizione fisica | 1 online resource (1072 p.) |
| Disciplina | 615/.19 |
| Altri autori (Persone) |
SupuranClaudiu T. <1962->
WinumJean-Yves |
| Collana | Wiley Series in Drug Discovery and Development |
| Soggetto topico |
Zinc enzymes - Inhibitors - Therapeutic use
Drugs - Design |
| ISBN |
1-282-34608-3
9786612346088 0-470-50816-7 0-470-50815-9 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
DRUG DESIGN OF ZINC-ENZYME INHIBITORS; CONTENTS; PREFACE; CONTRIBUTORS; PART I INTRODUCTION; 1. Introduction to Zinc Enzymes as Drug Targets; PART II DRUG DESIGN OF CARBONIC ANHYDRASE INHIBITORS AND ACTIVATORS; 2. Carbonic Anhydrases as Drug Targets: General Presentation; 3. Zinc Binding Functions in the Design of Carbonic Anhydrase Inhibitors; 4. X-Ray Crystallography of Carbonic Anhydrase Inhibitors and Its Importance in Drug Design; 5. Antiglaucoma Carbonic Anhydrase Inhibitors as Ophthalomologic Drugs
6. Diuretics with Carbonic Anhydrase Inhibitory Activity: Toward Novel Applications for Sulfonamide Drugs7. Drug Design of Carbonic Anhydrase Inhibitors as Anticonvulsant Agents; 8. Carbonic Anhydrase Inhibitors Targeting Cancer: Therapeutic, Immunologic, and Diagnostic Tools Targeting Isoforms IX and XII; 9. Fluorescent- and Spin-Labeled Sulfonamides as Probe for Carbonic Anhydrase IX; 10. Drug Design of Antiobesity Carbonic Anhydrase Inhibitors; 11. Dual Carbonic Anhydrase and Cyclooxygenase-2 Inhibition 12. Advances in the Inhibitory and Structural Investigations on Carbonic Anhydrase Isozymes XIII and XV13. Mechanism and Inhibition of the β-Class and γ-Class Carbonic Anhydrases; 14. Fungal and Nematode Carbonic Anhydrases: Their Inhibition in Drug Design; 15. Crystallographic Studies on Carbonic Anhydrases from Fungal Pathogens for Structure-Assisted Drug Development; 16. Malaria Parasite Carbonic Anhydrase and Its Inhibition in the Development of Novel Therapies of Malaria; 17. Inhibitors of Helicobacter pylori α- and β-Carbonic Anhydrases as Novel Drugs for Gastroduodenal Diseases 18. QSAR of Carbonic Anhydrase Inhibitors and Their Impact on Drug Design19. Selectivity Issues in the Design of CA Inhibitors; 20. Bicarbonate Transport Metabolons; 21. Metal Complexes of Sulfonamides as Dual Carbonic Anhydrase Inhibitors; 22. Drug Design Studies of Carbonic Anhydrase Activators; PART III DRUG DESIGN OF MATRIX METALLOPROTEINASE INHIBITORS; 23. Matrix Metalloproteinases: An Overview; 24. MMP Inhibitors Based on Earlier Succinimide Strategies: From Early to New Approaches; 25. Drug Design of Sulfonylated MMP Inhibitors; 26. ADAMs and ADAMTs Selective Synthetic Inhibitors 27. QSAR Studies of MMP InhibitorsPART IV DRUG DESIGN OF BACTERIAL ZINC PROTEASE INHIBITORS; 28. Bacterial Zinc Proteases as Orphan Targets; 29. Botulinus Toxin, Tetanus Toxin, and Anthrax Lethal Factor Inhibitors; 30. Clostridium histolyticum Collagenase Inhibitors in the Drug Design; 31. Other Bacterial Zinc Peptidases as Potential Drug Targets; PART V DRUG DESIGN STUDIES OF OTHER ZINC-CONTAINING ENZYMES; 32. Angiotensin Converting Enzyme (ACE) Inhibitors; 33. P-III Metalloproteinase (Leucurolysin-B) from Bothrops leucurus Venom: Isolation and Possible Inhibition 34. CaaX-Protein Prenyltransferase Inhibitors |
| Record Nr. | UNINA-9910139879003321 |
| Hoboken, NJ, : John Wiley & Sons, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug design of zinc-enzyme inhibitors [[electronic resource] ] : functional, structural, and disease applications / / edited by Claudiu T. Supuran, Jean-Yves Winum
| Drug design of zinc-enzyme inhibitors [[electronic resource] ] : functional, structural, and disease applications / / edited by Claudiu T. Supuran, Jean-Yves Winum |
| Pubbl/distr/stampa | Hoboken, NJ, : John Wiley & Sons, c2009 |
| Descrizione fisica | 1 online resource (1072 p.) |
| Disciplina | 615/.19 |
| Altri autori (Persone) |
SupuranClaudiu T. <1962->
WinumJean-Yves |
| Collana | Wiley Series in Drug Discovery and Development |
| Soggetto topico |
Zinc enzymes - Inhibitors - Therapeutic use
Drugs - Design |
| ISBN |
1-282-34608-3
9786612346088 0-470-50816-7 0-470-50815-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
DRUG DESIGN OF ZINC-ENZYME INHIBITORS; CONTENTS; PREFACE; CONTRIBUTORS; PART I INTRODUCTION; 1. Introduction to Zinc Enzymes as Drug Targets; PART II DRUG DESIGN OF CARBONIC ANHYDRASE INHIBITORS AND ACTIVATORS; 2. Carbonic Anhydrases as Drug Targets: General Presentation; 3. Zinc Binding Functions in the Design of Carbonic Anhydrase Inhibitors; 4. X-Ray Crystallography of Carbonic Anhydrase Inhibitors and Its Importance in Drug Design; 5. Antiglaucoma Carbonic Anhydrase Inhibitors as Ophthalomologic Drugs
6. Diuretics with Carbonic Anhydrase Inhibitory Activity: Toward Novel Applications for Sulfonamide Drugs7. Drug Design of Carbonic Anhydrase Inhibitors as Anticonvulsant Agents; 8. Carbonic Anhydrase Inhibitors Targeting Cancer: Therapeutic, Immunologic, and Diagnostic Tools Targeting Isoforms IX and XII; 9. Fluorescent- and Spin-Labeled Sulfonamides as Probe for Carbonic Anhydrase IX; 10. Drug Design of Antiobesity Carbonic Anhydrase Inhibitors; 11. Dual Carbonic Anhydrase and Cyclooxygenase-2 Inhibition 12. Advances in the Inhibitory and Structural Investigations on Carbonic Anhydrase Isozymes XIII and XV13. Mechanism and Inhibition of the β-Class and γ-Class Carbonic Anhydrases; 14. Fungal and Nematode Carbonic Anhydrases: Their Inhibition in Drug Design; 15. Crystallographic Studies on Carbonic Anhydrases from Fungal Pathogens for Structure-Assisted Drug Development; 16. Malaria Parasite Carbonic Anhydrase and Its Inhibition in the Development of Novel Therapies of Malaria; 17. Inhibitors of Helicobacter pylori α- and β-Carbonic Anhydrases as Novel Drugs for Gastroduodenal Diseases 18. QSAR of Carbonic Anhydrase Inhibitors and Their Impact on Drug Design19. Selectivity Issues in the Design of CA Inhibitors; 20. Bicarbonate Transport Metabolons; 21. Metal Complexes of Sulfonamides as Dual Carbonic Anhydrase Inhibitors; 22. Drug Design Studies of Carbonic Anhydrase Activators; PART III DRUG DESIGN OF MATRIX METALLOPROTEINASE INHIBITORS; 23. Matrix Metalloproteinases: An Overview; 24. MMP Inhibitors Based on Earlier Succinimide Strategies: From Early to New Approaches; 25. Drug Design of Sulfonylated MMP Inhibitors; 26. ADAMs and ADAMTs Selective Synthetic Inhibitors 27. QSAR Studies of MMP InhibitorsPART IV DRUG DESIGN OF BACTERIAL ZINC PROTEASE INHIBITORS; 28. Bacterial Zinc Proteases as Orphan Targets; 29. Botulinus Toxin, Tetanus Toxin, and Anthrax Lethal Factor Inhibitors; 30. Clostridium histolyticum Collagenase Inhibitors in the Drug Design; 31. Other Bacterial Zinc Peptidases as Potential Drug Targets; PART V DRUG DESIGN STUDIES OF OTHER ZINC-CONTAINING ENZYMES; 32. Angiotensin Converting Enzyme (ACE) Inhibitors; 33. P-III Metalloproteinase (Leucurolysin-B) from Bothrops leucurus Venom: Isolation and Possible Inhibition 34. CaaX-Protein Prenyltransferase Inhibitors |
| Record Nr. | UNINA-9910830981903321 |
| Hoboken, NJ, : John Wiley & Sons, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug design of zinc-enzyme inhibitors : functional, structural, and disease applications / / edited by Claudiu T. Supuran, Jean-Yves Winum
| Drug design of zinc-enzyme inhibitors : functional, structural, and disease applications / / edited by Claudiu T. Supuran, Jean-Yves Winum |
| Pubbl/distr/stampa | Hoboken, NJ, : John Wiley & Sons, c2009 |
| Descrizione fisica | 1 online resource (1072 p.) |
| Disciplina | 615/.19 |
| Altri autori (Persone) |
SupuranClaudiu T. <1962->
WinumJean-Yves |
| Collana | Wiley Series in Drug Discovery and Development |
| Soggetto topico |
Zinc enzymes - Inhibitors - Therapeutic use
Drugs - Design |
| ISBN |
1-282-34608-3
9786612346088 0-470-50816-7 0-470-50815-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
DRUG DESIGN OF ZINC-ENZYME INHIBITORS; CONTENTS; PREFACE; CONTRIBUTORS; PART I INTRODUCTION; 1. Introduction to Zinc Enzymes as Drug Targets; PART II DRUG DESIGN OF CARBONIC ANHYDRASE INHIBITORS AND ACTIVATORS; 2. Carbonic Anhydrases as Drug Targets: General Presentation; 3. Zinc Binding Functions in the Design of Carbonic Anhydrase Inhibitors; 4. X-Ray Crystallography of Carbonic Anhydrase Inhibitors and Its Importance in Drug Design; 5. Antiglaucoma Carbonic Anhydrase Inhibitors as Ophthalomologic Drugs
6. Diuretics with Carbonic Anhydrase Inhibitory Activity: Toward Novel Applications for Sulfonamide Drugs7. Drug Design of Carbonic Anhydrase Inhibitors as Anticonvulsant Agents; 8. Carbonic Anhydrase Inhibitors Targeting Cancer: Therapeutic, Immunologic, and Diagnostic Tools Targeting Isoforms IX and XII; 9. Fluorescent- and Spin-Labeled Sulfonamides as Probe for Carbonic Anhydrase IX; 10. Drug Design of Antiobesity Carbonic Anhydrase Inhibitors; 11. Dual Carbonic Anhydrase and Cyclooxygenase-2 Inhibition 12. Advances in the Inhibitory and Structural Investigations on Carbonic Anhydrase Isozymes XIII and XV13. Mechanism and Inhibition of the β-Class and γ-Class Carbonic Anhydrases; 14. Fungal and Nematode Carbonic Anhydrases: Their Inhibition in Drug Design; 15. Crystallographic Studies on Carbonic Anhydrases from Fungal Pathogens for Structure-Assisted Drug Development; 16. Malaria Parasite Carbonic Anhydrase and Its Inhibition in the Development of Novel Therapies of Malaria; 17. Inhibitors of Helicobacter pylori α- and β-Carbonic Anhydrases as Novel Drugs for Gastroduodenal Diseases 18. QSAR of Carbonic Anhydrase Inhibitors and Their Impact on Drug Design19. Selectivity Issues in the Design of CA Inhibitors; 20. Bicarbonate Transport Metabolons; 21. Metal Complexes of Sulfonamides as Dual Carbonic Anhydrase Inhibitors; 22. Drug Design Studies of Carbonic Anhydrase Activators; PART III DRUG DESIGN OF MATRIX METALLOPROTEINASE INHIBITORS; 23. Matrix Metalloproteinases: An Overview; 24. MMP Inhibitors Based on Earlier Succinimide Strategies: From Early to New Approaches; 25. Drug Design of Sulfonylated MMP Inhibitors; 26. ADAMs and ADAMTs Selective Synthetic Inhibitors 27. QSAR Studies of MMP InhibitorsPART IV DRUG DESIGN OF BACTERIAL ZINC PROTEASE INHIBITORS; 28. Bacterial Zinc Proteases as Orphan Targets; 29. Botulinus Toxin, Tetanus Toxin, and Anthrax Lethal Factor Inhibitors; 30. Clostridium histolyticum Collagenase Inhibitors in the Drug Design; 31. Other Bacterial Zinc Peptidases as Potential Drug Targets; PART V DRUG DESIGN STUDIES OF OTHER ZINC-CONTAINING ENZYMES; 32. Angiotensin Converting Enzyme (ACE) Inhibitors; 33. P-III Metalloproteinase (Leucurolysin-B) from Bothrops leucurus Venom: Isolation and Possible Inhibition 34. CaaX-Protein Prenyltransferase Inhibitors |
| Record Nr. | UNINA-9910877645303321 |
| Hoboken, NJ, : John Wiley & Sons, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
