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Enzyme systems that metabolise drugs and other xenobiotics
| Enzyme systems that metabolise drugs and other xenobiotics |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | [Place of publication not identified], : John Wiley & Sons, 2002 |
| Descrizione fisica | 1 online resource (578 pages) |
| Disciplina | 615.7 |
| Soggetto topico |
Pharmaceutical Preparations
Xenobiotics Enzymes Chemicals and Drugs Enzymes and Coenzymes Pharmacy, Therapeutics, & Pharmacology Health & Biological Sciences |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-65435-X
0-470-84630-5 9786610654352 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910142648703321 |
| [Place of publication not identified], : John Wiley & Sons, 2002 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Enzyme systems that metabolise drugs and other xenobiotics
| Enzyme systems that metabolise drugs and other xenobiotics |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | [Place of publication not identified], : John Wiley & Sons, 2002 |
| Descrizione fisica | 1 online resource (578 pages) |
| Disciplina | 615.7 |
| Soggetto topico |
Pharmaceutical Preparations
Xenobiotics Enzymes Chemicals and Drugs Enzymes and Coenzymes Pharmacy, Therapeutics, & Pharmacology Health & Biological Sciences |
| ISBN |
1-280-65435-X
0-470-84630-5 9786610654352 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910830113403321 |
| [Place of publication not identified], : John Wiley & Sons, 2002 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Enzyme systems that metabolise drugs and other xenobiotics
| Enzyme systems that metabolise drugs and other xenobiotics |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | [Place of publication not identified], : John Wiley & Sons, 2002 |
| Descrizione fisica | 1 online resource (578 pages) |
| Disciplina | 615.7 |
| Soggetto topico |
Pharmaceutical Preparations
Xenobiotics Enzymes Chemicals and Drugs Enzymes and Coenzymes Pharmacy, Therapeutics, & Pharmacology Health & Biological Sciences |
| ISBN |
1-280-65435-X
0-470-84630-5 9786610654352 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910877106803321 |
| [Place of publication not identified], : John Wiley & Sons, 2002 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Hydrolysis in drug and prodrug metabolism : chemistry, biochemistry, and enzymology
| Hydrolysis in drug and prodrug metabolism : chemistry, biochemistry, and enzymology |
| Autore | Testa Bernard |
| Pubbl/distr/stampa | [Place of publication not identified], : Wiley VCH, 2003 |
| Disciplina | 572.79343 |
| Soggetto topico |
Drugs - Metabolism
Xenobiotics - Metabolism Hydrolysis - Effect of drugs on Hydration Enzymes Hydrolysis Pharmaceutical Preparations Xenobiotics Biochemical Processes Chemicals and Drugs Chemical Processes Enzymes and Coenzymes Metabolism Biochemical Phenomena Chemical Phenomena Metabolic Phenomena Phenomena and Processes Pharmacy, Therapeutics, & Pharmacology Animal Biochemistry Health & Biological Sciences Human Anatomy & Physiology |
| ISBN | 3-906390-44-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910144012603321 |
Testa Bernard
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| [Place of publication not identified], : Wiley VCH, 2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Hydrolysis in drug and prodrug metabolism : chemistry, biochemistry, and enzymology
| Hydrolysis in drug and prodrug metabolism : chemistry, biochemistry, and enzymology |
| Autore | Testa Bernard |
| Pubbl/distr/stampa | [Place of publication not identified], : Wiley VCH, 2003 |
| Disciplina | 572.79343 |
| Soggetto topico |
Drugs - Metabolism
Xenobiotics - Metabolism Hydrolysis - Effect of drugs on Hydration Enzymes Hydrolysis Pharmaceutical Preparations Xenobiotics Biochemical Processes Chemicals and Drugs Chemical Processes Enzymes and Coenzymes Metabolism Biochemical Phenomena Chemical Phenomena Metabolic Phenomena Phenomena and Processes Pharmacy, Therapeutics, & Pharmacology Animal Biochemistry Health & Biological Sciences Human Anatomy & Physiology |
| ISBN | 3-906390-44-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910830842403321 |
|
Testa Bernard
|
||
| [Place of publication not identified], : Wiley VCH, 2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Hydrolysis in drug and prodrug metabolism : chemistry, biochemistry, and enzymology
| Hydrolysis in drug and prodrug metabolism : chemistry, biochemistry, and enzymology |
| Autore | Testa Bernard |
| Pubbl/distr/stampa | [Place of publication not identified], : Wiley VCH, 2003 |
| Disciplina | 572.79343 |
| Soggetto topico |
Drugs - Metabolism
Xenobiotics - Metabolism Hydrolysis - Effect of drugs on Hydration Enzymes Hydrolysis Pharmaceutical Preparations Xenobiotics Biochemical Processes Chemicals and Drugs Chemical Processes Enzymes and Coenzymes Metabolism Biochemical Phenomena Chemical Phenomena Metabolic Phenomena Phenomena and Processes Pharmacy, Therapeutics, & Pharmacology Animal Biochemistry Health & Biological Sciences Human Anatomy & Physiology |
| ISBN | 3-906390-44-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910877762203321 |
|
Testa Bernard
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||
| [Place of publication not identified], : Wiley VCH, 2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Journal of xenobiotics
| Journal of xenobiotics |
| Pubbl/distr/stampa | Pavia, Italy : , : PAGEPress, , [2011]- |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
Xenobiotics
Environmental Health |
| Soggetto genere / forma |
Periodicals.
Periodical |
| ISSN | 2039-4713 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910141155803321 |
| Pavia, Italy : , : PAGEPress, , [2011]- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Journal of xenobiotics
| Journal of xenobiotics |
| Pubbl/distr/stampa | Pavia, Italy : , : PAGEPress, , [2011]- |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
Xenobiotics
Environmental Health |
| Soggetto genere / forma |
Periodicals.
Periodical |
| ISSN | 2039-4713 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996321163203316 |
| Pavia, Italy : , : PAGEPress, , [2011]- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
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Physiologically based pharmacokinetic modeling [[electronic resource] ] : science and applications / / edited by Micaela B. Reddy ... [et al.]
| Physiologically based pharmacokinetic modeling [[electronic resource] ] : science and applications / / edited by Micaela B. Reddy ... [et al.] |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2005 |
| Descrizione fisica | 1 online resource (442 p.) |
| Disciplina |
615.7040724
615/.7 |
| Altri autori (Persone) | ReddyMicaela B |
| Soggetto topico |
Pharmacokinetics
Xenobiotics Toxicology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-27583-9
9786610275830 0-470-24616-2 0-471-47876-8 0-471-47877-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING; CONTENTS; PREFACE; ACKNOWLEDGMENTS; CONTRIBUTORS; CHAPTER 1 INTRODUCTION: A HISTORICAL PERSPECTIVE OF THE DEVELOPMENT AND APPLICATIONS OF PBPK MODELS; 1.1 Introduction; 1.2 A Historical Perspective; 1.2.1 Responses to Inhaled Compounds; 1.2.2 Pharmaceutical Applications; 1.2.3 Occupational and Environmental Applications; 1.2.4 Digital Computation and PBPK Modeling; 1.3 Expansion of PBPK Model Applications; 1.3.1 PBPK Models for Tissue Dosimetry from Secondary Data; 1.3.2 Biological Mechanisms Underlying Pharmacokinetic Behaviors
1.3.3 Chemicals as Probes of Biological Processes1.3.4 Risk Assessment Applications; 1.3.5 PBPK Models as Repository of Mechanistic Data on Distribution and Response; 1.4 Summary; Notation; References; PART I PBPK MODELING FOR VOLATILE ORGANIC COMPOUNDS; CHAPTER 2 HALOGENATED ALKANES; 2.1 Introduction; 2.2 PBPK Model Development for Volatile Organics; 2.2.1 Model Formulation; 2.2.2 Model Equations; 2.2.3 Model Parameterization; 2.2.4 Model Calculations; 2.3 Experimental Methods Demonstrated for Groups of Chemicals; 2.4 PBPK Models for Halogenated Alkanes; 2.4.1 Anesthetic Gases 2.4.2 Chlorofluorocarbons (CFCs), Refrigerants, and Halons2.4.3 Halogenated Alkanes; 2.5 Summary; Notation; References; CHAPTER 3 HALOGENATED ALKENES; 3.1 Introduction; 3.2 The Chloroethylenes: Background; 3.3 Review of PBPK Models; 3.3.1 Vinyl Chloride (VC); 3.3.2 Vinyl Fluoride (VF); 3.3.3 cis-1,2-Dichloroethylene (cDCE) and trans-1,2-Dichloroethylene (tDCE); 3.3.4 Vinylidene Chloride (VDC); 3.3.5 Trichloroethylene (TCE); 3.3.6 Tetrachloroethylene (PERC); 3.3.7 Allyl Chloride (AC); 3.3.8 b-Chloroprene (CD); 3.3.9 Hexachlorobutadiene, HCB; 3.4 Summary; Notation; References CHAPTER 4 ALKENE AND AROMATIC COMPOUNDS4.1 Introduction; 4.2 PK and Pharmacodynamic Properties Important in PBPK Model Development for Aromatic and Alkene Compounds; 4.2.1 Metabolism and Mode of Action; 4.2.2 Model Structures; 4.2.3 PK Differences; 4.2.4 Extrahepatic Metabolism and Transport of Metabolites; 4.2.5 GSH Conjugation; 4.2.6 Endogenous Production; 4.2.7 Reactivity with DNA and Protein; 4.2.8 Inhibition of Second Oxidative Steps; 4.2.9 Variability and PK Differences; 4.2.10 Subcompartments in PBPK Models; 4.2.11 "Privileged Access" of Epoxide Hydratase to Epoxide Substrates 4.3 Review of Aromatic and Alkene PBPK Models4.3.1 Benzene-A Known Human Carcinogen with an Uncertain Mode of Action; 4.3.2 Styrene-Early PBPK Models; 4.3.3 1,3-Butadiene; 4.3.4 Isoprene; 4.3.5 Ethylene, Propylene, and Their Oxides; 4.3.6 Naphthalene and Other PAHs; 4.3.7 Halobenzenes; 4.3.8 Miscellaneous Related Compounds; 4.4 Summary; Notation; References; CHAPTER 5 REACTIVE VAPORS IN THE NASAL CAVITY; 5.1 Introduction; 5.1.1 Nasal Effects and Risk Assessment; 5.1.2 General Models for Nasal Uptake; 5.2 No Air-Phase Models; 5.2.1 The "Perfused Nose" Model; 5.2.2 Vinyl Acetate 5.3 Creating the Air-Phase Compartments |
| Record Nr. | UNINA-9910143555503321 |
| Hoboken, N.J., : Wiley-Interscience, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Physiologically based pharmacokinetic modeling [[electronic resource] ] : science and applications / / edited by Micaela B. Reddy ... [et al.]
| Physiologically based pharmacokinetic modeling [[electronic resource] ] : science and applications / / edited by Micaela B. Reddy ... [et al.] |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2005 |
| Descrizione fisica | 1 online resource (442 p.) |
| Disciplina |
615.7040724
615/.7 |
| Altri autori (Persone) | ReddyMicaela B |
| Soggetto topico |
Pharmacokinetics
Xenobiotics Toxicology |
| ISBN |
1-280-27583-9
9786610275830 0-470-24616-2 0-471-47876-8 0-471-47877-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING; CONTENTS; PREFACE; ACKNOWLEDGMENTS; CONTRIBUTORS; CHAPTER 1 INTRODUCTION: A HISTORICAL PERSPECTIVE OF THE DEVELOPMENT AND APPLICATIONS OF PBPK MODELS; 1.1 Introduction; 1.2 A Historical Perspective; 1.2.1 Responses to Inhaled Compounds; 1.2.2 Pharmaceutical Applications; 1.2.3 Occupational and Environmental Applications; 1.2.4 Digital Computation and PBPK Modeling; 1.3 Expansion of PBPK Model Applications; 1.3.1 PBPK Models for Tissue Dosimetry from Secondary Data; 1.3.2 Biological Mechanisms Underlying Pharmacokinetic Behaviors
1.3.3 Chemicals as Probes of Biological Processes1.3.4 Risk Assessment Applications; 1.3.5 PBPK Models as Repository of Mechanistic Data on Distribution and Response; 1.4 Summary; Notation; References; PART I PBPK MODELING FOR VOLATILE ORGANIC COMPOUNDS; CHAPTER 2 HALOGENATED ALKANES; 2.1 Introduction; 2.2 PBPK Model Development for Volatile Organics; 2.2.1 Model Formulation; 2.2.2 Model Equations; 2.2.3 Model Parameterization; 2.2.4 Model Calculations; 2.3 Experimental Methods Demonstrated for Groups of Chemicals; 2.4 PBPK Models for Halogenated Alkanes; 2.4.1 Anesthetic Gases 2.4.2 Chlorofluorocarbons (CFCs), Refrigerants, and Halons2.4.3 Halogenated Alkanes; 2.5 Summary; Notation; References; CHAPTER 3 HALOGENATED ALKENES; 3.1 Introduction; 3.2 The Chloroethylenes: Background; 3.3 Review of PBPK Models; 3.3.1 Vinyl Chloride (VC); 3.3.2 Vinyl Fluoride (VF); 3.3.3 cis-1,2-Dichloroethylene (cDCE) and trans-1,2-Dichloroethylene (tDCE); 3.3.4 Vinylidene Chloride (VDC); 3.3.5 Trichloroethylene (TCE); 3.3.6 Tetrachloroethylene (PERC); 3.3.7 Allyl Chloride (AC); 3.3.8 b-Chloroprene (CD); 3.3.9 Hexachlorobutadiene, HCB; 3.4 Summary; Notation; References CHAPTER 4 ALKENE AND AROMATIC COMPOUNDS4.1 Introduction; 4.2 PK and Pharmacodynamic Properties Important in PBPK Model Development for Aromatic and Alkene Compounds; 4.2.1 Metabolism and Mode of Action; 4.2.2 Model Structures; 4.2.3 PK Differences; 4.2.4 Extrahepatic Metabolism and Transport of Metabolites; 4.2.5 GSH Conjugation; 4.2.6 Endogenous Production; 4.2.7 Reactivity with DNA and Protein; 4.2.8 Inhibition of Second Oxidative Steps; 4.2.9 Variability and PK Differences; 4.2.10 Subcompartments in PBPK Models; 4.2.11 "Privileged Access" of Epoxide Hydratase to Epoxide Substrates 4.3 Review of Aromatic and Alkene PBPK Models4.3.1 Benzene-A Known Human Carcinogen with an Uncertain Mode of Action; 4.3.2 Styrene-Early PBPK Models; 4.3.3 1,3-Butadiene; 4.3.4 Isoprene; 4.3.5 Ethylene, Propylene, and Their Oxides; 4.3.6 Naphthalene and Other PAHs; 4.3.7 Halobenzenes; 4.3.8 Miscellaneous Related Compounds; 4.4 Summary; Notation; References; CHAPTER 5 REACTIVE VAPORS IN THE NASAL CAVITY; 5.1 Introduction; 5.1.1 Nasal Effects and Risk Assessment; 5.1.2 General Models for Nasal Uptake; 5.2 No Air-Phase Models; 5.2.1 The "Perfused Nose" Model; 5.2.2 Vinyl Acetate 5.3 Creating the Air-Phase Compartments |
| Record Nr. | UNINA-9910830979003321 |
| Hoboken, N.J., : Wiley-Interscience, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
